| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFEDIVVNGKVLVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTEPQHPTADDRVSFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRSGPVGHPLPADPPPSPLYVPPPPDSPYAVPPPYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPPVNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9425 | |
| 2 | L | A | 1.9653 | |
| 3 | P | A | 0.6527 | |
| 4 | P | A | 0.3589 | |
| 5 | T | A | 0.1133 | |
| 6 | T | A | 0.1262 | |
| 7 | P | A | 0.1603 | |
| 8 | V | A | 1.2414 | |
| 9 | A | A | 0.0867 | |
| 10 | K | A | -1.0224 | |
| 11 | V | A | -0.1569 | |
| 12 | Q | A | -1.3967 | |
| 13 | S | A | -1.5480 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4120 | |
| 16 | E | A | -2.4347 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4593 | |
| 20 | P | A | 0.1280 | |
| 21 | T | A | 0.1572 | |
| 22 | S | A | -0.0960 | |
| 23 | L | A | 0.0922 | |
| 24 | F | A | -0.0227 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2930 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.9026 | |
| 31 | R | A | -2.6900 | |
| 32 | L | A | -0.8068 | |
| 33 | L | A | 1.1551 | |
| 34 | T | A | 1.3722 | |
| 35 | V | A | 1.8339 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2661 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6930 | |
| 40 | E | A | -1.8046 | |
| 41 | D | A | -0.7937 | |
| 42 | I | A | 1.2379 | |
| 43 | V | A | 2.1773 | |
| 44 | V | A | 1.6282 | |
| 45 | N | A | -0.5553 | |
| 46 | G | A | -0.3811 | |
| 47 | K | A | -0.1540 | |
| 48 | V | A | 1.9817 | |
| 49 | L | A | 2.5185 | |
| 50 | V | A | 1.4197 | |
| 51 | P | A | 0.2939 | |
| 52 | K | A | -0.7448 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1605 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3979 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2722 | |
| 70 | K | A | -1.7921 | |
| 71 | F | A | -0.6411 | |
| 72 | A | A | -0.5726 | |
| 73 | L | A | -0.8596 | |
| 74 | P | A | -1.2073 | |
| 75 | Q | A | -2.5010 | |
| 76 | K | A | -3.1071 | |
| 77 | D | A | -2.9884 | |
| 78 | F | A | -1.6771 | |
| 79 | Y | A | -1.8837 | |
| 80 | D | A | -2.6799 | |
| 81 | P | A | -2.3011 | |
| 82 | E | A | -3.0426 | |
| 83 | K | A | -3.3892 | |
| 84 | E | A | -2.4540 | |
| 85 | R | A | -1.2875 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6343 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9660 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3721 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7050 | |
| 99 | G | A | -0.5402 | |
| 100 | P | A | -0.4133 | |
| 101 | L | A | 0.0263 | |
| 102 | G | A | -0.2451 | |
| 103 | K | A | -0.6759 | |
| 104 | G | A | -0.4601 | |
| 105 | T | A | -0.4552 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.0940 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.3087 | |
| 110 | L | A | 0.3112 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1362 | |
| 113 | K | A | -0.4965 | |
| 114 | L | A | -0.9525 | |
| 115 | G | A | -1.0387 | |
| 116 | D | A | -1.4440 | |
| 117 | T | A | -1.0366 | |
| 118 | E | A | -1.7636 | |
| 119 | N | A | -2.1902 | |
| 120 | P | A | -1.9950 | |
| 121 | T | A | -1.6619 | |
| 122 | E | A | -2.4242 | |
| 123 | P | A | -1.3711 | |
| 124 | Q | A | -1.3678 | |
| 125 | H | A | -1.2306 | |
| 126 | P | A | -1.2327 | |
| 127 | T | A | -1.1505 | |
| 128 | A | A | -1.0743 | |
| 129 | D | A | -2.0582 | |
| 130 | D | A | -1.5545 | |
| 131 | R | A | -1.0507 | |
| 132 | V | A | 0.1650 | |
| 133 | S | A | 0.1893 | |
| 134 | F | A | 0.1535 | |
| 135 | S | A | -0.1352 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.6304 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5596 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2179 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1204 | |
| 157 | D | A | 0.2841 | |
| 158 | I | A | 0.8168 | |
| 159 | A | A | 0.1092 | |
| 160 | E | A | -1.4828 | |
| 161 | P | A | -0.2295 | |
| 162 | C | A | 0.1922 | |
| 163 | P | A | -0.1619 | |
| 164 | G | A | -0.0578 | |
| 165 | L | A | 0.6293 | |
| 166 | P | A | -0.0912 | |
| 167 | P | A | -0.3299 | |
| 168 | G | A | -0.4145 | |
| 169 | A | A | -0.0118 | |
| 170 | C | A | 0.7467 | |
| 171 | P | A | 0.5523 | |
| 172 | P | A | 0.7871 | |
| 173 | I | A | 2.0481 | |
| 174 | Q | A | 0.8577 | |
| 175 | L | A | 1.4556 | |
| 176 | V | A | 0.8391 | |
| 177 | N | A | -0.3127 | |
| 178 | S | A | -0.0907 | |
| 179 | V | A | 0.4223 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3758 | |
| 182 | D | A | 0.0648 | |
| 183 | G | A | -0.1599 | |
| 184 | D | A | -0.5480 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1181 | |
| 190 | F | A | 0.0623 | |
| 191 | G | A | -0.1038 | |
| 192 | N | A | -0.2761 | |
| 193 | M | A | -0.1436 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3981 | |
| 197 | E | A | -2.6212 | |
| 198 | L | A | -1.2244 | |
| 199 | Q | A | -2.5464 | |
| 200 | Q | A | -3.3159 | |
| 201 | D | A | -3.5834 | |
| 202 | R | A | -3.3246 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1637 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3640 | |
| 211 | S | A | -1.8994 | |
| 212 | T | A | -1.4531 | |
| 213 | R | A | -2.1312 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1638 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3242 | |
| 220 | L | A | 0.5777 | |
| 221 | K | A | -1.1622 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8307 | |
| 224 | N | A | -1.5950 | |
| 225 | E | A | -1.2548 | |
| 226 | A | A | -0.6073 | |
| 227 | Y | A | -0.3689 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6679 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0835 | |
| 234 | F | A | 0.2684 | |
| 235 | G | A | -0.8062 | |
| 236 | R | A | -2.5821 | |
| 237 | R | A | -2.8247 | |
| 238 | E | A | -2.1092 | |
| 239 | Q | A | -0.1754 | |
| 240 | V | A | 1.4191 | |
| 241 | Y | A | 1.0874 | |
| 242 | A | A | 0.1825 | |
| 243 | R | A | -1.0005 | |
| 244 | H | A | -0.9540 | |
| 245 | F | A | 0.0660 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.5169 | |
| 249 | S | A | -0.9673 | |
| 250 | G | A | -0.7660 | |
| 251 | P | A | -0.6169 | |
| 252 | V | A | -0.5561 | |
| 253 | G | A | -0.9245 | |
| 254 | H | A | -1.1299 | |
| 255 | P | A | -0.5272 | |
| 256 | L | A | 0.2975 | |
| 257 | P | A | -0.1612 | |
| 258 | A | A | -0.4924 | |
| 259 | D | A | -0.7929 | |
| 260 | P | A | -0.7862 | |
| 261 | P | A | -0.2708 | |
| 262 | P | A | -0.0910 | |
| 263 | S | A | 0.3290 | |
| 264 | P | A | 0.5675 | |
| 265 | L | A | 1.8181 | |
| 266 | Y | A | 1.7601 | |
| 267 | V | A | 1.8781 | |
| 268 | P | A | 0.9754 | |
| 269 | P | A | 0.3121 | |
| 270 | P | A | -0.6795 | |
| 271 | P | A | -0.9290 | |
| 272 | D | A | -1.7385 | |
| 273 | S | A | -0.6422 | |
| 274 | P | A | -0.1691 | |
| 275 | Y | A | 0.8190 | |
| 276 | A | A | 0.5763 | |
| 277 | V | A | 1.6277 | |
| 278 | P | A | 0.9384 | |
| 279 | P | A | 0.1177 | |
| 280 | P | A | 0.0000 | |
| 281 | Y | A | 0.2038 | |
| 282 | D | A | -0.3556 | |
| 283 | Y | A | 1.0623 | |
| 284 | F | A | 0.7946 | |
| 285 | G | A | 0.2377 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9143 | |
| 291 | L | A | 1.6151 | |
| 292 | V | A | 0.6268 | |
| 293 | S | A | -0.1589 | |
| 294 | S | A | -0.9614 | |
| 295 | D | A | -1.8427 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.0978 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6404 | |
| 301 | R | A | -1.8397 | |
| 302 | P | A | -0.9716 | |
| 303 | F | A | -0.1795 | |
| 304 | W | A | -0.5514 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0776 | |
| 307 | R | A | -2.8226 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.3583 | |
| 310 | G | A | -1.2153 | |
| 311 | N | A | -1.2621 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8041 | |
| 319 | N | A | -0.9283 | |
| 320 | E | A | -1.0353 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3575 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0845 | |
| 333 | N | A | 0.5734 | |
| 334 | F | A | 1.7920 | |
| 335 | T | A | 0.7638 | |
| 336 | I | A | 0.4304 | |
| 337 | S | A | -0.8330 | |
| 338 | Q | A | -1.4732 | |
| 339 | Q | A | -0.8426 | |
| 340 | L | A | 0.8448 | |
| 341 | C | A | 0.4858 | |
| 342 | T | A | 0.1835 | |
| 343 | P | A | -0.2591 | |
| 344 | P | A | 0.0843 | |
| 345 | V | A | 0.6502 | |
| 346 | N | A | -0.0694 | |
| 347 | V | A | 1.7045 | |
| 348 | Y | A | 1.5457 | |
| 349 | D | A | 0.0790 | |
| 350 | P | A | -0.3502 | |
| 351 | S | A | -0.2837 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.5455 | |
| 354 | K | A | -1.6598 | |
| 355 | N | A | -1.7054 | |
| 356 | Y | A | -0.0940 | |
| 357 | L | A | 0.6460 | |
| 358 | R | A | 0.9794 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3941 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0889 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0788 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6950 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3059 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3069 | |
| 376 | L | A | -1.6969 | |
| 377 | D | A | -1.9785 | |
| 378 | P | A | -1.0334 | |
| 379 | G | A | -1.0106 | |
| 380 | V | A | -0.9297 | |
| 381 | L | A | -0.5290 | |
| 382 | A | A | -0.6523 | |
| 383 | H | A | -0.8029 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4019 | |
| 386 | T | A | -0.5451 | |
| 387 | M | A | -0.2951 | |
| 388 | N | A | -0.8582 | |
| 389 | P | A | -1.2337 | |
| 390 | T | A | -1.4120 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.3979 | |
| 393 | E | A | -2.7182 | |
| 394 | N | A | -2.4972 | |
| 395 | W | A | -1.3120 | |
| 396 | N | A | -1.0092 | |
| 397 | L | A | -0.1293 | |
| 398 | G | A | 0.5747 | |
| 399 | F | A | 2.4277 | |
| 400 | V | A | 1.8359 | |
| 401 | P | A | 0.0607 | |
| 402 | P | A | -1.8073 | |
| 403 | K | A | -3.3003 | |
| 404 | E | A | -3.8221 | |
| 405 | R | A | -3.8444 | |
| 406 | E | A | -3.7605 | |
| 407 | D | A | -2.8716 | |
| 408 | P | A | -1.7614 | |
| 409 | Y | A | -0.9937 | |
| 410 | K | A | -2.1208 | |
| 411 | G | A | -0.6429 | |
| 412 | L | A | 0.6648 | |
| 413 | I | A | 1.5738 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.4234 | |
| 416 | E | A | -1.7486 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9663 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0572 | |
| 421 | E | A | -2.7861 | |
| 422 | R | A | -2.6417 | |
| 423 | F | A | -1.2827 | |
| 424 | S | A | -1.4715 | |
| 425 | Q | A | -1.8577 | |
| 426 | D | A | -2.9655 | |
| 427 | L | A | -2.1487 | |
| 428 | D | A | -3.0088 | |
| 429 | Q | A | -2.7452 | |
| 430 | F | A | -1.5931 | |
| 431 | A | A | -1.1139 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.2178 | |
| 435 | K | A | -1.0489 | |
| 436 | F | A | -0.0732 | |
| 437 | L | A | 0.8112 | |
| 438 | Y | A | 0.6488 | |
| 439 | Q | A | -0.3773 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine