Project name: 20%_pro_6fxn

Chain sequence(s)	A: SELTQDPAVSVALGQTVRVTCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCSSRDSSGNHWVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTVQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.296
• Maximal score value: 2.7888
• Average score: -0.7119
• Total score value: -306.8328

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	S	A	-1.6295
3	E	A	-2.4797
4	L	A	0.0000
5	T	A	-1.6339
6	Q	A	-1.5876
7	D	A	-2.4394
8	P	A	-1.8160
9	A	A	0.0000
10	V	A	-1.0741
11	S	A	-0.3639
12	V	A	0.0000
13	A	A	-0.0344
14	L	A	-0.1540
15	G	A	-0.9519
16	Q	A	-1.3192
17	T	A	-1.2054
18	V	A	0.0000
19	R	A	-1.8920
20	V	A	0.0000
21	T	A	-1.2177
22	C	A	0.0000
23	Q	A	-2.6173
24	G	A	-2.7634
25	D	A	-3.2960
26	S	A	0.0000
27	L	A	0.0000
28	R	A	-3.0666
29	S	A	-1.4717
30	Y	A	-0.7320
31	Y	A	-0.5205
32	A	A	0.0000
33	S	A	0.0000
34	W	A	0.0000
35	Y	A	0.0000
36	Q	A	0.0000
37	Q	A	0.0000
38	K	A	-1.6137
39	P	A	-1.4193
40	G	A	-1.5438
41	Q	A	-1.8996
42	A	A	-1.0910
43	P	A	0.0000
44	V	A	0.9529
45	L	A	0.0000
46	V	A	0.0000
47	I	A	0.0000
48	Y	A	-1.1958
49	G	A	0.0000
50	K	A	-2.5707
51	N	A	-2.4546
52	N	A	-2.2460
53	R	A	-2.1337
54	P	A	-0.7137
55	S	A	-0.7230
56	G	A	-0.8775
57	I	A	-0.7641
58	P	A	-1.2753
59	D	A	-2.1501
60	R	A	-1.2455
61	F	A	0.0000
62	S	A	-1.5447
63	G	A	-1.4103
64	S	A	-1.0584
65	S	A	-1.3195
66	S	A	-1.3367
67	G	A	-2.2813
68	N	A	-2.9918
69	T	A	-1.9123
70	A	A	0.0000
71	S	A	0.0000
72	L	A	0.0000
73	T	A	-0.9019
74	I	A	0.0000
75	T	A	-1.2010
76	G	A	-0.9349
77	A	A	0.0000
78	Q	A	-1.2987
79	A	A	0.0000
80	E	A	-2.2529
81	D	A	0.0000
82	E	A	-1.8362
83	A	A	0.0000
84	D	A	-1.8935
85	Y	A	0.0000
86	Y	A	0.0000
87	C	A	0.0000
88	S	A	-0.2689
89	S	A	0.0000
90	R	A	-0.8497
91	D	A	-1.3342
92	S	A	-1.4750
93	S	A	-0.6845
94	G	A	-0.6904
95	N	A	-0.8923
96	H	A	-0.7148
97	W	A	0.0000
98	V	A	-0.6014
99	F	A	-0.5457
100	G	A	0.0000
101	G	A	-1.7166
102	G	A	-1.5458
103	T	A	0.0000
104	E	A	-2.5760
105	L	A	0.0000
106	T	A	-0.4270
107	V	A	0.0000
108	L	A	0.7371
109	G	A	-0.1349
110	Q	A	0.0000
111	P	A	-1.0301
112	K	A	-2.1838
113	A	A	-1.3032
114	A	A	-0.7164
115	P	A	0.0000
116	S	A	-0.4237
117	V	A	0.0000
118	T	A	-0.1525
119	L	A	-0.3202
120	F	A	0.0000
121	P	A	-0.0863
122	P	A	-0.5561
123	S	A	-1.1674
124	S	A	-1.6988
125	E	A	-2.5406
126	E	A	0.0000
127	L	A	-2.1784
128	Q	A	-2.4603
129	A	A	-2.0099
130	N	A	-2.7807
131	K	A	-2.8643
132	A	A	0.0000
133	T	A	0.0000
134	L	A	0.0000
135	V	A	0.0000
136	C	A	0.0000
137	L	A	0.0000
138	I	A	0.0000
139	S	A	-0.5605
140	D	A	-1.1734
141	F	A	0.0000
142	Y	A	-1.1665
143	P	A	-0.9930
144	G	A	-0.6175
145	A	A	-0.2307
146	V	A	-0.0756
147	T	A	-0.0777
148	V	A	0.2530
149	A	A	-0.2213
150	W	A	0.0000
151	K	A	-1.1093
152	A	A	0.0000
153	D	A	-1.9820
154	S	A	-1.2014
155	S	A	-0.9825
156	P	A	-0.9480
157	V	A	-0.6526
158	K	A	-1.5317
159	A	A	-0.5090
160	G	A	0.0384
161	V	A	0.3936
162	E	A	0.0771
163	T	A	0.1390
164	T	A	0.0387
165	T	A	-0.1076
166	P	A	-0.2702
167	S	A	-0.5546
168	K	A	-1.3337
169	Q	A	-1.1974
170	S	A	-1.3120
171	N	A	-1.6841
172	N	A	-1.8204
173	K	A	-1.8345
174	Y	A	-0.8013
175	A	A	0.0000
176	A	A	0.0000
177	S	A	0.0000
178	S	A	0.0000
179	Y	A	0.0000
180	L	A	1.1381
181	S	A	0.0172
182	L	A	0.0000
183	T	A	-1.9503
184	P	A	-2.4883
185	E	A	-3.2248
186	Q	A	-2.4255
187	W	A	0.0000
188	K	A	-3.1056
189	S	A	0.0000
190	H	A	-2.4794
191	R	A	-2.6635
192	S	A	0.0000
193	Y	A	0.0000
194	S	A	0.0000
195	C	A	0.0000
196	Q	A	-1.0597
197	V	A	0.0000
198	T	A	-0.6716
199	H	A	0.0000
200	E	A	-2.2557
201	G	A	-1.4162
202	S	A	-0.9014
203	T	A	-0.7578
204	V	A	-0.7684
205	E	A	-2.1472
206	K	A	-1.8394
207	T	A	-1.1270
208	V	A	0.0000
209	A	A	-0.9409
210	P	A	-0.9556
2	V	A	1.0957
3	Q	A	-0.9860
4	L	A	0.0000
5	Q	A	-1.9692
6	Q	A	-1.3623
7	S	A	-1.2696
8	G	A	-1.1008
9	A	A	0.0000
10	E	A	-1.2389
11	V	A	-0.8240
12	K	A	-1.5945
13	K	A	-2.3241
14	P	A	-1.6018
15	G	A	-1.3128
16	S	A	-1.0607
17	S	A	-1.2306
18	V	A	0.0000
19	R	A	-2.2849
20	V	A	0.0000
21	S	A	-1.0532
22	C	A	0.0000
23	K	A	-1.6532
24	A	A	0.0000
25	S	A	-0.7933
26	G	A	-0.5946
27	G	A	-1.1131
28	T	A	-1.3826
29	F	A	-0.9209
30	N	A	-1.5216
31	N	A	-0.5845
32	N	A	-0.4247
33	A	A	0.0430
34	I	A	0.0000
35	N	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	R	A	-0.6957
39	Q	A	-0.9094
40	A	A	-1.1536
41	P	A	-0.8755
42	G	A	-1.2361
43	Q	A	-1.8824
44	G	A	-1.4536
45	L	A	0.0000
46	E	A	-1.2949
47	W	A	0.0000
48	M	A	0.0000
49	G	A	0.0000
50	G	A	0.0000
51	I	A	0.4380
52	I	A	0.3249
53	P	A	-0.2893
54	M	A	0.6453
55	F	A	1.4534
56	G	A	0.3018
57	T	A	0.0339
58	A	A	-0.0182
59	K	A	-0.5497
60	Y	A	-0.3192
61	S	A	-1.2103
62	Q	A	-2.0813
63	N	A	-2.1987
64	F	A	0.0000
65	Q	A	-2.0320
66	G	A	-1.4263
67	R	A	0.0000
68	V	A	-0.8371
69	A	A	-0.4932
70	I	A	0.0000
71	T	A	-0.6552
72	A	A	-1.2755
73	D	A	-2.7463
74	E	A	-2.7298
75	S	A	-1.5552
76	T	A	-1.3651
77	G	A	0.0000
78	T	A	-1.5677
79	A	A	0.0000
80	S	A	0.0000
81	M	A	0.0000
82	E	A	-1.5673
83	L	A	0.0000
84	S	A	-0.9843
85	S	A	-0.9546
86	L	A	0.0000
87	R	A	-1.7876
88	S	A	-1.6784
89	E	A	-2.1246
90	D	A	0.0000
91	T	A	-0.7137
92	A	A	0.0000
93	V	A	-0.1768
94	Y	A	0.0000
95	Y	A	0.0000
96	C	A	0.0000
97	A	A	0.0000
98	R	A	-0.4067
99	S	A	0.0000
100	R	A	-0.3697
101	D	A	0.7627
102	L	A	1.9193
103	L	A	2.7888
104	L	A	2.5018
105	F	A	1.3614
106	P	A	0.7093
107	H	A	-0.8743
108	H	A	-0.4899
109	A	A	0.0000
110	L	A	0.0000
111	S	A	0.0379
112	P	A	0.0343
113	W	A	-0.3934
114	G	A	0.0000
115	R	A	-2.4739
116	G	A	-1.3706
117	T	A	0.0000
118	M	A	-0.3631
119	V	A	0.0000
120	T	A	-0.6562
121	V	A	-1.2068
122	S	A	-0.9258
123	S	A	-0.9858
124	A	A	-0.6414
125	S	A	-0.6917
126	T	A	-0.6458
127	K	A	-0.7878
128	G	A	-1.0938
129	P	A	0.0000
130	S	A	-0.2079
131	V	A	0.0000
132	F	A	0.0000
133	P	A	-1.1535
134	L	A	0.0000
135	A	A	-0.7259
136	P	A	-0.8074
137	S	A	-0.7261
138	S	A	-1.2550
139	K	A	-1.9882
140	S	A	-1.4193
141	T	A	-0.8781
142	S	A	-0.8657
143	G	A	-0.8103
144	G	A	-1.0972
145	T	A	-0.8540
146	A	A	0.0000
147	A	A	-0.1447
148	L	A	0.0000
149	G	A	0.0000
150	C	A	0.0000
151	L	A	0.0000
152	V	A	0.0000
153	K	A	0.0000
154	D	A	-0.3111
155	Y	A	0.0000
156	F	A	-0.3018
157	P	A	0.0000
158	E	A	-0.8761
159	P	A	-0.9669
160	V	A	0.0000
161	T	A	-0.4101
162	V	A	-0.1477
163	S	A	-0.3472
164	W	A	0.0000
165	N	A	-0.8047
166	S	A	-0.6474
167	G	A	-0.4995
168	A	A	-0.2293
169	L	A	-0.0100
170	T	A	-0.1687
171	S	A	-0.2694
172	G	A	-0.3873
173	V	A	0.1116
174	H	A	-0.1897
175	T	A	-0.0224
176	F	A	0.0000
177	P	A	-0.1158
178	A	A	0.1136
179	V	A	0.0000
180	L	A	0.7843
181	Q	A	-0.0000
182	S	A	-0.3332
183	S	A	-0.3638
184	G	A	-0.2530
185	L	A	0.0287
186	Y	A	0.2590
187	S	A	0.0000
188	L	A	0.0000
189	S	A	0.0000
190	S	A	0.0000
191	V	A	0.0000
192	V	A	0.0000
193	T	A	-0.2552
194	V	A	0.0000
195	P	A	-0.5382
196	S	A	-0.9853
197	S	A	-0.7575
198	S	A	-0.5718
199	L	A	-0.8997
200	G	A	-1.0346
201	T	A	-0.7805
202	Q	A	-1.4305
203	T	A	-1.2319
204	Y	A	0.0000
205	I	A	-1.2126
206	C	A	0.0000
207	N	A	-1.3735
208	V	A	0.0000
209	N	A	-1.6360
210	H	A	0.0000
211	K	A	-2.4894
212	P	A	-1.5537
213	S	A	-1.6634
214	N	A	-2.3605
215	T	A	-1.9320
216	K	A	-2.4813
217	V	A	-1.2031
218	D	A	-2.1748
219	K	A	-2.0927
220	K	A	-2.5655
221	V	A	0.0000
222	E	A	-2.5117
223	P	A	-1.2112