Chain sequence(s) |
A: MDTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGMLIPHTYPDTPIHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTPTEEVPFWADVVLGFRKMTEAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRRIEDLWELHPSFDIVVNCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDGSGLTYIYPGTSHVTLGGTRQKGDWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQTELLARDGQRLPVVHHYGHGSGGISVHWGTALEAARLVSECVHALRTPIPKSNL |
Distance of aggregation | 10 Å |
Dynamic mode | No |
Mutated residues | VA131G, WA160E, LA244E |
Energy difference between WT (input) and mutated protein (by FoldX) | 3.19765 kcal/mol
CAUTION: Your mutation/s can destabilize the protein structure Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | M | A | 0.6641 | |
2 | D | A | -0.3478 | |
3 | T | A | -0.4900 | |
4 | A | A | 0.0000 | |
5 | R | A | -0.8456 | |
6 | I | A | 0.0000 | |
7 | A | A | 0.0000 | |
8 | V | A | 0.0000 | |
9 | V | A | 0.0000 | |
10 | G | A | -0.7236 | |
11 | A | A | 0.0000 | |
12 | G | A | -0.4266 | |
13 | V | A | 0.0000 | |
14 | V | A | 0.1664 | |
15 | G | A | 0.0000 | |
16 | L | A | 0.0000 | |
17 | S | A | 0.0000 | |
18 | T | A | 0.0000 | |
19 | A | A | 0.0000 | |
20 | V | A | 0.0000 | |
21 | C | A | 0.0000 | |
22 | I | A | 0.0000 | |
23 | S | A | 0.0000 | |
24 | K | A | -1.7335 | |
25 | L | A | 0.0000 | |
26 | V | A | 0.0000 | |
27 | P | A | -1.5801 | |
28 | R | A | -2.1077 | |
29 | C | A | -1.2255 | |
30 | S | A | -0.7850 | |
31 | V | A | 0.0000 | |
32 | T | A | 0.0000 | |
33 | I | A | 0.0000 | |
34 | I | A | 0.0000 | |
35 | S | A | 0.0000 | |
36 | D | A | -3.1088 | |
37 | K | A | -2.4990 | |
38 | F | A | -1.2709 | |
39 | T | A | -0.9682 | |
40 | P | A | -1.2413 | |
41 | D | A | -2.2925 | |
42 | T | A | -1.3424 | |
43 | T | A | -0.6224 | |
44 | S | A | -0.3764 | |
45 | D | A | 0.0000 | |
46 | V | A | -0.4104 | |
47 | A | A | -0.0727 | |
48 | A | A | 0.0227 | |
49 | G | A | 0.0000 | |
50 | M | A | -0.0038 | |
51 | L | A | 0.0000 | |
52 | I | A | 0.0000 | |
53 | P | A | 0.0000 | |
54 | H | A | -0.1142 | |
55 | T | A | 0.0257 | |
56 | Y | A | 0.4263 | |
57 | P | A | -0.7533 | |
58 | D | A | -1.8404 | |
59 | T | A | -0.9072 | |
60 | P | A | -0.8993 | |
61 | I | A | -0.9857 | |
62 | H | A | -1.8501 | |
63 | T | A | -1.4464 | |
64 | Q | A | 0.0000 | |
65 | K | A | -2.0212 | |
66 | Q | A | -2.4027 | |
67 | W | A | 0.0000 | |
68 | F | A | 0.0000 | |
69 | R | A | -3.2518 | |
70 | E | A | -2.6482 | |
71 | T | A | 0.0000 | |
72 | F | A | 0.0000 | |
73 | N | A | -1.6012 | |
74 | H | A | -0.9464 | |
75 | L | A | 0.0000 | |
76 | F | A | -0.0253 | |
77 | A | A | -0.2324 | |
78 | I | A | -0.3713 | |
79 | A | A | 0.0000 | |
80 | N | A | -1.3290 | |
81 | S | A | -0.7763 | |
82 | A | A | -0.8837 | |
83 | E | A | -1.4136 | |
84 | A | A | -1.3650 | |
85 | G | A | -1.7784 | |
86 | D | A | -2.0320 | |
87 | A | A | 0.0000 | |
88 | G | A | 0.0000 | |
89 | V | A | 0.0000 | |
90 | H | A | -0.9654 | |
91 | L | A | -0.0633 | |
92 | V | A | 0.0000 | |
93 | S | A | -0.2337 | |
94 | G | A | 0.0000 | |
95 | W | A | -0.2101 | |
96 | Q | A | 0.0000 | |
97 | I | A | 0.0000 | |
98 | F | A | -0.5664 | |
99 | Q | A | -1.3840 | |
100 | S | A | -0.7183 | |
101 | T | A | -0.4795 | |
102 | P | A | -0.5660 | |
103 | T | A | -0.6266 | |
104 | E | A | -1.1016 | |
105 | E | A | 0.0000 | |
106 | V | A | -0.3583 | |
107 | P | A | -0.3928 | |
108 | F | A | -0.8040 | |
109 | W | A | 0.0000 | |
110 | A | A | -0.5050 | |
111 | D | A | -1.5538 | |
112 | V | A | -1.2201 | |
113 | V | A | 0.0000 | |
114 | L | A | 0.9712 | |
115 | G | A | -0.0982 | |
116 | F | A | -0.2669 | |
117 | R | A | -0.8719 | |
118 | K | A | -1.0074 | |
119 | M | A | 0.0000 | |
120 | T | A | -1.4034 | |
121 | E | A | -2.5962 | |
122 | A | A | -1.9836 | |
123 | E | A | -1.9918 | |
124 | L | A | 0.0000 | |
125 | K | A | -3.2948 | |
126 | K | A | -3.0630 | |
127 | F | A | 0.0000 | |
128 | P | A | -1.7786 | |
129 | Q | A | -1.6199 | |
130 | Y | A | 0.0000 | |
131 | G | A | -1.2729 | mutated: VA131G |
132 | F | A | -0.6319 | |
133 | G | A | 0.0000 | |
134 | Q | A | 0.0000 | |
135 | A | A | 0.0000 | |
136 | F | A | 0.0000 | |
137 | T | A | 0.4241 | |
138 | T | A | 0.0000 | |
139 | L | A | 0.0000 | |
140 | K | A | 0.0000 | |
141 | C | A | 0.0000 | |
142 | E | A | -0.6658 | |
143 | C | A | 0.0000 | |
144 | P | A | -0.5103 | |
145 | A | A | -0.5867 | |
146 | Y | A | 0.0000 | |
147 | L | A | 0.0000 | |
148 | P | A | -0.7750 | |
149 | W | A | -1.0810 | |
150 | L | A | 0.0000 | |
151 | E | A | -1.5947 | |
152 | K | A | -2.1812 | |
153 | R | A | -1.9768 | |
154 | I | A | 0.0000 | |
155 | K | A | -2.5260 | |
156 | G | A | -1.9408 | |
157 | S | A | -1.7588 | |
158 | G | A | -1.5146 | |
159 | G | A | 0.0000 | |
160 | E | A | -1.9031 | mutated: WA160E |
161 | T | A | -0.7318 | |
162 | L | A | -0.2900 | |
163 | T | A | -1.0738 | |
164 | R | A | -2.3117 | |
165 | R | A | -3.2311 | |
166 | I | A | 0.0000 | |
167 | E | A | -3.1091 | |
168 | D | A | -2.5328 | |
169 | L | A | 0.0000 | |
170 | W | A | -1.2479 | |
171 | E | A | -1.5978 | |
172 | L | A | 0.0000 | |
173 | H | A | 0.0000 | |
174 | P | A | -0.7398 | |
175 | S | A | -0.6736 | |
176 | F | A | -0.9003 | |
177 | D | A | -1.7440 | |
178 | I | A | 0.0000 | |
179 | V | A | 0.0000 | |
180 | V | A | 0.0000 | |
181 | N | A | 0.0000 | |
182 | C | A | 0.0000 | |
183 | S | A | -0.4669 | |
184 | G | A | -0.0866 | |
185 | L | A | 0.0910 | |
186 | G | A | -0.6416 | |
187 | S | A | 0.0000 | |
188 | R | A | -1.4451 | |
189 | Q | A | -1.7086 | |
190 | L | A | -1.3621 | |
191 | A | A | -1.1109 | |
192 | G | A | -1.2196 | |
193 | D | A | -1.2670 | |
194 | S | A | -1.0990 | |
195 | K | A | -1.5017 | |
196 | I | A | 0.0000 | |
197 | F | A | -0.0188 | |
198 | P | A | 0.0000 | |
199 | V | A | 0.0000 | |
200 | R | A | 0.0000 | |
201 | G | A | 0.0000 | |
202 | Q | A | 0.0000 | |
203 | V | A | -0.4633 | |
204 | L | A | 0.0000 | |
205 | Q | A | -1.6353 | |
206 | V | A | 0.0000 | |
207 | Q | A | -1.2769 | |
208 | A | A | 0.0000 | |
209 | P | A | -0.4456 | |
210 | W | A | 0.3029 | |
211 | V | A | -0.5696 | |
212 | E | A | -1.6702 | |
213 | H | A | -0.9974 | |
214 | F | A | 0.0000 | |
215 | I | A | 0.0000 | |
216 | R | A | -0.3030 | |
217 | D | A | -0.4481 | |
218 | G | A | -0.6054 | |
219 | S | A | -0.9114 | |
220 | G | A | -0.8809 | |
221 | L | A | -0.2468 | |
222 | T | A | 0.0000 | |
223 | Y | A | -0.0579 | |
224 | I | A | 0.0000 | |
225 | Y | A | 0.0000 | |
226 | P | A | 0.0000 | |
227 | G | A | -0.9319 | |
228 | T | A | -0.8495 | |
229 | S | A | -0.6992 | |
230 | H | A | -1.0450 | |
231 | V | A | 0.0000 | |
232 | T | A | -0.7256 | |
233 | L | A | 0.0000 | |
234 | G | A | 0.0000 | |
235 | G | A | 0.0000 | |
236 | T | A | -1.4228 | |
237 | R | A | -2.8363 | |
238 | Q | A | -2.6474 | |
239 | K | A | -2.4076 | |
240 | G | A | -1.3106 | |
241 | D | A | -1.4263 | |
242 | W | A | -0.3959 | |
243 | N | A | -1.7146 | |
244 | E | A | -2.3439 | mutated: LA244E |
245 | S | A | -1.6389 | |
246 | P | A | -1.6971 | |
247 | D | A | -2.3173 | |
248 | A | A | -1.9855 | |
249 | E | A | -3.0284 | |
250 | N | A | 0.0000 | |
251 | S | A | -2.2372 | |
252 | R | A | -3.2002 | |
253 | E | A | -2.6939 | |
254 | I | A | 0.0000 | |
255 | L | A | -1.3332 | |
256 | S | A | -1.3540 | |
257 | R | A | -0.9710 | |
258 | C | A | 0.0000 | |
259 | C | A | -0.7057 | |
260 | A | A | -0.5415 | |
261 | L | A | 0.0000 | |
262 | E | A | -0.8921 | |
263 | P | A | -0.8593 | |
264 | S | A | -0.5928 | |
265 | L | A | 0.0000 | |
266 | H | A | -1.3456 | |
267 | G | A | -1.0773 | |
268 | A | A | -0.7358 | |
269 | C | A | -0.6370 | |
270 | N | A | -1.7860 | |
271 | I | A | -1.3894 | |
272 | R | A | -2.4905 | |
273 | E | A | -1.9817 | |
274 | K | A | -1.6534 | |
275 | V | A | 0.0000 | |
276 | G | A | 0.0000 | |
277 | L | A | 0.0000 | |
278 | R | A | -0.6175 | |
279 | P | A | 0.0622 | |
280 | Y | A | 0.0633 | |
281 | R | A | -0.4676 | |
282 | P | A | -0.5279 | |
283 | G | A | -0.4252 | |
284 | V | A | 0.0000 | |
285 | R | A | -0.6945 | |
286 | L | A | -0.5820 | |
287 | Q | A | -1.1682 | |
288 | T | A | -0.7626 | |
289 | E | A | -0.5143 | |
290 | L | A | 0.3100 | |
291 | L | A | -0.0839 | |
292 | A | A | -1.4877 | |
293 | R | A | -2.5962 | |
294 | D | A | -3.1174 | |
295 | G | A | -2.5706 | |
296 | Q | A | -3.0707 | |
297 | R | A | -2.7397 | |
298 | L | A | 0.0000 | |
299 | P | A | 0.0000 | |
300 | V | A | 0.0000 | |
301 | V | A | 0.0000 | |
302 | H | A | 0.0000 | |
303 | H | A | 0.0000 | |
304 | Y | A | 0.0000 | |
305 | G | A | 0.0000 | |
306 | H | A | 0.0000 | |
307 | G | A | -0.0107 | |
308 | S | A | -0.5862 | |
309 | G | A | -0.2536 | |
310 | G | A | -0.1697 | |
311 | I | A | 0.0000 | |
312 | S | A | 0.0000 | |
313 | V | A | 0.0000 | |
314 | H | A | 0.0000 | |
315 | W | A | -0.4324 | |
316 | G | A | 0.0000 | |
317 | T | A | 0.0000 | |
318 | A | A | 0.0000 | |
319 | L | A | -0.1726 | |
320 | E | A | -0.7998 | |
321 | A | A | 0.0000 | |
322 | A | A | 0.0000 | |
323 | R | A | -1.4427 | |
324 | L | A | -1.1542 | |
325 | V | A | 0.0000 | |
326 | S | A | -1.3405 | |
327 | E | A | -2.2559 | |
328 | C | A | -1.3898 | |
329 | V | A | 0.0000 | |
330 | H | A | -2.0093 | |
331 | A | A | -1.2750 | |
332 | L | A | -1.0375 | |
333 | R | A | -2.1134 | |
334 | T | A | -1.2245 | |
335 | P | A | -1.2344 | |
336 | I | A | -0.7167 | |
337 | P | A | -0.9514 | |
338 | K | A | -1.1780 | |
339 | S | A | -0.9336 | |
340 | N | A | -0.9853 | |
341 | L | A | 0.1833 |