Project name: 247bb8cbf2849ee
Status: done
submitted: 2018-04-12 18:13:05, status changed: 2018-04-16 01:19:07
Settings
|
Chain sequence(s)
|
B: EDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRKDSYVGDEAQSILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMHLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF
|
| Distance of aggregation |
10 Å |
| Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.6075
-
Maximal score value
-
1.6321
-
Average score
-
-0.7393
-
Total score value
-
-266.1652
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
| residue index |
residue name |
chain |
Aggrescan3D score |
|
| 3 |
E |
B |
-2.8674 |
|
| 4 |
D |
B |
-3.0733 |
|
| 5 |
S |
B |
-2.2698 |
|
| 6 |
T |
B |
-1.5257 |
|
| 7 |
A |
B |
-0.7979 |
|
| 8 |
L |
B |
0.0000 |
|
| 9 |
V |
B |
0.0000 |
|
| 10 |
C |
B |
0.0000 |
|
| 11 |
D |
B |
0.0000 |
|
| 12 |
N |
B |
0.0000 |
|
| 13 |
G |
B |
-0.1932 |
|
| 14 |
S |
B |
0.0000 |
|
| 15 |
G |
B |
-0.2134 |
|
| 16 |
L |
B |
0.7301 |
|
| 17 |
C |
B |
0.0000 |
|
| 18 |
K |
B |
-0.1747 |
|
| 19 |
A |
B |
0.0000 |
|
| 20 |
G |
B |
0.0000 |
|
| 21 |
F |
B |
-1.2541 |
|
| 22 |
A |
B |
-0.7664 |
|
| 23 |
G |
B |
-1.2119 |
|
| 24 |
D |
B |
-2.5433 |
|
| 25 |
D |
B |
-2.6928 |
|
| 26 |
A |
B |
-1.7914 |
|
| 27 |
P |
B |
-1.3597 |
|
| 28 |
R |
B |
-2.1655 |
|
| 29 |
A |
B |
0.0000 |
|
| 30 |
V |
B |
0.1533 |
|
| 31 |
F |
B |
0.0000 |
|
| 32 |
P |
B |
-0.3315 |
|
| 33 |
S |
B |
0.0000 |
|
| 34 |
I |
B |
0.0000 |
|
| 35 |
V |
B |
0.0000 |
|
| 36 |
G |
B |
0.0000 |
|
| 37 |
R |
B |
-1.5426 |
|
| 38 |
P |
B |
-1.2948 |
|
| 39 |
R |
B |
-1.4184 |
|
| 50 |
K |
B |
-2.7085 |
|
| 51 |
D |
B |
-2.8175 |
|
| 52 |
S |
B |
-1.7122 |
|
| 53 |
Y |
B |
-1.4407 |
|
| 54 |
V |
B |
0.0000 |
|
| 55 |
G |
B |
0.0000 |
|
| 56 |
D |
B |
-2.5665 |
|
| 57 |
E |
B |
-2.0424 |
|
| 58 |
A |
B |
0.0000 |
|
| 59 |
Q |
B |
-2.0941 |
|
| 60 |
S |
B |
-1.2530 |
|
| 64 |
I |
B |
1.4653 |
|
| 65 |
L |
B |
0.0626 |
|
| 66 |
T |
B |
-0.3689 |
|
| 67 |
L |
B |
-0.2029 |
|
| 68 |
K |
B |
-0.9153 |
|
| 69 |
Y |
B |
-0.3291 |
|
| 70 |
P |
B |
0.0000 |
|
| 71 |
I |
B |
0.0000 |
|
| 72 |
E |
B |
-2.0025 |
|
| 73 |
H |
B |
-2.1288 |
|
| 74 |
G |
B |
-0.9502 |
|
| 75 |
I |
B |
-0.2641 |
|
| 76 |
I |
B |
0.0000 |
|
| 77 |
T |
B |
-0.6585 |
|
| 78 |
N |
B |
-1.0852 |
|
| 79 |
W |
B |
-1.3117 |
|
| 80 |
D |
B |
-2.2404 |
|
| 81 |
D |
B |
0.0000 |
|
| 82 |
M |
B |
0.0000 |
|
| 83 |
E |
B |
-1.9483 |
|
| 84 |
K |
B |
-1.7152 |
|
| 85 |
I |
B |
0.0000 |
|
| 86 |
W |
B |
0.0000 |
|
| 87 |
H |
B |
-1.4378 |
|
| 88 |
H |
B |
0.0000 |
|
| 89 |
S |
B |
0.0000 |
|
| 90 |
F |
B |
0.0000 |
|
| 91 |
Y |
B |
-0.9203 |
|
| 92 |
N |
B |
-1.4734 |
|
| 93 |
E |
B |
-1.5735 |
|
| 94 |
L |
B |
0.0000 |
|
| 95 |
R |
B |
-1.9893 |
|
| 96 |
V |
B |
-1.7485 |
|
| 97 |
A |
B |
-1.4001 |
|
| 98 |
P |
B |
0.0000 |
|
| 99 |
E |
B |
-2.2970 |
|
| 100 |
E |
B |
-2.7917 |
|
| 101 |
H |
B |
0.0000 |
|
| 102 |
P |
B |
-0.7476 |
|
| 103 |
T |
B |
0.0000 |
|
| 104 |
L |
B |
0.0000 |
|
| 105 |
L |
B |
0.0000 |
|
| 106 |
T |
B |
0.0000 |
|
| 107 |
E |
B |
0.0000 |
|
| 108 |
A |
B |
0.0000 |
|
| 109 |
P |
B |
0.0000 |
|
| 110 |
L |
B |
0.5188 |
|
| 111 |
N |
B |
-0.0927 |
|
| 112 |
P |
B |
-0.8731 |
|
| 113 |
K |
B |
-2.0653 |
|
| 114 |
A |
B |
-1.4124 |
|
| 115 |
N |
B |
-1.3070 |
|
| 116 |
R |
B |
-1.5357 |
|
| 117 |
E |
B |
-1.7077 |
|
| 118 |
K |
B |
-1.6535 |
|
| 119 |
M |
B |
0.0000 |
|
| 120 |
T |
B |
0.0000 |
|
| 121 |
Q |
B |
-1.6946 |
|
| 122 |
I |
B |
0.0000 |
|
| 123 |
M |
B |
0.0000 |
|
| 124 |
F |
B |
0.0000 |
|
| 125 |
E |
B |
-2.5538 |
|
| 126 |
T |
B |
-1.5338 |
|
| 127 |
F |
B |
0.0000 |
|
| 128 |
N |
B |
-2.3369 |
|
| 129 |
V |
B |
0.0000 |
|
| 130 |
P |
B |
-1.3362 |
|
| 131 |
A |
B |
-0.8537 |
|
| 132 |
M |
B |
0.0000 |
|
| 133 |
Y |
B |
0.0000 |
|
| 134 |
V |
B |
0.0000 |
|
| 135 |
A |
B |
0.0000 |
|
| 136 |
I |
B |
0.7452 |
|
| 137 |
Q |
B |
-0.0166 |
|
| 138 |
A |
B |
0.0000 |
|
| 139 |
V |
B |
0.0000 |
|
| 140 |
L |
B |
0.0000 |
|
| 141 |
S |
B |
0.0000 |
|
| 142 |
L |
B |
0.0000 |
|
| 143 |
Y |
B |
0.1004 |
|
| 144 |
A |
B |
0.1097 |
|
| 145 |
S |
B |
-0.3030 |
|
| 146 |
G |
B |
-0.5181 |
|
| 147 |
R |
B |
-0.8412 |
|
| 148 |
T |
B |
-0.7550 |
|
| 149 |
