Chain sequence(s) |
A: EFDTPTQQLIQDIKENCLNSDVVEQIYKRNPILRYTHHPLHSPLLPLPYGDINLNLLKDKGYTTLQDEAIKIFNSLQQLESMSDPIPIIQGILQTGHDLRPLRDELYCQLIKQTNKVPHPGSVGNLYSWQILTCLSCTFLPSRGILKYLKFHLKRIREQFPGSEMEKYALFTYESLKKTKCREFVPSRDEIEALIHRQEMTSTVYCHGGGSCKITINSHTTAGEVVEKLIRGLAMEDSRNMFALFEYNGHVDKAIESRTVVADVLAKFEKLAATSEVGDLPWKFYFKLYCFLDTDNVPKDSVEFAFMFEQAHEAVIHGHHPAPEENLQVLAALRLQYLQGDYTLHAAIPPLEEVYSLQRLKARDMWIKEEVSSARASIIDKWRKFQGMNQEQAMAKYMALIKEWPGYGSTLFDVECKFPQELWLGVSADAVSVYKRGEGRPLEVFQYEHILSFGAPLANTYKIVVDERELLFETSEVVDVAKLMKAYISMIVKKRYST B: HKPTEDPASVYEQDDLSEQMASLEGLMKQLNAITGS |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1501 | E | A | -1.7051 | |
1502 | F | A | 0.0164 | |
1503 | D | A | -1.8095 | |
1504 | T | A | -1.1927 | |
1505 | P | A | -1.0776 | |
1506 | T | A | 0.0000 | |
1507 | Q | A | -1.6485 | |
1508 | Q | A | -2.2894 | |
1509 | L | A | 0.0000 | |
1510 | I | A | 0.0000 | |
1511 | Q | A | -2.8484 | |
1512 | D | A | -2.3102 | |
1513 | I | A | 0.0000 | |
1514 | K | A | -3.1652 | |
1515 | E | A | -2.9914 | |
1516 | N | A | -1.7464 | |
1517 | C | A | -1.0310 | |
1518 | L | A | 0.4104 | |
1519 | N | A | -1.0258 | |
1520 | S | A | -1.4338 | |
1521 | D | A | -2.3905 | |
1522 | V | A | -1.4290 | |
1523 | V | A | 0.0000 | |
1524 | E | A | -3.0433 | |
1525 | Q | A | -2.6483 | |
1526 | I | A | -1.9679 | |
1527 | Y | A | 0.0000 | |
1528 | K | A | -3.2329 | |
1529 | R | A | -3.0036 | |
1530 | N | A | -1.6903 | |
1531 | P | A | -1.1341 | |
1532 | I | A | -0.1307 | |
1533 | L | A | 0.0000 | |
1534 | R | A | -0.8266 | |
1535 | Y | A | -0.6408 | |
1536 | T | A | -0.9966 | |
1537 | H | A | -1.6087 | |
1538 | H | A | -1.7958 | |
1539 | P | A | -1.5639 | |
1540 | L | A | 0.0000 | |
1541 | H | A | -1.6129 | |
1542 | S | A | -1.2414 | |
1543 | P | A | -0.8940 | |
1544 | L | A | 0.0000 | |
1545 | L | A | 0.0000 | |
1546 | P | A | -0.7006 | |
1547 | L | A | 0.0000 | |
1548 | P | A | -0.6054 | |
1549 | Y | A | -0.3314 | |
1550 | G | A | -1.3975 | |
1551 | D | A | -2.0830 | |
1552 | I | A | -1.0791 | |
1553 | N | A | -0.9422 | |
1554 | L | A | -0.4766 | |
1555 | N | A | -1.6562 | |
1556 | L | A | -0.8401 | |
1557 | L | A | 0.0000 | |
1558 | K | A | -3.0861 | |
1559 | D | A | -3.2261 | |
1560 | K | A | -3.1293 | |
1561 | G | A | -2.1694 | |
1562 | Y | A | -1.6194 | |
1563 | T | A | -1.3137 | |
1564 | T | A | -0.8175 | |
1565 | L | A | 0.0000 | |
1566 | Q | A | -1.8282 | |
1567 | D | A | -2.3984 | |
1568 | E | A | -1.6998 | |
1569 | A | A | 0.0000 | |
