Project name: 24e4aac69b20630

Chain sequence(s)	A: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; C: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; B: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; E: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; D: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA; F: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.2727
• Maximal score value: 2.7494
• Average score: -0.8307
• Total score value: -209.3362

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	A	-2.9111
2	A	A	-2.3232
3	E	A	-2.9603
4	F	A	-1.8290
5	R	A	-3.2822
6	H	A	-3.1017
7	D	A	-3.3821
8	S	A	-2.1929
9	G	A	-1.4513
10	Y	A	-0.2016
11	E	A	-0.9250
12	V	A	0.4124
13	H	A	-1.0921
14	H	A	-2.0384
15	Q	A	-2.0000
16	K	A	-2.2575
17	L	A	0.0000
18	V	A	0.2711
19	F	A	0.7251
20	F	A	-0.4378
21	A	A	-1.4811
22	E	A	-3.1589
23	D	A	-3.0137
24	V	A	-0.5719
25	G	A	-0.6443
26	S	A	-1.0551
27	N	A	0.0000
28	K	A	-2.0041
29	G	A	-0.2627
30	A	A	0.0000
31	I	A	0.8974
32	I	A	0.9863
33	G	A	0.6984
34	L	A	1.0697
35	M	A	0.6356
36	V	A	0.5089
37	G	A	-0.5005
38	G	A	0.1432
39	V	A	1.6506
40	V	A	2.7494
41	I	A	1.3577
42	A	A	0.4047
1	D	B	-3.6193
2	A	B	-2.3607
3	E	B	-2.7213
4	F	B	-1.6413
5	R	B	-3.4276
6	H	B	-3.1069
7	D	B	-4.2353
8	S	B	0.0000
9	G	B	-1.1404
10	Y	B	0.1459
11	E	B	-0.5381
12	V	B	0.0000
13	H	B	-1.7680
14	H	B	-2.4364
15	Q	B	0.0000
16	K	B	-1.8041
17	L	B	0.0000
18	V	B	0.0000
19	F	B	0.0000
20	F	B	0.0000
21	A	B	-2.1451
22	E	B	-4.2062
23	D	B	-3.9889
24	V	B	0.0000
25	G	B	-1.1479
26	S	B	-1.3491
27	N	B	0.0000
28	K	B	-1.8024
29	G	B	0.0000
30	A	B	0.0000
31	I	B	0.0000
32	I	B	0.0000
33	G	B	0.0000
34	L	B	0.0000
35	M	B	0.0000
36	V	B	0.0000
37	G	B	0.0000
38	G	B	0.6033
39	V	B	0.0000
40	V	B	2.6897
41	I	B	0.0000
42	A	B	0.5350
1	D	C	-2.5967
2	A	C	-1.6034
3	E	C	-1.8357
4	F	C	-0.2962
5	R	C	-2.6849
6	H	C	-2.5063
7	D	C	-3.0408
8	S	C	-1.8833
9	G	C	-0.9038
10	Y	C	0.0793
11	E	C	-0.9237
12	V	C	-0.0971
13	H	C	-1.3075
14	H	C	-1.6912
15	Q	C	-0.9180
16	K	C	-0.6504
17	L	C	0.5702
18	V	C	1.2852
19	F	C	0.8433
20	F	C	-0.4547
21	A	C	-1.3240
22	E	C	-3.2838
23	D	C	-3.3593
24	V	C	-2.4875
25	G	C	-1.5668
26	S	C	-1.5003
27	N	C	-1.8954
28	K	C	-2.0141
29	G	C	0.0000
30	A	C	-0.3240
31	I	C	0.5656
32	I	C	0.9944
33	G	C	0.5340
34	L	C	0.0000
35	M	C	0.4105
36	V	C	0.5190
37	G	C	-0.3007
38	G	C	0.1941
39	V	C	1.4113
40	V	C	2.5692
41	I	C	1.3540
42	A	C	0.5114
1	D	D	-2.9831
2	A	D	-2.4147
3	E	D	-3.1640
4	F	D	-1.9989
5	R	D	-3.4054
6	H	D	-3.1183
7	D	D	-3.4364
8	S	D	-2.2169
9	G	D	-1.4731
10	Y	D	-1.2241
11	E	D	-1.2964
12	V	D	0.0858
13	H	D	-1.7422
14	H	D	-2.0219
15	Q	D	-1.8608
16	K	D	-2.3819
17	L	D	0.0000
18	V	D	0.3824
19	F	D	0.6920
20	F	D	-0.4060
21	A	D	-1.4366
22	E	D	-3.1077
23	D	D	-2.9655
24	V	D	-0.5334
25	G	D	-0.6349
26	S	D	-1.0604
27	N	D	0.0000
28	K	D	-2.0684
29	G	D	-0.2800
30	A	D	0.0000
31	I	D	0.9032
32	I	D	0.9325
33	G	D	0.6254
34	L	D	0.9147
35	M	D	0.6118
36	V	D	0.6246
37	G	D	-0.2832
38	G	D	0.3202
39	V	D	1.7233
40	V	D	2.7412
41	I	D	1.3419
42	A	D	0.3910
1	D	E	-3.6814
2	A	E	-2.5494
3	E	E	-3.1049
4	F	E	-1.8593
5	R	E	-3.9018
6	H	E	-3.3756
7	D	E	-4.2727
8	S	E	-2.2746
9	G	E	-0.9067
10	Y	E	0.3950
11	E	E	-1.0411
12	V	E	-1.4932
13	H	E	-1.8821
14	H	E	-1.8173
15	Q	E	0.0000
16	K	E	-1.7302
17	L	E	0.0000
18	V	E	0.0000
19	F	E	0.0000
20	F	E	0.0000
21	A	E	-2.1100
22	E	E	-4.1394
23	D	E	-3.8809
24	V	E	0.0000
25	G	E	-1.1332
26	S	E	-1.4202
27	N	E	0.0000
28	K	E	-2.0069
29	G	E	0.0000
30	A	E	0.0000
31	I	E	0.0000
32	I	E	0.0000
33	G	E	0.0000
34	L	E	0.0000
35	M	E	0.0000
36	V	E	0.0000
37	G	E	0.0000
38	G	E	0.5542
39	V	E	0.0000
40	V	E	2.6731
41	I	E	0.0000
42	A	E	0.4631
1	D	F	-2.5922
2	A	F	-1.5134
3	E	F	-1.6937
4	F	F	-0.1560
5	R	F	-2.3461
6	H	F	-2.2559
7	D	F	-2.9028
8	S	F	-1.4037
9	G	F	-0.5963
10	Y	F	0.1757
11	E	F	-1.0547
12	V	F	-0.8497
13	H	F	-1.7127
14	H	F	-1.7728
15	Q	F	-1.2630
16	K	F	-0.7604
17	L	F	0.5983
18	V	F	1.4058
19	F	F	0.9435
20	F	F	-0.4842
21	A	F	-1.3033
22	E	F	-3.2553
23	D	F	-3.3180
24	V	F	-2.4266
25	G	F	-1.5843
26	S	F	-1.6107
27	N	F	-2.0477
28	K	F	-2.3866
29	G	F	0.0000
30	A	F	-0.2767
31	I	F	0.8750
32	I	F	1.2552
33	G	F	0.7875
34	L	F	0.8512
35	M	F	0.7356
36	V	F	0.6350
37	G	F	-0.3685
38	G	F	0.0871
39	V	F	1.3418
40	V	F	2.5449
41	I	F	1.2701
42	A	F	0.4533