| Chain sequence(s) |
A: SLAVALARVAAYQEIKDSGLLGPGPGPSLSIRAHTVLEGEPGPGPGEWAGIAAGSAAAIGLGPGPGRNQLHALRFADIDTVGPGPGHKARKKGTSALLSAKKKRPSLSIRAHTVLEGEPKKHRDSVSFSRRNKKGYRDGAHAEHTAYAADRFRQVDGYYERDLSTGRRASTPKKERTEHKARKKGTSALLSAEAAAKMLSKDIIKLLNEQVNKEMNSSNLYMSMSSWCYTHSLDGAGLFLFDHAAEEYEHAKKLIIFLNENNVPVQLTSISAPEHKFEGLTQIFQKAYEHEQHISESINNIVDHAIKSKDHATFNFLQWYVAEQHEEEVLFKDILDKIELIGNENHGLYLADQYVKGIAKSRKS
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:12:01)
[INFO] Main: Simulation completed successfully. (00:12:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | S | A | 1.3464 | |
| 2 | L | A | 2.3068 | |
| 3 | A | A | 2.0742 | |
| 4 | V | A | 2.5153 | |
| 5 | A | A | 1.9621 | |
| 6 | L | A | 2.5953 | |
| 7 | A | A | 1.2725 | |
| 8 | R | A | -0.0751 | |
| 9 | V | A | 1.1850 | |
| 10 | A | A | 0.0738 | |
| 11 | A | A | -0.7991 | |
| 12 | Y | A | -0.4085 | |
| 13 | Q | A | -2.5262 | |
| 14 | E | A | -2.8930 | |
| 15 | I | A | -0.9174 | |
| 16 | K | A | -2.4800 | |
| 17 | D | A | -3.0408 | |
| 18 | S | A | -1.4777 | |
| 19 | G | A | -0.7721 | |
| 20 | L | A | 1.1505 | |
| 21 | L | A | 1.3979 | |
| 22 | G | A | 0.1097 | |
| 23 | P | A | -0.3612 | |
| 24 | G | A | -0.7671 | |
| 25 | P | A | -0.8994 | |
| 26 | G | A | -0.7393 | |
| 27 | P | A | -0.2806 | |
| 28 | S | A | 0.2252 | |
| 29 | L | A | 1.6566 | |
| 30 | S | A | 1.0534 | |
| 31 | I | A | 1.3120 | |
| 32 | R | A | -0.5593 | |
| 33 | A | A | -0.1456 | |
| 34 | H | A | -0.4455 | |
| 35 | T | A | 0.0075 | |
| 36 | V | A | 1.3298 | |
| 37 | L | A | 0.6270 | |
| 38 | E | A | -1.4602 | |
| 39 | G | A | -1.7444 | |
| 40 | E | A | -2.5675 | |
| 41 | P | A | -1.7679 | |
| 42 | G | A | -1.4528 | |
| 43 | P | A | -1.1517 | |
| 44 | G | A | -1.2005 | |
| 45 | P | A | -1.5383 | |
| 46 | G | A | -0.9414 | |
| 47 | E | A | -0.6608 | |
| 48 | W | A | 1.0317 | |
| 49 | A | A | 0.5797 | |
| 50 | G | A | 0.3960 | |
| 51 | I | A | 1.7696 | |
| 52 | A | A | 0.9273 | |
| 53 | A | A | 0.4927 | |
| 54 | G | A | 0.0806 | |
| 55 | S | A | 0.2082 | |
| 56 | A | A | 0.6369 | |
| 57 | A | A | 0.8102 | |
| 58 | A | A | 1.3184 | |
| 59 | I | A | 2.2289 | |
| 60 | G | A | 1.1645 | |
| 61 | L | A | 1.6336 | |
| 62 | G | A | 0.1748 | |
| 63 | P | A | -1.1747 | |
| 64 | G | A | -1.3091 | |
| 65 | P | A | -1.5490 | |
| 66 | G | A | -2.1597 | |
| 67 | R | A | -3.0447 | |
| 68 | N | A | -2.7453 | |
| 69 | Q | A | -1.9277 | |
| 70 | L | A | -0.7722 | |
| 71 | H | A | -1.6504 | |
| 72 | A | A | -0.8914 | |
| 73 | L | A | 0.1163 | |
| 74 | R | A | -0.7134 | |
| 75 | F | A | 1.0703 | |
| 76 | A | A | 0.0347 | |
| 77 | D | A | -0.8722 | |
| 78 | I | A | 0.7709 | |
| 79 | D | A | -0.8344 | |
| 80 | T | A | 0.2696 | |
| 81 | V | A | 1.2000 | |
| 82 | G | A | -0.0060 | |
| 83 | P | A | -0.7672 | |
| 84 | G | A | -0.9244 | |
| 85 | P | A | -1.2208 | |
| 86 | G | A | -1.8686 | |
| 87 | H | A | -3.2093 | |
| 88 | K | A | -4.0065 | |
| 89 | A | A | -3.2871 | |
| 90 | R | A | -4.1867 | |
| 91 | K | A | -4.1776 | |
| 92 | K | A | -3.4898 | |
| 93 | G | A | -2.1094 | |
| 94 | T | A | -0.9887 | |
| 95 | S | A | -0.8133 | |
| 96 | A | A | -0.1313 | |
| 97 | L | A | 1.0041 | |
| 98 | L | A | 0.7504 | |
| 99 | S | A | -0.5315 | |
| 100 | A | A | -0.8405 | |
| 101 | K | A | -1.9727 | |
| 102 | K | A | -3.0456 | |
| 103 | K | A | -3.4854 | |
| 104 | R | A | -3.1041 | |
| 105 | P | A | -1.2671 | |
| 106 | S | A | -0.9602 | |
| 107 | L | A | -0.0401 | |
| 108 | S | A | 0.2102 | |
| 109 | I | A | 1.0808 | |
| 110 | R | A | -0.6265 | |
| 111 | A | A | -0.4373 | |
| 112 | H | A | -0.9987 | |
| 113 | T | A | -0.7876 | |
| 114 | V | A | -0.1846 | |
| 115 | L | A | -0.6821 | |
| 116 | E | A | -2.1712 | |
| 117 | G | A | -2.0951 | |
| 118 | E | A | -2.9253 | |
| 119 | P | A | -2.5470 | |
| 120 | K | A | -3.5220 | |
| 121 | K | A | -3.9594 | |
| 122 | H | A | -3.7159 | |
| 123 | R | A | -3.5969 | |
| 124 | D | A | -2.8362 | |
| 125 | S | A | -0.7980 | |
| 126 | V | A | 1.3514 | |
| 127 | S | A | 0.9600 | |
| 128 | F | A | 1.1168 | |
| 129 | S | A | -1.0115 | |
| 130 | R | A | -3.3368 | |
| 131 | R | A | -3.8586 | |
| 132 | N | A | -3.3521 | |
| 133 | K | A | -3.8775 | |
| 134 | K | A | -3.8962 | |
| 135 | G | A | -2.5078 | |
| 136 | Y | A | -2.5069 | |
| 137 | R | A | -3.4564 | |
| 138 | D | A | -3.1526 | |
| 139 | G | A | -2.5191 | |
| 140 | A | A | -2.3642 | |
| 141 | H | A | -2.3491 | |
| 142 | A | A | -1.7698 | |
| 143 | E | A | -2.4154 | |
| 144 | H | A | -2.0004 | |
| 145 | T | A | -1.4403 | |
| 146 | A | A | -1.0134 | |
| 147 | Y | A | -0.9189 | |
| 148 | A | A | -1.0901 | |
| 149 | A | A | -1.2871 | |
| 150 | D | A | -2.3696 | |
| 151 | R | A | -2.5242 | |
| 152 | F | A | -1.2550 | |
| 153 | R | A | -2.8388 | |
| 154 | Q | A | -2.8157 | |
| 155 | V | A | -1.2212 | |
| 156 | D | A | -1.9514 | |
| 157 | G | A | -0.6553 | |
| 158 | Y | A | 0.8560 | |
| 159 | Y | A | 0.4286 | |
| 160 | E | A | -0.9143 | |
| 161 | R | A | -2.4609 | |
| 162 | D | A | -2.1379 | |
| 163 | L | A | -0.2333 | |
| 164 | S | A | -0.3588 | |
| 165 | T | A | -1.1960 | |
| 166 | G | A | -1.7356 | |
| 167 | R | A | -3.2956 | |
| 168 | R | A | -2.9369 | |
| 169 | A | A | -1.9408 | |
| 170 | S | A | -1.4150 | |
| 171 | T | A | -1.1646 | |
| 172 | P | A | -1.7694 | |
| 173 | K | A | -3.0916 | |
| 174 | K | A | -3.3581 | |
| 175 | E | A | -3.0683 | |
