Project name: a-lac_LK

Chain sequence(s)	A: MEQLTKCEVFRELKDLKGYGGVSLPEWVCTTFHTSGYDTQAIVQNNDSTEYGLFQINNKIWCKDDQNPHSSNICNISCDKFLDDDLTDDIVCVKKILDKVGINYWLAHKALCSEKLDQWLCEK; C: MEQLTKCEVFRELKDLKGYGGVSLPEWVCTTFHTSGYDTQAIVQNNDSTEYGLFQINNKIWCKDDQNPHSSNICNISCDKFLDDDLTDDIVCVKKILDKVGINYWLAHKALCSEKLDQWLCE; B: MEQLTKCEVFRELKDLKGYGGVSLPEWVCTTFHTSGYDTQAIVQNNDSTEYGLFQINNKIWCKDDQNPHSSNICNISCDKFLDDDLTDDIVCVKKILDKVGINYWLAHKALCSEKLDQWLCE; D: MEQLTKCEVFRELKDLKGYGGVSLPEWVCTTFHTSGYDTQAIVQNNDSTEYGLFQINNKIWCKDDQNPHSSNICNISCDKFLDDDLTDDIVCVKKILDKVGINYWLAHKALCSEKLDQWLCEKL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.529
• Maximal score value: 1.1217
• Average score: -1.0617
• Total score value: -521.2873

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1X	M	A	-0.1121
1	E	A	-2.3802
2	Q	A	-2.1078
3	L	A	-1.3365
4	T	A	-0.8058
5	K	A	-0.6489
6	C	A	-1.5397
7	E	A	-2.1597
8	V	A	0.0000
9	F	A	-2.1030
10	R	A	-3.4890
11	E	A	-3.2328
12	L	A	0.0000
13	K	A	-3.6843
14	D	A	-3.3722
15	L	A	0.0000
16	K	A	-2.9517
17	G	A	-1.8507
18	Y	A	-1.2815
19	G	A	-1.1843
20	G	A	-0.9814
21	V	A	0.0000
22	S	A	-1.0796
23	L	A	0.0000
24	P	A	-0.7038
25	E	A	-0.9064
26	W	A	0.0000
27	V	A	0.0000
28	C	A	0.0000
29	T	A	0.0000
30	T	A	0.0000
31	F	A	0.7674
32	H	A	0.3104
33	T	A	0.2396
34	S	A	0.0944
35	G	A	-0.2719
36	Y	A	0.0000
37	D	A	-1.0453
38	T	A	0.0000
39	Q	A	-1.6021
40	A	A	0.3274
41	I	A	1.1162
42	V	A	0.4530
43	Q	A	-1.7572
44	N	A	-2.5545
45	N	A	-2.9635
46	D	A	-3.2187
47	S	A	-2.2707
48	T	A	0.0000
49	E	A	-0.3621
50	Y	A	0.0000
51	G	A	0.0000
52	L	A	0.0000
53	F	A	0.0000
54	Q	A	0.0000
55	I	A	0.0000
56	N	A	-0.7774
57	N	A	0.0000
58	K	A	-1.8867
59	I	A	-0.2816
60	W	A	0.0000
61	C	A	0.0000
62	K	A	-2.2448
63	D	A	-2.5728
64	D	A	-2.9426
65	Q	A	-2.5160
66	N	A	-2.3993
67	P	A	-1.8981
68	H	A	-1.7135
69	S	A	-1.3583
70	S	A	-0.7511
71	N	A	-0.8238
72	I	A	0.0824
73	C	A	0.0000
74	N	A	-1.1457
75	I	A	-1.2262
76	S	A	-1.8370
77	C	A	0.0000
78	D	A	-3.1132
79	K	A	-3.6021
80	F	A	0.0000
81	L	A	0.0000
82	D	A	-4.3159
83	D	A	-4.1926
84	D	A	-3.7767
85	L	A	0.0000
86	T	A	-1.6533
87	D	A	-1.2870
88	D	A	0.0000
89	I	A	0.0000
90	V	A	0.0322
91	C	A	0.0000
92	V	A	0.0000
93	K	A	-1.2519
94	K	A	-1.1873
95	I	A	0.0000
96	L	A	-1.1799
97	D	A	-2.4200
98	K	A	-1.8379
99	V	A	0.1842
100	G	A	-0.5316
101	I	A	-0.5449
102	N	A	-0.5866
103	Y	A	0.2120
104	W	A	0.0000
105	L	A	0.8805
106	A	A	0.4060
107	H	A	-0.5725
108	K	A	-1.4051
109	A	A	-0.1569
110	L	A	0.3251
111	C	A	0.0000
112	S	A	-1.3413
113	E	A	-2.2290
114	K	A	-2.7858
115	L	A	-1.8251
116	D	A	-2.5489
117	Q	A	-1.8908
118	W	A	-0.5727
119	L	A	-0.3041
120	C	A	-1.5152
121	E	A	-2.3010
122	K	A	-2.6591
1X	M	B	-0.2374
1	E	B	-2.6004
2	Q	B	-2.3006
3	L	B	-1.3469
4	T	B	-0.5171
5	K	B	-0.5924
6	C	B	-0.6866
7	E	B	-1.7740
8	V	B	0.0000
9	F	B	0.0000
10	R	B	-3.5490
11	E	B	-3.2569
12	L	B	0.0000
13	K	B	-4.0529
14	D	B	-3.4358
15	L	B	0.0000
16	K	B	-3.0007
17	G	B	-1.8405
18	Y	B	-1.1794
19	G	B	-1.1195
20	G	B	-0.9716
21	V	B	0.0000
22	S	B	-1.2162
23	L	B	0.0000
24	P	B	-0.8678
25	E	B	-1.0340
26	W	B	0.0000
27	V	B	0.0000
28	C	B	0.0000
29	T	B	0.0000
30	T	B	0.0000
31	F	B	0.7571
32	H	B	0.3165
33	T	B	0.2633
34	S	B	0.0708
35	G	B	-0.0673
36	Y	B	0.0000
37	D	B	-1.1432
38	T	B	0.0000
39	Q	B	-1.4404
40	A	B	0.2059
41	I	B	1.1075
42	V	B	0.2639
43	Q	B	-1.8599
44	N	B	-2.5980
45	N	B	-2.9729
46	D	B	-3.2076
47	S	B	-2.3949
48	T	B	0.0000
49	E	B	-0.3752
50	Y	B	-0.1264
51	G	B	0.0000
52	L	B	0.0000
53	F	B	0.0000
54	Q	B	0.0000
55	I	B	0.0000
56	N	B	-0.8998
57	N	B	0.0000
58	K	B	-1.7760
59	I	B	-0.1506
60	W	B	0.0000
61	C	B	0.0000
62	K	B	-2.8699
63	D	B	-2.8759
64	D	B	-3.0383
65	Q	B	-2.6116
66	N	B	-2.5810
67	P	B	-2.0322
68	H	B	-1.8170
69	S	B	-1.5568
70	S	B	-0.8709
71	N	B	-1.1291
72	I	B	-0.0988
73	C	B	0.0000
74	N	B	-1.3571
75	I	B	-1.4238
76	S	B	-1.9066
77	C	B	0.0000
78	D	B	-2.6659
79	K	B	-3.0056
80	F	B	0.0000
81	L	B	-2.2714
82	D	B	-3.9792
83	D	B	-4.1088
84	D	B	-3.7425
85	L	B	0.0000
86	T	B	-1.6862
87	D	B	-1.5168
88	D	B	0.0000
89	I	B	0.0000
90	V	B	0.1897
91	C	B	0.0000
92	V	B	0.0000
93	K	B	-0.8820
94	K	B	-1.1345
95	I	B	0.0000
96	L	B	-1.2027
97	D	B	-2.4122
98	K	B	-2.1100
99	V	B	-0.4790
100	G	B	-0.8052
101	I	B	-0.5776
102	N	B	-0.6816
103	Y	B	0.2527
104	W	B	0.0000
105	L	B	0.8999
106	A	B	0.0000
107	H	B	-0.7013
108	K	B	-1.5586
109	A	B	-0.3147
110	L	B	-0.0879
111	C	B	0.0000
112	S	B	-1.7277
113	E	B	-2.9539
114	K	B	-3.1978
115	L	B	-2.0497
116	D	B	-2.5743
117	Q	B	-1.9070
118	W	B	-0.7304
119	L	B	-0.0539
120	C	B	-0.7817
121	E	B	-1.4824
1X	M	C	-0.3115
1	E	C	-2.3654
2	Q	C	-1.9163
3	L	C	-1.3683
4	T	C	-0.8341
5	K	C	-0.8586
6	C	C	-1.1081
7	E	C	-2.0056
8	V	C	0.0000
9	F	C	-1.8367
10	R	C	-3.5858
11	E	C	-3.8080
12	L	C	0.0000
13	K	C	-4.1448
14	D	C	-3.4469
15	L	C	0.0000
16	K	C	-2.9824
17	G	C	-1.8258
18	Y	C	-1.2600
19	G	C	-1.1741
20	G	C	-0.9859
21	V	C	0.0000
22	S	C	-1.1484
23	L	C	0.0000
24	P	C	-0.7217
25	E	C	-0.8631
26	W	C	0.0000
27	V	C	0.0000
28	C	C	0.0000
29	T	C	0.0000
30	T	C	0.0000
31	F	C	0.5658
32	H	C	0.3326
33	T	C	0.2010
34	S	C	0.0245
35	G	C	-0.2979
36	Y	C	0.0000
37	D	C	-1.0108
38	T	C	0.0000
39	Q	C	-1.7473
40	A	C	0.4015
41	I	C	1.1217
42	V	C	0.7035
43	Q	C	-1.6207
44	N	C	-2.5337
45	N	C	-2.8953
46	D	C	-3.2804
47	S	C	-2.4008
48	T	C	0.0000
49	E	C	-0.3088
50	Y	C	0.0000
51	G	C	0.0000
52	L	C	0.0000
53	F	C	0.0000
54	Q	C	0.0000
55	I	C	0.0000
56	N	C	-0.8308
57	N	C	0.0000
58	K	C	-1.7945
59	I	C	-0.1830
60	W	C	0.0000
61	C	C	0.0000
62	K	C	-2.3958
63	D	C	0.0000
64	D	C	-2.7580
65	Q	C	-2.3551
66	N	C	-2.3988
67	P	C	-2.0087
68	H	C	-1.8583
69	S	C	-1.7011
70	S	C	-0.8106
71	N	C	-1.0082
72	I	C	-0.4623
73	C	C	-0.4724
74	N	C	-1.1952
75	I	C	-1.3885
76	S	C	-1.9548
77	C	C	0.0000
78	D	C	-3.1720
79	K	C	-3.8952
80	F	C	0.0000
81	L	C	-2.7864
82	D	C	-4.5290
83	D	C	-4.1207
84	D	C	-3.9525
85	L	C	0.0000
86	T	C	-1.8740
87	D	C	-1.6112
88	D	C	0.0000
89	I	C	0.0000
90	V	C	0.7212
91	C	C	0.0000
92	V	C	0.0000
93	K	C	-1.1435
94	K	C	-1.5065
95	I	C	0.0000
96	L	C	0.0000
97	D	C	-3.2144
98	K	C	-2.6930
99	V	C	-0.4800
100	G	C	-1.0185
101	I	C	-0.6662
102	N	C	-0.6699
103	Y	C	0.2211
104	W	C	0.0000
105	L	C	1.0321
106	A	C	0.0000
107	H	C	-0.3239
108	K	C	-1.4381
109	A	C	0.0204
110	L	C	0.4773
111	C	C	0.0000
112	S	C	-1.5368
113	E	C	-2.9485
114	K	C	-3.1254
115	L	C	-2.1778
116	D	C	-2.5730
117	Q	C	-2.2073
118	W	C	-0.7353
119	L	C	-0.1214
120	C	C	-0.9285
121	E	C	-1.4811
1X	M	D	-0.4272
1	E	D	-2.6364
2	Q	D	-2.1623
3	L	D	-1.1439
4	T	D	-0.4137
5	K	D	-0.3524
6	C	D	-0.7126
7	E	D	-1.6452
8	V	D	0.0000
9	F	D	-2.1086
10	R	D	-3.5081
11	E	D	-3.2417
12	L	D	0.0000
13	K	D	-4.0436
14	D	D	-3.4239
15	L	D	0.0000
16	K	D	-3.1040
17	G	D	-1.8829
18	Y	D	-1.2687
19	G	D	-1.1682
20	G	D	-0.9899
21	V	D	0.0000
22	S	D	-1.1310
23	L	D	0.0000
24	P	D	-0.7377
25	E	D	-0.9571
26	W	D	0.0000
27	V	D	0.0000
28	C	D	0.0000
29	T	D	0.0000
30	T	D	0.0000
31	F	D	0.6500
32	H	D	0.3985
33	T	D	0.2292
34	S	D	0.0696
35	G	D	-0.1221
36	Y	D	0.0000
37	D	D	-1.2670
38	T	D	0.0000
39	Q	D	-1.8437
40	A	D	0.2055
41	I	D	1.0410
42	V	D	0.6621
43	Q	D	-1.7679
44	N	D	-2.6521
45	N	D	-2.9026
46	D	D	-3.3760
47	S	D	0.0000
48	T	D	0.0000
49	E	D	-0.3213
50	Y	D	0.0000
51	G	D	0.0000
52	L	D	0.0000
53	F	D	0.0000
54	Q	D	0.0000
55	I	D	0.0000
56	N	D	-0.9191
57	N	D	0.0000
58	K	D	-1.8603
59	I	D	-0.3746
60	W	D	0.0000
61	C	D	0.0000
62	K	D	-3.1829
63	D	D	0.0000
64	D	D	-3.1933
65	Q	D	-3.0654
66	N	D	-2.5548
67	P	D	-2.4310
68	H	D	-2.0730
69	S	D	-1.6553
70	S	D	-0.9158
71	N	D	-1.2442
72	I	D	-0.6478
73	C	D	-0.5076
74	N	D	-1.3727
75	I	D	-1.5534
76	S	D	-2.2124
77	C	D	0.0000
78	D	D	-3.1726
79	K	D	-3.3927
80	F	D	0.0000
81	L	D	-2.8184
82	D	D	-4.2826
83	D	D	-4.0430
84	D	D	-3.3999
85	L	D	0.0000
86	T	D	-1.4702
87	D	D	-0.9660
88	D	D	0.0000
89	I	D	0.0000
90	V	D	0.9524
91	C	D	0.0000
92	V	D	0.0000
93	K	D	-0.8863
94	K	D	-1.4722
95	I	D	0.0000
96	L	D	-1.1690
97	D	D	-2.9989
98	K	D	-2.4256
99	V	D	0.1108
100	G	D	-0.5386
101	I	D	-0.4631
102	N	D	-0.5150
103	Y	D	0.3797
104	W	D	0.0000
105	L	D	0.9363
106	A	D	0.0000
107	H	D	-0.4962
108	K	D	-1.5095
109	A	D	-0.2201
110	L	D	0.2789
111	C	D	0.0000
112	S	D	-1.6174
113	E	D	-3.0172
114	K	D	-3.1838
115	L	D	-2.0597
116	D	D	-2.6391
117	Q	D	-2.2640
118	W	D	-0.7263
119	L	D	-0.2350
120	C	D	-1.1531
121	E	D	-2.1992
122	K	D	-1.6547
123	L	D	0.5002