T |
B |
-0.7203 |
|
| 150 |
G |
B |
0.0000 |
|
| 151 |
I |
B |
0.0000 |
|
| 152 |
V |
B |
0.0000 |
|
| 153 |
L |
B |
0.0000 |
|
| 154 |
D |
B |
-0.5651 |
|
| 155 |
S |
B |
0.0000 |
|
| 156 |
G |
B |
-0.8575 |
|
| 157 |
D |
B |
-1.3257 |
|
| 158 |
G |
B |
-1.5397 |
|
| 159 |
V |
B |
-1.6024 |
|
| 160 |
T |
B |
0.0000 |
|
| 161 |
H |
B |
0.0000 |
|
| 162 |
N |
B |
0.0000 |
|
| 163 |
V |
B |
0.0000 |
|
| 164 |
P |
B |
0.0000 |
|
| 165 |
I |
B |
0.0000 |
|
| 166 |
Y |
B |
-0.1557 |
|
| 167 |
E |
B |
-1.4002 |
|
| 168 |
G |
B |
-0.0565 |
|
| 169 |
Y |
B |
0.7753 |
|
| 170 |
A |
B |
0.0000 |
|
| 171 |
L |
B |
-0.0075 |
|
| 172 |
P |
B |
-0.3986 |
|
| 173 |
H |
B |
-1.2316 |
|
| 174 |
A |
B |
0.0000 |
|
| 175 |
I |
B |
0.0000 |
|
| 176 |
M |
B |
-0.6664 |
|
| 177 |
H |
B |
-1.2912 |
|
| 178 |
L |
B |
0.0000 |
|
| 179 |
D |
B |
-2.5295 |
|
| 180 |
L |
B |
0.0000 |
|
| 181 |
A |
B |
0.0000 |
|
| 182 |
G |
B |
0.0000 |
|
| 183 |
R |
B |
-1.6194 |
|
| 184 |
D |
B |
-1.4075 |
|
| 185 |
L |
B |
0.0000 |
|
| 186 |
T |
B |
0.0000 |
|
| 187 |
D |
B |
-1.6201 |
|
| 188 |
Y |
B |
-0.9960 |
|
| 189 |
L |
B |
0.0000 |
|
| 190 |
M |
B |
0.0000 |
|
| 191 |
K |
B |
-1.9431 |
|
| 192 |
I |
B |
0.0000 |
|
| 193 |
L |
B |
0.0000 |
|
| 194 |
T |
B |
-1.8652 |
|
| 195 |
E |
B |
-2.9300 |
|
| 196 |
R |
B |
-2.3924 |
|
| 197 |
G |
B |
-1.7740 |
|
| 198 |
Y |
B |
-0.9095 |
|
| 199 |
S |
B |
-0.5514 |
|
| 200 |
F |
B |
0.0000 |
|
| 201 |
V |
B |
0.9877 |
|
| 202 |
T |
B |
0.3094 |
|
| 203 |
T |
B |
-0.1777 |
|
| 204 |
A |
B |
-0.5996 |
|
| 205 |
E |
B |
-0.7223 |
|
| 206 |
R |
B |
-1.2740 |
|
| 207 |
E |
B |
-1.5964 |
|
| 208 |
I |
B |
-1.1917 |
|
| 209 |
V |
B |
0.0000 |
|
| 210 |
R |
B |
-2.3971 |
|
| 211 |
D |
B |
-2.4961 |
|
| 212 |
I |
B |
0.0000 |
|
| 213 |
K |
B |
0.0000 |
|
| 214 |
E |
B |
-3.0821 |
|
| 215 |
K |
B |
-2.9001 |
|
| 216 |
L |
B |
0.0000 |
|
| 217 |
C |
B |
0.0000 |
|
| 218 |
Y |
B |
-0.4106 |
|
| 219 |
V |
B |
0.0000 |
|
| 220 |
A |
B |
0.0000 |
|
| 221 |
L |
B |
-0.7268 |
|
| 222 |
D |
B |
-1.3896 |
|
| 223 |
F |
B |
-1.3876 |
|
| 224 |
E |
B |
-2.4778 |
|
| 225 |
N |
B |
-2.3049 |
|
| 226 |
E |
B |
-1.5650 |
|
| 227 |
M |
B |
-1.0847 |
|
| 228 |
A |
B |
-0.9251 |
|
| 229 |
T |
B |
-0.8099 |
|
| 230 |
A |
B |
-0.8635 |
|
| 231 |
A |
B |
-0.2706 |
|
| 232 |
S |
B |
-0.3426 |
|
| 233 |
S |
B |
-0.6706 |
|
| 234 |
S |
B |
-0.9509 |
|
| 235 |
S |
B |
-0.9004 |
|
| 236 |
L |
B |
0.0000 |
|
| 237 |
E |
B |
-2.0409 |
|
| 238 |
K |
B |
-1.4864 |
|
| 239 |
S |
B |
-1.0184 |
|
| 240 |
Y |
B |
0.0000 |
|
| 241 |
E |
B |
-2.2930 |
|
| 242 |
L |
B |
-1.7728 |
|
| 243 |
P |
B |
-1.6843 |
|
| 244 |
D |
B |
-2.6229 |
|
| 245 |
G |
B |
-2.2673 |
|
| 246 |
Q |
B |
-2.0657 |
|
| 247 |
V |
B |
-0.9410 |
|
| 248 |
I |
B |
0.0000 |
|
| 249 |
T |
B |
-0.8515 |
|
| 250 |
I |
B |
0.0000 |
|
| 251 |
G |
B |
-1.2457 |
|
| 252 |
N |
B |
-0.7592 |
|
| 253 |
E |
B |
0.0000 |
|
| 254 |
R |
B |
-1.0354 |
|
| 255 |
F |
B |
0.0000 |
|
| 256 |
R |
B |
-0.2965 |
|
| 257 |
C |
B |
0.0000 |
|
| 258 |
P |
B |
0.0000 |
|
| 259 |
E |
B |
0.0000 |
|
| 260 |
T |
B |
0.0000 |
|
| 261 |
L |
B |
0.0000 |
|
| 262 |
F |
B |
0.0000 |
|
| 263 |
Q |
B |
-0.5996 |
|
| 264 |
P |
B |
0.0000 |
|
| 265 |
S |
B |
-0.5653 |
|
| 266 |
F |
B |
0.2172 |
|
| 267 |
I |
B |
-0.1002 |
|
| 268 |
G |
B |
-0.5459 |
|
| 269 |
M |
B |
-1.0106 |
|
| 270 |
E |
B |
-1.8374 |
|
| 271 |
S |
B |
-1.3072 |
|
| 272 |
A |
B |
-0.8396 |
|
| 273 |
G |
B |
0.0000 |
|
| 274 |
I |
B |
0.0000 |
|
| 275 |
H |
B |
-0.7391 |
|
| 276 |
E |
B |
-0.9172 |
|
| 277 |
T |
B |
-0.7261 |
|
| 278 |
T |
B |
0.0000 |
|
| 279 |
Y |
B |
-0.5818 |
|
| 280 |
N |
B |
-1.3068 |
|
| 281 |
S |
B |
0.0000 |
|
| 282 |
I |
B |
0.0000 |
|
| 283 |
M |
B |
-0.7673 |
|
| 284 |
K |
B |
-2.0767 |
|
| 285 |
C |
B |
0.0000 |
|
| 286 |
D |
B |
-1.6764 |
|
| 287 |
I |
B |
-0.2245 |
|
| 288 |
D |
B |
-1.8714 |
|
| 289 |
I |
B |
-1.4315 |
|
| 290 |
R |
B |
-1.7585 |
|
| 291 |
K |
B |
-2.7240 |
|
| 292 |
D |
B |
-2.5595 |
|
| 293 |
L |
B |
0.0000 |
|
| 294 |
Y |
B |
0.0000 |
|
| 295 |
A |
B |
-1.7954 |
|
| 296 |
N |
B |
-1.3021 |
|
| 297 |
N |
B |
0.0000 |
|
| 298 |
V |
B |
0.0000 |
|
| 299 |
L |
B |
0.0000 |
|
| 300 |
S |
B |
0.0000 |
|
| 301 |
G |
B |
-1.0252 |
|
| 302 |
G |
B |
-1.2950 |
|
| 303 |
T |
B |
0.0000 |
|
| 304 |
T |
B |
0.0000 |
|
| 305 |
M |
B |
-0.5758 |
|
| 306 |
Y |
B |
0.0000 |
|
| 307 |
P |
B |
-0.5841 |
|
| 308 |
G |
B |
-0.6208 |
|
| 309 |
I |
B |
0.0000 |
|
| 310 |
A |
B |
-1.1749 |
|
| 311 |
D |
B |
-2.1817 |
|
| 312 |
R |
B |
0.0000 |
|
| 313 |
M |
B |
0.0000 |
|
| 314 |
Q |
B |
-1.8474 |
|
| 315 |
K |
B |
-1.7602 |
|
| 316 |
E |
B |
-1.0446 |
|
| 317 |
I |
B |
0.0000 |
|
| 318 |
T |
B |
-0.7800 |
|
| 319 |
A |
B |
-0.1407 |
|
| 320 |
L |
B |
0.2589 |
|
| 321 |
A |
B |
0.0000 |
|
| 322 |
P |
B |
-0.5036 |
|
| 323 |
S |
B |
-0.4305 |
|
| 324 |
T |
B |
-0.5795 |
|
| 325 |
M |
B |
-1.4764 |
|
| 326 |
K |
B |
-2.4354 |
|
| 327 |
I |
B |
0.0000 |
|
| 328 |
K |
B |
-1.5577 |
|
| 329 |
I |
B |
0.0000 |
|
| 330 |
I |
B |
-0.0981 |
|
| 331 |
A |
B |
-0.4767 |
|
| 332 |
P |
B |
-0.5124 |
|
| 333 |
P |
B |
-0.8266 |
|
| 334 |
E |
B |
-1.5933 |
|
| 335 |
R |
B |
0.0000 |
|
| 336 |
K |
B |
-1.8355 |
|
| 337 |
Y |
B |
-1.0338 |
|
| 338 |
S |
B |
0.0000 |
|
| 339 |
V |
B |
0.0000 |
|
| 340 |
W |
B |
0.0000 |
|
| 341 |
I |
B |
0.0000 |
|
| 342 |
G |
B |
0.0000 |
|
| 343 |
G |
B |
0.0000 |
|
| 344 |
S |
B |
0.0000 |
|
| 345 |
I |
B |
0.3876 |
|
| 346 |
L |
B |
0.5333 |
|
| 347 |
A |
B |
0.0000 |
|
| 348 |
S |
B |
-0.0336 |
|
| 349 |
L |
B |
0.2785 |
|
| 350 |
S |
B |
-0.3938 |
|
| 351 |
T |
B |
-0.4365 |
|
| 352 |
F |
B |
0.0000 |
|
| 353 |
Q |
B |
-1.3091 |
|
| 354 |
Q |
B |
-1.4564 |
|
| 355 |
M |
B |
-0.6479 |
|
| 356 |
W |
B |
0.0000 |
|
| 357 |
I |
B |
0.0000 |
|
| 358 |
S |
B |
-1.1893 |
|
| 359 |
K |
B |
-2.2806 |
|
| 360 |
Q |
B |
-2.7693 |
|
| 361 |
E |
B |
-2.5416 |
|
| 362 |
Y |
B |
0.0000 |
|
| 363 |
D |
B |
-3.6075 |
|
| 364 |
E |
B |
-3.2572 |
|
| 365 |
A |
B |
-1.8169 |
|
| 366 |
G |
B |
-1.5666 |
|
| 367 |
P |
B |
-1.2391 |
|
| 368 |
S |
B |
-1.2248 |
|
| 369 |
I |
B |
0.0000 |
|
| 370 |
V |
B |
0.0000 |
|
| 371 |
H |
B |
-1.2351 |
|
| 372 |
R |
B |
-1.7139 |
|
| 373 |
K |
B |
-0.7889 |
|
| 374 |
C |
B |
0.0000 |
|
| 375 |
F |
B |
1.6321 |
|
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine