Project name: 427fb2c94ee0e74
Status: done
submitted: 2019-09-18 08:48:33, status changed: 2019-09-23 21:07:15
Settings
Chain sequence(s)
|
A: MQDYKKNKRRMMNQPMSTMNEEEVYTDEINSEDMRGFKKSHHHNGCNTDNKCECHDECNPCNPCNPCKPNPCNPCKPNPCDDKCECHDKCKCDCEPCEMDSDECFENKCGPECCNPISPRNFSVSNAVPFAIEANRIFDTMQFQTFTDATGPNGEPLTFETEVVEVFGSIPSAGQASVTIEKICLSNDGIVIDTGMTTLEDFDLDPLGDIVGRNCETTFEFAVCGERNAECCRQGKGKSVAYKQRGLTVAVRNLVLELRGRCGCTEFVALAFPAVRAGGGCKRRVDYVEFTFNTLSAPICLPADGRAVTLRQEYQTNLTVDCIGKSILKLECNECCEPFYELIIPNDIDLVLCLQETVSTLISEQIVVLASPNPIQPRLVDTFSKVCDFSQCGPNHGSGKPSCHR
|
Distance of aggregation |
10 Å |
Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.4861
-
Maximal score value
-
2.6573
-
Average score
-
-0.6365
-
Total score value
-
-257.7643
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
residue index |
residue name |
chain |
Aggrescan3D score |
|
1 |
M |
A |
-0.3385 |
|
2 |
Q |
A |
-1.6532 |
|
3 |
D |
A |
-2.2049 |
|
4 |
Y |
A |
-1.3001 |
|
5 |
K |
A |
-1.6494 |
|
6 |
K |
A |
-2.5437 |
|
7 |
N |
A |
0.0000 |
|
8 |
K |
A |
-2.8546 |
|
9 |
R |
A |
-3.2700 |
|
10 |
R |
A |
-3.0504 |
|
11 |
M |
A |
-1.2522 |
|
12 |
M |
A |
-0.4759 |
|
13 |
N |
A |
-0.6184 |
|
14 |
Q |
A |
-1.2989 |
|
15 |
P |
A |
-0.7266 |
|
16 |
M |
A |
0.3468 |
|
17 |
S |
A |
-0.5921 |
|
18 |
T |
A |
-0.7736 |
|
19 |
M |
A |
-1.0677 |
|
20 |
N |
A |
-2.2706 |
|
21 |
E |
A |
-3.3990 |
|
22 |
E |
A |
-3.1934 |
|
23 |
E |
A |
-3.1251 |
|
24 |
V |
A |
-0.8613 |
|
25 |
Y |
A |
0.0000 |
|
26 |
T |
A |
-1.4827 |
|
27 |
D |
A |
-2.4086 |
|
28 |
E |
A |
-3.0580 |
|
29 |
I |
A |
-1.0689 |
|
30 |
N |
A |
-2.6263 |
|
31 |
S |
A |
-1.3526 |
|
32 |
E |
A |
-2.0208 |
|
33 |
D |
A |
-2.2815 |
|
34 |
M |
A |
-1.2350 |
|
35 |
R |
A |
-2.0851 |
|
36 |
G |
A |
-1.8683 |
|
37 |
F |
A |
-0.8511 |
|
38 |
K |
A |
-2.0174 |
|
39 |
K |
A |
-2.4665 |
|
40 |
S |
A |
-1.8461 |
|
41 |
H |
A |
-1.7634 |
|
42 |
H |
A |
-2.3165 |
|
43 |
H |
A |
-2.1419 |
|
44 |
N |
A |
-2.4143 |
|
45 |
G |
A |
-1.6073 |
|
46 |
C |
A |
-1.7377 |
|
47 |
N |
A |
-2.4189 |
|
48 |
T |
A |
-2.1338 |
|
49 |
D |
A |
-3.0883 |
|
50 |
N |
A |
-3.1745 |
|
51 |
K |
A |
-2.6524 |
|
52 |
C |
A |
-1.5669 |
|
53 |
E |
A |
-2.4241 |
|
54 |
C |
A |
-0.9181 |
|
55 |
H |
A |
-1.9152 |
|
56 |
D |
A |
-2.4637 |
|
57 |
E |
A |
-3.0508 |
|
58 |
C |
A |
0.0000 |
|
59 |
N |
A |
-1.9335 |
|
60 |
P |
A |
-1.1084 |
|
61 |
C |
A |
-0.9100 |
|
62 |
N |
A |
-1.5884 |
|
63 |
P |
A |
0.0000 |
|
64 |
C |
A |
-0.9929 |
|
65 |
N |
A |
-1.0058 |
|
66 |
P |
A |
-0.5433 |
|
67 |
C |
A |
-0.2778 |
|
68 |
K |
A |
-0.7358 |
|
69 |
P |
A |
-1.4834 |
|
70 |
N |
A |
-2.1466 |
|
71 |
P |
A |
-2.2274 |
|
72 |
C |
A |
-1.8905 |
|
73 |
N |
A |
-1.2799 |
|
74 |
P |
A |
-0.6904 |
|
75 |
C |
A |
-0.0726 |
|
76 |
K |
A |
-1.4640 |
|
77 |
P |
A |
-0.9649 |
|
78 |
N |
A |
-1.4357 |
|
79 |
P |
A |
0.0000 |
|
80 |
C |
A |
-1.2316 |
|
81 |
D |
A |
-2.6105 |
|
82 |
D |
A |
-3.1695 |
|
83 |
K |
A |
-2.6297 |
|
84 |
C |
A |
-1.6038 |
|
85 |
E |
A |
-2.3786 |
|
86 |
C |
A |
-2.0931 |
|
87 |
H |
A |
-2.5622 |
|
88 |
D |
A |
-3.4861 |
|
89 |
K |
A |
-3.0352 |
|
90 |
C |
A |
-1.9260 |
|
91 |
K |
A |
-2.2289 |
|
92 |
C |
A |
0.0000 |
|
93 |
D |
A |
-2.9025 |
|
94 |
C |
A |
-2.1148 |
|
95 |
E |
A |
-1.9029 |
|
96 |
P |
A |
-0.4978 |
|
97 |
C |
A |
-0.6187 |
|
98 |
E |
A |
-1.5954 |
|
99 |
M |
A |
-1.1310 |
|
100 |
D |
A |
-2.9723 |
|
101 |
S |
A |
-2.6819 |
|
102 |
D |
A |
-3.0603 |
|
103 |
E |
A |
-2.7493 |
|
104 |
C |
A |
-1.9698 |
|
105 |
F |
A |
-1.0926 |
|
106 |
E |
A |
-2.4907 |
|
107 |
N |
A |
-2.6015 |
|
108 |
K |
A |
-2.0988 |
|
109 |
C |
A |
-1.2697 |
|
110 |
G |
A |
-0.8494 |
|
111 |
P |
A |
0.1254 |
|
112 |
E |
A |
-0.6193 |
|
113 |
C |
A |
0.1045 |
|
114 |
C |
A |
0.1423 |
|
115 |
N |
A |
-0.2977 |
|
116 |
P |
A |
0.9154 |
|
117 |
I |
A |
1.8391 |
|
118 |
S |
A |
0.0000 |
|
119 |
P |
A |
0.0396 |
|
120 |
R |
A |
0.0000 |
|
121 |
N |
A |
0.1868 |
|
122 |
F |
A |
0.9614 |
|
123 |
S |
A |
0.9990 |
|
124 |
V |
A |
0.8400 |
|
125 |
S |
A |
0.0683 |
|
126 |
N |
A |
-1.2952 |
|
127 |
A |
A |
-0.5390 |
|
128 |
V |
A |
0.9889 |
|
129 |
P |
A |
1.4016 |
|
130 |
F |
A |
2.6346 |
|
131 |
A |
A |
1.4807 |
|
132 |
I |
A |
1.6763 |
|
133 |
E |
A |
-0.0233 |
|
134 |
A |
A |
-0.9068 |
|
135 |
N |
A |
-1.7521 |
|
136 |
R |
A |
-2.2154 |
|
137 |
I |
A |
-0.4343 |
|
138 |
F |
A |
1.2604 |
|
139 |
D |
A |
0.6884 |
|
140 |
T |
A |
0.4989 |
|
141 |
M |
A |
0.8462 |
|
142 |
Q |
A |
-0.1118 |
|
143 |
F |
A |
1.0087 |
|
144 |
Q |
