| Chain sequence(s) |
A: ETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF C: EQAGRNALLSDISKGKKLKKTVTNDRSAPILD |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 4 | E | A | -1.8589 | |
| 5 | T | A | -1.3240 | |
| 6 | T | A | -0.7664 | |
| 7 | A | A | 0.0000 | |
| 8 | L | A | 0.0000 | |
| 9 | V | A | 0.0000 | |
| 10 | C | A | 0.0000 | |
| 11 | D | A | 0.0000 | |
| 12 | N | A | 0.0000 | |
| 13 | G | A | -0.3119 | |
| 14 | S | A | -0.5323 | |
| 15 | G | A | -0.6104 | |
| 16 | L | A | -0.1884 | |
| 17 | V | A | 0.0000 | |
| 18 | K | A | -0.5013 | |
| 19 | A | A | 0.0000 | |
| 20 | G | A | 0.0000 | |
| 21 | F | A | -0.1518 | |
| 22 | A | A | -0.1581 | |
| 23 | G | A | 0.0000 | |
| 24 | D | A | 0.0000 | |
| 25 | D | A | -2.3300 | |
| 26 | A | A | -1.1571 | |
| 27 | P | A | 0.0000 | |
| 28 | R | A | -1.0376 | |
| 29 | A | A | 0.0000 | |
| 30 | V | A | 0.0000 | |
| 31 | F | A | 0.0000 | |
| 32 | P | A | 0.0000 | |
| 33 | S | A | 0.0000 | |
| 34 | I | A | 0.0000 | |
| 35 | V | A | 0.0000 | |
| 36 | G | A | 0.0000 | |
| 37 | R | A | -3.1533 | |
| 38 | P | A | -2.9739 | |
| 39 | R | A | -2.9534 | |
| 40 | H | A | -2.3836 | |
| 41 | Q | A | -2.2713 | |
| 42 | G | A | -0.6092 | |
| 43 | V | A | 1.1232 | |
| 44 | M | A | 1.4494 | |
| 45 | V | A | 2.1217 | |
| 46 | G | A | 0.8199 | |
| 47 | M | A | 0.5437 | |
| 48 | G | A | -0.4938 | |
| 49 | Q | A | -1.9219 | |
| 50 | K | A | -2.7506 | |
| 51 | D | A | -3.2395 | |
| 52 | S | A | -2.3580 | |
| 53 | Y | A | 0.0000 | |
| 54 | V | A | -1.0105 | |
| 55 | G | A | 0.0000 | |
| 56 | D | A | -1.5254 | |
| 57 | E | A | -1.6621 | |
| 58 | A | A | 0.0000 | |
| 59 | Q | A | -1.1180 | |
| 60 | S | A | -0.9618 | |
| 61 | K | A | -1.3175 | |
| 62 | R | A | -1.6238 | |
| 63 | G | A | -0.8825 | |
| 64 | I | A | -1.0279 | |
| 65 | L | A | 0.0000 | |
| 66 | T | A | -1.4827 | |
| 67 | L | A | -0.8942 | |
| 68 | K | A | -0.7257 | |
| 69 | Y | A | -0.0109 | |
| 70 | P | A | 0.0000 | |
| 71 | I | A | 0.0000 | |
| 72 | E | A | -1.6412 | |
| 74 | G | A | -0.4740 | |
| 75 | I | A | -0.1447 | |
| 76 | I | A | 0.0000 | |
| 77 | T | A | -0.5786 | |
| 78 | N | A | -1.0204 | |
| 79 | W | A | -1.3215 | |
| 80 | D | A | -2.2682 | |
| 81 | D | A | 0.0000 | |
| 82 | M | A | 0.0000 | |
| 83 | E | A | -2.0010 | |
| 84 | K | A | -1.8990 | |
| 85 | I | A | 0.0000 | |
| 86 | W | A | 0.0000 | |
| 87 | H | A | -1.2564 | |
| 88 | H | A | -1.2690 | |
| 89 | T | A | 0.0000 | |
| 90 | F | A | 0.0000 | |
| 91 | Y | A | -0.8665 | |
| 92 | N | A | -1.8016 | |
| 93 | E | A | -1.6327 | |
| 94 | L | A | 0.0000 | |
| 95 | R | A | -1.9840 | |
| 96 | V | A | -1.2711 | |
| 97 | A | A | -1.3197 | |
| 98 | P | A | 0.0000 | |
| 99 | E | A | -2.9609 | |
| 100 | E | A | -2.8561 | |
| 101 | H | A | -1.5401 | |
| 102 | P | A | -0.9491 | |
| 103 | T | A | 0.0000 | |
| 104 | L | A | 0.0000 | |
| 105 | L | A | 0.0000 | |
| 106 | T | A | 0.0000 | |
| 107 | E | A | 0.0000 | |
| 108 | A | A | 0.0000 | |
| 109 | P | A | 0.0000 | |
| 110 | L | A | 0.9992 | |
| 111 | N | A | 0.0000 | |
| 112 | P | A | -0.7201 | |
| 113 | K | A | -1.9698 | |
| 114 | A | A | -1.3431 | |
| 115 | N | A | -1.2248 | |
| 116 | R | A | -1.4463 | |
| 117 | E | A | -1.5581 | |
| 118 | K | A | -1.4709 | |
| 119 | M | A | 0.0000 | |
| 120 | T | A | 0.0000 | |
| 121 | Q | A | -1.4716 | |
| 122 | I | A | 0.0000 | |
| 123 | M | A | 0.0000 | |
| 124 | F | A | 0.0000 | |
| 125 | E | A | -2.4148 | |
| 126 | T | A | -1.5852 | |
| 127 | F | A | 0.0000 | |
| 128 | N | A | -2.3469 | |
| 129 | V | A | 0.0000 | |
| 130 | P | A | -1.6418 | |
| 131 | A | A | 0.0000 | |
| 132 | M | A | 0.0000 | |
| 133 | Y | A | 0.1347 | |
| 134 | V | A | 0.0000 | |
| 135 | A | A | 0.0000 | |
| 136 | I | A | 0.6169 | |
| 137 | Q | A | 0.0404 | |
| 138 | A | A | 0.0000 | |
| 139 | V | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | S | A | 0.0000 | |
| 142 | L | A | 0.0000 | |
| 143 | Y | A | 0.0000 | |
| 144 | A | A | -0.4174 | |
| 145 | S | A | -0.2872 | |
| 146 | G | A | -1.0736 | |
| 147 | R | A | -1.1642 | |
| 148 | T | A | -0.7089 | |
| 149 | T | A | -0.7671 | |
| 150 | G | A | 0.0000 | |
| 151 | I | A | 0.0000 | |
| 152 | V | A | 0.0000 | |
| 153 | L | A | 0.0000 | |
| 154 | D | A | -0.3773 | |
| 155 | S | A | 0.0000 | |
| 156 | G | A | -0.7616 | |
| 157 | D | A | -1.6810 | |
| 158 | G | A | -1.6545 | |
| 159 | V | A | -1.3472 | |
| 160 | T | A | 0.0000 | |
| 161 | H | A | 0.0000 | |
| 162 | N | A | 0.0000 | |
| 163 | V | A | 0.0000 | |
| 164 | P | A | 0.0000 | |
| 165 | I | A | 0.0000 | |
| 166 | Y | A | -0.3218 | |
| 167 | E | A | -1.6038 | |
| 168 | G | A | 0.0000 | |
| 169 | Y | A | 0.4334 | |
| 170 | A | A | 0.0000 | |
| 171 | L | A | -0.0360 | |
| 172 | P | A | -0.0976 | |
| 173 | H | A | -0.9787 | |
| 174 | A | A | 0.0000 | |
| 175 | I | A | -0.1581 | |
| 176 | M | A | -0.3631 | |
| 177 | R | A | -0.9049 | |
| 178 | L | A | 0.0000 | |
| 179 | D | A | -2.0065 | |
| 180 | L | A | 0.0000 | |
| 181 | A | A | 0.0000 | |
| 182 | G | A | -1.9065 | |
| 183 | R | A | -2.8374 | |
| 184 | D | A | -2.3067 | |
| 185 | L | A | 0.0000 | |
| 186 | T | A | -2.5491 | |
| 187 | D | A | -3.0384 | |
| 188 | Y | A | 0.0000 | |
| 189 | L | A | 0.0000 | |
| 190 | M | A | -1.7298 | |
| 191 | K | A | -2.3456 | |
| 192 | I | A | 0.0000 | |
| 193 | L | A | 0.0000 | |
| 194 | T | A | -1.7047 | |
| 195 | E | A | -2.8981 | |
| 196 | R | A | -2.4918 | |
| 197 | G | A | -1.5813 | |
| 198 | Y | A | -0.8706 | |
| 199 | S | A | -0.5694 | |
| 200 | F | A | 0.0000 | |
| 201 | V | A | 1.0512 | |
| 202 | T | A | -0.1517 | |
| 203 | T | A | -0.6702 | |
| 204 | A | A | -0.8676 | |
| 205 | E | A | -1.1081 | |
| 206 | R | A | -1.8814 | |
| 207 | E | A | -1.0125 | |
| 208 | I | A | 0.0000 | |
| 209 | V | A | 0.0000 | |
| 210 | R | A | -1.9380 | |
| 211 | D | A | 0.0000 | |
| 212 | I | A | 0.0000 | |
| 213 | K | A | 0.0000 | |
| 214 | E | A | -2.6896 | |
| 215 | K | A | -2.5636 | |
| 216 | L | A | -1.3952 | |
| 217 | C | A | 0.0000 | |
| 218 | Y | A | -0.3699 | |
| 219 | V | A | 0.0000 | |
| 220 | A | A | 0.0000 | |
| 221 | L | A | -0.6475 | |
| 222 | D | A | -1.4321 | |
| 223 | F | A | -1.3786 | |
| 224 | E | A | -2.4705 | |
| 225 | N | A | -2.2615 | |
| 226 | E | A | -1.4042 | |
| 227 | M | A | -1.0402 | |
| 228 | A | A | -0.8809 | |
| 229 | T | A | -0.7318 | |
| 230 | A | A | -0.6589 | |
| 231 | A | A | -0.2360 | |
| 232 | S | A | -0.2536 | |
| 233 | S | A | -0.6335 | |
| 234 | S | A | -1.0972 | |
| 235 | S | A | -0.9341 | |
| 236 | L | A | -1.2224 | |
| 237 | E | A | -2.4145 | |
| 238 | K | A | -1.9340 | |
| 239 | S | A | -1.1498 | |
| 240 | Y | A | 0.0000 | |
| 241 | E | A | -2.1493 | |
| 242 | L | A | -1.7550 | |
| 243 | P | A | -1.9658 | |
| 244 | D | A | -2.7776 | |
| 245 | G | A | -2.1684 | |
| 246 | Q | A | -1.8350 | |
| 247 | V | A | -0.5058 | |
| 248 | I | A | -0.2775 | |
| 249 | T | A | -0.7239 | |
| 250 | I | A | 0.0000 | |
| 251 | G | A | -1.2367 | |
| 252 | N | A | -0.7808 | |
| 253 | E | A | 0.0000 | |
| 254 | R | A | -0.9061 | |
| 255 | F | A | 0.0000 | |
| 256 | R | A | -0.3695 | |
| 257 | C | A | 0.0000 | |
| 258 | P | A | 0.0000 | |
| 259 | E | A | 0.0000 | |
| 260 | T | A | 0.0000 | |
| 261 | L | A | 0.0000 | |
| 262 | F | A | 0.0000 | |
| 263 | Q | A | -0.7338 | |
| 264 | P | A | 0.0000 | |
| 265 | S | A | -0.5525 | |
| 266 | F | A | 0.1757 | |
| 267 | I | A | -0.1829 | |
| 268 | G | A | -0.5167 | |
| 269 | M | A | -0.9884 | |
| 270 | E | A | -1.8315 | |
| 271 | S | A | -1.3667 | |
| 272 | A | A | -0.8103 | |
| 273 | G | A | 0.0000 | |
| 274 | I | A | 0.0000 | |
| 275 | H | A | -0.7152 | |
| 276 | E | A | -0.8353 | |
| 277 | T | A | 0.0000 | |
| 278 | T | A | 0.0000 | |
| 279 | Y | A | -0.3395 | |
| 280 | N | A | -0.8047 | |
| 281 | S | A | 0.0000 | |
| 282 | I | A | 0.0000 | |
| 283 | M | A | -0.5407 | |
| 284 | K | A | -1.4763 | |
| 285 | C | A | 0.0000 | |
| 286 | D | A | -1.8145 | |
| 287 | I | A | -0.1711 | |
| 288 | D | A | -1.9603 | |
| 289 | I | A | 0.0000 | |
| 290 | R | A | -1.8665 | |
| 291 | K | A | -2.6548 | |
| 292 | D | A | -2.5130 | |
| 293 | L | A | 0.0000 | |
| 294 | Y | A | 0.0000 | |
| 295 | A | A | 0.0000 | |
| 296 | N | A | -1.2630 | |
| 297 | N | A | 0.0000 | |
| 298 | V | A | 0.0000 | |
| 299 | M | A | 0.0000 | |
| 300 | S | A | 0.0000 | |
| 301 | G | A | -0.6097 | |
| 302 | G | A | -0.8709 | |
| 303 | T | A | 0.0000 | |
| 304 | T | A | 0.0000 | |
| 305 | M | A | -0.6360 | |
| 306 | Y | A | 0.0000 | |
| 307 | P | A | -0.7552 | |
| 308 | G | A | -0.5454 | |
| 309 | I | A | 0.0000 | |
| 310 | A | A | -1.2573 | |
| 311 | D | A | -2.2764 | |
| 312 | R | A | 0.0000 | |
| 313 | M | A | 0.0000 | |
| 314 | Q | A | -2.0370 | |
| 315 | K | A | -1.5757 | |
| 316 | E | A | -1.0598 | |
| 317 | I | A | 0.0000 | |
| 318 | T | A | -0.7094 | |
| 319 | A | A | -0.1225 | |
| 320 | L | A | 0.2414 | |
| 321 | A | A | 0.0573 | |
| 322 | P | A | -0.3568 | |
| 323 | S | A | -0.4242 | |
| 324 | T | A | -0.5464 | |
| 325 | M | A | -1.3300 | |
| 326 | K | A | -2.2984 | |
| 327 | I | A | -1.8040 | |
| 328 | K | A | -1.9934 | |
| 329 | I | A | 0.0000 | |
| 330 | I | A | -0.2755 | |
| 331 | A | A | -0.5523 | |
| 332 | P | A | -0.6755 | |
| 333 | P | A | -1.1309 | |
| 334 | E | A | -2.1102 | |
| 335 | R | A | 0.0000 | |
| 336 | K | A | -1.0144 | |
| 337 | Y | A | -0.7211 | |
| 338 | S | A | 0.0000 | |
| 339 | V | A | 0.0000 | |
| 340 | W | A | 0.0000 | |
| 341 | I | A | -0.2580 | |
| 342 | G | A | 0.0000 | |
| 343 | G | A | 0.0000 | |
| 344 | S | A | 0.0000 | |
| 345 | I | A | 0.0000 | |
| 346 | L | A | 0.0000 | |
| 347 | A | A | 0.0000 | |
| 348 | S | A | -0.3212 | |
| 349 | L | A | 0.0000 | |
| 350 | S | A | -0.7836 | |
| 351 | T | A | -1.0032 | |
| 352 | F | A | 0.0000 | |
| 353 | Q | A | -1.8071 | |
| 354 | Q | A | -1.9282 | |
| 355 | M | A | 0.0000 | |
| 356 | W | A | 0.0000 | |
| 357 | I | A | 0.0000 | |
| 358 | T | A | -1.4570 | |
| 359 | K | A | -2.3871 | |
| 360 | Q | A | -2.7782 | |
| 361 | E | A | -2.4699 | |
| 362 | Y | A | 0.0000 | |
| 363 | D | A | -3.6111 | |
| 364 | E | A | -3.2335 | |
| 365 | A | A | -1.7358 | |
| 366 | G | A | -1.5674 | |
| 367 | P | A | -1.1473 | |
| 368 | S | A | -1.0986 | |
| 369 | I | A | 0.0000 | |
| 370 | V | A | 0.0000 | |
| 371 | H | A | -1.1337 | |
| 372 | R | A | -1.9318 | |
| 373 | K | A | 0.0000 | |
| 374 | C | A | -0.1817 | |
| 375 | F | A | 0.0715 | |
| 29 | E | C | -2.2930 | |
| 30 | Q | C | -1.9361 | |
| 31 | A | C | -1.2211 | |
| 32 | G | C | -1.3055 | |
| 33 | R | C | -1.5579 | |
| 34 | N | C | -1.9675 | |
| 35 | A | C | -0.8564 | |
| 36 | L | C | 0.0000 | |
| 37 | L | C | -1.1920 | |
| 38 | S | C | -1.0867 | |
| 39 | D | C | -1.3988 | |
| 40 | I | C | 0.0000 | |
| 41 | S | C | -1.4995 | |
| 42 | K | C | -2.2790 | |
| 43 | G | C | -2.0363 | |
| 44 | K | C | -2.3617 | |
| 45 | K | C | -2.7190 | |
| 46 | L | C | -2.3905 | |
| 47 | K | C | -3.0024 | |
| 48 | K | C | -2.5629 | |
| 49 | T | C | -0.9593 | |
| 50 | V | C | 0.4368 | |
| 51 | T | C | -0.8330 | |
| 52 | N | C | -1.8046 | |
| 53 | D | C | -1.9502 | |
| 54 | R | C | -1.4987 | |
| 55 | S | C | -0.6634 | |
| 56 | A | C | -0.2758 | |
| 57 | P | C | -0.1051 | |
| 58 | I | C | 0.6541 | |
| 59 | L | C | -0.2396 | |
| 60 | D | C | -1.5663 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine