Project name: 3fa379115af51cd

Chain sequence(s)	A: PVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAADQLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLMPVLKETEKIHNFKVHTFRGPHWCEYCVNFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.6103
• Maximal score value: 2.2228
• Average score: -0.8625
• Total score value: -346.7448

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
14	P	A	-0.5095
15	V	A	0.1996
16	W	A	0.0000
17	K	A	-0.8581
18	S	A	-0.5591
19	Y	A	-0.1951
20	L	A	0.0000
21	Y	A	-0.6788
22	Q	A	-1.6093
23	L	A	0.0000
24	Q	A	-1.1105
25	Q	A	-2.2869
26	E	A	-2.0138
27	A	A	-1.2493
28	P	A	-1.3782
29	H	A	-1.9597
30	P	A	-1.7981
31	R	A	-2.1399
32	R	A	-2.1018
33	I	A	-0.6592
34	T	A	-0.8882
35	C	A	-0.6200
36	T	A	-0.4042
37	C	A	-0.6440
38	E	A	-2.2879
39	V	A	-2.0647
40	E	A	-2.9506
41	N	A	-3.0826
42	R	A	-2.8820
43	P	A	-1.7863
44	K	A	-1.9897
45	Y	A	-0.7153
46	Y	A	0.0000
47	G	A	-1.5736
48	R	A	-2.1494
49	E	A	0.0000
50	F	A	0.0000
51	H	A	-0.5048
52	G	A	0.0000
53	M	A	-0.0369
54	I	A	-0.4958
55	S	A	-1.8115
56	R	A	-3.1905
57	E	A	-3.0883
58	A	A	-1.8068
59	A	A	0.0000
60	D	A	-1.5584
61	Q	A	-0.9822
62	L	A	0.4257
63	L	A	0.0000
64	I	A	1.9554
65	V	A	2.2228
66	A	A	0.7428
67	E	A	-0.9568
68	G	A	0.0000
69	S	A	0.0000
70	Y	A	0.0000
71	L	A	0.0000
72	I	A	0.0000
73	R	A	-0.6525
74	E	A	-1.2804
75	S	A	-2.2203
76	Q	A	-2.7755
77	R	A	-3.1762
78	Q	A	-2.7458
79	P	A	-1.8987
80	G	A	-1.3667
81	T	A	-1.3160
82	Y	A	-0.6830
83	T	A	0.0000
84	L	A	0.0000
85	A	A	0.0000
86	L	A	0.0000
87	R	A	-0.8615
88	F	A	0.0000
89	G	A	-1.0152
90	S	A	-0.7205
91	Q	A	-1.6318
92	T	A	-1.7502
93	R	A	-1.8463
94	N	A	-2.2694
95	F	A	-1.1030
96	R	A	-1.6429
97	L	A	0.0000
98	Y	A	-0.0656
99	Y	A	-0.5278
100	D	A	-2.0963
101	G	A	-1.9050
102	K	A	-2.6807
103	H	A	0.0000
104	F	A	-1.4235
105	V	A	-0.4006
106	G	A	-1.4786
107	E	A	-2.2501
108	K	A	-1.8263
109	R	A	-3.1554
110	F	A	0.0000
111	E	A	-2.8297
112	S	A	-1.7299
113	I	A	0.0000
114	H	A	-1.5423
115	D	A	-1.3304
116	L	A	0.0000
117	V	A	0.0000
118	T	A	-0.6878
119	D	A	0.0000
120	G	A	-0.0928
121	L	A	0.0000
122	I	A	0.0000
123	T	A	-0.5935
124	L	A	-0.7725
125	Y	A	-1.0043
126	I	A	0.0000
127	E	A	-2.3626
128	T	A	-1.8855
129	K	A	-2.3668
130	A	A	0.0000
131	A	A	-1.9988
132	E	A	-2.5227
133	Y	A	-1.5180
134	I	A	-1.2869
135	A	A	-1.2013
136	K	A	-1.5754
137	M	A	0.0000
138	T	A	0.0960
139	I	A	0.8444
140	N	A	-0.7016
141	P	A	-0.4369
142	I	A	-0.5509
143	Y	A	0.0000
144	E	A	-2.5844
145	H	A	-2.3801
146	V	A	-0.9789
147	G	A	-0.7225
148	Y	A	-0.4880
149	T	A	-0.4652
150	T	A	0.4697
151	L	A	1.5402
161	M	A	0.1474
162	P	A	-0.1850
163	V	A	0.0000
164	L	A	-1.6167
165	K	A	-3.0955
166	E	A	-2.8879
167	T	A	-1.5164
203	E	A	-2.4415
204	K	A	-1.6906
205	I	A	0.2302
206	H	A	0.0000
207	N	A	-1.2080
208	F	A	-0.7342
209	K	A	-0.7508
210	V	A	0.6332
211	H	A	-0.0900
212	T	A	-0.1776
213	F	A	0.0000
214	R	A	-1.9187
215	G	A	-1.3107
216	P	A	-0.5903
217	H	A	-0.6402
218	W	A	0.0000
219	C	A	0.0000
220	E	A	-0.4461
221	Y	A	0.0000
222	C	A	0.0000
223	V	A	0.0000
224	N	A	0.0000
225	F	A	0.0000
226	M	A	0.0000
227	W	A	0.0630
228	G	A	0.0000
229	L	A	0.2951
230	I	A	0.0696
231	A	A	-0.2527
232	Q	A	0.0581
233	G	A	0.0000
234	V	A	0.0000
235	K	A	-0.6851
236	C	A	0.0000
237	A	A	-0.9406
238	D	A	-1.4761
239	C	A	0.0000
240	G	A	-1.5033
241	L	A	-0.5649
242	N	A	-0.4903
243	V	A	0.0000
244	H	A	0.0000
245	K	A	-2.0806
246	Q	A	-1.9138
247	C	A	0.0000
248	S	A	-1.7420
249	K	A	-2.0593
250	M	A	-0.8316
251	V	A	0.0000
252	P	A	-1.1289
253	N	A	-1.6163
254	D	A	-1.8356
255	C	A	0.0000
256	K	A	-1.7118
257	P	A	-2.1795
258	D	A	-2.7293
259	L	A	-2.3590
260	K	A	-3.1900
261	H	A	-2.9684
262	V	A	-2.5470
263	K	A	-2.8816
264	K	A	-2.0541
265	V	A	0.0000
266	Y	A	0.0000
267	S	A	-0.1881
268	C	A	-0.0906
269	D	A	0.0000
270	L	A	0.0000
271	T	A	-0.6368
272	T	A	-0.9038
273	L	A	0.0000
274	V	A	-1.1591
275	K	A	-1.8775
276	A	A	-1.0193
277	H	A	-0.9525
278	T	A	-1.1402
279	T	A	-1.3052
280	K	A	-2.3830
281	R	A	-1.5981
282	P	A	0.0000
283	M	A	0.0000
284	V	A	0.0000
285	V	A	0.0000
286	D	A	-1.3782
287	M	A	-1.2248
288	C	A	0.0000
289	I	A	0.0000
290	R	A	-2.4204
291	E	A	-1.3365
292	I	A	0.0000
293	E	A	-2.0732
294	S	A	-1.3021
295	R	A	-0.9678
296	G	A	-1.3096
297	L	A	0.0000
298	N	A	-2.7473
299	S	A	-1.9475
300	E	A	-2.7201
301	G	A	-1.4150
302	L	A	0.0000
303	Y	A	0.0000
304	R	A	-1.5243
305	V	A	-0.1289
306	S	A	0.1384
307	G	A	0.4617
308	F	A	1.0824
309	S	A	-0.2827
310	D	A	-1.6070
311	L	A	-0.3501
312	I	A	0.0000
313	E	A	-1.1812
314	D	A	-1.0286
315	V	A	0.0000
316	K	A	-0.8560
317	M	A	-0.9323
318	A	A	0.0000
319	F	A	0.0000
320	D	A	0.0000
321	R	A	-2.9118
322	D	A	-2.7416
323	G	A	-2.6117
324	E	A	-3.1778
325	K	A	-3.3185
326	A	A	0.0000
327	D	A	-1.9746
328	I	A	0.0000
329	S	A	-0.3745
330	V	A	0.0738
331	N	A	-0.9234
332	M	A	-0.2739
333	Y	A	0.0000
334	E	A	-1.7291
335	D	A	-1.0792
336	I	A	-0.5239
337	N	A	-0.4994
338	I	A	0.0000
339	I	A	0.0000
340	T	A	0.0000
341	G	A	-0.0004
342	A	A	0.0000
343	L	A	0.0000
344	K	A	-0.3283
345	L	A	-0.3320
346	Y	A	0.0000
347	F	A	0.0000
348	R	A	-1.0305
349	D	A	0.0000
350	L	A	0.0000
351	P	A	0.0000
352	I	A	0.0000
353	P	A	0.0000
354	L	A	0.0000
355	I	A	0.0000
356	T	A	0.0000
357	Y	A	0.0000
358	D	A	-1.9653
359	A	A	0.0000
360	Y	A	0.0000
361	P	A	-1.3605
362	K	A	-1.8025
363	F	A	0.0000
364	I	A	0.0000
365	E	A	-2.3952
366	S	A	0.0000
367	A	A	0.0000
368	K	A	-1.7502
369	I	A	-0.8954
370	M	A	-0.0828
371	D	A	-1.7779
372	P	A	-1.8423
373	D	A	-3.1703
374	E	A	-3.2025
375	Q	A	-2.6524
376	L	A	-2.1654
377	E	A	-3.6103
378	T	A	0.0000
379	L	A	0.0000
380	H	A	-2.1068
381	E	A	-2.9505
382	A	A	0.0000
383	L	A	0.0000
384	K	A	-1.9788
385	L	A	-0.8204
386	L	A	0.0000
387	P	A	-0.5888
388	P	A	-0.8592
389	A	A	0.0000
390	H	A	0.0000
391	C	A	-0.9215
392	E	A	-1.8357
393	T	A	0.0000
394	L	A	0.0000
395	R	A	-1.4478
396	Y	A	-0.7249
397	L	A	0.0000
398	M	A	0.0000
399	A	A	-1.1453
400	H	A	0.0000
401	L	A	0.0000
402	K	A	-1.4463
403	R	A	-1.4091
404	V	A	0.0000
405	T	A	-1.2854
406	L	A	-0.2596
407	H	A	-1.9505
408	E	A	-2.7192
409	K	A	-3.1030
410	E	A	-3.3049
411	N	A	0.0000
412	L	A	-0.8170
413	M	A	0.0000
414	N	A	-1.1459
415	A	A	-1.3957
416	E	A	-1.6150
417	N	A	-0.9446
418	L	A	0.0000
419	G	A	0.0000
420	I	A	-0.6659
421	V	A	-0.3716
422	F	A	0.0000
423	G	A	0.0000
424	P	A	-0.4463
425	T	A	0.0000
426	L	A	0.0000
427	M	A	0.0000
428	R	A	-0.9917
429	S	A	-1.0248
430	P	A	-1.4220
431	E	A	-1.5477
432	L	A	0.1137
433	D	A	-0.7367
434	A	A	-0.0362
435	M	A	0.8688
436	A	A	0.0479
437	A	A	-0.1534
438	L	A	0.4995
439	N	A	-0.8772
440	D	A	-1.0850
441	I	A	-0.8496
442	R	A	-1.8765
443	Y	A	-1.6003
444	Q	A	0.0000
445	R	A	-1.2698
446	L	A	-0.8843
447	V	A	0.0000
448	V	A	0.0000
449	E	A	-1.1399
450	L	A	0.0000
451	L	A	0.0000
452	I	A	0.0000
453	K	A	-1.9341
454	N	A	-0.9880
455	E	A	-1.0508
456	D	A	-1.2255
457	I	A	1.0549
458	L	A	0.0000
459	F	A	0.3608