Project name: 52fa2f2352b5890

Status: done

submitted: 2019-09-19 19:34:15, status changed: 2019-09-23 21:35:57
Settings
Chain sequence(s) A: MERNSGDLQLPQEIAMLVPNKTQVVPKSGGEGKVKDIFASPALVRAGGVMIAFVEGRTKNKLFPEVIDLSSSDIVAGYIKAPETWQSLVAEVTKEYWQAHTVLESANNSNHRVGVARLPTGITRGNKVFLLVGSYEERREIDDYIWKAEAWNIKVIEGEATQSTEVQPTQPINWSEPKPLFQTDSPNNKGDLKEFLGGGGSGIVMGNGTLVFPLTAKDESNKVFSLITYSTDDGQKWEIPGGVSSVACRSPRVTEWEEGTLLMVTYCEDGRKVFESRDMGKTWTEAFGTLPGVWLKSGPELPEVSLRVDALITATIEGRKVMLYTQKVRHFLEVDEPNALHLWVTDNNRTFHLGPFSVDCAENKTFANTLLYSDDALHLLQAKGDHESTAVSLARLTEELNTINSVLSTWVQLDASFSESSIPTAGLVGFLSNTTSSGDTWIDGYRCMNATVTKAAKVENGFKFTGPGSRATWPVNSRWDIKQYGFVDYNFTIVAMATIHQVPSESTPLLGASLRGNKRTKLIGLSYGAGGKWETVYDGTKTVQGGTWEPGREYQVALMLQDGNKGFVYVDGVLVGNPAMLPTPEERWTEFSHFYFGGDEGDSGSDATLTDVFLYNRPLSVGELKMIKEVEDKKE
Distance of aggregation 10 Å
Dynamic mode No
Show buried residues
Minimal score value
-4.0829
Maximal score value
1.9377
Average score
-0.7869
Total score value
-499.6883

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A -0.3629
2 E A -2.4115
3 R A -2.9864
4 N A -2.1151
5 S A -1.4860
6 G A -1.0520
7 D A -1.7680
8 L A -0.6228
9 Q A -0.4502
10 L A 0.8872
11 P A -0.5487
12 Q A -1.2796
13 E A -2.1777
14 I A 0.0000
15 A A -0.2649
16 M A 0.0000
17 L A 0.0000
18 V A -0.4709
19 P A -1.2956
20 N A -2.2051
21 K A -2.4424
22 T A -1.6956
23 Q A -2.0932
24 V A 0.0000
25 V A -1.2016
26 P A 0.0000
27 K A -2.2332
28 S A -1.5599
29 G A -1.9717
30 G A -1.9310
31 E A -2.6203
32 G A -1.7589
33 K A -2.1946
34 V A -1.2136
35 K A 0.0000
36 D A -1.8505
37 I A 0.0000
38 F A 0.0000
39 A A 0.0000
40 S A -0.0258
41 P A 0.0000
42 A A 0.0000
43 L A 0.0000
44 V A 0.0000
45 R A -1.4393
46 A A 0.0000
47 G A -1.6393
48 G A -1.0701
49 V A 0.0000
50 M A 0.0000
51 I A 0.0000
52 A A 0.0000
53 F A 0.0000
54 V A 0.0000
55 E A 0.0000
56 G A 0.0000
57 R A 0.0000
58 T A -1.4843
59 K A -2.4349
60 N A -1.9751
61 K A -2.2972
62 L A -0.8630
63 F A 0.0000
64 P A -0.5290
65 E A -0.8420
66 V A 0.0000
67 I A 0.0577
68 D A -0.9241
69 L A -1.4820
70 S A 0.0000
71 S A -1.3954
72 S A 0.0000
73 D A -0.6722
74 I A 0.0000
75 V A 0.0000
76 A A 0.0000
77 G A 0.0000
78 Y A 0.0000
79 I A 0.0000
80 K A -0.6551
81 A A 0.0000
82 P A 0.0000
83 E A -1.2262
84 T A -1.0915
85 W A -0.5735
86 Q A -0.9224
87 S A -0.4697
88 L A 1.2239
89 V A 0.9165
90 A A 0.0000
91 E A -1.5070
92 V A -0.2606
93 T A -0.5383
94 K A -1.4855
95 E A -2.0219
96 Y A -0.5155
97 W A -0.1689
98 Q A -0.6018
99 A A -0.4796
100 H A -0.6807
101 T A 0.0000
102 V A 0.0000
103 L A 0.0000
104 E A -1.4151
105 S A 0.0000
106 A A -1.6279
107 N A -2.6922
108 N A -2.3592
109 S A -2.2022
110 N A -2.8546
111 H A -2.8707
112 R A -3.5192
113 V A 0.0000
114 G A 0.0000
115 V A 0.0000
116 A A 0.0000
117 R A 0.0000
118 L A 0.2940
119 P A 0.0000
120 T A 0.0000
121 G A 0.0000
122 I A 0.0000
123 T A -1.4946
124 R A -2.6634
125 G A -2.0143
126 N A -2.0025
127 K A -2.3599
128 V A 0.0000
129 F A 0.0000
130 L A 0.0000
131 L A 0.0000
132 V A 0.0000
133 G A 0.0000
134 S A 0.0000
135 Y A 0.0000
136 E A -3.4029
137 E A -3.7207
138 R A -3.0686
139 R A -2.8739
140 E A -1.1783
141 I A 0.7915
142 D A 0.3072
143 D A 0.4061
144 Y A 1.4023
145 I A 0.0000
146 W A 0.0453
147 K A -1.3494
148 A A -1.8678
149 E A -2.6989
150 A A 0.0000
151 W A 0.0000
152 N A -1.3982
153 I A 0.0000
154 K A -0.9644
155 V A 0.0000
156 I A 0.0000
157 E A -1.2320
158 G A 0.0000
159 E A -2.0532
160 A A 0.0000
161 T A -1.4694
162 Q A -1.5793
163 S A -1.3722
164 T A -1.1162
165 E A -1.2365
166 V A 0.6516
167 Q A -0.4806
168 P A -0.8106
169 T A -0.9069
170 Q A -1.2118
171 P A -1.0809
172 I A 0.0000
173 N A -1.6736
174 W A -1.4671
175 S A -1.5179
176 E A -2.1640
177 P A -1.4811
178 K A -1.4825
179 P A -0.9713
180 L A 0.0000
181 F A -0.4398
182 Q A -1.2474
183 T A -0.9895
184 D A 0.0000
185 S A -1.2860
186 P A -2.0572
187 N A -2.5812
188 N A 0.0000
189 K A -2.5188
190 G A -2.7398
191 D A -3.5319
192 L A 0.0000
193 K A -2.1460
194 E A 0.0000
195 F A 0.0000
196 L A 0.0000
197 G A 0.0000
198 G A 0.0000
199 G A 0.0000
200 G A 0.0000
201 S A 0.0967
202 G A 0.1184
203 I A 0.0226
204 V A -0.3553
205 M A 0.0000
206 G A -1.3714
207 N A -1.5509
208 G A -1.5997
209 T A 0.0000
210 L A 0.0000
211 V A 0.0000
212 F A 0.0000
213 P A 0.0000
214 L A 0.0000
215 T A -0.1808
216 A A 0.0000
217 K A 0.0000
218 D A 0.0000
219 E A -2.8801
220 S A -1.7188
221 N A -1.6138
222 K A -1.6652
223 V A 0.0000
224 F A 0.0000
225 S A 0.0000
226 L A 0.0000
227 I A 0.0000
228 T A 0.0000
229 Y A 0.0000
230 S A 0.0000
231 T A -2.2864
232 D A -3.3786
233 D A -3.5196
234 G A 0.0000
235 Q A -2.7779
236 K A -3.2177
237 W A -2.0819
238 E A -1.5852
239 I A -0.8464
240 P A 0.0000
241 G A -1.5927
242 G A -1.1132
243 V A -0.0712
244 S A 0.0000
245 S A 0.7052
246 V A 1.4019
247 A A 0.0225
248 C A 0.0000
249 R A -0.5786
250 S A -0.3288
251 P A 0.0000
252 R A 0.0000
253 V A 0.0000
254 T A 0.0000
255 E A -1.3383
256 W A 0.0000
257 E A -3.2847
258 E A -3.2290
259 G A -2.8720
260 T A 0.0000
261 L A 0.0000
262 L A 0.0000
263 M A 0.0000
264 V A 0.0000
265 T A 0.0000
266 Y A 0.0000
267 C A -1.1506
268 E A -2.8481
269 D A -3.0063
270 G A -1.8166
271 R A 0.0000
272 K A -0.8793
273 V A 0.0000
274 F A 0.0000
275 E A -1.1978
276 S A 0.0000
277 R A -3.3850
278 D A -3.2696
279 M A -1.8533
280 G A 0.0000
281 K A -2.5861
282 T A -1.6038
283 W A -1.0851
284 T A -0.6583
285 E A -0.8815
286 A A -0.3854
287 F A 0.1902
288 G A -0.3758
289 T A -0.2276
290 L A 0.0000
291 P A -0.3211
292 G A -0.5283
293 V A 0.0000
294 W A 0.0000
295 L A -0.6959
296 K A -1.3830
297 S A -0.9008
298 G A 0.0000
299 P A -0.7292
300 E A -1.8787
301 L A -1.0762
302 P A -1.4482
303 E A -2.5414
304 V A -1.5177
305 S A -1.5475
306 L A 0.0000
307 R A -1.0584
308 V A -0.2678
309 D A 0.0000
310 A A 0.0000
311 L A 0.3063
312 I A 0.3467
313 T A -0.3173
314 A A 0.0000
315 T A -1.2842
316 I A 0.0000
317 E A -2.5579
318 G A -1.6735
319 R A -1.6448
320 K A -2.0229
321 V A 0.0000
322 M A 0.0000
323 L A 0.0000
324 Y A 0.0000
325 T A 0.0000
326 Q A 0.0000
327 K A 0.0000
328 V A -0.0228
329 R A 0.0000
330 H A -0.8887
331 F A -0.2165
332 L A -0.5364
333 E A -1.3115
334 V A -0.2961
335 D A -1.0262
336 E A -1.3321
337 P A 0.0000
338 N A 0.0000
339 A A 0.0000
340 L A 0.0000
341 H A -0.0242
342 L A 0.0000
343 W A 0.0000
344 V A 0.0000
345 T A 0.0000
346 D A 0.0000
347 N A -0.3167
348 N A -0.4865
349 R A 0.0000
350 T A 0.0000
351 F A -0.1851
352 H A -0.3706
353 L A -0.1733
354 G A 0.0000
355 P A -0.2947
356 F A -0.0965
357 S A 0.0000
358 V A -0.8313
359 D A -1.6356
360 C A -1.0273
361 A A -1.2268
362 E A -2.0709
363 N A 0.0000
364 K A -1.9296
365 T A 0.0000
366 F A 0.0000
367 A A 0.0000
368 N A 0.0000
369 T A 0.0000
370 L A 0.0000
371 L A 0.1364
372 Y A -0.5295
373 S A -1.4770
374 D A -2.5993
375 D A -2.8706
376 A A 0.0000
377 L A 0.0000
378 H A 0.0000
379 L A 0.0000
380 L A 0.0000
381 Q A 0.0000
382 A A 0.0000
383 K A -1.3815
384 G A -2.1001
385 D A -2.8182
386 H A -2.3622
387 E A -2.3045
388 S A -1.8505
389 T A 0.0000
390 A A -0.6542
391 V A 0.0000
392 S A -0.4582
393 L A 0.0000
394 A A 0.0000
395 R A -0.9628
396 L A 0.0000
397 T A -0.7672
398 E A -1.0324
399 E A 0.0000
400 L A 0.0000
401 N A -1.6794
402 T A -0.9555
403 I A 0.0000
404 N A -1.5149
405 S A -0.9071
406 V A 0.0000
407 L A 0.0000
408 S A -0.7668
409 T A -0.4712
410 W A 0.0000
411 V A -0.1204
412 Q A -0.8088
413 L A -0.4710
414 D A -0.5705
415 A A -0.8475
416 S A -1.0647
417 F A 0.0000
418 S A -1.3581
419 E A -2.2761
420 S A -2.1021
421 S A -1.4503
422 I A 0.0000
423 P A 0.0000
424 T A -0.1615
425 A A -0.1573
426 G A -0.2967
427 L A 0.0000
428 V A 0.0000
429 G A 0.0000
430 F A 0.0000
431 L A 0.0000
432 S A -1.2364
433 N A -2.3207
434 T A -1.1194
435 T A -1.3358
436 S A -1.1406
437 S A -1.2838
438 G A -2.1181
439 D A -2.5464
440 T A -1.3811
441 W A 0.0000
442 I A -0.5040
443 D A 0.0000
444 G A -0.6849
445 Y A 0.0000
446 R A -1.4767
447 C A -0.6522
448 M A -0.5236
449 N A -0.6971
450 A A 0.0000
451 T A -0.7276
452 V A 0.0000
453 T A -1.8770
454 K A -2.5403
455 A A -1.8975
456 A A -1.6041
457 K A -2.6028
458 V A -1.7315
459 E A -2.7582
460 N A -2.0503
461 G A 0.0000
462 F A 0.0000
463 K A -1.5901
464 F A 0.0000
465 T A -1.1368
466 G A -1.3087
467 P A -1.9039
468 G A -2.1625
469 S A 0.0000
470 R A -1.5526
471 A A 0.0000
472 T A 0.0000
473 W A 0.0000
474 P A -0.2758
475 V A 0.0000
476 N A -0.6043
477 S A -0.3431
478 R A -0.2179
479 W A 0.2962
480 D A -0.1496
481 I A 0.0000
482 K A -0.3708
483 Q A 0.0000
484 Y A 0.0000
485 G A -0.4485
486 F A 0.0000
487 V A 0.0000
488 D A 0.0000
489 Y A -0.7393
490 N A -0.9883
491 F A 0.0000
492 T A 0.0000
493 I A 0.0000
494 V A 0.0000
495 A A 0.0000
496 M A 0.0000
497 A A 0.0000
498 T A -1.7798
499 I A 0.0000
500 H A -1.9651
501 Q A -1.4807
502 V A -0.7197
503 P A -0.8742
504 S A -1.1792
505 E A -1.9993
506 S A -1.2138
507 T A 0.0000
508 P A -0.4037
509 L A 0.0000
510 L A 0.0000
511 G A 0.0000
512 A A 0.0000
513 S A 0.0000
514 L A -1.7463
515 R A -2.9033
516 G A -2.2853
517 N A -2.9586
518 K A 0.0000
519 R A -2.7726
520 T A -2.1179
521 K A -1.5905
522 L A 0.0000
523 I A 0.0000
524 G A 0.0000
525 L A 0.0000
526 S A -0.2167
527 Y A 0.0000
528 G A 0.0000
529 A A -0.9781
530 G A -0.9907
531 G A 0.0000
532 K A -1.5198
533 W A -0.7716
534 E A 0.0000
535 T A 0.0000
536 V A -0.5302
537 Y A 0.0000
538 D A -1.3957
539 G A -1.3808
540 T A -1.1872
541 K A -2.0194
542 T A -1.1217
543 V A -1.0690
544 Q A -1.6111
545 G A -1.1711
546 G A -1.1942
547 T A -1.2868
548 W A 0.0000
549 E A -2.8953
550 P A -2.2974
551 G A -2.3906
552 R A -3.1494
553 E A -2.4622
554 Y A -1.3337
555 Q A 0.0000
556 V A 0.0000
557 A A 0.0000
558 L A 0.0000
559 M A 0.0000
560 L A 0.0000
561 Q A -1.6378
562 D A -2.2680
563 G A -1.6540
564 N A -1.5787
565 K A -0.8691
566 G A 0.0000
567 F A 0.1668
568 V A 0.0000
569 Y A 0.0000
570 V A 0.0000
571 D A -0.4797
572 G A 0.0000
573 V A 1.9377
574 L A 1.4367
575 V A 0.2418
576 G A -0.8484
577 N A -1.3507
578 P A -0.3901
579 A A -0.1051
580 M A 0.1413
581 L A 0.1021
582 P A 0.0000
583 T A 0.0000
584 P A -1.4724
585 E A -3.0264
586 E A -3.1894
587 R A -2.4548
588 W A -1.0282
589 T A 0.0000
590 E A -1.2191
591 F A 0.0000
592 S A -1.0918
593 H A 0.0000
594 F A 0.0000
595 Y A 0.0000
596 F A 0.0000
597 G A 0.0000
598 G A 0.0000
599 D A -1.9068
600 E A -3.0413
601 G A -2.3895
602 D A -2.4799
603 S A -1.9578
604 G A -1.5913
605 S A 0.0000
606 D A -0.8944
607 A A 0.0000
608 T A -0.7408
609 L A 0.0000
610 T A -0.7980
611 D A 0.0000
612 V A 0.0000
613 F A 0.0000
614 L A 0.0000
615 Y A 0.0000
616 N A 0.0000
617 R A -0.9840
618 P A -0.5924
619 L A 0.0000
620 S A 0.0216
621 V A 0.9978
622 G A -0.3077
623 E A -0.7419
624 L A 0.0000
625 K A -1.5038
626 M A -1.3832
627 I A 0.0000
628 K A -2.6984
629 E A -3.3987
630 V A 0.0000
631 E A -3.1931
632 D A -3.9145
633 K A -4.0829
634 K A -3.0621
635 E A -3.3992

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Laboratory of Theory of Biopolymers 2015