A |
-0.4093 |
|
145 |
T |
A |
-0.0715 |
|
146 |
F |
A |
0.0000 |
|
147 |
T |
A |
-0.3309 |
|
148 |
D |
A |
-0.8857 |
|
149 |
A |
A |
-0.4542 |
|
150 |
T |
A |
-0.4254 |
|
151 |
G |
A |
-0.8770 |
|
152 |
P |
A |
-0.7222 |
|
153 |
N |
A |
-0.5684 |
|
154 |
G |
A |
-0.4249 |
|
155 |
E |
A |
-0.1876 |
|
156 |
P |
A |
-0.0312 |
|
157 |
L |
A |
0.0000 |
|
158 |
T |
A |
0.0000 |
|
159 |
F |
A |
0.0000 |
|
160 |
E |
A |
-1.4023 |
|
161 |
T |
A |
-1.1522 |
|
162 |
E |
A |
-1.9438 |
|
163 |
V |
A |
-0.6306 |
|
164 |
V |
A |
0.0000 |
|
165 |
E |
A |
-0.7962 |
|
166 |
V |
A |
-0.4393 |
|
167 |
F |
A |
-0.0770 |
|
168 |
G |
A |
-0.0159 |
|
169 |
S |
A |
0.4218 |
|
170 |
I |
A |
1.5920 |
|
171 |
P |
A |
0.4989 |
|
172 |
S |
A |
0.0231 |
|
173 |
A |
A |
-0.2794 |
|
174 |
G |
A |
-1.0808 |
|
175 |
Q |
A |
-1.3817 |
|
176 |
A |
A |
-0.3609 |
|
177 |
S |
A |
0.0000 |
|
178 |
V |
A |
0.3720 |
|
179 |
T |
A |
0.0657 |
|
180 |
I |
A |
0.0000 |
|
181 |
E |
A |
0.0000 |
|
182 |
K |
A |
0.0000 |
|
183 |
I |
A |
0.0000 |
|
184 |
C |
A |
0.1407 |
|
185 |
L |
A |
0.0000 |
|
186 |
S |
A |
-0.4576 |
|
187 |
N |
A |
0.0000 |
|
188 |
D |
A |
-1.5258 |
|
189 |
G |
A |
-0.4528 |
|
190 |
I |
A |
0.5103 |
|
191 |
V |
A |
0.3629 |
|
192 |
I |
A |
0.0000 |
|
193 |
D |
A |
0.0000 |
|
194 |
T |
A |
0.0000 |
|
195 |
G |
A |
0.0000 |
|
196 |
M |
A |
-0.1474 |
|
197 |
T |
A |
-0.2715 |
|
198 |
T |
A |
0.1198 |
|
199 |
L |
A |
0.9957 |
|
200 |
E |
A |
0.4812 |
|
201 |
D |
A |
0.9014 |
|
202 |
F |
A |
0.0000 |
|
203 |
D |
A |
0.0000 |
|
204 |
L |
A |
0.4304 |
|
205 |
D |
A |
0.0000 |
|
206 |
P |
A |
0.1227 |
|
207 |
L |
A |
0.3219 |
|
208 |
G |
A |
-0.4082 |
|
209 |
D |
A |
-1.1067 |
|
210 |
I |
A |
0.0000 |
|
211 |
V |
A |
0.8838 |
|
212 |
G |
A |
-0.7632 |
|
213 |
R |
A |
-1.7875 |
|
214 |
N |
A |
-1.8917 |
|
215 |
C |
A |
-0.9695 |
|
216 |
E |
A |
-0.7263 |
|
217 |
T |
A |
-0.2451 |
|
218 |
T |
A |
0.7577 |
|
219 |
F |
A |
1.9114 |
|
220 |
E |
A |
2.0046 |
|
221 |
F |
A |
2.6573 |
|
222 |
A |
A |
1.8517 |
|
223 |
V |
A |
2.3286 |
|
224 |
C |
A |
1.4139 |
|
225 |
G |
A |
0.0000 |
|
226 |
E |
A |
-1.3092 |
|
227 |
R |
A |
-1.7038 |
|
228 |
N |
A |
0.0000 |
|
229 |
A |
A |
-0.3963 |
|
230 |
E |
A |
0.0000 |
|
231 |
C |
A |
0.0000 |
|
232 |
C |
A |
0.0000 |
|
233 |
R |
A |
-0.5819 |
|
234 |
Q |
A |
0.0000 |
|
235 |
G |
A |
-1.3624 |
|
236 |
K |
A |
0.0000 |
|
237 |
G |
A |
-0.8197 |
|
238 |
K |
A |
-1.9303 |
|
239 |
S |
A |
0.0000 |
|
240 |
V |
A |
0.0000 |
|
241 |
A |
A |
0.0000 |
|
242 |
Y |
A |
0.0000 |
|
243 |
K |
A |
0.0000 |
|
244 |
Q |
A |
0.0000 |
|
245 |
R |
A |
-2.4278 |
|
246 |
G |
A |
-1.8479 |
|
247 |
L |
A |
-1.1569 |
|
248 |
T |
A |
0.0000 |
|
249 |
V |
A |
0.0000 |
|
250 |
A |
A |
0.0000 |
|
251 |
V |
A |
0.0000 |
|
252 |
R |
A |
0.0000 |
|
253 |
N |
A |
0.1583 |
|
254 |
L |
A |
1.6308 |
|
255 |
V |
A |
2.5676 |
|
256 |
L |
A |
2.1667 |
|
257 |
E |
A |
0.2386 |
|
258 |
L |
A |
-0.2624 |
|
259 |
R |
A |
-0.7801 |
|
260 |
G |
A |
-0.9072 |
|
261 |
R |
A |
-1.5578 |
|
262 |
C |
A |
-0.4229 |
|
263 |
G |
A |
-0.5053 |
|
264 |
C |
A |
-1.1664 |
|
265 |
T |
A |
-1.5604 |
|
266 |
E |
A |
-2.0244 |
|
267 |
F |
A |
0.0000 |
|
268 |
V |
A |
0.8289 |
|
269 |
A |
A |
0.8071 |
|
270 |
L |
A |
0.0000 |
|
271 |
A |
A |
0.0198 |
|
272 |
F |
A |
0.0000 |
|
273 |
P |
A |
0.0000 |
|
274 |
A |
A |
-0.8627 |
|
275 |
V |
A |
-0.9765 |
|
276 |
R |
A |
-1.9681 |
|
277 |
A |
A |
-1.1743 |
|
278 |
G |
A |
-0.4527 |
|
279 |
G |
A |
0.0000 |
|
280 |
G |
A |
0.0000 |
|
281 |
C |
A |
0.0000 |
|
282 |
K |
A |
-0.8534 |
|
283 |
R |
A |
-1.8141 |
|
284 |
R |
A |
-2.1470 |
|
285 |
V |
A |
-1.1205 |
|
286 |
D |
A |
-0.2675 |
|
287 |
Y |
A |
0.5707 |
|
288 |
V |
A |
0.0000 |
|
289 |
E |
A |
0.2983 |
|
290 |
F |
A |
0.4243 |
|
291 |
T |
A |
0.0375 |
|
292 |
F |
A |
0.0667 |
|
293 |
N |
A |
-0.0294 |
|
294 |
T |
A |
0.3494 |
|
295 |
L |
A |
0.8728 |
|
296 |
S |
A |
0.3958 |
|
297 |
A |
A |
0.4484 |
|
298 |
P |
A |
0.6520 |
|
299 |
I |
A |
1.4453 |
|
300 |
C |
A |
1.2707 |
|
301 |
L |
A |
0.8913 |
|
302 |
P |
A |
-0.1487 |
|
303 |
A |
A |
-0.8756 |
|
304 |
D |
A |
-1.8596 |
|
305 |
G |
A |
-1.3376 |
|
306 |
R |
A |
-0.7892 |
|
307 |
A |
A |
-0.1876 |
|
308 |
V |
A |
0.1807 |
|
309 |
T |
A |
0.1205 |
|
310 |
L |
A |
0.0000 |
|
311 |
R |
A |
0.0000 |
|
312 |
Q |
A |
-1.0166 |
|
313 |
E |
A |
-1.4352 |
|
314 |
Y |
A |
-0.6712 |
|
315 |
Q |
A |
-1.2190 |
|
316 |
T |
A |
0.0000 |
|
317 |
N |
A |
0.0000 |
|
318 |
L |
A |
0.0000 |
|
319 |
T |
A |
0.0000 |
|
320 |
V |
A |
0.0621 |
|
321 |
D |
A |
0.0378 |
|
322 |
C |
A |
0.0000 |
|
323 |
I |
A |
-0.3639 |
|
324 |
G |
A |
-1.3379 |
|
325 |
K |
A |
-1.7766 |
|
326 |
S |
A |
-0.6577 |
|
327 |
I |
A |
0.2833 |
|
328 |
L |
A |
0.7074 |
|
329 |
K |
A |
0.2205 |
|
330 |
L |
A |
-0.5213 |
|
331 |
E |
A |
-2.1430 |
|
332 |
C |
A |
-2.0652 |
|
333 |
N |
A |
-3.0174 |
|
334 |
E |
A |
-2.9937 |
|
335 |
C |
A |
-1.4763 |
|
336 |
C |
A |
-1.6383 |
|
337 |
E |
A |
-2.8033 |
|
338 |
P |
A |
-1.1035 |
|
339 |
F |
A |
0.3107 |
|
340 |
Y |
A |
0.8550 |
|
341 |
E |
A |
0.5852 |
|
342 |
L |
A |
0.0000 |
|
343 |
I |
A |
0.0000 |
|
344 |
I |
A |
0.0000 |
|
345 |
P |
A |
-0.5996 |
|
346 |
N |
A |
-0.8922 |
|
347 |
D |
A |
-1.1793 |
|
348 |
I |
A |
0.0200 |
|
349 |
D |
A |
0.0000 |
|
350 |
L |
A |
0.0000 |
|
351 |
V |
A |
0.1175 |
|
352 |
L |
A |
0.0000 |
|
353 |
C |
A |
0.7586 |
|
354 |
L |
A |
1.2253 |
|
355 |
Q |
A |
-0.0144 |
|
356 |
E |
A |
-1.0679 |
|
357 |
T |
A |
-0.1913 |
|
358 |
V |
A |
0.5449 |
|
359 |
S |
A |
0.3253 |
|
360 |
T |
A |
0.3449 |
|
361 |
L |
A |
0.7519 |
|
362 |
I |
A |
0.3201 |
|
363 |
S |
A |
-0.7150 |
|
364 |
E |
A |
-1.7520 |
|
365 |
Q |
A |
0.0000 |
|
366 |
I |
A |
0.8263 |
|
367 |
V |
A |
0.6538 |
|
368 |
V |
A |
0.0000 |
|
369 |
L |
A |
0.1221 |
|
370 |
A |
A |
0.0000 |
|
371 |
S |
A |
0.0000 |
|
372 |
P |
A |
-0.9346 |
|
373 |
N |
A |
-1.7286 |
|
374 |
P |
A |
-1.5870 |
|
375 |
I |
A |
0.0000 |
|
376 |
Q |
A |
0.0000 |
|
377 |
P |
A |
-1.5859 |
|
378 |
R |
A |
-1.8665 |
|
379 |
L |
A |
-0.0057 |
|
380 |
V |
A |
1.4326 |
|
381 |
D |
A |
0.2865 |
|
382 |
T |
A |
0.4762 |
|
383 |
F |
A |
2.0864 |
|
384 |
S |
A |
1.0637 |
|
385 |
K |
A |
0.7002 |
|
386 |
V |
A |
1.4150 |
|
387 |
C |
A |
0.4277 |
|
388 |
D |
A |
-1.5154 |
|
389 |
F |
A |
-0.6581 |
|
390 |
S |
A |
-0.7809 |
|
391 |
Q |
A |
-0.5301 |
|
392 |
C |
A |
-0.5225 |
|
393 |
G |
A |
-1.3127 |
|
394 |
P |
A |
0.0000 |
|
395 |
N |
A |
-2.4380 |
|
396 |
H |
A |
-2.1103 |
|
397 |
G |
A |
-1.7547 |
|
398 |
S |
A |
-1.5122 |
|
399 |
G |
A |
-1.8988 |
|
400 |
K |
A |
-2.5683 |
|
401 |
P |
A |
-1.6093 |
|
402 |
S |
A |
-1.2434 |
|
403 |
C |
A |
-1.2981 |
|
404 |
H |
A |
-2.0540 |
|
405 |
R |
A |
-2.4570 |
|