Project name: >AFK30375.1

Chain sequence(s)	A: VTDLHIVNSFIQPDGFNRSGVLAEGVFPGPLITGNKGDNFQINVIDELTNGTMLLSTSIHWHGLFQKTTNWADGPAFVNQCPIAANDSFLYNFNVPDQAGTFWYHSHLSTQYCDGLRGPLVVYDPQDPYADLYDVDDDSTVITLADWYHVPAPQAGAVPTSDATLINGLGRSVNGPADAPFAVVNVVQGSRYRFRLVSISCDPNFLFSIDGHTFTVIEADGVNHEPIVADSIQIFAAQRYSFILTANQTADNYWIRANPNNGHTGFAGGINSAILRYSGAPVADPVTTQTSANLLKETSLVPRENPGAPGNATANGVDVDLNLVLSFVGGRFEINGVSFVPPTVPVLLQILSGATTAAELLPSGSVYTLPLNSVIQLSFNTVAVAAVGGPHPFHLHGHTFDVVRSAGSTEYNYINPPRRDVVSTGAATDNVTIRFTTDNAGPWFLHCHIDWHLEAGFAIVFAEDAPDVAAVNPVPDAWNQLCPTYDALTP
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.199
• Maximal score value: 1.9444
• Average score: -0.1221
• Total score value: -59.8494

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
23	V	A	1.7203
24	T	A	0.1222
25	D	A	-1.0277
26	L	A	0.0000
27	H	A	-0.5099
28	I	A	0.0000
29	V	A	0.2943
30	N	A	-0.1908
31	S	A	0.2174
32	F	A	1.9132
33	I	A	0.0000
34	Q	A	-1.3534
35	P	A	0.0000
36	D	A	0.0000
37	G	A	-0.3341
38	F	A	0.4255
39	N	A	-1.1970
40	R	A	0.0000
41	S	A	0.2215
42	G	A	0.0000
43	V	A	0.0000
44	L	A	0.0000
45	A	A	0.0000
46	E	A	-1.9419
47	G	A	-0.5896
48	V	A	1.1257
49	F	A	0.5169
50	P	A	0.0206
51	G	A	0.0000
52	P	A	0.0062
53	L	A	0.3522
54	I	A	0.0000
55	T	A	-0.0473
56	G	A	-0.2187
57	N	A	-0.9309
58	K	A	-1.1241
59	G	A	-0.8126
60	D	A	-0.9989
61	N	A	-0.8756
62	F	A	0.0000
63	Q	A	-0.2478
64	I	A	0.0000
65	N	A	-0.3075
66	V	A	0.0000
67	I	A	0.2315
68	D	A	0.0000
69	E	A	-1.8199
70	L	A	0.0000
71	T	A	-0.1364
72	N	A	-0.4562
73	G	A	-0.4847
74	T	A	-0.1222
75	M	A	0.0000
76	L	A	0.4689
77	L	A	0.6538
78	S	A	0.0867
79	T	A	0.0000
80	S	A	0.0000
81	I	A	0.0000
82	H	A	0.0000
83	W	A	0.0000
84	H	A	0.0000
85	G	A	-0.0571
86	L	A	0.0000
87	F	A	0.4088
88	Q	A	0.0000
89	K	A	-0.8346
90	T	A	-0.2079
91	T	A	-0.0184
92	N	A	0.0000
93	W	A	0.0000
94	A	A	0.0000
95	D	A	0.0000
96	G	A	0.0000
97	P	A	0.0000
98	A	A	0.0000
99	F	A	0.2415
100	V	A	0.0000
101	N	A	0.0000
102	Q	A	0.0000
103	C	A	0.0000
104	P	A	0.0000
105	I	A	0.0000
106	A	A	0.0000
107	A	A	-0.2214
108	N	A	-1.4671
109	D	A	-1.3219
110	S	A	-0.2445
111	F	A	0.0000
112	L	A	0.6317
113	Y	A	0.0000
114	N	A	-0.5465
115	F	A	0.0000
116	N	A	-1.3525
117	V	A	0.0000
118	P	A	-0.6540
119	D	A	-1.8693
120	Q	A	-0.5049
121	A	A	-0.0260
122	G	A	0.0000
123	T	A	0.0000
124	F	A	0.0000
125	W	A	0.0000
126	Y	A	0.0000
127	H	A	0.0000
128	S	A	0.0000
129	H	A	0.0000
130	L	A	0.0000
131	S	A	-0.0860
132	T	A	0.0000
133	Q	A	0.0000
134	Y	A	0.0000
135	C	A	0.0000
136	D	A	0.0000
137	G	A	0.0000
138	L	A	0.0000
139	R	A	0.0000
140	G	A	0.0000
141	P	A	0.0000
142	L	A	0.0000
143	V	A	0.0000
144	V	A	0.0000
145	Y	A	0.0694
146	D	A	-0.3242
147	P	A	-0.5239
148	Q	A	-1.2767
149	D	A	-0.4476
150	P	A	-0.1357
151	Y	A	0.0000
152	A	A	-0.2847
153	D	A	-1.7078
154	L	A	0.1301
155	Y	A	-0.1721
156	D	A	-1.6894
157	V	A	0.0181
