Project name: 455f80f9022adac

Chain sequence(s)	H: QVQLQESGPGLVRPSQTLSLTCTVSGFTFTDFYMNWVRQPPGRGLEWIGFIRDKAKGYTTEYNPSVKGRVTMLVDTSKNQFSLRLSSVTAADTAVYYCAREGHTAAPFDYWGQGSLVTVSSASTKGPSVFPLAPAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKV; L: DIQMTQSPSSLSASVGDRVTITCKASQNIDKYLNWYQQKPGKAPKLLIYNTNNLQTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCLQHISRPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.6025
• Maximal score value: 1.1944
• Average score: -0.7781
• Total score value: -329.9121

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	L	-2.6574
2	I	L	0.0000
3	Q	L	-2.3463
4	M	L	0.0000
5	T	L	-1.2538
6	Q	L	0.0000
7	S	L	-0.8856
8	P	L	-0.6737
9	S	L	-0.9513
10	S	L	-1.0884
11	L	L	-0.7199
12	S	L	-1.0580
13	A	L	-1.3539
14	S	L	-1.6446
15	V	L	-1.1992
16	G	L	-1.4756
17	D	L	-2.4062
18	R	L	-2.7366
19	V	L	0.0000
20	T	L	-0.7293
21	I	L	0.0000
22	T	L	-0.9117
23	C	L	0.0000
24	K	L	-3.0259
25	A	L	0.0000
26	S	L	-2.2671
27	Q	L	-2.7555
28	N	L	-2.7572
29	I	L	0.0000
30	D	L	-2.6256
31	K	L	-2.5869
32	Y	L	-0.9164
33	L	L	0.0000
34	N	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	-1.5583
39	K	L	-2.1457
40	P	L	-1.7750
41	G	L	-1.8688
42	K	L	-2.6971
43	A	L	-1.8161
44	P	L	0.0000
45	K	L	-2.0343
46	L	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	-0.4607
50	N	L	-1.1947
51	T	L	0.0000
52	N	L	-1.8819
53	N	L	-1.1239
54	L	L	-0.0391
55	Q	L	-0.3003
56	T	L	-0.2960
57	G	L	-0.4983
58	V	L	0.0000
59	P	L	-0.3873
60	S	L	-0.4915
61	R	L	-0.9994
62	F	L	0.0000
63	S	L	-0.6920
64	G	L	-0.9206
65	S	L	-1.3775
66	G	L	-1.7345
67	S	L	-2.4389
68	G	L	-2.4355
69	T	L	-2.8281
70	D	L	-2.8806
71	F	L	0.0000
72	T	L	-1.0684
73	F	L	0.0000
74	T	L	-0.6813
75	I	L	0.0000
76	S	L	-1.4991
77	S	L	-1.6715
78	L	L	0.0000
79	Q	L	-1.7936
80	P	L	-2.4059
81	E	L	-2.7323
82	D	L	0.0000
83	I	L	0.0000
84	A	L	0.0000
85	T	L	0.0000
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	L	L	0.0000
90	Q	L	0.0000
91	H	L	-0.1768
92	I	L	0.2474
93	S	L	-0.5395
94	R	L	-1.4898
95	P	L	0.0000
96	R	L	-1.0985
97	T	L	-1.1682
98	F	L	0.0000
99	G	L	0.0000
100	Q	L	-1.9050
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-1.9727
104	V	L	0.0000
105	E	L	-2.2029
106	I	L	0.0000
107	K	L	-1.6987
108	R	L	-1.4283
109	T	L	-0.0825
110	V	L	0.7238
111	A	L	0.2329
112	A	L	0.1376
113	P	L	0.0000
114	S	L	-0.1165
115	V	L	-0.0373
116	F	L	0.0261
117	I	L	0.0000
118	F	L	0.0000
119	P	L	-0.5580
120	P	L	-0.7005
121	S	L	0.0000
122	D	L	-2.5209
123	E	L	-2.3405
124	Q	L	0.0000
125	L	L	-2.0711
126	K	L	-2.6020
127	S	L	-1.4966
128	G	L	-1.2938
129	T	L	-0.9989
130	A	L	0.0000
131	S	L	0.0000
132	V	L	0.0000
133	V	L	0.0000
134	C	L	0.0000
135	L	L	0.0000
136	L	L	0.0000
137	N	L	0.0000
138	N	L	-1.0398
139	F	L	0.0000
140	Y	L	0.0000
141	P	L	-1.8156
142	R	L	-3.1402
143	E	L	-3.4342
144	A	L	0.0000
145	K	L	-2.7675
146	V	L	-1.3297
147	Q	L	-0.9299
148	W	L	-0.7244
149	K	L	-0.8458
150	V	L	0.0000
151	D	L	-2.0028
152	N	L	-1.7367
153	A	L	-0.5071
154	L	L	0.1929
155	Q	L	-0.7767
156	S	L	-0.9326
157	G	L	-1.0114
158	N	L	-0.9257
159	S	L	-1.5512
160	Q	L	-2.0862
161	E	L	-2.4491
162	S	L	-0.9810
163	V	L	-0.8330
164	T	L	-1.1722
165	E	L	-2.4365
166	Q	L	0.0000
167	D	L	-2.3840
168	S	L	-2.7162
169	K	L	-2.9701
170	D	L	-2.5399
171	S	L	0.0000
172	T	L	0.0000
173	Y	L	0.0000
174	S	L	0.0000
175	L	L	0.0000
176	S	L	0.0000
177	S	L	0.0000
178	T	L	-0.7367
179	L	L	0.0000
180	T	L	-0.3633
181	L	L	-0.3931
182	S	L	-0.8316
183	K	L	-1.6216
184	A	L	-1.4674
185	D	L	-2.2005
186	Y	L	0.0000
187	E	L	-3.4399
188	K	L	-3.3381
189	H	L	-3.0976
190	K	L	-3.6025
191	V	L	-2.0038
192	Y	L	0.0000
193	A	L	-1.1448
194	C	L	0.0000
195	E	L	-0.8619
196	V	L	0.0000
197	T	L	-1.0962
198	H	L	0.0000
199	Q	L	-1.9206
200	G	L	-0.5160
201	L	L	0.0180
202	S	L	-0.4419
203	S	L	-0.2407
204	P	L	-0.4359
205	V	L	0.1503
206	T	L	-0.4302
207	K	L	-0.9550
208	S	L	-0.7527
209	F	L	-1.1201
210	N	L	-2.4538
211	R	L	-2.2444
212	G	L	-1.9341
213	E	L	-2.3768
214	C	L	-0.8170
1	Q	H	-1.3287
2	V	H	-0.8279
3	Q	H	-1.5690
4	L	H	0.0000
5	Q	H	-1.7067
6	E	H	0.0000
7	S	H	-0.7230
8	G	H	-0.3508
9	P	H	-0.3934
10	G	H	-0.3779
11	L	H	-0.2005
12	V	H	0.0000
13	R	H	-1.6884
14	P	H	-1.2350
15	S	H	-1.2658
16	Q	H	-1.7932
17	T	H	-1.4739
18	L	H	0.0000
19	S	H	-1.0056
20	L	H	0.0000
21	T	H	-0.4668
22	C	H	0.0000
23	T	H	-1.1119
24	V	H	0.0000
25	S	H	-1.1100
26	G	H	-0.8393
27	F	H	-0.5228
28	T	H	-0.7418
29	F	H	0.0000
30	T	H	-1.6383
31	D	H	-2.1237
32	F	H	-0.9325
33	Y	H	-0.5380
34	M	H	0.0000
35	N	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.8750
40	P	H	-0.8999
41	P	H	-1.0195
42	G	H	-1.5691
43	R	H	-2.5496
44	G	H	-1.7195
45	L	H	0.0000
46	E	H	-1.0345
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	F	H	0.0000
51	I	H	0.0000
52	R	H	-1.1899
53	D	H	-1.9404
54	K	H	-2.5782
55	A	H	-1.9768
56	K	H	-2.3204
57	G	H	-1.6278
58	Y	H	-0.5550
59	T	H	-0.6114
60	T	H	-0.2918
61	E	H	-1.1184
62	Y	H	-1.1099
63	N	H	0.0000
64	P	H	-1.3941
65	S	H	-1.1902
66	V	H	0.0000
67	K	H	-2.2640
68	G	H	-1.5914
69	R	H	-1.6474
70	V	H	0.0000
71	T	H	-0.8213
72	M	H	0.0000
73	L	H	1.1568
74	V	H	0.0475
75	D	H	-1.3539
76	T	H	-1.2970
77	S	H	-1.5254
78	K	H	-2.4115
79	N	H	-1.7985
80	Q	H	-1.2862
81	F	H	0.0000
82	S	H	-0.3095
83	L	H	0.0000
84	R	H	-1.8352
85	L	H	0.0000
86	S	H	-1.2170
87	S	H	-1.1015
88	V	H	0.0000
89	T	H	-0.5065
90	A	H	-0.1433
91	A	H	0.0593
92	D	H	0.0000
93	T	H	0.0673
94	A	H	0.0000
95	V	H	0.0261
96	Y	H	0.0000
97	Y	H	0.0000
98	C	H	0.0000
99	A	H	0.0000
100	R	H	0.0000
101	E	H	0.0000
102	G	H	-0.7240
103	H	H	-1.2509
104	T	H	-0.6614
105	A	H	-0.4475
106	A	H	-0.3010
107	P	H	0.0000
108	F	H	0.0000
109	D	H	-0.6986
110	Y	H	-0.3631
111	W	H	-0.7929
112	G	H	-1.3292
113	Q	H	-2.0557
114	G	H	-1.3597
115	S	H	-0.6515
116	L	H	0.1287
117	V	H	0.0000
118	T	H	-0.1263
119	V	H	0.0000
120	S	H	-0.4860
121	S	H	-0.6820
122	A	H	-0.4464
123	S	H	-0.5173
124	T	H	-0.6630
125	K	H	-1.0908
126	G	H	-1.2871
127	P	H	0.0000
128	S	H	-0.4549
129	V	H	0.0000
130	F	H	0.0000
131	P	H	-0.8223
132	L	H	0.0000
133	A	H	-0.3363
134	P	H	-0.1090
144	A	H	-0.0545
145	A	H	0.0000
146	L	H	0.0000
147	G	H	0.0000
148	C	H	0.0000
149	L	H	0.0000
150	V	H	0.0000
151	K	H	0.0000
152	D	H	-0.2923
153	Y	H	0.0000
154	F	H	-0.1325
155	P	H	0.0000
156	E	H	-0.6063
157	P	H	-0.6935
158	V	H	0.0000
159	T	H	-0.7091
160	V	H	0.0000
161	S	H	-0.5851
162	W	H	0.0000
163	N	H	-0.6047
164	S	H	-0.6218
165	G	H	-0.5812
166	A	H	-0.1724
167	L	H	0.1210
168	T	H	-0.0885
169	S	H	-0.3478
170	G	H	-0.0877
171	V	H	0.2487
172	H	H	-0.3104
173	T	H	-0.0233
174	F	H	0.0000
175	P	H	-0.3440
176	A	H	0.1811
177	V	H	0.3831
178	L	H	1.1944
179	Q	H	0.1735
180	S	H	-0.0973
181	S	H	-0.2408
182	G	H	0.0407
183	L	H	0.2819
184	Y	H	0.5541
185	S	H	0.3254
186	L	H	0.0000
187	S	H	0.0000
188	S	H	0.0000
189	V	H	0.0000
190	V	H	0.0000
191	T	H	-0.0720
192	V	H	0.0000
193	P	H	-0.3539
194	S	H	-0.3362
195	S	H	-0.3294
196	S	H	-0.3451
197	L	H	-0.1147
198	G	H	-0.6948
199	T	H	-0.7521
200	Q	H	-1.1575
201	T	H	-0.6692
202	Y	H	-0.3383
203	I	H	-0.6318
204	C	H	0.0000
205	N	H	-1.5577
206	V	H	0.0000
207	N	H	-2.0444
208	H	H	0.0000
209	K	H	-2.7841
210	P	H	-1.5547
211	S	H	-1.8574
212	N	H	-2.5331
213	T	H	-2.1122
214	K	H	-2.6802
215	V	H	-1.5807
216	D	H	-2.2760
217	K	H	-1.7119
218	K	H	-1.7028
219	V	H	-0.4135