| Chain sequence(s) |
A: TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY E: NMGLEAIIRKALMGKYDQW |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 200 | T | A | -0.7765 | |
| 201 | A | A | -1.2081 | |
| 202 | D | A | -1.9971 | |
| 203 | L | A | -1.4222 | |
| 204 | K | A | -2.4827 | |
| 205 | S | A | -2.2409 | |
| 206 | L | A | -1.8461 | |
| 207 | A | A | -1.9643 | |
| 208 | K | A | -3.0600 | |
| 209 | R | A | -2.9737 | |
| 210 | I | A | 0.0000 | |
| 211 | Y | A | -1.6436 | |
| 212 | E | A | -2.5207 | |
| 213 | A | A | 0.0000 | |
| 214 | Y | A | 0.0000 | |
| 215 | L | A | -1.1875 | |
| 216 | K | A | -2.1278 | |
| 217 | N | A | -1.4356 | |
| 218 | F | A | -1.0627 | |
| 219 | N | A | -1.4617 | |
| 220 | M | A | -0.3460 | |
| 221 | N | A | -0.1357 | |
| 222 | K | A | 0.2927 | |
| 223 | V | A | 1.2198 | |
| 224 | K | A | 0.0304 | |
| 225 | A | A | 0.0000 | |
| 226 | R | A | 0.4978 | |
| 227 | V | A | 0.7758 | |
| 228 | I | A | 0.2078 | |
| 229 | L | A | 0.2735 | |
| 230 | S | A | -0.1962 | |
| 231 | G | A | -0.6193 | |
| 232 | K | A | -1.9741 | |
| 233 | A | A | -1.1862 | |
| 234 | S | A | -1.6926 | |
| 235 | N | A | -2.4881 | |
| 236 | N | A | -2.3743 | |
| 237 | P | A | -1.4250 | |
| 238 | P | A | -0.1375 | |
| 239 | F | A | 0.5232 | |
| 240 | V | A | 0.9157 | |
| 241 | I | A | 0.0000 | |
| 242 | H | A | -1.4162 | |
| 243 | D | A | -1.4871 | |
| 244 | M | A | -1.1145 | |
| 245 | E | A | -1.9921 | |
| 246 | T | A | -0.6819 | |
| 247 | L | A | 0.0000 | |
| 248 | C | A | -0.6807 | |
| 249 | M | A | 0.2703 | |
| 250 | A | A | 0.4607 | |
| 251 | E | A | 0.0000 | |
| 252 | K | A | -0.2069 | |
| 253 | T | A | 0.3102 | |
| 254 | L | A | 0.5273 | |
| 255 | V | A | 0.2691 | |
| 256 | A | A | -0.3371 | |
| 257 | K | A | -1.3949 | |
| 258 | L | A | 0.0000 | |
| 259 | V | A | 0.8072 | |
| 260 | A | A | -0.2078 | |
| 261 | N | A | -1.3987 | |
| 262 | G | A | -1.4540 | |
| 263 | I | A | -1.1746 | |
| 264 | Q | A | -2.2988 | |
| 265 | N | A | -3.1631 | |
| 266 | K | A | -3.2415 | |
| 267 | E | A | -3.0890 | |
| 268 | A | A | 0.0000 | |
| 269 | E | A | 0.0000 | |
| 270 | V | A | -0.7402 | |
| 271 | R | A | 0.0000 | |
| 272 | I | A | 0.4034 | |
| 273 | F | A | 0.6580 | |
| 274 | H | A | 0.2127 | |
| 275 | C | A | 0.6465 | |
| 276 | C | A | 0.7182 | |
| 277 | Q | A | 0.4231 | |
| 278 | C | A | 0.5636 | |
| 279 | T | A | 0.2163 | |
| 280 | S | A | -0.1124 | |
| 281 | V | A | -0.1521 | |
| 282 | E | A | -1.1354 | |
| 283 | T | A | -0.5909 | |
| 284 | V | A | 0.0000 | |
| 285 | T | A | 0.0000 | |
| 286 | E | A | -1.0887 | |
| 287 | L | A | 0.0000 | |
| 288 | T | A | 0.0000 | |
| 289 | E | A | -0.9274 | |
| 290 | F | A | 0.0000 | |
| 291 | A | A | 0.0000 | |
| 292 | K | A | -1.0143 | |
| 293 | A | A | -1.2158 | |
| 294 | I | A | 0.0000 | |
| 295 | P | A | -0.9704 | |
| 296 | G | A | -1.0391 | |
| 297 | F | A | 0.0000 | |
| 298 | A | A | -1.1660 | |
| 299 | N | A | -1.9358 | |
| 300 | L | A | 0.0000 | |
| 301 | D | A | -2.1489 | |
| 302 | L | A | -1.0775 | |
| 303 | N | A | -1.4503 | |
| 304 | D | A | 0.0000 | |
| 305 | Q | A | 0.0000 | |
| 306 | V | A | 0.0000 | |
| 307 | T | A | -0.4078 | |
| 308 | L | A | 0.0000 | |
| 309 | L | A | 0.0000 | |
| 310 | K | A | -0.3959 | |
| 311 | Y | A | -0.4200 | |
| 312 | G | A | 0.0000 | |
| 313 | V | A | 0.0000 | |
| 314 | Y | A | 0.0745 | |
| 315 | E | A | 0.0000 | |
| 316 | A | A | 0.0000 | |
| 317 | I | A | 0.4594 | |
| 318 | F | A | 0.0000 | |
| 319 | A | A | 0.0000 | |
| 320 | M | A | 0.3119 | |
| 321 | L | A | 0.3492 | |
| 322 | S | A | 0.0000 | |
| 323 | S | A | 0.0000 | |
| 324 | V | A | 0.5860 | |
| 325 | M | A | 0.0000 | |
| 326 | N | A | -1.8862 | |
| 327 | K | A | -3.1416 | |
| 328 | D | A | -3.0365 | |
| 329 | G | A | 0.0000 | |
| 330 | M | A | 0.0000 | |
| 331 | L | A | 0.0000 | |
| 332 | V | A | 0.9048 | |
| 333 | A | A | 0.7403 | |
| 334 | Y | A | 0.7622 | |
| 335 | G | A | 0.0000 | |
| 336 | N | A | -0.5538 | |
| 337 | G | A | 0.0000 | |
| 338 | F | A | 0.5250 | |
| 339 | I | A | 0.0000 | |
| 340 | T | A | -1.7484 | |
| 341 | R | A | -2.6507 | |
| 342 | E | A | -3.3176 | |
| 343 | F | A | 0.0000 | |
| 344 | L | A | -1.8599 | |
| 345 | K | A | -3.0002 | |
| 346 | S | A | -2.3080 | |
| 347 | L | A | 0.0000 | |
| 348 | R | A | -3.2196 | |
| 349 | K | A | -2.9448 | |
| 350 | P | A | -1.4906 | |
| 351 | F | A | 0.0000 | |
| 352 | C | A | -2.1858 | |
| 353 | D | A | -1.3709 | |
| 354 | I | A | -0.5757 | |
| 355 | M | A | -0.5950 | |
| 356 | E | A | -1.4097 | |
| 357 | P | A | -0.9612 | |
| 358 | K | A | 0.0000 | |
| 359 | F | A | 0.0000 | |
| 360 | D | A | -2.4606 | |
| 361 | F | A | 0.0000 | |
| 362 | A | A | 0.0000 | |
| 363 | M | A | -1.7154 | |
| 364 | K | A | -2.1974 | |
| 365 | F | A | 0.0000 | |
| 366 | N | A | -1.3053 | |
| 367 | A | A | -1.1467 | |
| 368 | L | A | -1.4923 | |
| 369 | E | A | -2.1596 | |
| 370 | L | A | 0.0000 | |
| 371 | D | A | -0.9402 | |
| 372 | D | A | 0.0000 | |
| 373 | S | A | -0.6051 | |
| 374 | D | A | 0.0000 | |
| 375 | I | A | 0.0000 | |
| 376 | S | A | 0.0000 | |
| 377 | L | A | 0.0000 | |
| 378 | F | A | 0.0000 | |
| 379 | V | A | 0.0000 | |
| 380 | A | A | 0.0000 | |
| 381 | A | A | 0.0000 | |
| 382 | I | A | 0.0000 | |
| 383 | I | A | 0.0000 | |
| 384 | C | A | 0.0000 | |
| 385 | C | A | -1.0544 | |
| 386 | G | A | -1.4704 | |
| 387 | D | A | -1.9205 | |
| 388 | R | A | -1.0067 | |
| 389 | P | A | -0.5746 | |
| 390 | G | A | -0.4702 | |
| 391 | L | A | -0.0225 | |
| 392 | L | A | 0.7308 | |
| 393 | N | A | -0.5817 | |
| 394 | V | A | 0.0646 | |
| 395 | G | A | -1.3342 | |
| 396 | H | A | -2.1852 | |
| 397 | I | A | 0.0000 | |
| 398 | E | A | -3.3791 | |
| 399 | K | A | -3.2534 | |
| 400 | M | A | -2.2607 | |
| 401 | Q | A | -2.3755 | |
| 402 | E | A | -3.0671 | |
| 403 | G | A | 0.0000 | |
| 404 | I | A | 0.0000 | |
| 405 | V | A | -0.8672 | |
| 406 | H | A | -1.2997 | |
| 407 | V | A | 0.0000 | |
| 408 | L | A | 0.0000 | |
| 409 | R | A | -1.3133 | |
| 410 | L | A | -0.5950 | |
| 411 | H | A | -0.9198 | |
| 412 | L | A | 0.0000 | |
| 413 | Q | A | -1.3840 | |
| 414 | S | A | -1.1357 | |
| 415 | N | A | -1.5682 | |
| 416 | H | A | -1.4854 | |
| 417 | P | A | -1.3301 | |
| 418 | D | A | -1.8821 | |
| 419 | D | A | -0.8956 | |
| 420 | I | A | 1.1785 | |
| 421 | F | A | 1.8138 | |
| 422 | L | A | 0.0000 | |
| 423 | F | A | 0.0000 | |
| 424 | P | A | 0.1518 | |
| 425 | K | A | -0.3008 | |
| 426 | L | A | 0.0000 | |
| 427 | L | A | -0.0868 | |
| 428 | Q | A | -0.9142 | |
| 429 | K | A | -1.1018 | |
| 430 | M | A | -0.8380 | |
| 431 | A | A | -1.3954 | |
| 432 | D | A | -1.6666 | |
| 433 | L | A | 0.0000 | |
| 434 | R | A | -2.6867 | |
| 435 | Q | A | -2.6349 | |
| 436 | L | A | -1.6913 | |
| 437 | V | A | 0.0000 | |
| 438 | T | A | -2.1203 | |
| 439 | E | A | -2.4317 | |
| 440 | H | A | -1.4560 | |
| 441 | A | A | -1.1643 | |
| 442 | Q | A | -1.6168 | |
| 443 | L | A | -0.6583 | |
| 444 | V | A | -0.6003 | |
| 445 | Q | A | -1.1354 | |
| 446 | I | A | 0.1189 | |
| 447 | I | A | 0.0000 | |
| 448 | K | A | -2.0692 | |
| 449 | K | A | -2.4401 | |
| 450 | T | A | -1.6258 | |
| 451 | E | A | -2.0772 | |
| 452 | S | A | -2.1515 | |
| 453 | D | A | -2.3503 | |
| 454 | A | A | -0.7730 | |
| 455 | A | A | -0.2942 | |
| 456 | L | A | 1.2329 | |
| 457 | H | A | 0.4089 | |
| 458 | P | A | 0.3172 | |
| 459 | L | A | 1.2693 | |
| 460 | L | A | 0.7708 | |
| 461 | Q | A | -0.9702 | |
| 462 | E | A | -1.3888 | |
| 463 | I | A | 0.4175 | |
| 464 | Y | A | -0.5109 | |
| 465 | R | A | -2.3078 | |
| 466 | D | A | -2.0623 | |
| 467 | M | A | -0.2632 | |
| 468 | Y | A | 0.3123 | |
| 682 | N | E | -0.6517 | |
| 683 | M | E | 0.0476 | |
| 684 | G | E | -0.4142 | |
| 685 | L | E | -0.2031 | |
| 686 | E | E | -0.7934 | |
| 687 | A | E | -0.5423 | |
| 688 | I | E | 0.0000 | |
| 689 | I | E | 0.0000 | |
| 690 | R | E | -0.9608 | |
| 691 | K | E | -0.6098 | |
| 692 | A | E | 0.0000 | |
| 693 | L | E | 0.0000 | |
| 694 | M | E | 0.4577 | |
| 695 | G | E | -0.1315 | |
| 696 | K | E | -1.0590 | |
| 697 | Y | E | -0.4422 | |
| 698 | D | E | -1.7882 | |
| 699 | Q | E | -1.5291 | |
| 700 | W | E | -0.3303 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine