Project name: full

Chain sequence(s)	A: MAVFVVLLALVAGVLGNEFSILKSPGSVVFRNGNWPIPGERIPDVAALSMGFSVKEDLSWPGLAVGNLFHRPRATVMVMVKGVNKLALPPGSVISYPLENAVPFSLDSVANSIHSLFSEETPVVLQLAPSEERVYMVGKANSVFEDLSVTLRQLRNRLFQENSVLSSLPLNSLSRNNEVDLLFLSELQVLHDISSLLSRHKHLAKDHSPDLYSLELAGLDEIGKRYGEDSEQFRDASKILVDALQKFADDMYSLYGGNAVVELVTVKSFDTSLIRKTRTILEAKQAKNPASPYNLAYKYNFEYSVVFNMVLWIMIALALAVIITSYNIWNMDPGYDSIIYRMTNQKIRMD
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.3818
• Maximal score value: 2.7793
• Average score: -0.4779
• Total score value: -167.2804

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	1.7268
2	A	A	1.5343
3	V	A	1.4424
4	F	A	1.3911
5	V	A	1.4279
6	V	A	1.5482
7	L	A	0.0000
8	L	A	0.2135
9	A	A	0.5870
10	L	A	0.0000
11	V	A	0.5380
12	A	A	-0.1542
13	G	A	0.8085
14	V	A	0.5028
15	L	A	-0.2301
16	G	A	-0.7260
17	N	A	-0.7492
18	E	A	-0.7110
19	F	A	0.0000
20	S	A	-0.1056
21	I	A	0.0000
22	L	A	0.0809
23	K	A	0.0302
24	S	A	-0.3952
25	P	A	-0.5467
26	G	A	-0.4408
27	S	A	0.0000
28	V	A	0.1715
29	V	A	0.0000
30	F	A	0.2352
31	R	A	-0.3795
32	N	A	-0.5902
33	G	A	-0.5710
34	N	A	-0.6995
35	W	A	-0.2283
36	P	A	-0.1666
37	I	A	-0.1962
38	P	A	-0.8008
39	G	A	-1.2097
40	E	A	-2.3102
41	R	A	-1.8857
42	I	A	-0.9541
43	P	A	-1.0700
44	D	A	-1.2352
45	V	A	0.0000
46	A	A	0.0000
47	A	A	0.0000
48	L	A	0.9281
49	S	A	0.0000
50	M	A	0.7418
51	G	A	0.3404
52	F	A	-0.2109
53	S	A	-0.8705
54	V	A	-1.0720
55	K	A	-2.4758
56	E	A	-2.5052
57	D	A	-2.5466
58	L	A	-1.3013
59	S	A	-0.8914
60	W	A	0.0000
61	P	A	-0.3970
62	G	A	-0.5983
63	L	A	0.0000
64	A	A	0.0000
65	V	A	0.0000
66	G	A	-0.1172
67	N	A	-0.0816
68	L	A	0.0432
69	F	A	-0.6038
70	H	A	-1.6493
71	R	A	-2.6121
72	P	A	-2.1808
73	R	A	-2.2235
74	A	A	0.0000
75	T	A	0.0000
76	V	A	0.2720
77	M	A	0.0000
78	V	A	0.1140
79	M	A	0.0000
80	V	A	0.0000
81	K	A	0.0000
82	G	A	0.8037
83	V	A	1.5273
84	N	A	0.4358
85	K	A	-0.5676
86	L	A	1.0608
87	A	A	0.7076
88	L	A	1.0865
89	P	A	0.2850
90	P	A	-0.3387
91	G	A	-0.1964
92	S	A	-0.0326
93	V	A	0.0000
94	I	A	0.0369
95	S	A	-0.4109
96	Y	A	0.0743
97	P	A	-0.1169
98	L	A	0.0000
99	E	A	-0.8826
100	N	A	-0.4807
101	A	A	-0.1514
102	V	A	0.8631
103	P	A	0.6254
104	F	A	0.0000
105	S	A	0.3405
106	L	A	0.6425
107	D	A	-0.5077
108	S	A	0.0000
109	V	A	-0.1856
110	A	A	0.0000
111	N	A	-0.7508
112	S	A	0.0000
113	I	A	0.0000
114	H	A	-0.7773
115	S	A	-0.9776
116	L	A	0.0000
117	F	A	0.0000
118	S	A	-1.7803
119	E	A	-2.8780
120	E	A	-2.8172
121	T	A	-1.7979
122	P	A	-1.1444
123	V	A	0.0000
124	V	A	-0.2272
125	L	A	0.0000
126	Q	A	-0.2091
127	L	A	-0.5435
128	A	A	0.0000
129	P	A	-1.2471
130	S	A	0.0000
131	E	A	-2.8023
132	E	A	-2.6260
133	R	A	-1.3960
134	V	A	1.3566
135	Y	A	1.4443
136	M	A	1.8156
137	V	A	1.8227
138	G	A	-0.0443
139	K	A	-0.6337
140	A	A	-0.5999
141	N	A	-1.1754
142	S	A	-1.0807
143	V	A	-0.9768
144	F	A	0.0000
145	E	A	-1.2971
146	D	A	-0.6432
147	L	A	1.0955
148	S	A	0.7214
149	V	A	1.2022
150	T	A	0.0511
151	L	A	-0.8304
152	R	A	-2.1955
153	Q	A	-2.3917
154	L	A	-2.0910
155	R	A	-2.8221
156	N	A	-2.6367
157	R	A	-1.9094
158	L	A	-0.7406
159	F	A	-0.0157
160	Q	A	-1.4278
161	E	A	-2.5446
162	N	A	-2.0766
163	S	A	0.0000
164	V	A	0.0000
165	L	A	-0.7762
166	S	A	-1.0591
167	S	A	-0.3258
168	L	A	0.1774
169	P	A	-0.1178
170	L	A	-0.3755
171	N	A	-1.0319
172	S	A	-0.2791
173	L	A	0.7066
174	S	A	-0.8456
175	R	A	-2.5292
176	N	A	-2.7247
177	N	A	-2.0967
178	E	A	-1.3659
179	V	A	0.0000
180	D	A	-0.8927
181	L	A	-0.1511
182	L	A	0.0000
183	F	A	0.0000
184	L	A	0.5094
185	S	A	-0.4049
186	E	A	0.0000
187	L	A	0.0000
188	Q	A	-1.7274
189	V	A	0.0000
190	L	A	0.0000
191	H	A	-1.8261
192	D	A	-2.2940
193	I	A	0.0000
194	S	A	-1.5354
195	S	A	-1.1802
196	L	A	-0.9588
197	L	A	0.0000
198	S	A	-1.3778
199	R	A	-2.0550
200	H	A	-1.5825
201	K	A	-1.6989
202	H	A	-1.9203
203	L	A	-0.4010
204	A	A	-1.3897
205	K	A	-2.3319
206	D	A	-1.5227
207	H	A	-1.7929
208	S	A	0.0000
209	P	A	-1.0593
210	D	A	-0.5270
211	L	A	0.0000
212	Y	A	0.0000
213	S	A	0.0000
214	L	A	0.0000
215	E	A	0.0000
216	L	A	0.0000
217	A	A	0.0000
218	G	A	-0.7249
219	L	A	-0.3354
220	D	A	-0.7568
221	E	A	-1.2609
222	I	A	0.0000
223	G	A	-1.6312
224	K	A	-2.7550
225	R	A	-2.3256
226	Y	A	0.0000
227	G	A	-2.7061
228	E	A	-3.0076
229	D	A	-2.6913
230	S	A	-2.3425
231	E	A	-3.1380
232	Q	A	-2.8342
233	F	A	-2.6298
234	R	A	-3.3818
235	D	A	-3.1767
236	A	A	0.0000
237	S	A	-1.5572
238	K	A	-2.3653
239	I	A	-0.6142
240	L	A	0.0000
241	V	A	-0.8424
242	D	A	-2.0650
243	A	A	0.0000
244	L	A	0.0000
245	Q	A	-1.7694
246	K	A	-2.5518
247	F	A	0.0000
248	A	A	0.0000
249	D	A	-1.8481
250	D	A	-1.0778
251	M	A	0.0000
252	Y	A	0.0354
253	S	A	0.4437
254	L	A	1.4221
255	Y	A	1.3504
256	G	A	0.0000
257	G	A	0.0000
258	N	A	0.0000
259	A	A	0.0000
260	V	A	0.0000
261	V	A	0.0000
262	E	A	0.0000
263	L	A	0.0000
264	V	A	0.0000
265	T	A	0.0000
266	V	A	0.0349
267	K	A	-0.4053
268	S	A	0.2714
269	F	A	0.9625
270	D	A	-0.6201
271	T	A	-0.6138
272	S	A	-0.7662
273	L	A	-0.5429
274	I	A	0.0000
275	R	A	-1.7620
276	K	A	-1.9899
277	T	A	0.0000
278	R	A	-1.4161
279	T	A	-1.7795
280	I	A	-1.1322
281	L	A	-0.8335
282	E	A	-2.0742
283	A	A	-0.9959
284	K	A	-1.9556
285	Q	A	-1.7730
286	A	A	-1.9490
287	K	A	-2.6170
288	N	A	-2.3653
289	P	A	-1.7414
290	A	A	0.0000
291	S	A	-0.6816
292	P	A	-0.0904
293	Y	A	0.1585
294	N	A	-0.8389
295	L	A	0.2780
296	A	A	0.1231
297	Y	A	-0.9958
298	K	A	-1.6658
299	Y	A	-0.6264
300	N	A	-0.9403
301	F	A	0.0000
302	E	A	-0.4990
303	Y	A	0.0969
304	S	A	0.3454
305	V	A	0.8199
306	V	A	0.0000
307	F	A	2.4745
308	N	A	1.7161
309	M	A	0.0000
310	V	A	2.7793
311	L	A	2.7675
312	W	A	2.2628
313	I	A	2.2230
314	M	A	2.5587
315	I	A	2.1408
316	A	A	0.0000
317	L	A	2.3420
318	A	A	1.0894
319	L	A	1.5741
320	A	A	1.6561
321	V	A	0.5251
322	I	A	0.0000
323	I	A	0.7514
324	T	A	0.8528
325	S	A	0.0000
326	Y	A	0.0000
327	N	A	0.0000
328	I	A	0.4681
329	W	A	0.7264
330	N	A	-1.0459
331	M	A	-0.8121
332	D	A	-1.9087
333	P	A	-1.0268
334	G	A	-0.6753
335	Y	A	0.1968
336	D	A	-0.3942
337	S	A	0.3659
338	I	A	1.7352
339	I	A	1.4192
340	Y	A	0.6117
341	R	A	-0.7862
342	M	A	0.0000
343	T	A	-1.1459
344	N	A	-1.8690
345	Q	A	-2.4347
346	K	A	-2.6470
347	I	A	-1.7687
348	R	A	-2.5040
349	M	A	-1.1756
350	D	A	-1.8461