Project name: 18abada13ff9396

Chain sequence(s)	A: PLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN; B: PLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTTAVVTN
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4602
• Maximal score value: 1.7657
• Average score: -0.7486
• Total score value: -170.6775

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
11	P	A	-2.0370
12	L	A	0.0000
13	M	A	-0.5797
14	V	A	0.0000
15	K	A	-0.5113
16	V	A	0.0000
17	L	A	0.6315
18	D	A	0.0000
19	A	A	0.5567
20	V	A	0.9249
21	R	A	-0.8762
22	G	A	-0.6488
23	S	A	-0.4798
24	P	A	-0.5765
25	A	A	0.0000
26	I	A	-0.8128
27	N	A	-1.9793
28	V	A	0.0000
29	A	A	-1.4370
30	V	A	0.0000
31	H	A	-1.0923
32	V	A	0.0000
33	F	A	-0.7507
34	R	A	-1.3045
35	K	A	-1.7873
36	A	A	-1.8971
37	A	A	-1.6969
38	D	A	-2.8612
39	D	A	-3.0162
40	T	A	-1.9999
41	W	A	-1.4552
42	E	A	-2.3215
43	P	A	-1.1094
44	F	A	-0.6749
45	A	A	-0.6027
46	S	A	-0.8514
47	G	A	-1.5263
48	K	A	-2.5457
49	T	A	0.0000
50	S	A	-1.8745
51	E	A	-2.1615
52	S	A	-1.1879
53	G	A	0.0000
54	E	A	-1.4954
55	L	A	0.0000
56	H	A	-1.5406
57	G	A	-0.9129
58	L	A	-0.6646
59	T	A	-1.3505
60	T	A	-2.1017
61	E	A	-3.4602
62	E	A	-3.4039
63	E	A	-3.1649
64	F	A	0.0000
65	V	A	-1.4590
66	E	A	-2.2842
67	G	A	-1.1477
68	I	A	-0.3916
69	Y	A	0.0000
70	K	A	0.0000
71	V	A	0.0000
72	E	A	-0.6749
73	I	A	0.0000
74	D	A	-1.3974
75	T	A	0.0000
76	K	A	-1.4687
77	S	A	-1.3441
78	Y	A	0.0000
79	W	A	0.0000
80	K	A	-1.8080
81	A	A	-0.7092
82	L	A	-0.0866
83	G	A	-0.6338
84	I	A	-0.1681
85	S	A	-0.4846
86	P	A	-0.5916
87	F	A	0.0000
88	H	A	0.0000
89	E	A	-0.6038
90	H	A	-0.7097
91	A	A	0.0000
92	E	A	0.0000
93	V	A	0.0000
94	V	A	0.0000
95	F	A	0.0000
96	T	A	-0.7904
97	A	A	0.0000
98	N	A	0.0000
99	D	A	-2.4665
100	S	A	-1.5377
101	G	A	-1.4213
102	P	A	-2.1033
103	R	A	-2.7299
104	R	A	-2.3579
105	Y	A	0.0000
106	T	A	0.0946
107	I	A	0.0000
108	A	A	0.3269
109	A	A	0.0000
110	L	A	1.2605
111	L	A	0.0000
112	S	A	0.6263
113	P	A	0.3265
114	Y	A	0.6034
115	S	A	0.4124
116	Y	A	0.0000
117	S	A	0.3758
118	T	A	0.0000
119	T	A	0.6871
120	A	A	0.0000
121	V	A	1.7657
122	V	A	0.3933
123	T	A	-0.8529
124	N	A	-1.9499
11	P	B	-1.5438
12	L	B	0.0000
13	M	B	-0.4836
14	V	B	0.0000
15	K	B	-0.4680
16	V	B	0.0000
17	L	B	0.3196
18	D	B	0.0000
19	A	B	0.3940
20	V	B	0.8292
21	R	B	-1.0537
22	G	B	-0.6749
23	S	B	-0.6211
24	P	B	-0.7639
25	A	B	0.0000
26	I	B	-1.0943
27	N	B	-2.1217
28	V	B	0.0000
29	A	B	-1.3847
30	V	B	0.0000
31	H	B	-0.9909
32	V	B	0.0000
33	F	B	-0.8239
34	R	B	-1.3081
35	K	B	-1.8446
36	A	B	-1.9068
37	A	B	-1.6978
38	D	B	-2.8658
39	D	B	-3.0315
40	T	B	-2.0412
41	W	B	-1.5709
42	E	B	-2.3854
43	P	B	-1.1842
44	F	B	-0.6609
45	A	B	-0.5257
46	S	B	-0.8390
47	G	B	-1.5282
48	K	B	-2.6206
49	T	B	0.0000
50	S	B	-1.9569
51	E	B	-2.2529
52	S	B	-1.2203
53	G	B	0.0000
54	E	B	-1.4612
55	L	B	0.0000
56	H	B	-1.5125
57	G	B	-0.9084
58	L	B	-0.6356
59	T	B	-1.0968
60	T	B	-1.7004
61	E	B	-2.8271
62	E	B	-2.8423
63	E	B	-2.1230
64	F	B	-1.1606
65	V	B	-0.8122
66	E	B	-2.0800
67	G	B	-1.1067
68	I	B	-0.3327
69	Y	B	0.0000
70	K	B	0.0000
71	V	B	0.0000
72	E	B	-0.6442
73	I	B	0.0000
74	D	B	-1.3575
75	T	B	0.0000
76	K	B	-1.4228
77	S	B	-1.3700
78	Y	B	0.0000
79	W	B	0.0000
80	K	B	-1.7898
81	A	B	-0.6956
82	L	B	-0.0704
83	G	B	-0.6054
84	I	B	-0.0594
85	S	B	-0.4484
86	P	B	-0.5346
87	F	B	0.0000
88	H	B	0.0000
89	E	B	-0.6348
90	H	B	-0.7119
91	A	B	0.0000
92	E	B	0.0000
93	V	B	0.0000
94	V	B	0.0000
95	F	B	0.0000
96	T	B	-0.9870
97	A	B	0.0000
98	N	B	-2.7104
99	D	B	-3.1632
100	S	B	-1.9689
101	G	B	-1.8585
102	P	B	-1.8175
103	R	B	-2.2413
104	R	B	-1.9097
105	Y	B	0.0000
106	T	B	0.0033
107	I	B	0.0000
108	A	B	0.2202
109	A	B	0.0000
110	L	B	0.8656
111	L	B	0.0000
112	S	B	0.6000
113	P	B	0.2756
114	Y	B	0.9003
115	S	B	0.5172
116	Y	B	0.0000
117	S	B	0.2902
118	T	B	0.0000
119	T	B	0.4787
120	A	B	0.0000
121	V	B	1.2032
122	V	B	0.1781
123	T	B	-0.8514
124	N	B	-1.8978