1570 | I | A | -1.6746 | |
1571 | K | A | -2.5242 | |
1572 | I | A | 0.0000 | |
1573 | F | A | 0.0000 | |
1574 | N | A | -1.9526 | |
1575 | S | A | 0.0000 | |
1576 | L | A | 0.0000 | |
1577 | Q | A | -1.8147 | |
1578 | Q | A | -1.6861 | |
1579 | L | A | 0.0000 | |
1580 | E | A | -0.8136 | |
1581 | S | A | -0.6944 | |
1582 | M | A | -0.5376 | |
1583 | S | A | -0.8455 | |
1584 | D | A | -1.7423 | |
1585 | P | A | -0.9740 | |
1586 | I | A | -1.1128 | |
1587 | P | A | -0.5751 | |
1588 | I | A | -0.2533 | |
1589 | I | A | 0.0000 | |
1590 | Q | A | -0.4113 | |
1591 | G | A | -0.3664 | |
1592 | I | A | 0.0000 | |
1593 | L | A | 0.0000 | |
1594 | Q | A | -0.4388 | |
1595 | T | A | -0.8769 | |
1596 | G | A | 0.0000 | |
1597 | H | A | -1.1446 | |
1598 | D | A | -1.1750 | |
1599 | L | A | 0.0000 | |
1600 | R | A | -2.3240 | |
1601 | P | A | -1.4136 | |
1602 | L | A | 0.0000 | |
1603 | R | A | -1.0509 | |
1604 | D | A | -0.9412 | |
1605 | E | A | 0.0000 | |
1606 | L | A | 0.0000 | |
1607 | Y | A | 0.0000 | |
1608 | C | A | 0.0000 | |
1609 | Q | A | 0.0000 | |
1610 | L | A | 0.0000 | |
1611 | I | A | 0.0000 | |
1612 | K | A | 0.0000 | |
1613 | Q | A | 0.0000 | |
1614 | T | A | 0.0000 | |
1615 | N | A | 0.0000 | |
1616 | K | A | -1.7313 | |
1617 | V | A | -0.9551 | |
1618 | P | A | -0.9677 | |
1619 | H | A | -1.1795 | |
1620 | P | A | -0.8193 | |
1621 | G | A | -0.3894 | |
1622 | S | A | 0.1671 | |
1623 | V | A | 1.4494 | |
1624 | G | A | 0.2423 | |
1625 | N | A | 0.0000 | |
1626 | L | A | 0.5067 | |
1627 | Y | A | 0.5378 | |
1628 | S | A | 0.2035 | |
1629 | W | A | 0.0000 | |
1630 | Q | A | 0.0000 | |
1631 | I | A | 0.0000 | |
1632 | L | A | 0.0000 | |
1633 | T | A | 0.0000 | |
1634 | C | A | 0.0000 | |
1635 | L | A | 0.0000 | |
1636 | S | A | 0.0000 | |
1637 | C | A | 0.0000 | |
1638 | T | A | 0.0000 | |
1639 | F | A | 0.0000 | |
1640 | L | A | -0.3605 | |
1641 | P | A | 0.0000 | |
1642 | S | A | -1.2723 | |
1643 | R | A | -2.4213 | |
1644 | G | A | -2.0084 | |
1645 | I | A | -1.2944 | |
1646 | L | A | -1.4887 | |
1647 | K | A | -2.5383 | |
1648 | Y | A | 0.0000 | |
1649 | L | A | 0.0000 | |
1650 | K | A | -1.1930 | |
1651 | F | A | -1.0423 | |
1652 | H | A | 0.0000 | |
1653 | L | A | 0.0000 | |
1654 | K | A | -1.9728 | |
1655 | R | A | -2.0591 | |
1656 | I | A | 0.0000 | |
1657 | R | A | -2.4312 | |
1658 | E | A | -3.0322 | |
1659 | Q | A | -2.3484 | |
1660 | F | A | -1.4218 | |
1661 | P | A | -1.4636 | |
1662 | G | A | -1.2682 | |
1663 | S | A | -1.1966 | |
1664 | E | A | -1.4819 | |
1665 | M | A | 0.0000 | |
1666 | E | A | 0.0000 | |
1667 | K | A | -1.4213 | |
1668 | Y | A | 0.0000 | |
1669 | A | A | 0.0000 | |
1670 | L | A | -0.4255 | |
1671 | F | A | -0.3272 | |
1672 | T | A | 0.0000 | |
1673 | Y | A | -0.9386 | |
1674 | E | A | -1.6774 | |
1675 | S | A | 0.0000 | |
1676 | L | A | 0.0000 | |
1677 | K | A | -2.8269 | |
1678 | K | A | -2.6624 | |
1679 | T | A | 0.0000 | |
1680 | K | A | -1.9538 | |
1681 | C | A | -0.5596 | |
1682 | R | A | 0.0000 | |
1683 | E | A | -1.7996 | |
1684 | F | A | -0.9048 | |
1685 | V | A | 0.0000 | |
1686 | P | A | 0.0000 | |
1687 | S | A | 0.0000 | |
1688 | R | A | -2.4380 | |
1689 | D | A | -3.0714 | |
1690 | E | A | 0.0000 | |
1691 | I | A | 0.0000 | |
1692 | E | A | -3.2007 | |
1693 | A | A | -2.8329 | |
1694 | L | A | 0.0000 | |
1695 | I | A | -1.3464 | |
1696 | H | A | -2.1534 | |
1697 | R | A | -2.2194 | |
1698 | Q | A | -2.8450 | |
1699 | E | A | -3.0551 | |
1700 | M | A | 0.0000 | |
1701 | T | A | -1.3178 | |
1702 | S | A | -0.7828 | |
1703 | T | A | -0.6894 | |
1704 | V | A | 0.0000 | |
1705 | Y | A | -0.2589 | |
1706 | C | A | -0.2759 | |
1707 | H | A | -0.6310 | |
1708 | G | A | -0.9404 | |
1709 | G | A | -0.9087 | |
1710 | G | A | -0.7367 | |
1711 | S | A | -0.7067 | |
1712 | C | A | -0.7828 | |
1713 | K | A | -1.6827 | |
1714 | I | A | 0.0000 | |
1715 | T | A | -1.1088 | |
1716 | I | A | 0.0000 | |
1717 | N | A | -1.3542 | |
1718 | S | A | 0.0000 | |
1719 | H | A | -0.9372 | |
1720 | T | A | -1.1634 | |
1721 | T | A | -1.4560 | |
1722 | A | A | 0.0000 | |
1723 | G | A | -2.3896 | |
1724 | E | A | -3.0861 | |
1725 | V | A | 0.0000 | |
1726 | V | A | -1.9791 | |
1727 | E | A | -3.6706 | |
1728 | K | A | -3.6262 | |
1729 | L | A | 0.0000 | |
1730 | I | A | -2.2284 | |
1731 | R | A | -3.2195 | |
1732 | G | A | -1.8387 | |
1733 | L | A | -0.5583 | |
1734 | A | A | -1.3220 | |
1735 | M | A | 0.0000 | |
1736 | E | A | -3.7471 | |
1737 | D | A | -3.2794 | |
1738 | S | A | -2.3973 | |
1739 | R | A | -2.6369 | |
1740 | N | A | 0.0000 | |
1741 | M | A | -0.0096 | |
1742 | F | A | 0.0000 | |
1743 | A | A | -0.3329 | |
1744 | L | A | 0.0000 | |
1745 | F | A | 0.0000 | |
1746 | E | A | 0.0000 | |
1747 | Y | A | -0.3062 | |
1748 | N | A | 0.0000 | |
1749 | G | A | -0.4286 | |
1750 | H | A | -0.9454 | |
1751 | V | A | -0.1002 | |
1752 | D | A | -1.2781 | |
1753 | K | A | -1.4359 | |
1754 | A | A | -0.9565 | |
1755 | I | A | 0.0000 | |
1756 | E | A | -2.1872 | |
1757 | S | A | -2.0517 | |
1758 | R | A | -2.5989 | |
1759 | T | A | -1.5064 | |
1760 | V | A | -1.0369 | |
1761 | V | A | 0.0000 | |
1762 | A | A | 0.0000 | |
1763 | D | A | -0.4281 | |
1764 | V | A | 0.0000 | |
1765 | L | A | -0.4242 | |
1766 | A | A | 0.0000 | |
1767 | K | A | -0.7420 | |
1768 | F | A | 0.0000 | |
1769 | E | A | -1.2002 | |
1770 | K | A | -0.8824 | |
1771 | L | A | -0.1682 | |
1772 | A | A | -0.4346 | |
1773 | A | A | -0.4083 | |
1774 | T | A | -0.5052 | |
1775 | S | A | -0.6675 | |
1776 | E | A | -1.2061 | |
1777 | V | A | 0.6587 | |
1778 | G | A | -0.3879 | |
1779 | D | A | -0.4047 | |
1780 | L | A | 0.8655 | |
1781 | P | A | 0.0879 | |
1782 | W | A | 0.1507 | |
1783 | K | A | -0.1486 | |
1784 | F | A | 0.0000 | |
1785 | Y | A | -0.0395 | |
1786 | F | A | 0.0000 | |
1787 | K | A | 0.0000 | |
1788 | L | A | 0.0000 | |
1789 | Y | A | 0.3088 | |
1790 | C | A | 0.0000 | |
1791 | F | A | -0.1275 | |
1792 | L | A | -0.6950 | |
1793 | D | A | -1.3955 | |
1794 | T | A | -1.5673 | |
1795 | D | A | -2.6581 | |
1796 | N | A | -2.6343 | |
1797 | V | A | -1.9815 | |
1798 | P | A | -1.9787 | |
1799 | K | A | -3.2478 | |
1800 | D | A | -2.8246 | |
1801 | S | A | -1.0399 | |
1802 | V | A | 0.2004 | |
1803 | E | A | 0.0000 | |
1804 | F | A | 0.0000 | |
1805 | A | A | -0.5707 | |
1806 | F | A | 0.1588 | |
1807 | M | A | 0.0000 | |
1808 | F | A | 0.0000 | |
1809 | E | A | -0.5459 | |
1810 | Q | A | -0.4227 | |
1811 | A | A | 0.0000 | |
1812 | H | A | 0.0000 | |
1813 | E | A | -0.9919 | |
1814 | A | A | -0.6442 | |
1815 | V | A | 0.0000 | |
1816 | I | A | -1.3031 | |
1817 | H | A | -1.9543 | |
1818 | G | A | -1.6248 | |
1819 | H | A | -1.1177 | |
1820 | H | A | 0.0000 | |
1821 | P | A | -1.3414 | |
1822 | A | A | -1.7565 | |
1823 | P | A | -2.0722 | |
1824 | E | A | -3.1294 | |
1825 | E | A | -3.0512 | |
1826 | N | A | -2.0279 | |
1827 | L | A | -1.2839 | |
1828 | Q | A | 0.0000 | |
1829 | V | A | -0.7589 | |
1830 | L | A | 0.0000 | |
1831 | A | A | 0.0000 | |
1832 | A | A | 0.0000 | |
1833 | L | A | 0.0000 | |
1834 | R | A | 0.0000 | |
1835 | L | A | 0.0000 | |
1836 | Q | A | 0.0000 | |
1837 | Y | A | -0.8658 | |
1838 | L | A | 0.2867 | |
1839 | Q | A | -0.7108 | |
1840 | G | A | -1.6437 | |
1841 | D | A | -2.7326 | |
1842 | Y | A | -1.7256 | |
1843 | T | A | -0.3689 | |
1844 | L | A | 0.7310 | |
1845 | H | A | -0.1589 | |
1846 | A | A | -0.1570 | |
1847 | A | A | 0.0811 | |
1848 | I | A | 0.0527 | |
1849 | P | A | -0.6910 | |
1850 | P | A | -1.2618 | |
1851 | L | A | 0.0000 | |
1852 | E | A | -2.9268 | |
1853 | E | A | -2.7966 | |
1854 | V | A | 0.0000 | |
1855 | Y | A | 0.0000 | |
1856 | S | A | -2.1070 | |
1857 | L | A | -2.0728 | |
1858 | Q | A | -3.0665 | |
1859 | R | A | -3.4868 | |
1860 | L | A | -2.6392 | |
1861 | K | A | -3.4115 | |
1862 | A | A | -2.4532 | |
1863 | R | A | -2.7341 | |
1910 | D | A | -1.9078 | |
1911 | M | A | -0.5578 | |
1912 | W | A | -1.2357 | |
1913 | I | A | -2.1521 | |
1914 | K | A | -2.9590 | |
1915 | E | A | -3.2581 | |
1916 | E | A | -2.7653 | |
1917 | V | A | -2.0527 | |
1918 | S | A | -2.2391 | |
1919 | S | A | -1.9014 | |
1920 | A | A | 0.0000 | |
1921 | R | A | -2.2607 | |
1922 | A | A | -1.1694 | |
1923 | S | A | -1.2488 | |
1924 | I | A | 0.0000 | |
1925 | I | A | -0.9888 | |
1926 | D | A | -1.7726 | |
1927 | K | A | -1.9845 | |
1928 | W | A | 0.0000 | |
1929 | R | A | -3.0929 | |
1930 | K | A | -3.1934 | |
1931 | F | A | -2.3324 | |
1932 | Q | A | -2.9708 | |
1933 | G | A | -2.2018 | |
1934 | M | A | -2.2885 | |
1935 | N | A | -2.7864 | |
1936 | Q | A | -2.7457 | |
1937 | E | A | -3.8971 | |
1938 | Q | A | -3.1326 | |
1939 | A | A | 0.0000 | |
1940 | M | A | 0.0000 | |
1941 | A | A | -1.9935 | |
1942 | K | A | -1.5362 | |
1943 | Y | A | 0.0000 | |
1944 | M | A | 0.0000 | |
1945 | A | A | -0.8994 | |
1946 | L | A | -0.6402 | |
1947 | I | A | 0.0000 | |
1948 | K | A | -1.6466 | |
1949 | E | A | -1.9629 | |
1950 | W | A | -1.2278 | |
1951 | P | A | -1.0702 | |
1952 | G | A | -0.7549 | |
1953 | Y | A | -0.3992 | |
1954 | G | A | 0.0000 | |
1955 | S | A | -0.1462 | |
1956 | T | A | 0.0642 | |
1957 | L | A | -0.3316 | |
1958 | F | A | -0.9498 | |
1959 | D | A | -2.4173 | |
1960 | V | A | 0.0000 | |
1961 | E | A | -2.4946 | |
1962 | C | A | -1.5034 | |
1963 | K | A | -2.1012 | |
1967 | F | A | 0.6867 | |
1968 | P | A | -0.7209 | |
1969 | Q | A | -2.1312 | |
1970 | E | A | -2.5585 | |
1971 | L | A | 0.0000 | |
1972 | W | A | 0.0000 | |
1973 | L | A | 0.0000 | |
1974 | G | A | 0.0000 | |
1975 | V | A | 0.0000 | |
1976 | S | A | -0.5126 | |
1977 | A | A | -0.7412 | |
1978 | D | A | -1.6471 | |
1979 | A | A | -0.9076 | |
1980 | V | A | 0.0000 | |
1981 | S | A | 0.0000 | |
1982 | V | A | 0.0000 | |
1983 | Y | A | 0.0000 | |
1984 | K | A | -2.1256 | |
1985 | R | A | -2.2801 | |
1986 | G | A | -2.1477 | |
1987 | E | A | -2.4028 | |
1988 | G | A | -1.9492 | |
1989 | R | A | -2.3780 | |
1990 | P | A | -0.8522 | |
1991 | L | A | 0.2168 | |
1992 | E | A | 0.4292 | |
1993 | V | A | 1.2789 | |
1994 | F | A | 0.0000 | |
1995 | Q | A | -1.3164 | |
1996 | Y | A | 0.0000 | |
1997 | E | A | -2.0713 | |
1998 | H | A | -1.5283 | |
1999 | I | A | 0.0000 | |
2000 | L | A | 0.1503 | |
2001 | S | A | -0.0834 | |
2002 | F | A | 0.0000 | |
2003 | G | A | -0.1468 | |
2004 | A | A | -0.0441 | |
2005 | P | A | 0.3135 | |
2006 | L | A | 0.8950 | |
2007 | A | A | -0.0599 | |
2008 | N | A | -1.2280 | |
2009 | T | A | 0.0000 | |
2010 | Y | A | 0.0000 | |
2011 | K | A | -0.6442 | |
2012 | I | A | 0.0000 | |
2013 | V | A | -1.1781 | |
2014 | V | A | -1.8987 | |
2015 | D | A | -3.2292 | |
2016 | E | A | -3.7047 | |
2017 | R | A | -3.8202 | |
2018 | E | A | -3.0740 | |
2019 | L | A | -0.8623 | |
2020 | L | A | -0.5388 | |
2021 | F | A | 0.0000 | |
2022 | E | A | -2.3255 | |
2023 | T | A | -1.7785 | |
2024 | S | A | -1.3166 | |
2025 | E | A | -1.3616 | |
2026 | V | A | 0.0000 | |
2027 | V | A | 0.2688 | |
2028 | D | A | -0.7562 | |
2029 | V | A | 0.0000 | |
2030 | A | A | 0.0000 | |
2031 | K | A | -0.6522 | |
2032 | L | A | 0.0000 | |
2033 | M | A | 0.0000 | |
2034 | K | A | -0.8779 | |
2035 | A | A | -0.0911 | |
2036 | Y | A | 0.0000 | |
2037 | I | A | 0.0000 | |
2038 | S | A | -0.7258 | |
2039 | M | A | -0.8565 | |
2040 | I | A | 0.0000 | |
2041 | V | A | 0.0000 | |
2042 | K | A | -1.8956 | |
2043 | K | A | -1.8991 | |
2044 | R | A | -1.0658 | |
2045 | Y | A | 0.2042 | |
2046 | S | A | -0.7907 | |
2047 | T | A | -0.7938 | |
1408 | H | B | -1.8883 | |
1409 | K | B | -2.5560 | |
1410 | P | B | -1.7402 | |
1411 | T | B | -1.8308 | |
1412 | E | B | -2.6697 | |
1413 | D | B | -1.9928 | |
1414 | P | B | -0.9655 | |
1415 | A | B | -0.5595 | |
1416 | S | B | -0.9307 | |
1417 | V | B | -0.4484 | |
1418 | Y | B | -0.0376 | |
1419 | E | B | -1.8962 | |
1420 | Q | B | -2.4077 | |
1421 | D | B | -3.5069 | |
1422 | D | B | -2.9367 | |
1423 | L | B | -0.9429 | |
1424 | S | B | -1.4521 | |
1425 | E | B | -3.0701 | |
1426 | Q | B | -2.3042 | |
1427 | M | B | 0.0000 | |
1428 | A | B | -1.2349 | |
1429 | S | B | -1.3178 | |
1430 | L | B | 0.0000 | |
1431 | E | B | -2.0627 | |
1432 | G | B | -1.4108 | |
1433 | L | B | 0.0000 | |
1434 | M | B | -1.6507 | |
1435 | K | B | -2.5412 | |
1436 | Q | B | -1.8513 | |
1437 | L | B | 0.0000 | |
1438 | N | B | -1.1289 | |
1439 | A | B | -0.8072 | |
1440 | I | B | -0.3502 | |
1441 | T | B | -0.3395 | |
1442 | G | B | -0.7006 | |
1443 | S | B | -0.7143 |