Project name: daclizumab

Chain sequence(s)	A: NPSPDHYAVWGKAIMAENNRRVGPEHMFRTAIRAQQQLQGLADKWTPDAKVYCCGSMVTYGQMERGSDLDLACMFDDPYPSHEVQAKRTDDKLRTVIKRYVPHYLRNNLLGLTEARTPVVKLRFANDEKVARARYTPLSEEEDRKARTALLDVRNQCVGDNDVEYIAEKMGRDNVEGIRVDRTTYGCRIAIQCTSKEQMIEAIGFFPDGKIMTRGMREDYTRDVLDVRFVPEMFMYRWDISFVGYGVKNSYLIRHYLHNGPVAARHTAMAVKAWGKATNVGAGSGAMLTSYAVTVMFIYYLLVTRQVLWVDPWSLPHPAHLPRYPDFSPLYDCDPTELGRLLHGFFIFYAHHFDYEREVVSLNRNRRSYRSDIGWNFPQNKKGTFSYNFCIEDPYEDVGTGGLNLVRHLHPAKFQLVKQEFLRAAQCMERFLPTNAPEKSILGVK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.0523
• Maximal score value: 1.0407
• Average score: -0.8982
• Total score value: -398.8038

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
30	N	A	-1.6698
31	P	A	-1.6896
32	S	A	-1.5169
33	P	A	-1.7035
34	D	A	-2.0517
35	H	A	-1.4085
36	Y	A	0.0000
37	A	A	-1.5968
38	V	A	-0.2537
39	W	A	0.0000
40	G	A	0.0000
41	K	A	-1.9300
42	A	A	-0.8063
43	I	A	0.0000
44	M	A	0.0000
45	A	A	-1.7166
46	E	A	-1.5940
47	N	A	0.0000
48	N	A	-2.1511
49	R	A	-2.7483
50	R	A	-1.9942
51	V	A	0.0000
52	G	A	0.0000
53	P	A	-1.6994
54	E	A	-2.3584
55	H	A	-2.0408
56	M	A	0.0000
57	F	A	0.0000
58	R	A	-2.6590
59	T	A	-1.4832
60	A	A	0.0000
61	I	A	-1.0466
62	R	A	-1.3207
63	A	A	0.0000
64	Q	A	0.0000
65	Q	A	-1.1101
66	Q	A	0.0000
67	L	A	0.0000
68	Q	A	0.0000
69	G	A	-1.1864
70	L	A	0.0000
71	A	A	0.0000
72	D	A	-2.1516
73	K	A	-2.0039
74	W	A	-1.4599
75	T	A	-1.5755
76	P	A	-1.9127
77	D	A	-2.3765
78	A	A	0.0000
79	K	A	-1.4604
80	V	A	0.0000
81	Y	A	0.0000
82	C	A	0.0000
83	C	A	-0.1971
84	G	A	-0.3168
85	S	A	-0.2604
86	M	A	0.0000
87	V	A	0.0000
88	T	A	0.0000
89	Y	A	0.0000
90	G	A	0.0000
91	Q	A	0.0000
92	M	A	0.0000
93	E	A	0.0000
94	R	A	-1.5281
95	G	A	-1.5003
96	S	A	-1.2579
97	D	A	-1.9550
98	L	A	0.0000
99	D	A	-0.9701
100	L	A	0.0000
101	A	A	0.0000
102	C	A	0.0000
103	M	A	0.0000
104	F	A	-1.7059
105	D	A	-2.8407
106	D	A	-2.5154
107	P	A	0.0000
108	Y	A	-0.3244
109	P	A	-0.7909
110	S	A	-1.0267
111	H	A	-2.0977
112	E	A	-2.6021
113	V	A	-1.2331
114	Q	A	0.0000
115	A	A	-2.6271
116	K	A	-3.1111
117	R	A	-2.3504
118	T	A	0.0000
119	D	A	-2.7367
120	K	A	-2.6487
121	L	A	0.0000
122	R	A	-1.8192
123	T	A	-1.3927
124	V	A	-1.1907
125	I	A	0.0000
126	K	A	-1.8637
127	R	A	-1.3479
128	Y	A	-0.9044
129	V	A	0.0000
130	P	A	0.0000
131	H	A	-1.7769
132	Y	A	-0.8284
133	L	A	0.0000
134	R	A	-2.8012
135	N	A	-2.4558
136	N	A	-1.9069
137	L	A	0.0000
138	L	A	-1.0435
139	G	A	-1.0546
140	L	A	-0.6954
141	T	A	-1.8701
142	E	A	-2.4478
143	A	A	-1.7262
144	R	A	-2.3291
145	T	A	-1.2705
146	P	A	0.0000
147	V	A	0.0000
148	V	A	0.0000
149	K	A	-1.2284
150	L	A	0.0000
151	R	A	-2.2897
152	F	A	-1.1682
153	A	A	0.0000
154	N	A	0.0000
155	D	A	-3.2518
156	E	A	-3.4791
157	K	A	-2.9369
158	V	A	0.0000
159	A	A	-2.3943
160	R	A	-2.4769
161	A	A	0.0000
162	R	A	0.0000
163	Y	A	-0.9066
164	T	A	-0.7053
165	P	A	-0.7836
166	L	A	-1.3785
167	S	A	-2.0722
168	E	A	-3.4173
169	E	A	-3.6836
170	E	A	-2.8921
171	D	A	-2.6997
172	R	A	-3.1229
173	K	A	-2.2243
174	A	A	0.0000
175	R	A	-1.5851
176	T	A	0.0000
177	A	A	0.0000
178	L	A	0.0000
179	L	A	0.0000
180	D	A	-1.3394
181	V	A	0.0000
182	R	A	-2.3633
183	N	A	-1.8654
184	Q	A	-1.2400
185	C	A	-0.6821
186	V	A	0.0000
187	G	A	-1.6688
188	D	A	-3.1003
189	N	A	-2.9357
190	D	A	-2.4456
191	V	A	-2.4816
192	E	A	-3.5516
193	Y	A	-2.6235
194	I	A	0.0000
195	A	A	-2.9649
196	E	A	-3.7235
197	K	A	-2.7800
198	M	A	-2.2346
199	G	A	0.0000
200	R	A	-4.0523
201	D	A	-3.3359
202	N	A	-2.7218
203	V	A	-2.4392
204	E	A	-2.6049
205	G	A	-1.4276
206	I	A	-1.3496
207	R	A	-1.9893
208	V	A	-1.5306
209	D	A	-1.9621
210	R	A	-2.0712
211	T	A	-1.3960
212	T	A	-0.5166
213	Y	A	-0.8111
214	G	A	-1.4632
215	C	A	0.0000
216	R	A	-2.0958
217	I	A	0.0000
218	A	A	-0.9630
219	I	A	0.0000
220	Q	A	-1.6127
221	C	A	0.0000
222	T	A	-1.6197
223	S	A	-0.9605
224	K	A	0.0000
225	E	A	-1.0532
226	Q	A	-1.0237
227	M	A	0.0000
228	I	A	0.0000
229	E	A	-0.8941
230	A	A	0.0000
231	I	A	0.0000
232	G	A	0.0000
233	F	A	0.0000
234	F	A	0.0000
235	P	A	-1.3649
236	D	A	-1.4278
237	G	A	-1.8145
238	K	A	-2.2267
239	I	A	0.0000
240	M	A	0.0000
241	T	A	-1.8997
242	R	A	-2.7546
243	G	A	-1.8635
244	M	A	-1.7685
245	R	A	-2.3362
246	E	A	-2.7352
247	D	A	-2.2461
248	Y	A	0.0000
249	T	A	-1.2991
250	R	A	0.0000
251	D	A	-0.7831
252	V	A	0.0000
253	L	A	0.0213
254	D	A	-0.4821
255	V	A	-0.6152
256	R	A	-1.8485
257	F	A	-1.1889
258	V	A	0.0000
259	P	A	0.0000
260	E	A	0.0000
261	M	A	0.0000
262	F	A	0.0000
263	M	A	0.0000
264	Y	A	0.0000
265	R	A	-2.5340
266	W	A	0.0000
267	D	A	-1.2557
268	I	A	0.0000
269	S	A	-0.1964
270	F	A	0.0000
271	V	A	0.0000
272	G	A	0.0000
273	Y	A	0.1290
274	G	A	-0.0503
275	V	A	0.0000
276	K	A	0.0000
277	N	A	0.0000
278	S	A	0.0000
279	Y	A	-0.1182
280	L	A	0.0000
281	I	A	0.0000
282	R	A	-0.7845
283	H	A	-1.1129
284	Y	A	0.0000
285	L	A	0.0000
286	H	A	-0.9467
287	N	A	-1.0373
288	G	A	-0.4658
289	P	A	0.0946
290	V	A	1.0407
291	A	A	0.0000
292	A	A	0.0000
293	R	A	0.0000
294	H	A	0.0000
295	T	A	0.0000
296	A	A	0.0000
297	M	A	0.0000
298	A	A	0.0000
299	V	A	0.0000
300	K	A	0.0000
301	A	A	0.0000
302	W	A	0.0000
303	G	A	0.0000
304	K	A	-1.6533
305	A	A	-1.2318
306	T	A	-0.7354
307	N	A	-0.8132
308	V	A	0.0000
309	G	A	-1.0792
310	A	A	-0.8454
311	G	A	-0.9656
312	S	A	-0.6537
313	G	A	-0.7809
314	A	A	-0.8342
315	M	A	-0.7104
316	L	A	0.0000
317	T	A	-0.2525
318	S	A	-0.1913
319	Y	A	0.2309
320	A	A	0.0000
321	V	A	0.0000
322	T	A	0.0000
323	V	A	0.0000
324	M	A	0.0000
325	F	A	0.0000
326	I	A	0.0000
327	Y	A	0.0000
328	Y	A	0.0000
329	L	A	0.0000
330	L	A	0.0000
331	V	A	-0.9574
332	T	A	-1.1860
333	R	A	-1.9688
334	Q	A	-1.1750
335	V	A	0.0000
336	L	A	0.8390
337	W	A	0.1129
338	V	A	0.2957
339	D	A	-0.2798
340	P	A	0.0000
341	W	A	0.8596
342	S	A	0.1974
343	L	A	0.1455
344	P	A	-0.3343
345	H	A	-1.0176
346	P	A	0.0000
347	A	A	-1.3323
348	H	A	-1.2209
349	L	A	-0.6454
350	P	A	-0.8551
351	R	A	-1.2684
352	Y	A	-0.5485
353	P	A	0.0000
354	D	A	-1.7896
355	F	A	-1.0123
356	S	A	0.0000
357	P	A	-0.2362
358	L	A	0.0562
359	Y	A	0.6592
360	D	A	-1.4545
361	C	A	-1.0158
362	D	A	-2.0290
363	P	A	-2.1879
364	T	A	-1.9478
365	E	A	-1.5256
366	L	A	0.0000
367	G	A	0.0000
368	R	A	-2.2799
369	L	A	0.0000
370	L	A	0.0000
371	H	A	-0.8730
372	G	A	-0.6184
373	F	A	0.0000
374	F	A	0.0000
375	I	A	-0.6164
376	F	A	0.0000
377	Y	A	0.0000
378	A	A	-1.0002
379	H	A	-1.4211
380	H	A	-1.4947
381	F	A	0.0000
382	D	A	-2.0073
383	Y	A	-1.8055
384	E	A	-2.9583
385	R	A	-2.8991
386	E	A	0.0000
387	V	A	0.0000
388	V	A	0.0000
389	S	A	0.0000
390	L	A	0.0000
391	N	A	-0.6937
392	R	A	-1.6898
393	N	A	-2.1325
394	R	A	-2.4122
395	R	A	-1.4430
396	S	A	0.0000
397	Y	A	-0.9767
398	R	A	0.0000
399	S	A	-0.9826
400	D	A	-0.7704
401	I	A	-0.5008
402	G	A	-0.8960
403	W	A	0.0000
404	N	A	-2.3178
405	F	A	-1.5639
406	P	A	-1.5193
407	Q	A	-2.0554
408	N	A	-2.1645
409	K	A	-2.0457
410	K	A	-2.2910
411	G	A	-1.2163
412	T	A	-0.7182
413	F	A	-0.5741
414	S	A	0.0000
415	Y	A	0.0000
416	N	A	0.0000
417	F	A	0.0000
418	C	A	0.0000
419	I	A	0.0000
420	E	A	0.0000
421	D	A	0.0000
422	P	A	0.0000
423	Y	A	0.0000
424	E	A	-1.0346
425	D	A	-1.9484
426	V	A	-0.8814
427	G	A	-0.8759
428	T	A	-0.9782
429	G	A	-1.0963
430	G	A	-1.0177
431	L	A	0.0000
432	N	A	0.0000
433	L	A	0.0324
434	V	A	0.0000
435	R	A	-0.7874
436	H	A	-1.0606
437	L	A	0.0000
438	H	A	-1.1605
439	P	A	-0.9643
440	A	A	-0.4305
441	K	A	-0.7144
442	F	A	-0.7704
443	Q	A	-1.1030
444	L	A	-0.0705
445	V	A	0.0000
446	K	A	-1.1673
447	Q	A	-1.2492
448	E	A	0.0000
449	F	A	0.0000
450	L	A	-1.0793
451	R	A	-2.1264
452	A	A	0.0000
453	A	A	0.0000
454	Q	A	-1.7978
455	C	A	-1.6275
456	M	A	0.0000
457	E	A	-1.8542
458	R	A	-2.1900
459	F	A	-0.9440
460	L	A	-0.0807
461	P	A	0.0000
462	T	A	-0.6522
463	N	A	-1.6093
464	A	A	0.0000
465	P	A	-1.4620
466	E	A	-2.3786
467	K	A	-1.5426
468	S	A	-1.0316
469	I	A	0.0000
470	L	A	0.0000
471	G	A	-0.5804
472	V	A	-0.1311
473	K	A	-1.7020