Project name: 24cbda432787a36

Chain sequence(s)	A: TLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEFSLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.3503
• Maximal score value: 0.9737
• Average score: -0.6408
• Total score value: -189.6767

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
28	T	A	-0.3274
29	L	A	-0.3628
30	P	A	-1.5495
31	K	A	-2.7540
32	R	A	-3.2600
33	V	A	0.0000
34	K	A	-1.2135
35	I	A	0.0000
36	V	A	0.0000
37	E	A	0.0000
38	V	A	0.0000
39	G	A	0.0000
40	P	A	0.0000
41	R	A	0.0000
42	D	A	-0.3502
43	G	A	0.0000
44	L	A	0.0000
45	Q	A	-0.6374
46	N	A	-0.9480
47	E	A	-1.2401
48	K	A	-2.0216
49	N	A	-1.3109
50	I	A	0.7647
51	V	A	0.0000
52	S	A	0.2657
53	T	A	-0.4808
54	P	A	-0.7159
55	V	A	-0.0612
56	K	A	0.0000
57	I	A	-1.0951
58	K	A	-1.3093
59	L	A	0.0000
60	I	A	0.0000
61	D	A	-1.4209
62	M	A	-1.3643
63	L	A	0.0000
64	S	A	0.0000
65	E	A	-2.1790
66	A	A	0.0000
67	G	A	-1.1728
68	L	A	0.0000
69	S	A	-0.6409
70	V	A	0.0000
71	I	A	0.0000
72	E	A	0.0000
73	T	A	0.0000
74	T	A	0.0000
75	S	A	0.0000
76	F	A	0.0000
77	V	A	0.0000
78	S	A	-0.6547
79	P	A	-0.8908
80	K	A	-1.3187
81	W	A	0.2388
82	V	A	-0.1174
83	P	A	-0.4484
84	Q	A	-0.4779
85	M	A	0.0000
86	G	A	-0.8705
87	D	A	-1.0259
88	H	A	-1.1370
89	T	A	-1.5391
90	E	A	-2.6232
91	V	A	0.0000
92	L	A	0.0000
93	K	A	-2.8903
94	G	A	-2.3172
95	I	A	0.0000
96	Q	A	-2.3658
97	K	A	-2.3681
98	F	A	-1.3123
99	P	A	-0.8557
100	G	A	-0.8375
101	I	A	-0.7724
102	N	A	-1.4012
103	Y	A	0.0000
104	P	A	0.0000
105	V	A	0.0000
106	L	A	0.0000
107	T	A	0.0000
108	P	A	0.0000
109	N	A	-1.0373
110	L	A	-1.2219
111	K	A	-2.1818
112	G	A	0.0000
113	F	A	0.0000
114	E	A	-2.0779
115	A	A	-1.0692
116	A	A	0.0000
117	V	A	-0.4189
118	A	A	-0.2247
119	A	A	0.0000
120	G	A	-0.7907
121	A	A	0.0000
122	K	A	-1.9526
123	E	A	0.0000
124	V	A	0.0000
125	V	A	0.0000
126	I	A	0.0000
127	F	A	0.6740
128	G	A	0.2706
129	A	A	0.0000
130	A	A	0.0000
131	S	A	0.0000
132	E	A	-2.0986
133	L	A	-1.3546
134	F	A	0.0000
135	T	A	0.0000
136	K	A	-2.7503
137	K	A	-2.5460
138	N	A	-1.5289
139	I	A	-0.6857
140	N	A	-2.1044
141	C	A	-2.1493
142	S	A	-2.1854
143	I	A	-1.9661
144	E	A	-3.2136
145	E	A	-3.3503
146	S	A	0.0000
147	F	A	0.0000
148	Q	A	-2.6784
149	R	A	-2.1629
150	F	A	0.0000
151	D	A	-1.5693
152	A	A	-1.2421
153	I	A	0.0000
154	L	A	0.0000
155	K	A	-2.2929
156	A	A	-1.6471
157	A	A	0.0000
158	Q	A	-2.3515
159	S	A	-1.5394
160	A	A	-1.3931
161	N	A	-1.9579
162	I	A	-1.3184
163	S	A	-0.8684
164	V	A	0.0000
165	R	A	0.0000
166	G	A	0.0000
167	Y	A	0.0000
168	V	A	0.0000
169	S	A	0.0839
170	C	A	0.0000
171	A	A	0.0000
172	L	A	0.0000
173	G	A	0.0000
174	C	A	0.0000
175	P	A	-0.0407
176	Y	A	-0.3004
177	E	A	-1.1200
178	G	A	-1.1769
179	K	A	-1.8484
180	I	A	0.0000
181	S	A	-1.0376
182	P	A	-1.1692
183	A	A	-1.1931
184	K	A	-1.0982
185	V	A	0.0000
186	A	A	0.0000
187	E	A	-2.6639
188	V	A	0.0000
189	T	A	0.0000
190	K	A	-2.1774
191	K	A	-2.0150
192	F	A	0.0000
193	Y	A	-0.2940
194	S	A	-0.4464
195	M	A	-0.5959
196	G	A	-0.7525
197	C	A	0.0000
198	Y	A	0.6704
199	E	A	0.0000
200	F	A	0.0000
201	S	A	0.0000
202	L	A	0.0000
203	G	A	0.0000
204	D	A	0.0000
205	T	A	0.0645
206	I	A	0.0000
207	G	A	0.0000
208	V	A	0.6876
209	G	A	0.0000
210	T	A	0.0072
211	P	A	-0.6311
212	G	A	-1.1142
213	I	A	-0.8699
214	M	A	0.0000
215	K	A	-2.0764
216	D	A	-2.3320
217	M	A	0.0000
218	L	A	0.0000
219	S	A	-1.3083
220	A	A	-1.5610
221	V	A	0.0000
222	M	A	-0.9429
223	Q	A	-1.9917
224	E	A	-2.7106
225	V	A	0.0000
226	P	A	-0.4277
227	L	A	0.2378
228	A	A	0.3949
229	A	A	0.0000
230	L	A	0.0000
231	A	A	0.0000
232	V	A	0.0000
233	H	A	0.0000
234	C	A	0.0000
235	H	A	0.0000
236	D	A	-0.3087
237	T	A	0.0494
238	Y	A	0.9737
239	G	A	-0.0721
240	Q	A	-0.1123
241	A	A	0.0000
242	L	A	0.1538
243	A	A	0.0987
244	N	A	0.0000
245	T	A	0.0000
246	L	A	0.3918
247	M	A	-0.2019
248	A	A	0.0000
249	L	A	0.0000
250	Q	A	-0.9004
251	M	A	-0.3163
252	G	A	-0.1879
253	V	A	0.0000
254	S	A	-0.7586
255	V	A	-0.2932
256	V	A	0.0000
257	D	A	0.0000
258	S	A	0.0000
259	S	A	0.0000
260	V	A	0.0000
261	A	A	0.0000
262	G	A	0.0000
263	L	A	0.0000
264	G	A	0.0000
265	G	A	-0.7581
266	C	A	-0.3689
267	P	A	-0.3826
268	Y	A	0.0408
269	A	A	-0.4969
270	Q	A	-1.3694
271	G	A	-1.0271
272	A	A	-0.4960
273	S	A	-0.3642
274	G	A	0.0000
275	N	A	0.0000
276	L	A	0.0000
277	A	A	0.0000
278	T	A	0.0000
279	E	A	0.0000
280	D	A	0.0000
281	L	A	0.0000
282	V	A	0.0000
283	Y	A	0.7515
284	M	A	0.2706
285	L	A	0.0000
286	E	A	-1.7361
287	G	A	-0.7640
288	L	A	-0.3812
289	G	A	-1.5584
290	I	A	0.0000
291	H	A	-2.8090
292	T	A	-2.1126
293	G	A	-1.5380
294	V	A	0.0000
295	N	A	-1.7692
296	L	A	-1.3468
297	Q	A	-2.2258
298	K	A	-2.7855
299	L	A	0.0000
300	L	A	0.0000
301	E	A	-2.6363
302	A	A	0.0000
303	G	A	0.0000
304	N	A	-2.2646
305	F	A	-1.0702
306	I	A	0.0000
307	C	A	0.0000
308	Q	A	-2.2099
309	A	A	-0.8907
310	L	A	0.0000
311	N	A	-2.2493
312	R	A	-2.6636
313	K	A	-2.7377
314	T	A	-2.0017
315	S	A	-1.2990
316	S	A	0.0000
317	K	A	-2.1607
318	V	A	0.0000
319	A	A	0.0000
320	Q	A	-1.8238
321	A	A	-0.7906
322	T	A	-0.4256
323	C	A	0.3625