| Chain sequence(s) |
A: MDTVCIAVVGAGVIGLSTAACISQLVPGCTVTVISDRFTPDTTSNVAAGMLIPHTYADTPVPTQKRWFRETFEHLSEIAKSAEAADAGVHLVSGWQIFHSTPAEEVPFWADVVLGFRKMTEAELKRFPQYEFGQAFTTLKCETSAYLPWLERRIKGSGGETLTWRIEDLWELQPSFDIVVNCSGLGSRRLVGDPMISPVRGQVLQARAPWVKHFIRDGGGLTYVYPGMSYVTLGGTRQKGDWNRSPDAELSREIFSRCCTLEPSLHRAYDIKEKVGLRPSRPGVRLQKELLVRGQQTLPVVHNYGHGSGGISVHWGSALEATRLVMECIHTLRTPASLSKL |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
| Mutated residues | LA290Q |
| Energy difference between WT (input) and mutated protein (by FoldX) | 0.791234 kcal/mol
Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 0.1117 | |
| 2 | D | A | -1.3416 | |
| 3 | T | A | -0.7954 | |
| 4 | V | A | 0.0000 | |
| 5 | C | A | -0.4177 | |
| 6 | I | A | 0.0000 | |
| 7 | A | A | 0.0000 | |
| 8 | V | A | 0.0000 | |
| 9 | V | A | 0.0000 | |
| 10 | G | A | -0.8105 | |
| 11 | A | A | 0.0000 | |
| 12 | G | A | -0.3999 | |
| 13 | V | A | 0.0000 | |
| 14 | I | A | 0.1641 | |
| 15 | G | A | 0.0000 | |
| 16 | L | A | 0.0000 | |
| 17 | S | A | 0.0000 | |
| 18 | T | A | 0.0000 | |
| 19 | A | A | 0.0000 | |
| 20 | A | A | -0.7990 | |
| 21 | C | A | 0.0000 | |
| 22 | I | A | 0.0000 | |
| 23 | S | A | -0.7064 | |
| 24 | Q | A | -1.1995 | |
| 25 | L | A | 0.0000 | |
| 26 | V | A | 0.0000 | |
| 27 | P | A | -0.6877 | |
| 28 | G | A | -0.9125 | |
| 29 | C | A | -0.6877 | |
| 30 | T | A | -0.7487 | |
| 31 | V | A | 0.0000 | |
| 32 | T | A | 0.0000 | |
| 33 | V | A | 0.0000 | |
| 34 | I | A | 0.0000 | |
| 35 | S | A | 0.0000 | |
| 36 | D | A | -3.2119 | |
| 37 | R | A | -2.9367 | |
| 38 | F | A | -1.1814 | |
| 39 | T | A | 0.0000 | |
| 40 | P | A | -0.8099 | |
| 41 | D | A | -1.3973 | |
| 42 | T | A | -1.0122 | |
| 43 | T | A | -0.4509 | |
| 44 | S | A | 0.0000 | |
| 45 | N | A | 0.0000 | |
| 46 | V | A | -0.1545 | |
| 47 | A | A | -0.0508 | |
| 48 | A | A | -0.0283 | |
| 49 | G | A | 0.0000 | |
| 50 | M | A | 0.0000 | |
| 51 | L | A | 0.0000 | |
| 52 | I | A | 0.1113 | |
| 53 | P | A | -0.2023 | |
| 54 | H | A | -0.4880 | |
| 55 | T | A | -0.3172 | |
| 56 | Y | A | 0.0073 | |
| 57 | A | A | -0.4582 | |
| 58 | D | A | -0.7836 | |
| 59 | T | A | -0.3519 | |
| 60 | P | A | -0.3159 | |
| 61 | V | A | -0.3045 | |
| 62 | P | A | -0.7125 | |
| 63 | T | A | -0.6896 | |
| 64 | Q | A | -0.8354 | |
| 65 | K | A | -1.2093 | |
| 66 | R | A | -1.4788 | |
| 67 | W | A | 0.0000 | |
| 68 | F | A | 0.0000 | |
| 69 | R | A | -1.9578 | |
| 70 | E | A | -1.6628 | |
| 71 | T | A | 0.0000 | |
| 72 | F | A | 0.0000 | |
| 73 | E | A | -2.7914 | |
| 74 | H | A | -2.1278 | |
| 75 | L | A | 0.0000 | |
| 76 | S | A | -1.9946 | |
| 77 | E | A | -2.8349 | |
| 78 | I | A | -1.9991 | |
| 79 | A | A | -1.8455 | |
| 80 | K | A | -2.3877 | |
| 81 | S | A | -1.6994 | |
| 82 | A | A | -1.4436 | |
| 83 | E | A | -2.5288 | |
| 84 | A | A | -2.0018 | |
| 85 | A | A | -1.6735 | |
| 86 | D | A | -2.4047 | |
| 87 | A | A | 0.0000 | |
| 88 | G | A | 0.0000 | |
| 89 | V | A | 0.0000 | |
| 90 | H | A | -0.7523 | |
| 91 | L | A | 0.4680 | |
| 92 | V | A | -0.0624 | |
| 93 | S | A | -0.0899 | |
| 94 | G | A | 0.0000 | |
| 95 | W | A | -0.2640 | |
| 96 | Q | A | 0.0000 | |
| 97 | I | A | 0.0000 | |
| 98 | F | A | -0.7235 | |
| 99 | H | A | -1.6594 | |
| 100 | S | A | -0.9252 | |
| 101 | T | A | -0.8364 | |
| 102 | P | A | -0.6320 | |
| 103 | A | A | -0.7040 | |
| 104 | E | A | -1.5300 | |
| 105 | E | A | 0.0000 | |
| 106 | V | A | -0.3903 | |
| 107 | P | A | -0.4319 | |
| 108 | F | A | -0.2885 | |
| 109 | W | A | 0.0000 | |
| 110 | A | A | -0.0292 | |
| 111 | D | A | -1.1502 | |
| 112 | V | A | 0.0000 | |
| 113 | V | A | 0.0000 | |
| 114 | L | A | 1.0486 | |
| 115 | G | A | 0.3915 | |
| 116 | F | A | 0.8692 | |
| 117 | R | A | -0.9550 | |
| 118 | K | A | -1.9182 | |
| 119 | M | A | 0.0000 | |
| 120 | T | A | -1.6831 | |
| 121 | E | A | -2.9489 | |
| 122 | A | A | -2.0244 | |
| 123 | E | A | -2.1575 | |
| 124 | L | A | -2.7394 | |
| 125 | K | A | -3.5970 | |
| 126 | R | A | -3.1802 | |
| 127 | F | A | 0.0000 | |
| 128 | P | A | -2.1565 | |
| 129 | Q | A | -2.2027 | |
| 130 | Y | A | -2.0062 | |
| 131 | E | A | -2.6301 | |
| 132 | F | A | -1.2247 | |
| 133 | G | A | 0.0000 | |
| 134 | Q | A | 0.0000 | |
| 135 | A | A | 0.0000 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | 0.7585 | |
| 138 | T | A | 0.0000 | |
| 139 | L | A | 0.0000 | |
| 140 | K | A | 0.0000 | |
| 141 | C | A | 0.0000 | |
| 142 | E | A | -0.5269 | |
| 143 | T | A | 0.0000 | |
| 144 | S | A | -0.3578 | |
| 145 | A | A | -0.5037 | |
| 146 | Y | A | 0.0000 | |
| 147 | L | A | 0.0000 | |
| 148 | P | A | -1.0456 | |
| 149 | W | A | -1.7212 | |
| 150 | L | A | 0.0000 | |
| 151 | E | A | -2.2632 | |
| 152 | R | A | -3.3981 | |
| 153 | R | A | -3.4451 | |
| 154 | I | A | 0.0000 | |
| 155 | K | A | -3.5016 | |
| 156 | G | A | -2.7011 | |
| 157 | S | A | -2.2024 | |
| 158 | G | A | -1.7930 | |
| 159 | G | A | -2.2394 | |
| 160 | E | A | -2.1662 | |
| 161 | T | A | -0.7079 | |
| 162 | L | A | -0.0944 | |
| 163 | T | A | -0.7537 | |
