Project name: HTT tesy
Status: done
submitted: 2017-12-08 04:57:08, status changed: 2017-12-08 05:06:37
Settings
|
Chain sequence(s)
|
B: KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDAALAAAQTNAAAMATLEKLMKAFESLKSFQQQQQQQQQQQQQQ
|
| Distance of aggregation |
10 Å |
| Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-4.422
-
Maximal score value
-
0.9617
-
Average score
-
-1.1101
-
Total score value
-
-445.1593
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
| residue index |
residue name |
chain |
Aggrescan3D score |
|
| 1 |
K |
B |
-2.8436 |
|
| 2 |
I |
B |
0.0000 |
|
| 3 |
E |
B |
-3.6178 |
|
| 4 |
E |
B |
-3.4322 |
|
| 5 |
G |
B |
-2.3129 |
|
| 6 |
K |
B |
-2.3778 |
|
| 7 |
L |
B |
0.0000 |
|
| 8 |
V |
B |
0.0000 |
|
| 9 |
I |
B |
0.0000 |
|
| 10 |
W |
B |
0.0000 |
|
| 11 |
I |
B |
0.0000 |
|
| 12 |
N |
B |
-2.1362 |
|
| 13 |
G |
B |
-2.5506 |
|
| 14 |
D |
B |
-2.6590 |
|
| 15 |
K |
B |
-2.3436 |
|
| 16 |
G |
B |
0.0000 |
|
| 17 |
Y |
B |
-1.7338 |
|
| 18 |
N |
B |
-2.2004 |
|
| 19 |
G |
B |
0.0000 |
|
| 20 |
L |
B |
0.0000 |
|
| 21 |
A |
B |
-1.8909 |
|
| 22 |
E |
B |
-2.9066 |
|
| 23 |
V |
B |
0.0000 |
|
| 24 |
G |
B |
0.0000 |
|
| 25 |
K |
B |
-3.7085 |
|
| 26 |
K |
B |
-3.1844 |
|
| 27 |
F |
B |
0.0000 |
|
| 28 |
E |
B |
-3.3439 |
|
| 29 |
K |
B |
-3.5852 |
|
| 30 |
D |
B |
-3.1822 |
|
| 31 |
T |
B |
-1.9599 |
|
| 32 |
G |
B |
-2.2427 |
|
| 33 |
I |
B |
-2.0392 |
|
| 34 |
K |
B |
-2.6138 |
|
| 35 |
V |
B |
0.0000 |
|
| 36 |
T |
B |
-0.9919 |
|
| 37 |
V |
B |
-0.8123 |
|
| 38 |
E |
B |
-1.5610 |
|
| 39 |
H |
B |
-2.2076 |
|
| 40 |
P |
B |
-2.2026 |
|
| 41 |
D |
B |
-3.3874 |
|
| 42 |
K |
B |
-3.5213 |
|
| 43 |
L |
B |
0.0000 |
|
| 44 |
E |
B |
-2.4256 |
|
| 45 |
E |
B |
-3.1683 |
|
| 46 |
K |
B |
-2.7265 |
|
| 47 |
F |
B |
0.0000 |
|
| 48 |
P |
B |
-1.4601 |
|
| 49 |
Q |
B |
-1.7816 |
|
| 50 |
V |
B |
-0.8617 |
|
| 51 |
A |
B |
0.0000 |
|
| 52 |
A |
B |
-0.4932 |
|
| 53 |
T |
B |
-0.5966 |
|
| 54 |
G |
B |
-0.7917 |
|
| 55 |
D |
B |
-1.4576 |
|
| 56 |
G |
B |
-1.0219 |
|
| 57 |
P |
B |
0.0000 |
|
| 58 |
D |
B |
0.0000 |
|
| 59 |
I |
B |
0.0000 |
|
| 60 |
I |
B |
0.0000 |
|
| 61 |
F |
B |
0.0000 |
|
| 62 |
W |
B |
-0.2336 |
|
| 63 |
A |
B |
-0.5220 |
|
| 64 |
H |
B |
0.0000 |
|
| 65 |
D |
B |
-1.2997 |
|
| 66 |
R |
B |
-1.7030 |
|
| 67 |
F |
B |
0.0000 |
|
| 68 |
G |
B |
0.0000 |
|
| 69 |
G |
B |
-1.4266 |
|
| 70 |
Y |
B |
0.0000 |
|
| 71 |
A |
B |
-1.6074 |
|
| 72 |
Q |
B |
-1.7420 |
|
| 73 |
S |
B |
-1.0977 |
|
| 74 |
G |
B |
-1.1578 |
|
| 75 |
L |
B |
0.0000 |
|
| 76 |
L |
B |
0.0000 |
|
| 77 |
A |
B |
-1.1640 |
|
| 78 |
E |
B |
-2.2496 |
|
| 79 |
I |
B |
0.0000 |
|
| 80 |
T |
B |
-1.5566 |
|
| 81 |
P |
B |
0.0000 |
|
| 82 |
D |
B |
-2.8143 |
|
| 83 |
K |
B |
-3.0828 |
|
| 84 |
A |
B |
-1.9648 |
|
| 85 |
F |
B |
-1.9351 |
|
| 86 |
Q |
B |
-2.2994 |
|
| 87 |
D |
B |
-2.9551 |
|
| 88 |
K |
B |
-2.1234 |
|
| 89 |
L |
B |
0.0000 |
|
| 90 |
Y |
B |
0.0000 |
|
| 91 |
P |
B |
-0.8320 |
|
| 92 |
F |
B |
-0.3255 |
|
| 93 |
T |
B |
0.0000 |
|
| 94 |
W |
B |
0.0000 |
|
| 95 |
D |
B |
-0.9504 |
|
| 96 |
A |
B |
0.0000 |
|
| 97 |
V |
B |
0.0000 |
|
| 98 |
R |
B |
-1.7581 |
|
| 99 |
Y |
B |
-1.9934 |
|
| 100 |
N |
B |
-2.3651 |
|
| 101 |
G |
B |
-2.2362 |
|
| 102 |
K |
B |
-2.6479 |
|
| 103 |
L |
B |
-1.4996 |
|
| 104 |
I |
B |
0.0000 |
|
| 105 |
A |
B |
0.0000 |
|
| 106 |
Y |
B |
0.0000 |
|
| 107 |
P |
B |
0.0000 |
|
| 108 |
I |
B |
0.0000 |
|
| 109 |
A |
B |
0.0000 |
|
| 110 |
V |
B |
0.0000 |
|
| 111 |
E |
B |
-1.0567 |
|
| 112 |
A |
B |
0.0000 |
|
| 113 |
L |
B |
0.0000 |
|
| 114 |
S |
B |
0.0000 |
|
| 115 |
L |
B |
0.0000 |
|
| 116 |
I |
B |
0.0000 |
|
| 117 |
Y |
B |
-0.7703 |
|
| 118 |
N |
B |
0.0000 |
|
| 119 |
K |
B |
-2.8188 |
|
| 120 |
D |
B |
-2.7719 |
|
| 121 |
L |
B |
-1.8000 |
|
| 122 |
L |
B |
0.0000 |
|
| 123 |
P |
B |
-1.8527 |
|
| 124 |
N |
B |
-2.0464 |
|
| 125 |
P |
B |
-1.2585 |
|
| 126 |
P |
B |
0.0000 |
|
| 127 |
K |
B |
-2.1632 |
|
| 128 |
T |
B |
-1.8898 |
|
| 129 |
W |
B |
0.0000 |
|
| 130 |
E |
B |
-1.8975 |
|
| 131 |
E |
B |
-1.6077 |
|
| 132 |
I |
B |
0.0000 |
|
| 133 |
P |
B |
-1.6633 |
|
| 134 |
A |
B |
-1.2264 |
|
| 135 |
L |
B |
-1.5076 |
|
| 136 |
D |
B |
0.0000 |
|
| 137 |
K |
B |
-3.6271 |
|
| 138 |
E |
B |
-3.5146 |
|
| 139 |
L |
B |
0.0000 |
|
| 140 |
K |
B |
-3.6226 |
|
| 141 |
A |
B |
-2.7683 |
|
| 142 |
K |
B |
-3.0942 |
|
| 143 |
G |
B |
-2.7999 |
|
| 144 |
K |
B |
-2.8129 |
|
| 145 |
S |
B |
-2.0374 |
|
| 146 |
A |
B |
0.0000 |
|
| 147 |
L |
B |
0.0000 |
|
| 148 |
M |
B |
0.0000 |
|
| 149 |
F |
B |
0.0000 |
|
| 150 |
N |
B |
0.0000 |
|
| 151 |
L |
B |
0.0000 |
|
| 152 |
Q |
B |
-1.3495 |
|
| 153 |
E |
B |
-1.2932 |
|
| 154 |
P |
B |
0.0000 |
|
| 155 |
Y |
B |
-0.2688 |
|
| 156 |
F |
B |
0.0000 |
|
| 157 |
T |
B |
0.0000 |
|
| 158 |
W |
B |
0.0000 |
|
| 159 |
P |
B |
0.0000 |
|
| 160 |
L |
B |
0.0000 |
|
| 161 |
I |
B |
0.0000 |
|
| 162 |
A |
B |
0.0000 |
|
| 163 |
A |
B |
0.0000 |
|
| 164 |
D |
B |
-1.3378 |
|
| 165 |
G |
B |
-0.8094 |
|
| 166 |
G |
B |
0.0000 |
|
| 167 |
Y |
B |
-0.1847 |
|
| 168 |
A |
B |
0.0000 |
|
| 169 |
F |
B |
0.0000 |
|
| 170 |
K |
B |
-2.0036 |
|
| 171 |
Y |
B |
-1.8877 |
|
| 172 |
E |
B |
-3.1483 |
|
| 173 |
N |
B |
-2.7191 |
|
| 174 |
G |
B |
-2.5249 |
|
| 175 |
K |
B |
-3.1614 |
|
| 176 |
Y |
B |
-1.9752 |
|
| 177 |
D |
B |
-1.9372 |
|
| 178 |
I |
B |
-0.4221 |
|
| 179 |
K |
B |
-1.6623 |
|
| 180 |
D |
B |
-1.2289 |
|
| 181 |
V |
B |
-0.6849 |
|
| 182 |
G |
B |
0.0000 |
|
| 183 |
V |
B |
0.0000 |
|
| 184 |
D |
B |
-1.3762 |
|
| 185 |
N |
B |
-1.0885 |
|
| 186 |
A |
B |
-0.8001 |
|
| 187 |
G |
B |
-0.8428 |
|
| 188 |
A |
B |
0.0000 |
|
| 189 |
K |
B |
-1.1810 |
|
| 190 |
A |
B |
-0.7273 |
|
| 191 |
G |
B |
0.0000 |
|
| 192 |
L |
B |
0.0000 |
|
| 193 |
T |
B |
-0.5381 |
|
| 194 |
F |
B |
-0.4852 |
|
| 195 |
L |
B |
0.0000 |
|
| 196 |
V |
B |
-1.3072 |
|
| 197 |
D |
B |
-2.3233 |
|
| 198 |
L |
B |
0.0000 |
|
| 199 |
I |
B |
0.0000 |
|
| 200 |
K |
B |
-3.0979 |
|
| 201 |
N |
B |
-3.2391 |
|
| 202 |
K |
B |
-3.4472 |
|
| 203 |
H |
B |
-2.4768 |
|
| 204 |
M |
B |
0.0000 |
|
| 205 |
N |
B |
-2.6127 |
|
| 206 |
A |
B |
-1.9469 |
|
| 207 |
D |
B |
-2.1533 |
|
| 208 |
T |
B |
0.0000 |
|
| 209 |
D |
B |
-0.9856 |
|
| 210 |
Y |
B |
0.0865 |
|
| 211 |
S |
B |
0.3891 |
|
| 212 |
I |
B |
0.9617 |
|
| 213 |
A |
B |
0.0000 |
|
| 214 |
E |
B |
-0.3334 |
|
| 215 |
A |
B |
-0.5617 |
|
| 216 |
A |
B |
-0.9309 |
|
| 217 |
F |
B |
0.0000 |
|
| 218 |
N |
B |
-1.9927 |
|
| 219 |
K |
B |
-2.5850 |
|
| 220 |
G |
B |
-2.1638 |
|
| 221 |
E |
B |
-2.6143 |
|
| 222 |
T |
B |
0.0000 |
|
| 223 |
A |
B |
0.0000 |
|
| 224 |
M |
B |
0.0000 |
|
| 225 |
T |
B |
0.0000 |
|
| 226 |
I |
B |
0.0000 |
|
| 227 |
N |
B |
0.0000 |
|
| 228 |
G |
B |
0.0000 |
|
| 229 |
P |
B |
-0.0655 |
|
| 230 |
W |
B |
0.2688 |
|
| 231 |
A |
B |
0.0000 |
|
| 232 |
W |
B |
0.0000 |
|
| 233 |
S |
B |
-1.1217 |
|
| 234 |
N |
B |
-1.8407 |
|
| 235 |
I |
B |
0.0000 |
|
| 236 |
D |
B |
-2.6565 |
|
| 237 |
T |
B |
-1.7996 |
|
| 238 |
S |
B |
-2.1641 |
|
| 239 |
K |
B |
-2.7852 |
|
| 240 |
V |
B |
-2.4210 |
|
| 241 |
N |
B |
-2.4953 |
|
| 242 |
Y |
B |
-1.5954 |
|
| 243 |
G |
B |
-0.8916 |
|
| 244 |
V |
B |
0.0000 |
|
| 245 |
T |
B |
-0.3256 |
|
| 246 |
V |
B |
-0.3000 |
|
| 247 |
L |
B |
0.0000 |
|
| 248 |
P |
B |
0.0000 |
|
| 249 |
T |
B |
-1.5812 |
|
| 250 |
F |
B |
0.0000 |
|
| 251 |
K |
B |
-2.3392 |
|
| 252 |
G |
B |
-2.0161 |
|
| 253 |
Q |
B |
-1.9079 |
|
| 254 |
P |
B |
-1.3526 |
|
| 255 |
S |
B |
0.0000 |
|
| 256 |
K |
B |
-1.1047 |
|
| 257 |
P |
B |
0.0000 |
|
| 258 |
F |
B |
0.0000 |
|
| 259 |
V |
B |
0.0000 |
|
| 260 |
G |
B |
-0.5633 |
|
| 261 |
V |
B |
0.0000 |
|
| 262 |
L |
B |
-0.0879 |
|
| 263 |
S |
B |
0.0000 |
|
| 264 |
A |
B |
0.0000 |
|
| 265 |
G |
B |
0.0000 |
|
| 266 |
I |
B |
0.0000 |
|
| 267 |
N |
B |
0.0000 |
|
| 268 |
A |
B |
-0.5195 |
|
| 269 |
A |
B |
-0.5030 |
|
| 270 |
S |
B |
0.0000 |
|
| 271 |
P |
B |
-1.6556 |
|
| 272 |
N |
B |
0.0000 |
|
| 273 |
K |
B |
-1.8925 |
|
| 274 |
E |
B |
-2.4743 |
|
| 275 |
L |
B |
-1.5398 |
|
| 276 |
A |
B |
0.0000 |
|
| 277 |
K |
B |
-2.0253 |
|
| 278 |
E |
B |
-2.1072 |
|
| 279 |
F |
B |
0.0000 |
|
| 280 |
L |
B |
0.0000 |
|
| 281 |
E |
B |
-1.2329 |
|
| 282 |
N |
B |
-1.6681 |
|
| 283 |
Y |
B |
-1.3941 |
|
| 284 |
L |
B |
0.0000 |
|
| 285 |
L |
B |
0.0000 |
|
| 286 |
T |
B |
-1.8455 |
|
| 287 |
D |
B |
-2.7492 |
|
| 288 |
E |
B |
-2.7871 |
|
| 289 |
G |
B |
0.0000 |
|
| 290 |
L |
B |
0.0000 |
|
| 291 |
E |
B |
-2.7344 |
|
| 292 |
A |
B |
-2.6930 |
|
| 293 |
V |
B |
0.0000 |
|
| 294 |
N |
B |
-2.2890 |
|
| 295 |
K |
B |
-3.0118 |
|
| 296 |
D |
B |
-2.9104 |
|
| 297 |
K |
B |
-3.0479 |
|
| 298 |
P |
B |
-1.8111 |
|
| 299 |
L |
B |
-1.0590 |
|
| 300 |
G |
B |
0.0000 |
|
| 301 |
A |
B |
0.0000 |
|
| 302 |
V |
B |
0.0000 |
|
| 303 |
A |
B |
0.0000 |
|
| 304 |
L |
B |
0.0000 |
|
| 305 |
K |
B |
-1.9462 |
|
| 306 |
S |
B |
-1.7952 |
|
| 307 |
Y |
B |
0.0000 |
|
| 308 |
E |
B |
0.0000 |
|
| 309 |
E |
B |
-3.1216 |
|
| 310 |
E |
B |
-3.3326 |
|
| 311 |
L |
B |
-2.1126 |
|
| 312 |
A |
B |
-2.1540 |
|
| 313 |
K |
B |
-2.7647 |
|
| 314 |
D |
B |
-1.7087 |
|
| 315 |
P |
B |
-1.1541 |
|
| 316 |
R |
B |
-0.8994 |
|
| 317 |
I |
B |
0.0000 |
|
| 318 |
A |
B |
-1.4200 |
|
| 319 |
A |
B |
0.0000 |
|
| 320 |
T |
B |
0.0000 |
|
| 321 |
M |
B |
0.0000 |
|
| 322 |
E |
B |
-1.9942 |
|
| 323 |
N |
B |
0.0000 |
|
| 324 |
A |
B |
0.0000 |
|
| 325 |
Q |
B |
-2.1054 |
|
| 326 |
K |
B |
-1.9014 |
|
| 327 |
G |
B |
-1.2614 |
|
| 328 |
E |
B |
-0.5470 |
|
| 329 |
I |
B |
-0.2301 |
|
| 330 |
M |
B |
0.0000 |
|
| 331 |
P |
B |
0.0000 |
|
| 332 |
N |
B |
0.0000 |
|
| 333 |
I |
B |
-0.4335 |
|
| 334 |
P |
B |
-0.8091 |
|
| 335 |
Q |
B |
-0.3930 |
|
| 336 |
M |
B |
0.0000 |
|
| 337 |
S |
B |
-0.0385 |
|
| 338 |
A |
B |
0.0000 |
|
| 339 |
F |
B |
0.0000 |
|
| 340 |
W |
B |
0.3035 |
|
| 341 |
Y |
B |
0.7342 |
|
| 342 |
A |
B |
0.0000 |
|
| 343 |
V |
B |
0.0000 |
|
| 344 |
R |
B |
-0.8390 |
|
| 345 |
T |
B |
-0.3527 |
|
| 346 |
A |
B |
0.0000 |
|
| 347 |
V |
B |
0.0000 |
|
| 348 |
I |
B |
-0.7311 |
|
| 349 |
N |
B |
-1.1505 |
|
| 350 |
A |
B |
0.0000 |
|
| 351 |
A |
B |
0.0000 |
|
| 352 |
S |
B |
-1.6109 |
|
| 353 |
G |
B |
-1.8436 |
|
| 354 |
R |
B |
-2.5571 |
|
| 355 |
Q |
B |
-2.2131 |
|
| 356 |
T |
B |
-1.4774 |
|
| 357 |
V |
B |
-1.1025 |
|
| 358 |
D |
B |
-2.0987 |
|
| 359 |
A |
B |
-1.3729 |
|
| 360 |
A |
B |
0.0000 |
|
| 361 |
L |
B |
0.0000 |
|
| 362 |
A |
B |
-0.9397 |
|
| 363 |
A |
B |
-0.6353 |
|
| 364 |
A |
B |
0.0000 |
|
| 365 |
Q |
B |
-0.8057 |
|
| 366 |
T |
B |
-0.5637 |
|
| 367 |
N |
B |
-0.5929 |
|
| 368 |
A |
B |
-0.0035 |
|
| 369 |
A |
B |
-0.2752 |
|
| 370 |
A |
B |
-0.0908 |
|
| 371 |
M |
B |
-0.1455 |
|
| 372 |
A |
B |
-0.4996 |
|
| 373 |
T |
B |
-0.0469 |
|
| 374 |
L |
B |
0.5031 |
|
| 375 |
E |
B |
-1.6123 |
|
| 376 |
K |
B |
-1.5497 |
|
| 377 |
L |
B |
-0.0602 |
|
| 378 |
M |
B |
-0.0309 |
|
| 379 |
K |
B |
-1.8357 |
|
| 380 |
A |
B |
-0.5200 |
|
| 381 |
F |
B |
0.6471 |
|
| 382 |
E |
B |
-1.2318 |
|
| 383 |
S |
B |
-0.2560 |
|
| 384 |
L |
B |
0.5565 |
|
| 385 |
K |
B |
-1.6353 |
|
| 386 |
S |
B |
-1.0321 |
|
| 387 |
F |
B |
-0.1321 |
|
| 388 |
Q |
B |
-2.2396 |
|
| 389 |
Q |
B |
-3.1212 |
|
| 390 |
Q |
B |
-3.1696 |
|
| 391 |
Q |
B |
-3.8088 |
|
| 392 |
Q |
B |
-4.0928 |
|
| 393 |
Q |
B |
-4.2482 |
|
| 394 |
Q |
B |
-4.4220 |
|
| 395 |
Q |
B |
-4.2490 |
|
| 396 |
Q |
B |
-4.0851 |
|
| 397 |
Q |
B |
-4.0784 |
|
| 398 |
Q |
B |
-3.8927 |
|
| 399 |
Q |
B |
-3.4832 |
|
| 400 |
Q |
B |
-3.4179 |
|
| 401 |
Q |
B |
-3.0734 |
|
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine