Project name: 20p_pro

Chain sequence(s)	A: QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECQVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.9243
• Maximal score value: 1.7752
• Average score: -0.6876
• Total score value: -299.0861

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	A	-1.0915
2	I	A	0.0302
3	V	A	0.8311
4	L	A	0.0024
5	S	A	-0.6813
6	Q	A	-0.8430
7	S	A	-0.3828
8	P	A	0.3481
9	A	A	0.0000
10	I	A	1.7566
11	L	A	0.7758
12	S	A	-0.3699
13	A	A	0.0000
14	S	A	-2.1598
15	P	A	-2.3422
16	G	A	-2.5313
17	E	A	-3.4308
18	K	A	-3.2704
19	V	A	-1.4434
20	T	A	-0.3370
21	M	A	0.0000
22	T	A	-0.6775
23	C	A	0.0000
24	R	A	-1.9741
25	A	A	0.0000
26	S	A	-0.4466
27	S	A	-0.5144
28	S	A	-0.5106
29	V	A	0.1335
30	S	A	0.2257
31	Y	A	0.7854
32	I	A	0.0000
33	H	A	0.0000
34	W	A	0.0000
35	F	A	0.0000
36	Q	A	0.0000
37	Q	A	-0.7753
38	K	A	0.0000
39	P	A	-0.8018
40	G	A	-0.7312
41	S	A	-0.5323
42	S	A	-0.3815
43	P	A	0.0000
44	K	A	-0.8081
45	P	A	0.0000
46	W	A	-0.2495
47	I	A	0.0000
48	Y	A	0.0000
49	A	A	-0.0920
50	T	A	-0.1998
51	S	A	-0.6703
52	N	A	-1.0090
53	L	A	-0.0073
54	A	A	0.0000
55	S	A	-0.4932
56	G	A	-0.1305
57	V	A	0.3386
58	P	A	0.7185
59	V	A	1.2636
60	R	A	-0.3836
61	F	A	0.0000
62	S	A	-0.1923
63	G	A	-0.5328
64	S	A	-0.5714
65	G	A	-0.6914
66	S	A	-0.6096
67	G	A	-0.6451
68	T	A	-0.9491
69	S	A	-1.1919
70	Y	A	0.0000
71	S	A	-0.5907
72	L	A	0.0000
73	T	A	-0.7646
74	I	A	0.0000
75	S	A	-2.1827
76	R	A	-3.3796
77	V	A	0.0000
78	E	A	-2.8604
79	A	A	0.0000
80	E	A	-3.0228
81	D	A	0.0000
82	A	A	-1.9438
83	A	A	0.0000
84	T	A	0.0000
85	Y	A	0.0000
86	Y	A	0.0000
87	C	A	0.0000
88	Q	A	0.0000
89	Q	A	0.0000
90	W	A	-0.2120
91	T	A	-0.3938
92	S	A	-0.8651
93	N	A	-1.6618
94	P	A	0.0000
95	P	A	0.0000
96	T	A	0.0543
97	F	A	0.1227
98	G	A	0.0000
99	G	A	-1.2012
100	G	A	-1.0738
101	T	A	0.0000
102	K	A	-1.5254
103	L	A	0.0000
104	E	A	-1.7366
105	I	A	0.0000
106	K	A	-2.0941
107	R	A	-1.4687
108	T	A	-0.2413
109	V	A	0.4901
110	A	A	0.0528
111	A	A	-0.2719
112	P	A	0.0000
113	S	A	-0.2814
114	V	A	-0.0074
115	F	A	0.2280
116	I	A	0.1305
117	F	A	0.0000
118	P	A	-0.4864
119	P	A	0.0000
120	S	A	-1.1914
121	D	A	-2.3883
122	E	A	-2.2714
123	Q	A	0.0000
124	L	A	-0.9069
125	K	A	-1.9120
126	S	A	-1.3662
127	G	A	-1.3156
128	T	A	-1.0162
129	A	A	0.0000
130	S	A	0.0000
131	V	A	0.0000
132	V	A	0.0000
133	C	A	0.0000
134	L	A	0.0000
135	L	A	0.0000
136	N	A	-0.6335
137	N	A	-1.6020
138	F	A	0.0000
139	Y	A	0.0000
140	P	A	-1.5412
141	R	A	-2.4196
142	E	A	-2.9247
143	A	A	-2.1660
144	K	A	-2.5494
145	V	A	-1.3848
146	Q	A	-1.1231
147	W	A	0.0000
148	K	A	-1.0985
149	V	A	0.0000
150	D	A	-2.9928
151	N	A	-2.2689
152	A	A	-0.8411
153	L	A	-0.0824
154	Q	A	-1.0356
155	S	A	-0.8826
156	G	A	-1.0347
157	N	A	-0.8922
158	S	A	-0.9295
159	Q	A	-1.1774
160	E	A	-1.7922
161	S	A	-0.7689
162	V	A	-0.6135
163	T	A	0.0000
164	E	A	-1.5291
165	Q	A	-1.8473
166	D	A	-2.3076
167	S	A	-2.6092
168	K	A	-2.9466
169	D	A	-2.2972
170	S	A	0.0000
171	T	A	0.0000
172	Y	A	0.0000
173	S	A	0.0000
174	L	A	0.0000
175	S	A	-0.4301
176	S	A	0.0000
177	T	A	-0.2117
178	L	A	0.2054
179	T	A	-0.1564
180	L	A	0.0000
181	S	A	-1.8560
182	K	A	-2.8493
183	A	A	-2.4756
184	D	A	-2.9892
185	Y	A	0.0000
186	E	A	-3.9243
187	K	A	-3.8450
188	H	A	-3.4394
189	K	A	-3.6825
190	V	A	0.0000
191	Y	A	0.0000
192	A	A	0.0000
193	C	A	0.0000
194	E	A	-0.8641
195	V	A	0.0000
196	T	A	-1.2316
197	H	A	0.0000
198	Q	A	-1.5231
199	G	A	-0.4597
200	L	A	-0.2403
201	S	A	-0.4325
202	S	A	-0.4047
203	P	A	-0.3207
204	V	A	0.1805
205	T	A	-0.3938
206	K	A	-0.7577
207	S	A	-0.8537
208	F	A	-1.0893
209	N	A	-2.0738
210	R	A	-2.7547
211	G	A	-2.1973
212	E	A	-2.4408
1	Q	A	-1.2581
2	V	A	-0.5307
3	Q	A	-1.1877
4	L	A	-1.0622
5	Q	A	-1.6329
6	Q	A	-0.9251
7	P	A	-0.9815
8	G	A	-1.1756
9	A	A	0.0000
10	E	A	-0.7902
11	L	A	-0.1497
12	V	A	0.0000
13	K	A	-1.7375
14	P	A	-1.2925
15	G	A	-1.0618
16	A	A	-0.8910
17	S	A	-1.1440
18	V	A	0.0000
19	K	A	-2.0449
20	M	A	0.0000
21	S	A	-0.7222
22	C	A	0.0000
23	K	A	-1.4255
24	A	A	0.0000
25	S	A	-0.8968
26	G	A	-0.7826
27	Y	A	-0.2045
28	T	A	0.0034
29	F	A	0.0000
30	T	A	-0.7237
31	S	A	-0.0596
32	Y	A	0.4270
33	N	A	0.1125
34	M	A	0.0000
35	H	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	K	A	0.0000
39	Q	A	0.0000
40	T	A	0.0000
41	P	A	-1.1393
42	G	A	-1.4357
43	R	A	-1.9790
44	G	A	0.0000
45	L	A	0.0000
46	E	A	-0.5403
47	W	A	0.0000
48	I	A	0.0000
49	G	A	0.0000
50	A	A	0.0000
51	I	A	0.0000
52	Y	A	-0.5840
53	P	A	0.0000
54	G	A	-1.2718
55	N	A	-2.0863
56	G	A	-2.0133
57	D	A	-2.2561
58	T	A	-1.1054
59	S	A	-0.8208
60	Y	A	-1.0766
61	N	A	0.0000
62	Q	A	-2.5995
63	K	A	-2.3993
64	F	A	0.0000
65	K	A	-2.8324
66	G	A	-2.0354
67	K	A	-1.8507
68	A	A	-1.4414
69	T	A	-0.8754
70	L	A	0.0000
71	T	A	-0.7559
72	A	A	-1.5276
73	D	A	-2.3397
74	K	A	-2.4067
75	S	A	-1.4070
76	S	A	-1.2807
77	S	A	-1.1887
78	T	A	-1.2875
79	A	A	0.0000
80	Y	A	-0.5640
81	M	A	0.0000
82	Q	A	-1.4876
83	L	A	0.0000
84	S	A	-0.9555
85	S	A	-0.5926
86	L	A	-0.7495
87	T	A	-0.8042
88	S	A	-0.7529
89	E	A	-1.1890
90	D	A	-0.7100
91	S	A	-0.5089
92	A	A	-0.2139
93	V	A	0.2598
94	Y	A	0.0000
95	Y	A	0.0000
96	C	A	0.0000
97	A	A	0.0000
98	R	A	0.0000
99	S	A	0.0000
100	T	A	0.0000
101	Y	A	1.7752
102	Y	A	1.6236
103	G	A	0.1958
104	G	A	-0.2960
105	D	A	0.1015
106	W	A	0.6640
107	Y	A	0.7100
108	F	A	0.0000
109	N	A	-0.2251
110	V	A	-0.0593
111	W	A	-0.2405
112	G	A	0.0000
113	A	A	-0.3076
114	G	A	-0.2193
115	T	A	0.0000
116	T	A	-0.2366
117	V	A	0.0000
118	T	A	0.0000
119	V	A	-0.6291
120	S	A	-0.5003
121	A	A	-0.5924
122	A	A	-0.3410
123	S	A	-0.3669
124	T	A	-0.7830
125	K	A	-1.5286
126	G	A	-1.4324
127	P	A	-0.8546
128	S	A	-0.6146
129	V	A	0.0000
130	F	A	0.0000
131	P	A	-1.1785
132	L	A	0.0000
133	A	A	-0.8629
134	P	A	-1.0537
135	S	A	-1.6969
136	S	A	-2.1015
137	K	A	-2.2803
138	S	A	-1.1943
139	T	A	-0.9885
140	S	A	-0.9306
141	G	A	-0.9253
142	G	A	-0.8642
143	T	A	-0.5801
144	A	A	-0.2696
145	A	A	0.0000
146	L	A	0.0000
147	G	A	0.0000
148	C	A	0.0000
149	L	A	0.0000
150	V	A	0.0000
151	K	A	-0.3854
152	D	A	-0.5911
153	Y	A	0.0000
154	F	A	-0.5244
155	P	A	0.0000
156	E	A	-0.6207
157	P	A	-0.6145
158	V	A	0.0000
159	T	A	-0.5916
160	V	A	-0.3923
161	S	A	-0.3972
162	W	A	0.0000
163	N	A	-0.7216
164	S	A	-0.5982
165	G	A	-0.3804
166	A	A	-0.1662
167	L	A	0.0169
168	T	A	-0.2140
169	S	A	-0.3418
170	G	A	-0.6042
171	V	A	-0.1602
172	H	A	-0.5751
173	T	A	-0.2273
174	F	A	0.0000
175	P	A	-0.2480
176	A	A	0.1612
177	V	A	0.2719
178	L	A	0.7189
179	Q	A	-0.1355
180	S	A	-0.3014
181	S	A	-0.3390
182	G	A	-0.0946
183	L	A	-0.1543
184	Y	A	0.2085
185	S	A	0.2113
186	L	A	0.2542
187	S	A	0.0094
188	S	A	0.0000
189	V	A	0.0000
190	V	A	0.0000
191	T	A	-0.4461
192	V	A	0.0000
193	P	A	-0.5492
194	S	A	0.0000
195	S	A	-0.9513
196	S	A	0.0000
197	L	A	-1.4077
198	G	A	-1.9620
199	T	A	-1.0983
200	Q	A	-1.6411
201	T	A	-1.3258
202	Y	A	0.0000
203	I	A	-1.2735
204	C	A	0.0000
205	N	A	-1.4601
206	V	A	0.0000
207	N	A	-1.8041
208	H	A	0.0000
209	K	A	-2.1220
210	P	A	-1.2559
211	S	A	-1.6200
212	N	A	-2.3478
213	T	A	-1.8176
214	K	A	-2.4848
215	V	A	-1.3810
216	D	A	-2.4920
217	K	A	-2.1176
218	K	A	-2.6711
219	V	A	0.0000
220	E	A	-3.0480
221	P	A	0.0000
222	K	A	-2.6927
223	S	A	-1.7597