Project name: f219887f451bf68

Chain sequence(s)	H: EVQLVQSGAEVKKPGESLKISCKGSGYSFTTYWLGWVRQMPGKGLDWIGIMSPVDSDIRYSPSFQGQVTMSVDKSITTAYLQWNSLKASDTAMYYCARRRPGQGYFDFWGQGTLVTVSSSSTKGPSVFPLAPSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKS; L: DIQMTQSPSSLSASVGDRVTITCRASQGISSWLAWYQQKPEKAPKSLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNIYPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:02)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:02)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:02)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:02)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:02)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:09:54)
[INFO]       Main:     Simulation completed successfully.                                          (00:09:59)

• Minimal score value: -3.7671
• Maximal score value: 1.3406
• Average score: -0.6937
• Total score value: -299.6721

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	L	-1.9455
2	I	L	0.0000
3	Q	L	-2.3382
4	M	L	0.0000
5	T	L	-1.4077
6	Q	L	0.0000
7	S	L	-0.7553
8	P	L	-0.4066
9	S	L	-0.6950
10	S	L	-0.6113
11	L	L	-0.4075
12	S	L	-0.7290
13	A	L	0.0000
14	S	L	-1.1689
15	V	L	-0.5254
16	G	L	-1.0305
17	D	L	-1.8214
18	R	L	-2.4466
19	V	L	0.0000
20	T	L	-0.5759
21	I	L	0.0000
22	T	L	-0.7644
23	C	L	0.0000
24	R	L	-2.8212
25	A	L	-2.1706
26	S	L	-2.0837
27	Q	L	-2.2446
28	G	L	-1.4187
29	I	L	0.0000
30	S	L	-0.6805
31	S	L	-0.3416
32	W	L	0.3161
33	L	L	0.0000
34	A	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	-1.3678
39	K	L	-1.8846
40	P	L	-1.9613
41	E	L	-3.0515
42	K	L	-3.1391
43	A	L	-1.8002
44	P	L	0.0000
45	K	L	-1.2268
46	S	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	0.1894
50	A	L	0.0613
51	A	L	0.0000
52	S	L	-0.1953
53	S	L	0.0732
54	L	L	0.3065
55	Q	L	-0.1577
56	S	L	-0.3110
57	G	L	-0.4587
58	V	L	-0.2831
59	P	L	-0.3292
60	S	L	-0.4524
61	R	L	-0.8681
62	F	L	0.0000
63	S	L	-0.3204
64	G	L	0.0000
65	S	L	-0.6110
66	G	L	-1.0190
67	S	L	-0.9946
68	G	L	-1.1666
69	T	L	-1.7851
70	D	L	-2.1880
71	F	L	0.0000
72	T	L	-0.7295
73	L	L	0.0000
74	T	L	-0.6341
75	I	L	0.0000
76	S	L	-1.5342
77	S	L	-1.3240
78	L	L	0.0000
79	Q	L	-1.1725
80	P	L	-1.5949
81	E	L	-1.6508
82	D	L	0.0000
83	F	L	0.0000
84	A	L	0.0000
85	T	L	-0.6671
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	Q	L	0.0000
90	Q	L	0.0000
91	Y	L	0.0000
92	N	L	0.3413
93	I	L	1.1938
94	Y	L	0.4631
95	P	L	-0.1131
96	Y	L	0.0000
97	T	L	-0.5772
98	F	L	0.0000
99	G	L	0.0000
100	Q	L	-1.6268
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-1.1105
104	L	L	0.0000
105	E	L	-1.2408
106	I	L	0.0000
107	K	L	-1.4962
108	R	L	-1.0898
109	T	L	-0.1502
110	V	L	0.3677
111	A	L	0.1547
112	A	L	-0.1092
113	P	L	0.0000
114	S	L	-0.1692
115	V	L	0.0000
116	F	L	0.0918
117	I	L	0.1252
118	F	L	0.0000
119	P	L	-0.5421
120	P	L	0.0000
121	S	L	-1.5111
122	D	L	-2.5793
123	E	L	-2.2336
124	Q	L	0.0000
125	L	L	-1.9609
126	K	L	-2.5635
127	S	L	-1.6295
128	G	L	-1.2165
129	T	L	-1.0075
130	A	L	0.0000
131	S	L	0.0000
132	V	L	0.0000
133	V	L	0.0000
134	C	L	0.0000
135	L	L	0.0000
136	L	L	0.0000
137	N	L	0.0000
138	N	L	-1.0186
139	F	L	0.0000
140	Y	L	-1.1106
141	P	L	-1.6996
142	R	L	-2.9804
143	E	L	-3.1791
144	A	L	-2.2567
145	K	L	-2.2728
146	V	L	-1.0275
147	Q	L	-0.6884
148	W	L	0.0000
149	K	L	-0.6452
150	V	L	0.0000
151	D	L	-2.2066
152	N	L	-1.6717
153	A	L	-0.2985
154	L	L	0.7263
155	Q	L	-0.2762
156	S	L	-0.5859
157	G	L	-1.2081
158	N	L	-1.3407
159	S	L	-1.3537
160	Q	L	-1.3959
161	E	L	-1.9179
162	S	L	-0.8434
163	V	L	-0.7806
164	T	L	-1.0533
165	E	L	-2.1031
166	Q	L	0.0000
167	D	L	-2.1285
168	S	L	-2.0608
169	K	L	-2.5658
170	D	L	-1.9924
171	S	L	0.0000
172	T	L	0.0000
173	Y	L	0.0000
174	S	L	0.0000
175	L	L	0.0000
176	S	L	0.0000
177	S	L	0.0000
178	T	L	-0.7047
179	L	L	0.0000
180	T	L	-0.4585
181	L	L	-0.7621
182	S	L	-1.1302
183	K	L	-2.1185
184	A	L	-2.0142
185	D	L	-2.9577
186	Y	L	0.0000
187	E	L	-3.4918
188	K	L	-3.7671
189	H	L	-3.3570
190	K	L	-3.2688
191	V	L	-1.6964
192	Y	L	0.0000
193	A	L	0.0000
194	C	L	0.0000
195	E	L	-0.9345
196	V	L	0.0000
197	T	L	-1.1102
198	H	L	0.0000
199	Q	L	-1.7051
200	G	L	-0.4173
201	L	L	-0.2287
202	S	L	-0.4355
203	S	L	-0.3917
204	P	L	-0.4706
205	V	L	0.0882
206	T	L	-0.4651
207	K	L	-0.6929
208	S	L	-0.6761
209	F	L	-1.0553
210	N	L	-2.1178
211	R	L	-2.6190
212	G	L	-2.2740
213	E	L	-2.0869
214	C	L	-0.8392
1	E	H	-2.1233
2	V	H	-1.1017
3	Q	H	-1.3052
4	L	H	0.0000
5	V	H	0.1764
6	Q	H	0.0000
7	S	H	-0.5358
8	G	H	-0.7303
9	A	H	-0.5635
10	E	H	-0.7153
11	V	H	-0.4408
12	K	H	-1.5626
13	K	H	-2.5782
14	P	H	-2.2664
15	G	H	-2.1896
16	E	H	-2.4226
17	S	H	-2.1926
18	L	H	0.0000
19	K	H	-2.0555
20	I	H	0.0000
21	S	H	-0.5441
22	C	H	0.0000
23	K	H	-0.2907
24	G	H	0.0000
25	S	H	-0.7471
26	G	H	-1.2741
27	Y	H	-0.5458
28	S	H	-0.1818
29	F	H	0.0000
30	T	H	0.0699
31	T	H	0.2167
32	Y	H	0.3001
33	W	H	0.3277
34	L	H	0.0000
35	G	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	-0.5892
39	Q	H	-0.7862
40	M	H	-0.7237
41	P	H	-0.8912
42	G	H	-1.3970
43	K	H	-2.2577
44	G	H	-1.5302
45	L	H	0.0000
46	D	H	-0.9535
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	I	H	0.0000
51	M	H	0.0000
52	S	H	0.0000
53	P	H	0.0000
54	V	H	0.4056
55	D	H	-1.3933
56	S	H	-1.0795
57	D	H	-1.3626
58	I	H	-0.6125
59	R	H	-1.1142
60	Y	H	-0.8413
61	S	H	0.0000
62	P	H	-1.2787
63	S	H	-0.9910
64	F	H	0.0000
65	Q	H	-2.0621
66	G	H	-1.6783
67	Q	H	-2.1469
68	V	H	0.0000
69	T	H	-1.0367
70	M	H	0.0000
71	S	H	-0.3938
72	V	H	-0.2439
73	D	H	-0.6467
74	K	H	-1.0477
75	S	H	-0.2713
76	I	H	0.7382
77	T	H	-0.2278
78	T	H	0.0000
79	A	H	0.0000
80	Y	H	-0.5208
81	L	H	0.0000
82	Q	H	-1.6609
83	W	H	0.0000
84	N	H	-2.3976
85	S	H	-2.2275
86	L	H	0.0000
87	K	H	-2.6366
88	A	H	-1.4312
89	S	H	-0.8840
90	D	H	-0.9310
91	T	H	-0.4694
92	A	H	0.0000
93	M	H	0.0582
94	Y	H	0.0000
95	Y	H	0.0000
96	C	H	0.0000
97	A	H	0.0000
98	R	H	0.0000
99	R	H	-0.3403
100	R	H	-0.7097
101	P	H	-0.7519
102	G	H	-0.8506
103	Q	H	-0.7034
104	G	H	0.0000
105	Y	H	0.0000
106	F	H	0.0000
107	D	H	0.0000
108	F	H	0.4657
109	W	H	0.0409
110	G	H	0.0000
111	Q	H	-1.5126
112	G	H	-0.7051
113	T	H	0.0000
114	L	H	-0.0847
115	V	H	0.0000
116	T	H	0.0000
117	V	H	0.0000
118	S	H	-1.2103
119	S	H	-0.9761
120	S	H	-0.7659
121	S	H	-0.7489
122	T	H	-0.6233
123	K	H	-1.1429
124	G	H	-1.3274
125	P	H	-0.5529
126	S	H	-0.2820
127	V	H	0.0000
128	F	H	0.0000
129	P	H	-1.0613
130	L	H	0.0000
131	A	H	-1.1823
132	P	H	0.0000
133	S	H	-0.4602
137	T	H	-0.2724
138	S	H	-0.6256
139	G	H	-0.9334
140	G	H	-0.9082
141	T	H	-0.5850
142	A	H	0.0000
143	A	H	0.0000
144	L	H	0.0000
145	G	H	0.0000
146	C	H	0.0000
147	L	H	0.0000
148	V	H	0.0000
149	K	H	0.0000
150	D	H	-0.2917
151	Y	H	0.0000
152	F	H	-0.2388
153	P	H	0.0000
154	E	H	-0.5809
155	P	H	-0.7891
156	V	H	0.0000
157	T	H	-0.6272
158	V	H	-0.1700
159	S	H	-0.3806
160	W	H	0.0000
161	N	H	-0.8807
162	S	H	-0.6963
163	G	H	-0.4849
164	A	H	-0.2299
165	L	H	-0.0016
166	T	H	-0.1719
167	S	H	-0.1807
168	G	H	-0.2120
169	V	H	0.1671
170	H	H	-0.3170
171	T	H	0.0094
172	F	H	0.0000
173	P	H	-0.2940
174	A	H	0.1765
175	V	H	0.5294
176	L	H	1.3406
177	Q	H	0.3769
178	S	H	-0.0466
179	S	H	-0.1979
180	G	H	0.0442
181	L	H	0.1505
182	Y	H	0.4475
183	S	H	0.2625
184	L	H	0.0000
185	S	H	0.0000
186	S	H	0.0000
187	V	H	0.0000
188	V	H	0.0000
189	T	H	-0.1193
190	V	H	0.0000
191	P	H	-0.5710
192	S	H	-0.6726
193	S	H	-0.7807
194	S	H	0.0000
195	L	H	-0.8845
196	G	H	-1.1396
197	T	H	-0.8602
198	Q	H	-1.5461
199	T	H	-1.3895
200	Y	H	0.0000
201	I	H	-1.2982
202	C	H	0.0000
203	N	H	-1.4468
204	V	H	0.0000
205	N	H	-1.7664
206	H	H	0.0000
207	K	H	-2.7544
208	P	H	-1.5363
209	S	H	-1.7559
210	N	H	-2.4823
211	T	H	-2.0236
212	K	H	-2.6240
213	V	H	-1.6176
214	D	H	-2.5376
215	K	H	-2.2663
216	R	H	-2.7283
217	V	H	0.0000
218	E	H	-2.9404
219	P	H	-1.9656
220	K	H	-2.1963
221	S	H	-1.2754