158	D	A	-0.4746
159	D	A	-1.3976
160	D	A	-2.0092
161	S	A	-0.5322
162	T	A	0.0000
163	V	A	0.0000
164	I	A	0.0000
165	T	A	0.0000
166	L	A	0.0000
167	A	A	0.0000
168	D	A	0.0000
169	W	A	0.0000
170	Y	A	0.0000
171	H	A	0.0620
172	V	A	0.9921
173	P	A	0.1529
174	A	A	0.0000
175	P	A	-0.4723
176	Q	A	-1.2406
177	A	A	-0.2822
178	G	A	-0.4546
179	A	A	0.2654
180	V	A	1.6028
181	P	A	0.1961
182	T	A	-0.0817
183	S	A	-0.1783
184	D	A	-0.7550
185	A	A	0.0000
186	T	A	0.0000
187	L	A	0.0000
188	I	A	0.0000
189	N	A	-0.4780
190	G	A	0.0000
191	L	A	0.4186
192	G	A	0.0000
193	R	A	-0.2355
194	S	A	0.0000
195	V	A	1.5454
196	N	A	-0.9685
197	G	A	-0.3250
198	P	A	-0.1683
199	A	A	-0.2976
200	D	A	-1.7787
201	A	A	0.0000
202	P	A	-0.1833
203	F	A	0.3254
204	A	A	0.0000
205	V	A	0.7198
206	V	A	0.0000
207	N	A	-1.2730
208	V	A	0.0000
209	V	A	1.5536
210	Q	A	-0.9582
211	G	A	-0.6876
212	S	A	-0.2122
213	R	A	-0.5325
214	Y	A	0.0000
215	R	A	0.0000
216	F	A	0.0000
217	R	A	0.0000
218	L	A	0.0000
219	V	A	0.0000
220	S	A	0.0000
221	I	A	0.0000
222	S	A	0.0000
223	C	A	0.0000
224	D	A	-0.1752
225	P	A	0.0000
226	N	A	0.0000
227	F	A	0.0000
228	L	A	0.3997
229	F	A	0.0000
230	S	A	-0.0253
231	I	A	0.0000
232	D	A	0.0000
233	G	A	-0.4663
234	H	A	0.0000
235	T	A	-0.0977
236	F	A	0.0000
237	T	A	0.2124
238	V	A	0.0000
239	I	A	0.0000
240	E	A	0.0000
241	A	A	0.0000
242	D	A	0.0000
243	G	A	-0.0406
244	V	A	0.1014
245	N	A	-0.5078
246	H	A	0.0000
247	E	A	-1.1788
248	P	A	-0.2880
249	I	A	0.5496
250	V	A	1.4601
251	A	A	0.0000
252	D	A	-0.2657
253	S	A	0.0000
254	I	A	0.0000
255	Q	A	-0.4216
256	I	A	0.0000
257	F	A	0.2066
258	A	A	0.0000
259	A	A	0.0000
260	Q	A	0.0000
261	R	A	0.0000
262	Y	A	0.0000
263	S	A	0.0000
264	F	A	0.0000
265	I	A	0.0000
266	L	A	0.0000
267	T	A	-0.1106
268	A	A	0.0000
269	N	A	-1.3575
270	Q	A	-0.7087
271	T	A	-0.1457
272	A	A	-0.1255
273	D	A	-0.8759
274	N	A	0.0000
275	Y	A	0.0000
276	W	A	0.1366
277	I	A	0.0000
278	R	A	0.0000
279	A	A	0.0000
280	N	A	-0.2195
281	P	A	0.0000
282	N	A	-1.1638
283	N	A	-0.6627
284	G	A	-0.4792
285	H	A	-0.7051
286	T	A	-0.2123
287	G	A	-0.1009
288	F	A	0.2957
289	A	A	0.0312
290	G	A	-0.4558
291	G	A	0.0000
292	I	A	0.0000
293	N	A	0.0000
294	S	A	0.0000
295	A	A	0.0000
296	I	A	0.0000
297	L	A	0.0000
298	R	A	0.0000
299	Y	A	0.0000
300	S	A	-0.2708
301	G	A	-0.4988
302	A	A	-0.2140
303	P	A	0.0728
304	V	A	1.7323
305	A	A	0.1798
306	D	A	-0.9611
307	P	A	0.0000
308	V	A	1.7702
309	T	A	0.2953
310	T	A	-0.2870
311	Q	A	-1.2234
312	T	A	-0.3146
313	S	A	-0.1916
314	A	A	-0.1653
315	N	A	-0.9335
316	L	A	0.5622
317	L	A	-0.0038
318	K	A	-1.7081
319	E	A	-0.5459
320	T	A	-0.1017
321	S	A	-0.2013
322	L	A	0.0000
323	V	A	0.1926
324	P	A	0.0000
325	R	A	-1.8126
326	E	A	-2.1990
327	N	A	-1.0996
328	P	A	-0.2215
329	G	A	-0.0548
330	A	A	-0.0334
331	P	A	-0.1153
332	G	A	-0.7104
333	N	A	-1.3580
334	A	A	-0.1831
335	T	A	-0.0317
336	A	A	-0.1786
337	N	A	-1.2761
338	G	A	-0.3959
339	V	A	-0.0833
340	D	A	-1.6662
341	V	A	-0.0209
342	D	A	-0.5787
343	L	A	-0.0356
344	N	A	-0.8768
345	L	A	0.0000
346	V	A	1.5655
347	L	A	0.0000
348	S	A	0.0584
349	F	A	1.1076
350	V	A	1.8351
351	G	A	-0.2340
352	G	A	-0.6830
353	R	A	-0.8061
354	F	A	0.0000
355	E	A	-0.2440
356	I	A	0.0000
357	N	A	-0.6373
358	G	A	-0.5335
359	V	A	0.2232
360	S	A	-0.0185
361	F	A	0.0000
362	V	A	1.7365
363	P	A	0.1042
364	P	A	-0.0743
365	T	A	0.1048
366	V	A	0.9710
367	P	A	0.0000
368	V	A	0.0000
369	L	A	0.0000
370	L	A	0.3697
371	Q	A	-0.0538
372	I	A	0.0000
373	L	A	0.3848
374	S	A	-0.2282
375	G	A	-0.5040
376	A	A	-0.0902
377	T	A	-0.0796
378	T	A	-0.0667
379	A	A	0.0111
380	A	A	-0.1536
381	E	A	-1.1829
382	L	A	0.0000
383	L	A	1.1631
384	P	A	0.0000
385	S	A	-0.1670
386	G	A	-0.5051
387	S	A	0.0000
388	V	A	0.0000
389	Y	A	0.1693
390	T	A	-0.0099
391	L	A	0.0000
392	P	A	0.0658
393	L	A	0.7174
394	N	A	-1.1013
395	S	A	-0.2072
396	V	A	0.2649
397	I	A	0.0000
398	Q	A	0.0000
399	L	A	0.0000
400	S	A	0.0000
401	F	A	0.0000
402	N	A	-0.7539
403	T	A	0.0000
404	V	A	0.3878
405	A	A	0.4422
406	V	A	1.7855
407	A	A	0.3324
408	A	A	0.0000
409	V	A	0.9577
410	G	A	-0.3541
411	G	A	-0.5172
412	P	A	-0.1738
413	H	A	0.0000
414	P	A	0.0000
415	F	A	0.0000
416	H	A	0.0000
417	L	A	0.0000
418	H	A	0.0000
419	G	A	0.0000
420	H	A	0.0000
421	T	A	-0.0154
422	F	A	0.0000
423	D	A	0.0000
424	V	A	0.0000
425	V	A	0.0000
426	R	A	-0.1915
427	S	A	0.0000
428	A	A	-0.0663
429	G	A	-0.4672
430	S	A	-0.1198
431	T	A	-0.4062
432	E	A	-1.7807
433	Y	A	-0.1357
434	N	A	-0.2337
435	Y	A	0.4531
436	I	A	1.9444
437	N	A	-0.0732
438	P	A	0.0000
439	P	A	0.0000
440	R	A	-0.4987
441	R	A	0.0000
442	D	A	0.0000
443	V	A	0.0000
444	V	A	0.0000
445	S	A	0.0000
446	T	A	0.0000
447	G	A	0.0000
448	A	A	0.0685
449	A	A	0.0928
450	T	A	-0.0611
451	D	A	0.0000
452	N	A	-0.3514
453	V	A	0.0000
454	T	A	0.0000
455	I	A	0.0000
456	R	A	0.0000
457	F	A	0.0000
458	T	A	-0.0147
459	T	A	0.0000
460	D	A	-1.7894
461	N	A	0.0000
462	A	A	0.0000
463	G	A	0.0000
464	P	A	0.0000
465	W	A	0.0000
466	F	A	0.0000
467	L	A	0.0000
468	H	A	0.0000
469	C	A	0.0000
470	H	A	0.0000
471	I	A	0.0000
472	D	A	0.0000
473	W	A	0.0000
474	H	A	0.0000
475	L	A	-0.0152
476	E	A	-1.0050
477	A	A	-0.2568
478	G	A	0.0000
479	F	A	0.0000
480	A	A	0.0000
481	I	A	0.0000
482	V	A	0.0000
483	F	A	0.0000
484	A	A	0.0000
485	E	A	0.0000
486	D	A	-0.0854
487	A	A	0.0000
488	P	A	-0.4464
489	D	A	-1.1194
490	V	A	0.0000
491	A	A	0.0566
492	A	A	0.1625
493	V	A	0.5426
494	N	A	0.0000
495	P	A	-0.1840
496	V	A	0.3273
497	P	A	-0.3262
498	D	A	-1.7976
499	A	A	-0.2961
500	W	A	0.0000
501	N	A	-1.0251
502	Q	A	-1.3442
503	L	A	0.0000
504	C	A	0.0306
505	P	A	-0.2471
506	T	A	-0.0219
507	Y	A	-0.0312
508	D	A	-1.7260
509	A	A	-0.1339
510	L	A	0.7206
511	T	A	0.0185
512	P	A	-0.2676