| 176 | R | A | -3.8943 | |
| 177 | T | A | -3.6056 | |
| 178 | E | A | 0.0000 | |
| 179 | H | A | -4.3903 | |
| 180 | K | A | -4.4968 | |
| 181 | A | A | -3.8050 | |
| 182 | R | A | -4.7243 | |
| 183 | K | A | -4.3869 | |
| 184 | K | A | -3.8936 | |
| 185 | G | A | -2.2964 | |
| 186 | T | A | -1.4296 | |
| 187 | S | A | -1.2019 | |
| 188 | A | A | -0.1621 | |
| 189 | L | A | 1.4848 | |
| 190 | L | A | 0.9678 | |
| 191 | S | A | 0.2708 | |
| 192 | A | A | -1.0990 | |
| 193 | E | A | -2.0950 | |
| 194 | A | A | -0.9837 | |
| 195 | A | A | 0.0000 | |
| 196 | A | A | -1.4968 | |
| 197 | K | A | -2.1938 | |
| 198 | M | A | -1.0561 | |
| 199 | L | A | 0.0000 | |
| 200 | S | A | -2.1311 | |
| 201 | K | A | -3.0061 | |
| 202 | D | A | -3.0125 | |
| 203 | I | A | 0.0000 | |
| 204 | I | A | -1.7709 | |
| 205 | K | A | -2.4858 | |
| 206 | L | A | -1.6312 | |
| 207 | L | A | 0.0000 | |
| 208 | N | A | -1.1656 | |
| 209 | E | A | -1.5024 | |
| 210 | Q | A | 0.0000 | |
| 211 | V | A | 0.0000 | |
| 212 | N | A | 0.0000 | |
| 213 | K | A | -1.3991 | |
| 214 | E | A | 0.0000 | |
| 215 | M | A | -0.5684 | |
| 216 | N | A | -0.6093 | |
| 217 | S | A | 0.0000 | |
| 218 | S | A | 0.0000 | |
| 219 | N | A | -0.4420 | |
| 220 | L | A | 0.0000 | |
| 221 | Y | A | 0.0000 | |
| 222 | M | A | 0.3918 | |
| 223 | S | A | -0.5537 | |
| 224 | M | A | 0.0000 | |
| 225 | S | A | 0.0000 | |
| 226 | S | A | 0.1695 | |
| 227 | W | A | -0.6189 | |
| 228 | C | A | 0.0000 | |
| 229 | Y | A | 0.4623 | |
| 230 | T | A | -0.1535 | |
| 231 | H | A | -0.8403 | |
| 232 | S | A | -0.4293 | |
| 233 | L | A | 0.0000 | |
| 234 | D | A | -1.0404 | |
| 235 | G | A | 0.0000 | |
| 236 | A | A | 0.0000 | |
| 237 | G | A | 0.0000 | |
| 238 | L | A | 0.1494 | |
| 239 | F | A | 0.0000 | |
| 240 | L | A | 0.0000 | |
| 241 | F | A | 1.1273 | |
| 242 | D | A | -0.0850 | |
| 243 | H | A | 0.0000 | |
| 244 | A | A | 0.0000 | |
| 245 | A | A | -0.2151 | |
| 246 | E | A | -0.9663 | |
| 247 | E | A | 0.0000 | |
| 248 | Y | A | -0.9207 | |
| 249 | E | A | -2.2853 | |
| 250 | H | A | -1.4581 | |
| 251 | A | A | 0.0000 | |
| 252 | K | A | -1.7565 | |
| 253 | K | A | -1.2186 | |
| 254 | L | A | 0.0000 | |
| 255 | I | A | -0.5843 | |
| 256 | I | A | -0.3376 | |
| 257 | F | A | -0.3829 | |
| 258 | L | A | 0.0000 | |
| 259 | N | A | -1.7841 | |
| 260 | E | A | -2.1159 | |
| 261 | N | A | 0.0000 | |
| 262 | N | A | -1.4774 | |
| 263 | V | A | 0.0000 | |
| 264 | P | A | -0.7006 | |
| 265 | V | A | -0.4160 | |
| 266 | Q | A | -0.8275 | |
| 267 | L | A | 0.4770 | |
| 268 | T | A | -0.0066 | |
| 269 | S | A | 0.2088 | |
| 270 | I | A | 0.2334 | |
| 271 | S | A | -0.4322 | |
| 272 | A | A | -0.6502 | |
| 273 | P | A | -1.4890 | |
| 274 | E | A | -2.9387 | |
| 275 | H | A | -2.8617 | |
| 276 | K | A | -3.1819 | |
| 277 | F | A | 0.0000 | |
| 278 | E | A | -2.4352 | |
| 279 | G | A | -1.6243 | |
| 280 | L | A | 0.0000 | |
| 281 | T | A | -1.7745 | |
| 282 | Q | A | -1.6919 | |
| 283 | I | A | 0.0000 | |
| 284 | F | A | 0.0000 | |
| 285 | Q | A | -2.0141 | |
| 286 | K | A | -1.5668 | |
| 287 | A | A | 0.0000 | |
| 288 | Y | A | -1.4720 | |
| 289 | E | A | -2.0416 | |
| 290 | H | A | -1.7810 | |
| 291 | E | A | 0.0000 | |
| 292 | Q | A | -1.9887 | |
| 293 | H | A | -2.1460 | |
| 294 | I | A | 0.0000 | |
| 295 | S | A | 0.0000 | |
| 296 | E | A | -2.8965 | |
| 297 | S | A | -2.2885 | |
| 298 | I | A | 0.0000 | |
| 299 | N | A | -2.7176 | |
| 300 | N | A | -2.7017 | |
| 301 | I | A | 0.0000 | |
| 302 | V | A | 0.0000 | |
| 303 | D | A | -2.4242 | |
| 304 | H | A | -2.2826 | |
| 305 | A | A | 0.0000 | |
| 306 | I | A | -1.2693 | |
| 307 | K | A | -2.3408 | |
| 308 | S | A | -1.9773 | |
| 309 | K | A | -2.2508 | |
| 310 | D | A | 0.0000 | |
| 311 | H | A | -1.4631 | |
| 312 | A | A | -0.5870 | |
| 313 | T | A | 0.0000 | |
| 314 | F | A | -0.7306 | |
| 315 | N | A | -0.9111 | |
| 316 | F | A | -0.0069 | |
| 317 | L | A | 0.0000 | |
| 318 | Q | A | -0.3769 | |
| 319 | W | A | 0.2527 | |
| 320 | Y | A | 0.0000 | |
| 321 | V | A | -0.7652 | |
| 322 | A | A | -0.7849 | |
| 323 | E | A | -1.5149 | |
| 324 | Q | A | 0.0000 | |
| 325 | H | A | -1.8193 | |
| 326 | E | A | -2.2493 | |
| 327 | E | A | -1.5199 | |
| 328 | E | A | -1.4846 | |
| 329 | V | A | -0.2990 | |
| 330 | L | A | -0.7927 | |
| 331 | F | A | 0.0000 | |
| 332 | K | A | -2.5584 | |
| 333 | D | A | -2.3355 | |
| 334 | I | A | 0.0000 | |
| 335 | L | A | -2.2937 | |
| 336 | D | A | -3.2181 | |
| 337 | K | A | -2.3207 | |
| 338 | I | A | 0.0000 | |
| 339 | E | A | -2.1541 | |
| 340 | L | A | -0.0188 | |
| 341 | I | A | -0.4863 | |
| 342 | G | A | -1.6815 | |
| 343 | N | A | -2.6403 | |
| 344 | E | A | -3.0697 | |
| 345 | N | A | -2.4494 | |
| 346 | H | A | -1.6776 | |
| 347 | G | A | -0.9381 | |
| 348 | L | A | -0.8495 | |
| 349 | Y | A | 0.3304 | |
| 350 | L | A | 0.8252 | |
| 351 | A | A | 0.0000 | |
| 352 | D | A | 0.0000 | |
| 353 | Q | A | -0.4155 | |
| 354 | Y | A | 0.7430 | |
| 355 | V | A | 0.0000 | |
| 356 | K | A | -1.1540 | |
| 357 | G | A | -1.1007 | |
| 358 | I | A | -0.7446 | |
| 359 | A | A | 0.0000 | |
| 360 | K | A | -2.5383 | |
| 361 | S | A | -2.0113 | |
| 362 | R | A | -2.3983 | |
| 363 | K | A | -2.8584 | |
| 364 | S | A | -1.7694 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine