Project name: 20b036afdf36b92

Chain sequence(s)	A: CVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRRLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAKGDSGGPLSCKHNEVWHLVGITSWGEGERPGVYTNVVEYVDWILEKV
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.96
• Maximal score value: 2.3355
• Average score: -0.7195
• Total score value: -419.4723

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	C	A	1.1597
3	V	A	1.8154
4	T	A	0.5669
5	Q	A	-0.9019
6	L	A	-0.5973
7	L	A	-0.8839
8	K	A	-2.1355
9	D	A	-2.1306
10	T	A	0.0000
11	C	A	-1.7683
12	F	A	0.0000
13	E	A	-2.5458
14	G	A	-1.7135
15	G	A	-1.2489
16	D	A	-1.8589
17	I	A	-0.3248
18	T	A	-0.1937
19	T	A	-0.0002
20	V	A	-0.1309
21	F	A	-0.4368
22	T	A	0.0000
23	P	A	0.0000
24	S	A	-0.5170
25	A	A	0.0000
26	K	A	-1.6918
27	Y	A	-0.7193
28	C	A	0.0000
29	Q	A	0.0000
30	V	A	-0.0213
31	V	A	0.0000
32	C	A	0.0000
33	T	A	0.0000
34	Y	A	0.3266
35	H	A	-0.2709
36	P	A	-0.5839
37	R	A	-0.5047
38	R	A	0.0000
39	L	A	0.0000
40	L	A	0.0000
41	F	A	0.0000
42	T	A	0.0000
43	F	A	0.0000
44	T	A	-0.8840
45	A	A	-0.9781
46	E	A	-2.1668
47	S	A	-1.4701
48	P	A	-1.4291
49	S	A	-1.7174
50	E	A	-2.8203
51	D	A	-3.1510
52	P	A	-2.3446
53	T	A	-2.1871
54	R	A	-2.8095
55	W	A	-2.2087
56	F	A	0.0000
57	T	A	-0.8134
58	C	A	0.0000
59	V	A	-0.0584
60	L	A	0.0000
61	K	A	0.0000
62	D	A	0.0000
63	S	A	0.1813
64	V	A	1.3502
65	T	A	0.3117
66	E	A	-0.4118
67	T	A	-0.5774
68	L	A	-0.9216
69	P	A	-1.5484
70	R	A	-2.5425
71	V	A	-1.8637
72	N	A	-2.6140
73	R	A	-2.8734
74	T	A	-1.8287
75	A	A	-1.4493
76	A	A	0.0000
77	I	A	-0.7487
78	S	A	0.0000
79	G	A	0.0000
80	Y	A	0.4457
81	S	A	0.0000
82	F	A	0.2538
83	K	A	0.0000
84	Q	A	-0.8620
85	C	A	0.0000
86	S	A	-0.9292
87	H	A	-1.2851
88	Q	A	-1.0841
89	I	A	-0.3165
90	S	A	-0.3570
91	A	A	-0.0469
92	C	A	-0.6406
93	N	A	-1.6389
94	K	A	-2.1848
95	D	A	-1.3738
96	I	A	-0.0352
97	Y	A	0.7734
98	V	A	0.9638
99	D	A	-0.9058
100	L	A	0.0000
101	D	A	0.0000
102	M	A	0.0000
103	K	A	-1.2962
104	G	A	-0.4714
105	I	A	0.7275
106	N	A	-0.5171
107	Y	A	-0.5223
108	N	A	-1.0677
109	S	A	-0.2605
110	S	A	0.5807
111	V	A	1.2514
112	A	A	0.0000
113	K	A	-1.7714
114	S	A	-1.5224
115	A	A	-1.3783
116	Q	A	-2.0518
117	E	A	-2.0741
118	C	A	0.0000
119	Q	A	0.0000
120	E	A	-2.8115
121	R	A	-2.0538
122	C	A	0.0000
123	T	A	0.0000
124	D	A	-1.5286
125	D	A	-1.0122
126	V	A	0.0754
127	H	A	-0.5136
128	C	A	0.0000
129	H	A	-0.3662
130	F	A	0.0000
131	F	A	0.0000
132	T	A	0.0000
133	Y	A	0.0000
134	A	A	0.0000
135	T	A	-1.9385
136	R	A	-2.6238
137	Q	A	-2.2750
138	F	A	-2.0082
139	P	A	-1.2856
140	S	A	-0.8750
141	L	A	-0.3670
142	E	A	-1.7779
143	H	A	-1.6789
144	R	A	-1.7767
145	N	A	-1.2224
146	I	A	-0.0235
147	C	A	0.0000
148	L	A	0.1502
149	L	A	0.0000
150	K	A	0.0000
151	H	A	-0.2551
152	T	A	0.0000
153	Q	A	-1.1740
154	T	A	-0.7753
155	G	A	-0.5862
156	T	A	-0.5876
157	P	A	0.0000
158	T	A	-1.0968
159	R	A	-2.2964
160	I	A	0.0000
161	T	A	-1.6818
162	K	A	-1.9837
163	L	A	-1.1698
164	D	A	-2.3677
165	K	A	-2.3690
166	V	A	0.0000
167	V	A	0.0000
168	S	A	0.0000
169	G	A	0.0000
170	F	A	0.0000
171	S	A	-0.9702
172	L	A	0.0000
173	K	A	0.0000
174	S	A	-0.3002
175	C	A	-0.1898
176	A	A	-0.1252
177	L	A	-0.6333
178	S	A	0.0000
179	N	A	-1.4580
180	L	A	-0.2656
181	A	A	-0.3623
182	C	A	-0.1569
183	I	A	0.4766
184	R	A	-0.2792
185	D	A	-0.7269
186	I	A	1.0930
187	F	A	0.1149
188	P	A	-0.7437
189	N	A	-2.4364
190	T	A	-1.6823
191	V	A	-1.0717
192	F	A	0.0000
193	A	A	-0.5394
194	D	A	-0.8872
195	S	A	-1.1165
196	N	A	-1.3640
197	I	A	-0.6913
198	D	A	-1.3285
199	S	A	-0.4697
200	V	A	-0.0268
201	M	A	-0.0111
202	A	A	0.0000
203	P	A	-0.0310
204	D	A	-0.0431
205	A	A	0.6364
206	F	A	1.4837
207	V	A	0.0000
208	C	A	0.0000
209	G	A	0.5999
210	R	A	0.1514
211	I	A	0.1846
212	C	A	0.0000
213	T	A	0.0000
214	H	A	-0.4530
215	H	A	-0.6784
216	P	A	-0.6338
217	G	A	-0.8138
218	C	A	0.0000
219	L	A	0.0000
220	F	A	0.0000
221	F	A	0.0000
222	T	A	0.0000
223	F	A	0.0000
224	F	A	0.0000
225	S	A	-2.0845
226	Q	A	-2.6059
227	E	A	-3.3097
228	W	A	0.0000
229	P	A	-2.4902
230	K	A	-3.2345
231	E	A	-3.6432
232	S	A	-2.0972
233	Q	A	-2.2635
234	R	A	-2.6220
235	N	A	0.0000
236	L	A	-0.4495
237	C	A	0.0000
238	L	A	-0.2426
239	L	A	0.0000
240	K	A	0.0000
241	T	A	-0.6044
242	S	A	-0.8806
243	E	A	-1.7000
244	S	A	-0.6288
245	G	A	0.0000
246	L	A	0.9331
247	P	A	-0.1474
248	S	A	-0.5928
249	T	A	-0.6016
250	R	A	-1.8611
251	I	A	-1.2217
252	K	A	-2.6630
253	K	A	-3.0068
254	S	A	-2.4162
255	K	A	-2.4549
256	A	A	0.0000
257	L	A	-0.1550
258	S	A	0.0000
259	G	A	0.0000
260	F	A	0.0000
261	S	A	0.0353
262	L	A	0.2171
263	Q	A	-0.0381
264	S	A	0.0000
265	C	A	0.0000
266	R	A	-0.4720
267	H	A	-0.4993
268	S	A	0.0000
269	I	A	0.0000
270	P	A	-0.7031
271	V	A	0.0000
272	F	A	0.0000
273	C	A	0.1631
274	H	A	0.0000
275	S	A	-0.0949
276	S	A	-0.0757
277	F	A	0.0971
278	Y	A	-0.3038
279	H	A	-1.2612
280	D	A	-1.8397
281	T	A	0.0000
282	D	A	-0.6662
283	F	A	0.0000
284	L	A	0.1684
285	G	A	-1.0534
286	E	A	-2.6273
287	E	A	-2.4786
288	L	A	-1.0026
289	D	A	-1.0511
290	I	A	0.4223
291	V	A	0.4169
292	A	A	-0.6047
293	A	A	0.0000
294	K	A	-3.1548
295	S	A	-1.9907
296	H	A	-1.9036
297	E	A	-2.5389
298	A	A	-1.8442
299	C	A	0.0000
300	Q	A	0.0000
301	K	A	-2.2999
302	L	A	-0.9239
303	C	A	0.0000
304	T	A	-1.2733
305	N	A	-1.6996
306	A	A	-1.0476
307	V	A	0.0000
308	R	A	-0.4663
309	C	A	0.0000
310	Q	A	0.0000
311	F	A	0.0000
312	F	A	0.0000
313	T	A	0.0000
314	Y	A	0.0000
315	T	A	-1.3494
316	P	A	-1.8157
317	A	A	-2.2500
318	Q	A	-1.9172
319	A	A	-0.9746
320	S	A	-0.8913
321	C	A	-0.6783
322	N	A	-2.4955
323	E	A	-3.2784
324	G	A	-3.0407
325	K	A	-3.3733
326	G	A	0.0000
327	K	A	-1.0520
328	C	A	0.0000
329	Y	A	0.0155
330	L	A	0.0000
331	K	A	0.0000
332	L	A	0.0000
333	S	A	-1.1983
334	S	A	-0.9454
335	N	A	-1.0934
336	G	A	-0.4305
337	S	A	0.0000
338	P	A	-0.1879
339	T	A	0.2655
340	K	A	0.0000
341	I	A	-0.1943
342	L	A	-0.9244
343	H	A	-1.9228
344	G	A	-1.9860
345	R	A	-2.4834
346	G	A	-2.2053
347	G	A	0.0000
348	I	A	0.0000
349	S	A	0.0000
350	G	A	0.0000
351	Y	A	0.0000
352	T	A	0.0000
353	L	A	0.0839
354	R	A	0.0000
355	L	A	0.2163
356	C	A	-0.0858
357	K	A	-0.8786
358	M	A	0.0000
359	D	A	0.0000
360	N	A	-1.0400
361	E	A	-1.1420
362	C	A	0.0000
363	T	A	0.0000
364	T	A	-1.2536
365	K	A	-2.4799
366	I	A	-1.7614
367	K	A	-2.0643
368	P	A	-0.5610
369	R	A	0.3541
370	I	A	2.2808
371	V	A	2.3355
372	G	A	0.6937
373	G	A	0.0100
374	T	A	-0.1477
375	A	A	0.0853
376	S	A	0.0000
377	V	A	0.2581
378	R	A	-1.4429
379	G	A	-1.3555
380	E	A	-0.6020
381	W	A	0.0000
382	P	A	0.0000
383	W	A	0.0000
384	Q	A	0.0000
385	V	A	0.0000
386	T	A	0.0000
387	L	A	0.0000
388	H	A	0.0000
389	T	A	0.0000
390	T	A	-1.0295
391	S	A	-0.6668
392	P	A	-0.7541
393	T	A	-0.9840
394	Q	A	-1.4886
395	R	A	-2.1163
396	H	A	0.0000
397	L	A	-0.6065
398	C	A	0.0000
399	G	A	0.0000
400	G	A	0.0000
401	S	A	0.0000
402	I	A	0.0000
403	I	A	0.0718
404	G	A	-0.3333
405	N	A	-1.2633
406	Q	A	-1.2914
407	W	A	-0.4355
408	I	A	0.0000
409	L	A	0.0000
410	T	A	0.0000
411	A	A	0.0000
412	A	A	0.0000
413	H	A	0.2267
414	C	A	0.0000
415	F	A	0.0000
416	Y	A	0.9031
417	G	A	-0.2443
418	V	A	-0.6231
419	E	A	-1.8586
420	S	A	-1.6780
421	P	A	-1.7523
422	K	A	-2.2315
423	I	A	-1.0565
424	L	A	0.0000
425	R	A	-0.7729
426	V	A	0.0000
427	Y	A	0.0000
428	S	A	0.1268
429	G	A	-0.4785
430	I	A	-0.1961
431	L	A	-0.5136
432	N	A	-1.1171
433	Q	A	-1.1985
434	S	A	-1.1575
435	E	A	-1.3610
436	I	A	-1.7804
437	K	A	-3.2851
438	E	A	-3.5683
439	D	A	-3.1493
440	T	A	-2.0063
441	S	A	-0.8314
442	F	A	0.2102
443	F	A	-0.2458
444	G	A	-1.3691
445	V	A	0.0000
446	Q	A	-2.6874
447	E	A	-2.1302
448	I	A	-0.4274
449	I	A	0.1408
450	I	A	0.3679
451	H	A	-0.9372
452	D	A	-2.2912
453	Q	A	-2.2305
454	Y	A	0.0000
455	K	A	-1.8846
456	M	A	-0.3249
457	A	A	0.0000
458	E	A	-0.9044
459	S	A	-1.0578
460	G	A	0.0000
461	Y	A	-0.5111
462	D	A	0.0000
463	I	A	0.0000
464	A	A	0.0000
465	L	A	0.0000
466	L	A	0.0000
467	K	A	-1.7323
468	L	A	0.0000
469	E	A	-2.4522
470	T	A	-1.4108
471	T	A	-1.2436
472	V	A	0.0000
473	N	A	-1.3934
474	Y	A	-1.0112
475	T	A	-1.1582
476	D	A	-2.3579
477	S	A	-1.2655
478	Q	A	-1.0005
479	R	A	0.0000
480	P	A	0.0000
481	I	A	0.0000
482	C	A	0.0000
483	L	A	0.3044
484	P	A	0.0000
485	S	A	-0.4748
486	K	A	-1.1170
487	G	A	0.0000
488	D	A	0.0000
489	R	A	-2.2056
490	N	A	-1.4017
491	V	A	0.1010
492	I	A	1.5220
493	Y	A	0.0000
494	T	A	0.0680
495	D	A	-0.6512
496	C	A	0.0000
497	W	A	-0.5507
498	V	A	-0.1909
499	T	A	0.0000
500	G	A	0.0000
501	W	A	0.0000
502	G	A	-1.5222
509	K	A	-1.8980
510	I	A	-1.2851
511	Q	A	-1.4985
512	N	A	-1.5153
513	T	A	-0.9651
514	L	A	0.0000
515	Q	A	-0.9700
516	K	A	0.0000
517	A	A	-0.7970
518	K	A	-1.5263
519	I	A	-0.3734
520	P	A	-0.1525
521	L	A	0.7486
522	V	A	-0.2220
523	T	A	-1.0241
524	N	A	-2.0729
525	E	A	-3.1969
526	E	A	-3.2786
527	C	A	0.0000
528	Q	A	-3.5042
529	K	A	-3.9166
530	R	A	-3.9600
531	Y	A	0.0000
532	R	A	-3.4442
533	G	A	-2.3682
534	H	A	-2.8634
535	K	A	-2.9581
536	I	A	0.0000
537	T	A	-1.4417
538	H	A	-1.6913
539	K	A	-0.9193
540	M	A	0.0000
541	I	A	-0.3085
542	C	A	0.0000
543	A	A	-0.0794
554	K	A	-2.0930
555	G	A	0.0000
556	D	A	-1.1686
557	S	A	-0.8422
558	G	A	0.0000
559	G	A	0.0000
560	P	A	0.0000
561	L	A	0.0000
562	S	A	0.0000
563	C	A	0.0000
564	K	A	-1.6726
565	H	A	-1.4479
566	N	A	-2.0014
567	E	A	-2.7476
568	V	A	0.0000
569	W	A	-0.9630
570	H	A	0.0000
571	L	A	0.0000
572	V	A	0.0000
573	G	A	0.0000
574	I	A	0.0000
575	T	A	-0.3228
576	S	A	0.0000
577	W	A	-0.6109
578	G	A	-1.6625
579	E	A	-2.3926
580	G	A	-1.9461
585	E	A	-3.5666
586	R	A	-3.7041
587	P	A	-2.1294
588	G	A	-1.2778
589	V	A	0.0000
590	Y	A	0.0214
591	T	A	0.0000
592	N	A	-0.4876
593	V	A	0.0000
594	V	A	-0.8109
595	E	A	-1.3633
596	Y	A	0.0000
597	V	A	0.0000
598	D	A	-1.4054
599	W	A	-1.0189
600	I	A	0.0000
601	L	A	-0.5614
602	E	A	-1.7360
603	K	A	-0.9592
604	V	A	0.6386