Project name: a85b5ea66cf9ee4

Chain sequence(s)	A: EVQLVESGGGLVQPGRSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSAITWNSGHIDYADSVEGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAKVSYLSTASSLDYWGQGTLVTVSSASTKGPSVFPLTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSTQTYICNVNHKPSNT
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:28)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:30)

• Minimal score value: -2.9694
• Maximal score value: 2.3077
• Average score: -0.4526
• Total score value: -90.0737

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	A	-1.9403
2	V	A	-0.7118
3	Q	A	-0.7875
4	L	A	0.0000
5	V	A	0.7434
6	E	A	0.0000
7	S	A	-0.3529
8	G	A	-0.9434
9	G	A	-0.6963
10	G	A	-0.3688
11	L	A	-0.2421
12	V	A	0.0000
13	Q	A	-2.0207
14	P	A	-2.1431
15	G	A	-2.3491
16	R	A	-2.9288
17	S	A	-2.1594
18	L	A	-1.6077
19	R	A	-2.1361
20	L	A	0.0000
21	S	A	-0.4814
22	C	A	0.0000
23	A	A	-0.2420
24	A	A	-0.3960
25	S	A	-0.6745
26	G	A	-0.9349
27	F	A	-0.5735
28	T	A	-0.8882
29	F	A	0.0000
30	D	A	-2.7149
31	D	A	-1.2645
32	Y	A	-0.1604
33	A	A	0.0000
34	M	A	0.0000
35	H	A	-0.0468
36	W	A	0.0000
37	V	A	0.0000
38	R	A	0.0000
39	Q	A	-0.4317
40	A	A	-1.0868
41	P	A	-0.9936
42	G	A	-1.3643
43	K	A	-2.0463
44	G	A	-0.9312
45	L	A	0.5487
46	E	A	-0.1811
47	W	A	0.4107
48	V	A	0.0000
49	S	A	0.0000
50	A	A	-0.3433
51	I	A	0.0000
52	T	A	0.0000
53	W	A	-1.0906
54	N	A	-1.9228
55	S	A	-1.0063
56	G	A	-1.0691
57	H	A	-1.2168
58	I	A	-0.4058
59	D	A	-1.8409
60	Y	A	-1.5103
61	A	A	-1.6987
62	D	A	-2.6783
63	S	A	-1.6530
64	V	A	0.0000
65	E	A	-2.9694
66	G	A	-1.8282
67	R	A	-1.2987
68	F	A	0.0000
69	T	A	-0.9914
70	I	A	0.0000
71	S	A	-0.3707
72	R	A	-1.2020
73	D	A	-1.8237
74	N	A	-2.2314
75	A	A	-1.6026
76	K	A	-2.4523
77	N	A	-2.1517
78	S	A	0.0000
79	L	A	0.0000
80	Y	A	-0.6098
81	L	A	0.0000
82	Q	A	-1.5706
83	M	A	0.0000
84	N	A	-2.3275
85	S	A	-1.8390
86	L	A	0.0000
87	R	A	-2.7693
88	A	A	-1.8197
89	E	A	-2.2901
90	D	A	0.0000
91	T	A	-0.8216
92	A	A	0.0000
93	V	A	0.2291
94	Y	A	0.0000
95	Y	A	0.2719
96	C	A	0.0000
97	A	A	0.0000
98	K	A	0.0000
99	V	A	0.0000
100	S	A	0.3411
101	Y	A	1.4226
102	L	A	1.5048
103	S	A	0.7040
104	T	A	0.3142
105	A	A	0.3114
106	S	A	0.1929
107	S	A	-0.2799
108	L	A	-0.1653
109	D	A	-0.8873
110	Y	A	0.5351
111	W	A	0.6085
112	G	A	0.1758
113	Q	A	-0.8306
114	G	A	0.0000
115	T	A	-0.0194
116	L	A	0.0551
117	V	A	0.0000
118	T	A	-0.5114
119	V	A	0.0000
120	S	A	-0.7031
121	S	A	-0.6918
122	A	A	-0.5229
123	S	A	-0.7197
124	T	A	-1.0164
125	K	A	-2.1397
126	G	A	-1.7576
127	P	A	-0.7206
128	S	A	0.0183
129	V	A	1.1728
130	F	A	1.6484
131	P	A	1.4608
132	L	A	2.0083
143	T	A	-0.2460
144	A	A	-0.1266
145	A	A	0.3928
146	L	A	1.0500
147	G	A	0.0000
148	C	A	0.0000
149	L	A	1.2037
150	V	A	0.0000
151	K	A	-0.3900
152	D	A	-0.5106
153	Y	A	0.0000
154	F	A	0.0000
155	P	A	0.0000
156	E	A	-0.7495
157	P	A	-0.8851
158	V	A	0.0000
159	T	A	-0.9394
160	V	A	0.0000
161	S	A	-0.5925
162	W	A	0.0000
163	N	A	-0.1397
164	S	A	-0.4756
165	G	A	-0.7624
166	A	A	-0.2125
167	L	A	0.1154
168	T	A	-0.1551
169	S	A	-0.3157
170	G	A	-0.3381
171	V	A	0.2307
172	H	A	-0.2041
173	T	A	0.2417
174	F	A	0.9073
175	P	A	0.5043
176	A	A	1.1371
177	V	A	2.3077
178	L	A	1.7985
179	Q	A	0.2718
180	S	A	-0.0901
181	S	A	-0.2990
182	G	A	0.1923
183	L	A	0.0736
184	Y	A	0.7717
185	S	A	0.5356
186	L	A	0.0000
187	S	A	0.6515
188	S	A	0.0000
189	V	A	0.9091
190	V	A	0.0000
191	T	A	-0.0964
192	V	A	0.0000
193	P	A	-0.4657
194	S	A	-0.3569
199	T	A	-0.3970
200	Q	A	-0.5621
201	T	A	0.0674
202	Y	A	0.8086
203	I	A	1.1550
204	C	A	0.5802
205	N	A	-1.0367
206	V	A	-0.6879
207	N	A	-2.1425
208	H	A	0.0000
209	K	A	-2.6599
210	P	A	-1.9022
211	S	A	-1.9476
212	N	A	-2.3826
213	T	A	-1.4167