| 164 | W | A | -1.3308 | |
| 165 | R | A | -2.9100 | |
| 166 | I | A | 0.0000 | |
| 167 | E | A | -2.1686 | |
| 168 | D | A | -1.8626 | |
| 169 | L | A | 0.0000 | |
| 170 | W | A | -0.2702 | |
| 171 | E | A | -1.6722 | |
| 172 | L | A | 0.0000 | |
| 173 | Q | A | -0.7662 | |
| 174 | P | A | -0.6343 | |
| 175 | S | A | -0.5848 | |
| 176 | F | A | -0.1417 | |
| 177 | D | A | -0.4516 | |
| 178 | I | A | 0.0000 | |
| 179 | V | A | 0.0000 | |
| 180 | V | A | 0.0000 | |
| 181 | N | A | 0.0000 | |
| 182 | C | A | 0.0000 | |
| 183 | S | A | -0.6790 | |
| 184 | G | A | -0.2932 | |
| 185 | L | A | -0.3990 | |
| 186 | G | A | -0.9717 | |
| 187 | S | A | 0.0000 | |
| 188 | R | A | -1.9237 | |
| 189 | R | A | -2.5307 | |
| 190 | L | A | 0.0000 | |
| 191 | V | A | -0.8957 | |
| 192 | G | A | -1.0922 | |
| 193 | D | A | 0.0000 | |
| 194 | P | A | -0.3154 | |
| 195 | M | A | 0.0244 | |
| 196 | I | A | 0.0000 | |
| 197 | S | A | -0.6264 | |
| 198 | P | A | 0.0000 | |
| 199 | V | A | -1.0216 | |
| 200 | R | A | 0.0000 | |
| 201 | G | A | 0.0000 | |
| 202 | Q | A | 0.0000 | |
| 203 | V | A | 0.0000 | |
| 204 | L | A | 0.0000 | |
| 205 | Q | A | -1.1084 | |
| 206 | A | A | 0.0000 | |
| 207 | R | A | -0.9182 | |
| 208 | A | A | 0.0000 | |
| 209 | P | A | -0.2791 | |
| 210 | W | A | -0.0179 | |
| 211 | V | A | -0.5977 | |
| 212 | K | A | -1.6845 | |
| 213 | H | A | -1.0498 | |
| 214 | F | A | 0.0000 | |
| 215 | I | A | 0.0000 | |
| 216 | R | A | 0.0000 | |
| 217 | D | A | 0.0000 | |
| 218 | G | A | -0.3658 | |
| 219 | G | A | -0.5650 | |
| 220 | G | A | -0.6083 | |
| 221 | L | A | -0.2072 | |
| 222 | T | A | 0.0000 | |
| 223 | Y | A | 0.0000 | |
| 224 | V | A | 0.0000 | |
| 225 | Y | A | 0.0000 | |
| 226 | P | A | 0.0000 | |
| 227 | G | A | -0.2568 | |
| 228 | M | A | 0.1398 | |
| 229 | S | A | 0.0531 | |
| 230 | Y | A | 0.0405 | |
| 231 | V | A | 0.0000 | |
| 232 | T | A | 0.0000 | |
| 233 | L | A | 0.0000 | |
| 234 | G | A | 0.0000 | |
| 235 | G | A | 0.0000 | |
| 236 | T | A | 0.0000 | |
| 237 | R | A | -1.3081 | |
| 238 | Q | A | -1.7191 | |
| 239 | K | A | -2.1769 | |
| 240 | G | A | -1.3990 | |
| 241 | D | A | -1.2201 | |
| 242 | W | A | -0.3255 | |
| 243 | N | A | -1.6397 | |
| 244 | R | A | -2.2470 | |
| 245 | S | A | -1.5088 | |
| 246 | P | A | -1.4396 | |
| 247 | D | A | -1.7606 | |
| 248 | A | A | -1.6692 | |
| 249 | E | A | -2.5691 | |
| 250 | L | A | -1.5109 | |
| 251 | S | A | -1.6918 | |
| 252 | R | A | -2.5825 | |
| 253 | E | A | -1.6471 | |
| 254 | I | A | 0.0000 | |
| 255 | F | A | -0.7274 | |
| 256 | S | A | -0.9390 | |
| 257 | R | A | -0.9301 | |
| 258 | C | A | 0.0000 | |
| 259 | C | A | 0.0000 | |
| 260 | T | A | -0.7088 | |
| 261 | L | A | 0.0000 | |
| 262 | E | A | -0.8677 | |
| 263 | P | A | -1.1134 | |
| 264 | S | A | -1.0778 | |
| 265 | L | A | 0.0000 | |
| 266 | H | A | -1.7556 | |
| 267 | R | A | -2.3694 | |
| 268 | A | A | -1.2357 | |
| 269 | Y | A | -0.5359 | |
| 270 | D | A | -1.8651 | |
| 271 | I | A | -1.2131 | |
| 272 | K | A | -2.3612 | |
| 273 | E | A | -1.9972 | |
| 274 | K | A | -1.3762 | |
| 275 | V | A | 0.0000 | |
| 276 | G | A | -0.5903 | |
| 277 | L | A | -0.6637 | |
| 278 | R | A | -0.6379 | |
| 279 | P | A | 0.0000 | |
| 280 | S | A | -0.5684 | |
| 281 | R | A | -0.3512 | |
| 282 | P | A | -0.3333 | |
| 283 | G | A | -0.1868 | |
| 284 | V | A | -0.0762 | |
| 285 | R | A | -0.3873 | |
| 286 | L | A | -0.4797 | |
| 287 | Q | A | -1.2624 | |
| 288 | K | A | -2.0730 | |
| 289 | E | A | -1.5881 | |
| 290 | Q | A | -1.2718 | mutated: LA290Q |
| 291 | L | A | 0.0131 | |
| 292 | V | A | 0.6530 | |
| 293 | R | A | -0.6205 | |
| 294 | G | A | -1.1184 | |
| 295 | Q | A | -1.5933 | |
| 296 | Q | A | -1.2639 | |
| 297 | T | A | -0.5352 | |
| 298 | L | A | 0.0000 | |
| 299 | P | A | 0.0000 | |
| 300 | V | A | 0.0000 | |
| 301 | V | A | 0.0000 | |
| 302 | H | A | 0.0000 | |
| 303 | N | A | 0.0000 | |
| 304 | Y | A | 0.0000 | |
| 305 | G | A | 0.0000 | |
| 306 | H | A | 0.0000 | |
| 307 | G | A | -0.4185 | |
| 308 | S | A | -0.4578 | |
| 309 | G | A | -0.3015 | |
| 310 | G | A | -0.1388 | |
| 311 | I | A | 0.0000 | |
| 312 | S | A | 0.0000 | |
| 313 | V | A | 0.0000 | |
| 314 | H | A | 0.0000 | |
| 315 | W | A | -0.1980 | |
| 316 | G | A | 0.0000 | |
| 317 | S | A | 0.0000 | |
| 318 | A | A | 0.0000 | |
| 319 | L | A | -0.0495 | |
| 320 | E | A | 0.0000 | |
| 321 | A | A | 0.0000 | |
| 322 | T | A | 0.0000 | |
| 323 | R | A | -1.2125 | |
| 324 | L | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | M | A | -0.7372 | |
| 327 | E | A | -1.5690 | |
| 328 | C | A | 0.0000 | |
| 329 | I | A | 0.0000 | |
| 330 | H | A | -1.0467 | |
| 331 | T | A | -0.6676 | |
| 332 | L | A | -0.4611 | |
| 333 | R | A | -1.7528 | |
| 334 | T | A | -0.8796 | |
| 335 | P | A | -0.9331 | |
| 336 | A | A | -0.6310 | |
| 337 | S | A | -0.5685 | |
| 338 | L | A | -0.7129 | |
| 339 | S | A | -0.9065 | |
| 340 | K | A | -1.6251 | |
| 341 | L | A | -0.7318 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine