Project name: BSAprotein

Chain sequence(s)	A: DTHKSEIAHRFKDLGEEHFKGLVLIAFSQYLQQCPFDEHVKLVNELTEFAKTCVADESHAGCEKSSLHTLFGDELCKVASLRRETYGDMADCCEKQEPERNECFLSHKDDSPDLPKLKPDPNTLCDEFKADEKKFWGKYLYEIARRHPYFYAPELLYYANKYNGVFQECCQAEDKGACLLPKIETMRREKVLTSSARQRLRCASIQKFGERALKAWSVARLSQKFPKAEFVEVTKLVTDLTKVHKECCHGDLLECADDRADLAKYICDNQDTISSKLKECCDKPLLEKSHCIAEVEKDAIPENLPPLTADFAEDKDVCKNYQEAKDAFLGSFLYEYSRRHPEYAVSVLLRLAKEYEATLEECCAKDDPHACYSTVFDKLKHLVDEPQNLIKQNCDQFEKLGEYGFQNALIVRYTRKVPQVSTPTLVEVSRSLGKVGTRCCTKPESERMPCTEDYLSLILNRLCVLHEKTPVSEKVTKCCTESLVNRRPCFSALTPDETYVPKAFDEKLFTFHADICTLPDTEKQIKKQTALVELLKHKPKATEEQLKTVMENFVAFVDKCCAADDKEACFAVEGPKLVVSTQTALA
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.4264
• Maximal score value: 1.8114
• Average score: -0.4708
• Total score value: -274.4909

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	A	-1.8024
2	T	A	-0.5754
3	H	A	-1.2426
4	K	A	-1.4456
5	S	A	0.0000
6	E	A	-0.7389
7	I	A	0.0000
8	A	A	0.0000
9	H	A	-0.7112
10	R	A	-0.3318
11	F	A	-0.1556
12	K	A	-1.9994
13	D	A	-2.0732
14	L	A	-0.1792
15	G	A	-0.3381
16	E	A	-1.7305
17	E	A	-1.8375
18	H	A	-0.5627
19	F	A	0.0000
20	K	A	-0.7822
21	G	A	0.0000
22	L	A	0.0000
23	V	A	0.0000
24	L	A	0.0000
25	I	A	0.0000
26	A	A	0.0000
27	F	A	0.0000
28	S	A	0.0000
29	Q	A	0.0000
30	Y	A	0.0000
31	L	A	0.0000
32	Q	A	0.0000
33	Q	A	-1.1983
34	C	A	0.0000
35	P	A	-0.2070
36	F	A	-0.1000
37	D	A	-1.8997
38	E	A	-1.1838
39	H	A	0.0000
40	V	A	0.3629
41	K	A	-1.1007
42	L	A	-0.0595
43	V	A	0.0000
44	N	A	-0.9203
45	E	A	-1.9267
46	L	A	0.0000
47	T	A	0.0000
48	E	A	-1.7560
49	F	A	0.0064
50	A	A	0.0000
51	K	A	-1.5875
52	T	A	-0.3241
53	C	A	0.0000
54	V	A	0.5860
55	A	A	-0.1633
56	D	A	-1.9908
57	E	A	-1.5281
58	S	A	-0.6124
59	H	A	-1.0194
60	A	A	-0.1345
61	G	A	-0.0691
62	C	A	0.0000
63	E	A	-1.9499
64	K	A	-1.0806
65	S	A	-0.2306
66	L	A	0.1078
67	H	A	-0.2189
68	T	A	0.0000
69	L	A	0.0000
70	F	A	0.1855
71	G	A	0.0000
72	D	A	-0.4441
73	E	A	-0.4962
74	L	A	0.0000
75	C	A	-0.1260
76	K	A	-1.6656
77	V	A	0.0000
78	A	A	0.0357
79	S	A	-0.1117
80	L	A	0.0000
81	R	A	-2.2120
82	E	A	-2.1611
83	T	A	-0.3377
84	Y	A	0.1077
85	G	A	-0.8137
86	D	A	-1.8404
87	M	A	0.0000
88	A	A	-0.2755
89	D	A	-1.5584
90	C	A	0.0000
91	C	A	-0.3075
92	E	A	-1.9840
93	K	A	-1.6342
94	Q	A	-1.6380
95	E	A	-1.6129
96	P	A	-0.8678
97	E	A	-1.6082
98	R	A	-0.6374
99	N	A	0.0000
100	E	A	-1.7917
101	C	A	-0.1998
102	F	A	0.0000
103	L	A	0.1155
104	S	A	-0.2394
105	H	A	-0.3482
106	K	A	0.0000
107	D	A	-1.0572
108	D	A	0.0000
109	S	A	-0.2196
110	P	A	-0.3950
111	D	A	-1.7600
112	L	A	-0.1771
113	P	A	-0.5408
114	K	A	-1.4652
115	L	A	0.9111
116	K	A	-1.4226
117	P	A	-0.6195
118	D	A	-1.3948
119	P	A	-0.4916
120	N	A	-1.2919
121	T	A	-0.4658
122	L	A	0.1719
123	C	A	0.0000
124	D	A	-2.0287
125	E	A	-1.5439
126	F	A	-0.5315
127	K	A	-1.6503
128	A	A	-0.4194
129	D	A	-1.2909
130	E	A	-2.2856
131	K	A	-2.2776
132	K	A	-1.6426
133	F	A	0.0000
134	W	A	0.0000
135	G	A	-0.4059
136	K	A	-1.1394
137	Y	A	-0.0824
138	L	A	0.0000
139	Y	A	0.0000
140	E	A	0.0000
141	I	A	0.2584
142	A	A	0.0000
143	R	A	-0.2436
144	R	A	-0.4267
145	H	A	-0.2368
146	P	A	0.0000
147	Y	A	0.1724
148	F	A	0.0000
149	Y	A	0.0000
150	A	A	0.0000
151	P	A	0.0000
152	E	A	0.0000
153	L	A	0.0000
154	L	A	0.0000
155	Y	A	0.0000
156	Y	A	0.0000
157	A	A	0.0000
158	N	A	-1.4259
159	K	A	-1.3871
160	Y	A	0.0000
161	N	A	-0.1746
162	G	A	-0.4013
163	V	A	0.0000
164	F	A	0.0000
165	Q	A	-1.5255
166	E	A	-2.0271
167	C	A	0.0000
168	C	A	0.0000
169	Q	A	-1.1962
170	A	A	-0.5313
171	E	A	-2.1267
172	D	A	-2.1071
173	K	A	-0.8360
174	G	A	-0.2247
175	A	A	0.0639
176	C	A	0.1872
177	L	A	0.0000
178	L	A	0.2928
179	P	A	-0.3654
180	K	A	-0.9996
181	I	A	0.0000
182	E	A	-1.8055
183	T	A	-0.3861
184	M	A	0.0000
185	R	A	-1.1639
186	E	A	-2.2448
187	K	A	-2.0245
188	V	A	0.0000
189	L	A	1.3357
190	T	A	0.2325
191	S	A	-0.0346
192	S	A	0.0000
193	A	A	-0.0865
194	R	A	-0.5738
195	Q	A	0.0000
196	R	A	-0.1451
197	L	A	0.1539
198	R	A	-0.1803
199	C	A	0.0000
200	A	A	0.0306
201	S	A	0.0000
202	I	A	-0.1153
203	Q	A	-1.4091
204	K	A	-1.5552
205	F	A	-0.0162
206	G	A	-0.2335
207	E	A	-1.5171
208	R	A	-2.0587
209	A	A	-0.3330
210	L	A	0.0000
211	K	A	-1.0497
212	A	A	-0.1469
213	W	A	0.1628
214	S	A	0.0000
215	V	A	0.0000
216	A	A	0.0000
217	R	A	-0.7107
218	L	A	0.0000
219	S	A	0.0000
220	Q	A	0.0000
221	K	A	0.0000
222	F	A	0.0000
223	P	A	0.0000
224	K	A	-1.0309
225	A	A	0.0000
226	E	A	-1.5971
227	F	A	0.4754
228	V	A	1.8107
229	E	A	0.1060
230	V	A	0.0000
231	T	A	-0.0873
232	K	A	-1.3303
233	L	A	0.0000
234	V	A	0.0000
235	T	A	-0.2389
236	D	A	-1.0777
237	L	A	-0.0244
238	T	A	0.0000
239	K	A	-1.1991
240	V	A	0.0000
241	H	A	0.0000
242	K	A	-0.7583
243	E	A	-0.5451
244	C	A	0.0000
245	C	A	0.0000
246	H	A	-0.4880
247	G	A	-0.1810
248	D	A	-0.2169
249	L	A	0.0000
250	L	A	0.0000
251	E	A	-0.2954
252	C	A	0.0000
253	A	A	0.0000
254	D	A	-0.4440
255	D	A	-1.1982
256	R	A	0.0000
257	A	A	-0.3205
258	D	A	-2.0614
259	L	A	0.0000
260	A	A	0.0000
261	K	A	-1.8265
262	Y	A	0.0088
263	I	A	0.0000
264	C	A	-0.2506
265	D	A	-1.8455
266	N	A	-0.7808
267	Q	A	-0.7250
268	D	A	-1.8622
269	T	A	-0.4024
270	I	A	0.0000
271	S	A	0.0000
272	S	A	-0.3540
273	K	A	-0.8245
274	L	A	0.0000
275	K	A	-2.0385
276	E	A	-2.1360
277	C	A	0.0000
278	C	A	-0.2401
279	D	A	-1.9290
280	K	A	-1.2573
281	P	A	-0.2528
282	L	A	0.8813
283	L	A	0.2584
284	E	A	-0.4583
285	K	A	-0.3098
286	S	A	0.0000
287	H	A	-0.0996
288	C	A	0.0841
289	I	A	0.0000
290	A	A	-0.2924
291	E	A	-1.8154
292	V	A	0.0000
293	E	A	-2.1023
294	K	A	-1.8132
295	D	A	0.0000
296	A	A	0.2100
297	I	A	0.8161
298	P	A	-0.2343
299	E	A	-2.0636
300	N	A	-1.5510
301	L	A	0.0205
302	P	A	-0.2279
303	P	A	-0.2696
304	L	A	0.1100
305	T	A	0.0047
306	A	A	-0.3078
307	D	A	-1.7842
308	F	A	0.0000
309	A	A	0.0000
310	E	A	-1.9309
311	D	A	-1.2473
312	K	A	-1.9239
313	D	A	-0.9398
314	V	A	0.0000
315	C	A	-0.1930
316	K	A	-1.8278
317	N	A	-1.1386
318	Y	A	0.0000
319	Q	A	-1.5297
320	E	A	-2.0325
321	A	A	-0.4945
322	K	A	-1.4440
323	D	A	-1.9918
324	A	A	-0.2579
325	F	A	0.2279
326	L	A	0.1925
327	G	A	-0.0274
328	S	A	-0.0305
329	F	A	0.0000
330	L	A	0.0000
331	Y	A	0.0000
332	E	A	-0.2938
333	Y	A	0.0000
334	S	A	0.0000
335	R	A	-0.2329
336	R	A	-0.3069
337	H	A	-0.1972
338	P	A	-0.4074
339	E	A	-1.7985
340	Y	A	-0.1702
341	A	A	0.0000
342	V	A	0.2527
343	S	A	0.0190
344	V	A	0.0000
345	L	A	0.0000
346	L	A	0.1735
347	R	A	0.0000
348	L	A	0.0000
349	A	A	-0.1825
350	K	A	-1.2453
351	E	A	-0.7704
352	Y	A	0.0000
353	E	A	-1.0288
354	A	A	-0.2074
355	T	A	0.0000
356	L	A	0.0000
357	E	A	-2.1620
358	E	A	-2.1620
359	C	A	0.0000
360	C	A	0.2292
361	A	A	-0.2049
362	K	A	-2.0133
363	D	A	-2.4264
364	D	A	-2.1284
365	P	A	-0.3994
366	H	A	-0.2368
367	A	A	0.0519
368	C	A	0.1972
369	Y	A	0.0000
370	S	A	-0.1081
371	T	A	-0.0708
372	V	A	0.0000
373	F	A	-0.0848
374	D	A	-2.1005
375	K	A	-1.4562
376	L	A	0.0000
377	K	A	-1.7210
378	H	A	-1.1931
379	L	A	0.1074
380	V	A	-0.0013
381	D	A	-2.0738
382	E	A	-2.1529
383	P	A	0.0000
384	Q	A	-0.7450
385	N	A	-1.2951
386	L	A	0.1456
387	I	A	0.0000
388	K	A	-1.9208
389	Q	A	-1.5465
390	N	A	-0.4108
391	C	A	0.0000
392	D	A	-1.8454
393	Q	A	-0.8118
394	F	A	0.0000
395	E	A	-2.1404
396	K	A	-1.9252
397	L	A	0.4877
398	G	A	-0.1649
399	E	A	-0.9574
400	Y	A	0.5203
401	G	A	0.0392
402	F	A	0.0000
403	Q	A	0.0000
404	N	A	-0.1240
405	A	A	-0.0169
406	L	A	0.0000
407	I	A	0.0000
408	V	A	0.0182
409	R	A	-0.9475
410	Y	A	0.0000
411	T	A	0.0000
412	R	A	-0.3350
413	K	A	-0.2563
414	V	A	0.0000
415	P	A	0.0000
416	Q	A	-1.0797
417	V	A	0.0000
418	S	A	-0.1346
419	T	A	0.0000
420	P	A	-0.2549
421	T	A	0.0000
422	L	A	0.0000
423	V	A	0.0000
424	E	A	-1.8199
425	V	A	0.0000
426	S	A	0.0000
427	R	A	-0.2882
428	S	A	-0.1579
429	L	A	0.0000
430	G	A	0.0000
431	K	A	-0.7822
432	V	A	0.0000
433	G	A	0.0000
434	T	A	-0.1217
435	R	A	-0.5144
436	C	A	0.0000
437	C	A	0.0000
438	T	A	-0.1793
439	K	A	-0.6496
440	P	A	-0.7010
441	E	A	-1.9071
442	S	A	-0.8441
443	E	A	-1.6718
444	R	A	-0.6135
445	M	A	0.0000
446	P	A	-0.0247
447	C	A	0.0675
448	T	A	0.0000
449	E	A	0.0000
450	D	A	-0.4328
451	Y	A	0.1862
452	L	A	0.2210
453	S	A	-0.0025
454	L	A	0.0000
455	I	A	0.2167
456	L	A	0.0000
457	N	A	0.0000
458	R	A	-0.7725
459	L	A	0.0000
460	C	A	0.0000
461	V	A	0.0000
462	L	A	0.1987
463	H	A	0.0000
464	E	A	-1.6363
465	K	A	-1.4205
466	T	A	-0.3235
467	P	A	-0.1415
468	V	A	0.6554
469	S	A	0.0000
470	E	A	-1.8732
471	K	A	-0.6040
472	V	A	0.0000
473	T	A	-0.3879
474	K	A	-0.9168
475	C	A	0.0000
476	C	A	0.0000
477	T	A	-0.3810
478	E	A	-1.8336
479	S	A	-0.3243
480	L	A	0.2725
481	V	A	0.2550
482	N	A	-0.2225
483	R	A	0.0000
484	R	A	0.0000
485	P	A	-0.0194
486	C	A	0.1534
487	F	A	0.0000
488	S	A	-0.1181
489	A	A	0.0677
490	L	A	0.1754
491	T	A	-0.0752
492	P	A	-0.3573
493	D	A	-0.8429
494	E	A	-1.9205
495	T	A	-0.3869
496	Y	A	0.4756
497	V	A	1.7850
498	P	A	-0.0453
499	K	A	-1.4576
500	A	A	-0.1000
501	F	A	0.4312
502	D	A	-1.0810
503	E	A	-2.2842
504	K	A	-1.9651
505	L	A	0.0912
506	F	A	0.2762
507	T	A	0.0137
508	F	A	0.0414
509	H	A	-0.9452
510	A	A	-0.5048
511	D	A	-1.7948
512	I	A	0.0000
513	C	A	0.1453
514	T	A	-0.1701
515	L	A	0.2431
516	P	A	-0.3859
517	D	A	-1.8193
518	T	A	-0.4921
519	E	A	-0.6486
520	K	A	-0.7158
521	Q	A	-0.2860
522	I	A	0.2556
523	K	A	-0.7782
524	K	A	-0.4892
525	Q	A	0.0000
526	T	A	-0.0231
527	A	A	-0.0237
528	L	A	0.0000
529	V	A	0.0000
530	E	A	-0.2132
531	L	A	0.1092
532	L	A	0.0000
533	K	A	0.0000
534	H	A	-0.3831
535	K	A	-0.3335
536	P	A	-0.3981
537	K	A	-1.7062
538	A	A	0.0000
539	T	A	-0.3724
540	E	A	-2.1593
541	E	A	-2.2209
542	Q	A	-0.7069
543	L	A	0.0000
544	K	A	-1.7094
545	T	A	-0.4013
546	V	A	0.0000
547	M	A	-0.0134
548	E	A	-1.9367
549	N	A	-1.1959
550	F	A	0.2962
551	V	A	1.2541
552	A	A	0.0914
553	F	A	0.0000
554	V	A	-0.0958
555	D	A	-2.0539
556	K	A	-2.0307
557	C	A	0.0000
558	C	A	0.1943
559	A	A	0.0948
560	A	A	-0.2864
561	D	A	-2.0252
562	D	A	-1.7764
563	K	A	-1.1533
564	E	A	-1.7951
565	A	A	-0.2808
566	C	A	0.0000
567	F	A	0.0000
568	A	A	0.3903
569	V	A	1.6667
570	E	A	-0.5135
571	G	A	-0.2274
572	P	A	-0.5861
573	K	A	-1.7792
574	L	A	-0.0303
575	V	A	0.7879
576	V	A	1.8114
577	S	A	0.1111
578	T	A	-0.1581
579	Q	A	-0.6142
580	T	A	-0.1779
581	A	A	0.0119
582	L	A	0.0000
583	A	A	0.0585