Project name: 3od3

Chain sequence(s)	A: AERRPTLPIPDLLLTTTDDARNRIQQLTIGAGQQSTFGGKTTATTWGYNGNLLGPAVKLQRGKAVTVDIYNQLTEEETTLHWHGLLEVPGEEVDGGPQGIIPPGGKRSSVTLNVDQPAATCWFHPHQHGKTGRQVAMGLAGLLVVIEDDDEILKLMMLPKQWGIDDVVPVIVQDKKFSSADGQIDYQLDVVMTAAVGWFGDTLLTNGAIYYPQHAAPRGWLRLRLLNGCNARSLNFATSDNNRPLYVIASDGGLLPEPVKVSSELPVLMGERFEVLVEVNNDNKPFDDLVTLPVSQMGMAIIAPFDKPHPVMMRRIQQQPIAISSASGALPDDTLSSSLPALPSLEGLTVRKKLQLSMDPMMLDMMMGMQMLMEKYGDQAMAGMDHSQMMGHMGHHGNMMNHMNHGGKFDFHHHANKKINGQAFDMNKPMFAAAKGQYERRWVISGVGDMMMLHPFHIHGTQFRILSENGKPPAAHRAGWKDTVKVEGNVSEEVLVVKKFNHDAPKEHAYMAHCHLLEHEDTGMMLGFTV
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4925
• Maximal score value: 1.6629
• Average score: -0.628
• Total score value: -306.46

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
29	A	A	-1.0150
30	E	A	-2.2156
31	R	A	-1.5999
32	P	A	-0.8589
33	T	A	-0.4825
34	L	A	0.0000
35	P	A	-0.0786
36	I	A	0.3853
37	P	A	-0.3957
38	D	A	-1.3833
39	L	A	-0.1427
40	L	A	-0.3098
41	T	A	-0.8126
42	T	A	-1.5208
43	D	A	-2.0756
44	A	A	-1.6062
45	R	A	-2.6441
46	N	A	-2.1286
47	R	A	-2.5931
48	I	A	0.0000
49	Q	A	-1.7091
50	L	A	0.0000
51	T	A	-0.9260
52	I	A	0.0000
53	G	A	-0.9527
54	A	A	-0.8452
55	G	A	-1.1949
56	Q	A	-1.6864
57	S	A	-1.2620
58	T	A	-1.1984
59	F	A	0.0000
60	G	A	-1.0226
61	G	A	-1.4971
62	K	A	-2.3380
63	T	A	-1.6697
64	A	A	0.0000
65	T	A	-0.7551
66	T	A	0.0000
67	W	A	0.0000
68	G	A	0.0000
69	Y	A	0.0000
70	N	A	-1.4964
71	G	A	-1.4764
72	N	A	-1.7797
73	L	A	-0.8238
74	L	A	0.0000
75	G	A	-0.6377
76	P	A	0.0000
77	A	A	0.0000
78	V	A	0.0000
79	K	A	-0.8117
80	L	A	0.0000
81	Q	A	-3.1375
82	R	A	-3.4925
83	G	A	-2.8901
84	K	A	-2.5584
85	A	A	-1.9114
86	V	A	0.0000
87	T	A	-1.2805
88	V	A	0.0000
89	D	A	-1.4567
90	I	A	0.0000
91	Y	A	-1.2067
92	N	A	0.0000
93	Q	A	-1.6605
94	L	A	0.0000
95	T	A	-0.9129
96	E	A	-1.1945
97	E	A	-1.3836
98	T	A	0.0000
99	T	A	0.0000
100	L	A	0.0000
101	H	A	0.0000
102	W	A	0.0000
103	H	A	0.0000
104	G	A	0.0000
105	L	A	0.0000
106	E	A	-0.9279
107	V	A	0.0000
108	P	A	-1.4112
109	G	A	0.0000
110	E	A	-2.2883
111	V	A	-0.8625
112	D	A	0.0000
113	G	A	0.0000
114	G	A	0.0000
115	P	A	0.0000
116	Q	A	-0.9240
117	G	A	-0.5551
118	I	A	0.2222
119	I	A	0.0000
120	P	A	-1.0073
121	P	A	-1.2115
122	G	A	-1.3490
123	G	A	-1.3144
124	K	A	-1.8144
125	R	A	-1.7915
126	S	A	-1.2600
127	V	A	-0.6884
128	T	A	-0.6217
129	L	A	0.0000
130	N	A	-2.4156
131	V	A	0.0000
132	D	A	-3.1473
133	Q	A	0.0000
134	P	A	-1.5401
135	A	A	0.0000
136	A	A	0.0000
137	T	A	0.0000
138	C	A	0.0000
139	W	A	0.0000
140	F	A	0.0000
141	H	A	0.0000
142	P	A	0.0000
143	H	A	0.0000
144	Q	A	0.0000
145	H	A	-0.8068
146	G	A	-1.1289
147	K	A	-1.3872
148	T	A	0.0000
149	G	A	0.0000
150	R	A	-1.0202
151	Q	A	0.0000
152	V	A	0.0000
153	A	A	0.0000
154	M	A	-0.2126
155	G	A	0.0000
156	L	A	0.0000
157	A	A	0.0000
158	G	A	0.0000
159	L	A	0.0000
160	V	A	0.0000
161	V	A	0.0000
162	I	A	0.0000
163	E	A	-1.8917
164	D	A	-2.9971
165	D	A	-3.4112
166	E	A	-3.0996
167	I	A	0.0000
168	L	A	-1.0481
169	K	A	-1.8401
170	L	A	-0.4290
171	M	A	0.4985
172	L	A	0.0000
173	P	A	0.0000
174	K	A	-1.6282
175	Q	A	-1.2581
176	W	A	-0.4247
177	G	A	0.1446
178	I	A	0.7054
179	D	A	0.0000
180	D	A	0.0000
181	V	A	0.0000
182	P	A	0.0000
183	V	A	0.0000
184	I	A	0.0000
185	V	A	0.0000
186	Q	A	0.0000
187	D	A	0.0000
188	K	A	0.0000
189	K	A	-0.7776
190	F	A	-0.7563
191	S	A	-0.7535
192	A	A	-1.1042
193	D	A	-2.1746
194	G	A	0.0000
195	Q	A	-1.3235
196	I	A	-0.4957
197	D	A	-0.7780
198	Y	A	-0.4155
199	Q	A	-0.4951
200	L	A	-0.4139
201	D	A	-0.4681
202	V	A	0.0422
203	M	A	0.0000
204	T	A	0.0000
205	A	A	0.0000
206	A	A	0.0000
207	V	A	0.0000
208	G	A	0.0000
209	W	A	0.0000
210	F	A	0.0000
211	G	A	0.0000
212	D	A	-1.7791
213	T	A	-0.7612
214	L	A	0.0000
215	L	A	0.0000
216	T	A	0.0000
217	N	A	0.0000
218	G	A	0.0912
219	A	A	0.2970
220	I	A	0.8500
221	Y	A	0.3499
222	P	A	0.0000
223	Q	A	-0.8461
224	H	A	0.0000
225	A	A	0.0208
226	A	A	0.0000
227	P	A	0.0000
228	R	A	-1.5669
229	G	A	-0.9845
230	W	A	-0.5324
231	L	A	0.0000
232	R	A	0.0000
233	L	A	0.0000
234	R	A	0.0000
235	L	A	0.0000
236	L	A	0.0000
237	N	A	0.0000
238	G	A	0.0000
239	C	A	0.0000
240	N	A	0.0000
241	A	A	0.0000
242	R	A	0.0000
243	S	A	0.0000
244	L	A	0.0000
245	N	A	-0.4381
246	F	A	0.0000
247	A	A	0.0000
248	T	A	0.0000
249	S	A	-1.0980
250	D	A	-1.6668
251	N	A	-1.9529
252	R	A	0.0000
253	P	A	-1.1598
254	L	A	0.0000
255	Y	A	-0.6005
256	V	A	0.0000
257	I	A	0.0000
258	A	A	0.0000
259	S	A	0.0000
260	D	A	0.0000
261	G	A	0.0000
262	G	A	0.0000
263	L	A	-0.1325
264	L	A	0.0000
265	P	A	-1.0112
266	E	A	-2.1638
267	P	A	-1.3845
268	V	A	-0.8850
269	K	A	-1.8049
270	V	A	-1.0843
271	S	A	-1.4090
272	E	A	-1.7893
273	L	A	0.0000
274	P	A	-0.4385
275	V	A	0.0000
276	L	A	0.0000
277	M	A	0.0000
278	G	A	0.0000
279	E	A	0.0000
280	R	A	0.0000
281	F	A	0.0000
282	E	A	0.0000
283	V	A	0.0000
284	L	A	0.0000
285	V	A	0.0000
286	E	A	-1.0283
287	V	A	0.0000
288	N	A	-2.7123
289	D	A	-2.0252
290	N	A	-2.5517
291	K	A	-2.6399
292	P	A	-1.7381
293	F	A	0.0000
294	D	A	-0.8279
295	L	A	0.0000
296	V	A	0.0000
297	T	A	0.0000
298	L	A	-0.7427
299	P	A	-0.9942
300	V	A	-0.4423
301	S	A	-0.5273
302	Q	A	0.0000
303	M	A	0.0000
304	G	A	0.0000
305	M	A	0.0000
306	A	A	0.0000
307	I	A	-0.9285
308	A	A	-1.1589
309	P	A	-1.3565
310	F	A	0.0000
311	D	A	-2.3945
312	K	A	-2.4752
313	P	A	-1.3319
314	H	A	-0.9224
315	P	A	-0.3129
316	V	A	0.0000
317	M	A	0.0000
318	R	A	-0.8527
319	I	A	0.0000
320	Q	A	-1.2294
321	P	A	-1.1309
322	I	A	0.2674
323	A	A	0.3921
324	I	A	1.6629
325	S	A	0.1267
326	A	A	-0.2472
327	S	A	-0.4419
328	G	A	-0.4013
329	A	A	0.0421
330	L	A	-0.0974
331	P	A	-0.8652
332	D	A	-2.1913
333	T	A	-1.5711
334	L	A	0.0000
335	S	A	-0.9113
336	S	A	-0.3564
337	L	A	0.0569
338	P	A	0.0498
339	A	A	0.2894
340	L	A	0.7114
341	P	A	0.0943
342	S	A	-0.3974
343	L	A	-0.3882
344	E	A	-1.8436
345	G	A	-0.9835
346	L	A	-0.3232
347	T	A	0.0673
348	V	A	0.4520
349	R	A	-0.6467
350	K	A	-1.7958
351	L	A	0.0000
352	Q	A	-1.1032
353	L	A	0.0000
354	S	A	-0.6643
355	M	A	-0.5447
356	D	A	-0.5339
357	P	A	-0.2274
358	M	A	0.6079
359	L	A	0.0000
360	D	A	0.2762
361	M	A	0.9457
362	M	A	0.4786
363	G	A	0.0000
364	M	A	0.1214
365	Q	A	-0.8283
366	M	A	-0.5653
367	L	A	0.0000
368	M	A	-1.8120
369	E	A	-2.8282
370	K	A	-2.4878
371	Y	A	-1.2538
372	G	A	-1.8795
373	D	A	-2.3359
374	Q	A	-1.5054
375	A	A	0.0000
376	M	A	0.0000
377	A	A	-1.3085
378	G	A	-1.2720
379	M	A	0.0000
380	D	A	-2.3986
381	H	A	-1.8232
382	S	A	-1.1479
383	Q	A	-1.0042
384	M	A	-1.0534
385	M	A	-0.1575
386	G	A	-1.1240
387	H	A	-0.8490
388	M	A	0.0841
389	G	A	-1.0014
390	H	A	-1.9026
391	G	A	-1.6112
392	N	A	-2.0044
393	M	A	-0.9246
394	N	A	-1.6578
395	H	A	-1.4598
396	M	A	-0.5877
397	N	A	-1.6285
398	H	A	-1.8842
399	G	A	-1.5711
400	G	A	-1.7905
401	K	A	-1.8367
402	F	A	-0.5964
403	D	A	-1.3823
404	F	A	-0.6834
405	H	A	-1.0987
406	H	A	-1.9212
407	A	A	-1.1225
408	N	A	0.0000
409	K	A	-1.4750
410	I	A	0.0000
411	N	A	-1.5918
412	G	A	-1.4606
413	Q	A	-1.8921
414	A	A	-1.5463
415	F	A	0.0000
416	D	A	-2.3825
417	M	A	-2.0013
418	N	A	-2.9075
419	K	A	-2.9907
420	P	A	-1.7180
421	M	A	-0.5683
422	F	A	0.0804
423	A	A	-0.0230
424	A	A	0.0000
425	A	A	-1.3606
426	K	A	-2.7056
427	G	A	-2.1699
428	Q	A	-1.9372
429	Y	A	-0.6837
430	E	A	0.0000
431	R	A	-0.3315
432	W	A	0.0000
433	V	A	-0.3627
434	I	A	0.0000
435	S	A	-0.3369
436	G	A	0.0000
437	V	A	1.0111
438	G	A	-0.0652
439	D	A	-0.1664
440	M	A	-0.1478
441	M	A	0.0000
442	L	A	0.0000
443	H	A	0.0000
444	P	A	0.0000
445	F	A	0.0000
446	H	A	0.0000
447	I	A	0.0000
448	H	A	0.0000
449	G	A	0.0000
450	T	A	0.0000
451	Q	A	0.0000
452	F	A	0.0000
453	R	A	0.0000
454	I	A	0.0000
455	L	A	-0.1922
456	S	A	-0.8618
457	E	A	0.0000
458	N	A	-1.2524
459	G	A	-1.6842
460	K	A	-2.1429
461	P	A	-1.2070
462	P	A	-0.7160
463	A	A	-0.2793
464	A	A	-0.3203
465	H	A	-0.3523
466	R	A	0.0000
467	A	A	0.0622
468	G	A	0.0000
469	W	A	0.2419
470	K	A	0.0000
471	D	A	0.0000
472	T	A	0.0000
473	V	A	0.0000
474	K	A	-1.0006
475	V	A	0.0000
476	E	A	-0.8253
477	G	A	-0.3911
478	N	A	-0.7273
479	V	A	-0.2043
480	S	A	0.0000
481	E	A	-0.5405
482	V	A	0.0000
483	L	A	0.0000
484	V	A	0.0000
485	K	A	-1.6009
486	F	A	0.0000
487	N	A	-2.4622
488	H	A	-1.9966
489	D	A	-2.2086
490	A	A	0.0000
491	P	A	-1.9290
492	K	A	-2.9109
493	E	A	-3.2621
494	H	A	-2.2545
495	A	A	0.0000
496	Y	A	0.0000
497	M	A	0.0000
498	A	A	0.0000
499	H	A	0.0000
500	C	A	0.0000
501	H	A	0.0000
502	L	A	0.0000
503	L	A	0.0000
504	E	A	0.0000
505	H	A	0.0000
506	E	A	0.0000
507	D	A	-0.8694
508	T	A	0.0000
509	G	A	0.0000
510	M	A	0.0000
511	M	A	0.0000
512	L	A	0.0000
513	G	A	0.0000
514	F	A	0.0000
515	T	A	-0.8496
516	V	A	-0.9746