Chain sequence(s) |
A: SVSIYPSSAEVLKACRNLGKNGLSNSSILLDKCPPPRPPSSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPNNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWHCESNRSHTTIAKYAQYQASSFQESLREENEKRSHHKDHSDSESTSSDNSGRRRKGPFKTIKFGTNIDLSDDKKWKLQLHELTKLPAFVRVVSAGNLLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEGYWGVLNDFCEKNNLNFLMGSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAIGWCNNIAWNVGPLTACQYKLAVERYEWNKLQSVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLRTLKQCQTLREALIAAGKEIIWHGRTKEEPAHYCSICEVEVFDLLFVTNESNSRKTYIVHCQDCARKTSGNLENFVVLEQYKMEDLMQVYDQFTLAPP |
Distance of aggregation | 10 Å |
Dynamic mode | No |
Mutated residues | HA1060L |
Energy difference between WT (input) and mutated protein (by FoldX) | -0.155859 kcal/mol
Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
886 | S | A | 0.8511 | |
887 | V | A | 2.1422 | |
888 | S | A | 1.5725 | |
889 | I | A | 2.3501 | |
890 | Y | A | 1.1658 | |
891 | P | A | 0.1212 | |
892 | S | A | -0.7722 | |
893 | S | A | 0.0000 | |
894 | A | A | -1.1754 | |
895 | E | A | -1.5069 | |
896 | V | A | 0.0000 | |
897 | L | A | -1.2032 | |
898 | K | A | -2.0058 | |
899 | A | A | 0.0000 | |
900 | C | A | -1.1756 | |
901 | R | A | -2.1885 | |
902 | N | A | -2.0432 | |
903 | L | A | -0.6262 | |
904 | G | A | -1.3947 | |
905 | K | A | -2.5610 | |
906 | N | A | -2.3531 | |
907 | G | A | -1.1693 | |
908 | L | A | -0.1764 | |
909 | S | A | -1.1450 | |
910 | N | A | -1.4723 | |
911 | S | A | -0.5102 | |
912 | S | A | 0.0255 | |
913 | I | A | 0.3779 | |
914 | L | A | 0.3806 | |
915 | L | A | 0.4799 | |
916 | D | A | -1.7839 | |
917 | K | A | -1.7651 | |
918 | C | A | -0.3989 | |
919 | P | A | -0.6172 | |
920 | P | A | -0.8488 | |
921 | P | A | -1.3413 | |
922 | R | A | -2.1559 | |
923 | P | A | -1.4247 | |
924 | P | A | -0.9005 | |
925 | S | A | -0.5129 | |
926 | S | A | -0.2567 | |
927 | P | A | 0.2228 | |
928 | Y | A | 0.9987 | |
929 | P | A | 0.4320 | |
930 | P | A | -0.2949 | |
931 | L | A | -0.9918 | |
932 | P | A | -1.9768 | |
933 | K | A | -3.5605 | |
934 | D | A | -3.6964 | |
935 | K | A | -3.5246 | |
936 | L | A | 0.0000 | |
937 | N | A | -2.6345 | |
938 | P | A | -1.6377 | |
939 | P | A | -0.8576 | |
940 | T | A | -0.3598 | |
941 | P | A | -0.2185 | |
942 | S | A | 0.1517 | |
943 | I | A | 0.7084 | |
944 | Y | A | 0.6260 | |
945 | L | A | 0.0000 | |
946 | E | A | -2.7579 | |
947 | N | A | -3.1120 | |
948 | K | A | -2.9328 | |
949 | R | A | -2.1513 | |
950 | D | A | -0.9512 | |
951 | A | A | 0.0000 | |
952 | F | A | 1.3263 | |
953 | F | A | 1.6487 | |
954 | P | A | 0.5997 | |
955 | P | A | 0.1571 | |
956 | L | A | 0.0000 | |
957 | H | A | -0.3358 | |
958 | Q | A | -1.0888 | |
959 | F | A | -0.4526 | |
960 | C | A | 0.0000 | |
961 | T | A | -0.7738 | |
962 | N | A | -1.2352 | |
963 | P | A | -1.2297 | |
964 | N | A | -1.6115 | |
965 | N | A | -0.9534 | |
966 | P | A | 0.0000 | |
967 | V | A | 0.0000 | |
968 | T | A | 0.0000 | |
969 | V | A | 0.0000 | |
970 | I | A | 0.0000 | |
971 | R | A | -0.3027 | |
972 | G | A | -1.0321 | |
973 | L | A | 0.0000 | |
974 | A | A | 0.0000 | |
975 | G | A | -2.1469 | |
976 | A | A | 0.0000 | |
977 | L | A | 0.0000 | |
978 | K | A | -2.7618 | |
979 | L | A | 0.0000 | |
980 | D | A | -2.0766 | |
981 | L | A | -1.0045 | |
982 | G | A | -0.9453 | |
983 | L | A | -0.3733 | |
984 | F | A | 0.0000 | |
985 | S | A | -0.9622 | |
986 | T | A | -1.2623 | |
987 | K | A | -2.2124 | |
988 | T | A | -1.5138 | |
989 | L | A | 0.0000 | |
990 | V | A | -2.3197 | |
991 | E | A | -2.6120 | |
992 | A | A | -1.7953 | |
993 | N | A | -1.6617 | |
994 | N | A | -2.6376 | |
995 | E | A | -2.5287 | |
996 | H | A | -1.1263 | |
997 | M | A | -0.2330 | |
998 | V | A | 0.0000 | |
999 | E | A | -1.2292 | |
1000 | V | A | 0.0000 | |
1001 | R | A | -2.2496 | |
1002 | T | A | -1.5685 | |
1003 | Q | A | 0.0000 | |
1004 | L | A | -0.0611 | |
1005 | L | A | 0.2594 | |
1006 | Q | A | 0.0000 | |
1007 | P | A | -0.3259 | |
1008 | A | A | -0.0522 | |
1009 | D | A | -0.5109 | |
1010 | E | A | -0.7166 | |
1011 | N | A | 0.0000 | |
1012 | W | A | -0.7146 | |
1013 | D | A | 0.0000 | |
1014 | P | A | -0.4439 | |
1015 | T | A | -0.7461 | |
1016 | G | A | 0.0000 | |
1017 | T | A | -1.1759 | |
1018 | K | A | -1.7745 | |
1019 | K | A | -1.1108 | |
1020 | I | A | -0.4354 | |
1021 | W | A | 0.0000 | |
1022 | H | A | -1.0395 | |
1023 | C | A | 0.0000 | |
1024 | E | A | -1.0879 | |
1025 | S | A | -1.6431 | |
1026 | N | A | -2.5521 | |
1027 | R | A | -3.0876 | |
1028 | S | A | -2.0034 | |
1029 | H | A | -1.3354 | |
1030 | T | A | -0.9015 | |
1031 | T | A | 0.0000 | |
1032 | I | A | 0.0000 | |
1033 | A | A | -2.2840 | |
1034 | K | A | -2.3609 | |
1035 | Y | A | 0.0000 | |
1036 | A | A | -1.4335 | |
1037 | Q | A | -1.6545 | |
1038 | Y | A | -0.7358 | |
1039 | Q | A | 0.0000 | |
1040 | A | A | -0.5222 | |
1041 | S | A | -0.6064 | |
1042 | S | A | -0.3439 | |
1043 | F | A | 0.1674 | |
1044 | Q | A | -1.1513 | |
1045 | E | A | -1.5615 | |
1046 | S | A | -1.2712 | |
1047 | L | A | -1.4565 | |
1048 | R | A | -3.0428 | |
1049 | E | A | -3.0374 | |
1050 | E | A | -3.3989 | |
1051 | N | A | -3.7697 | |
1052 | E | A | -3.8345 | |
1053 | K | A | -3.2886 | |
1054 | R | A | -3.6241 | |
1055 | S | A | -2.8494 | |
1056 | H | A | -2.7353 | |
1057 | H | A | -2.9669 | |
1058 | K | A | -3.0882 | |
1059 | D | A | -1.7349 | |
1060 | L | A | 0.4092 | mutated: HA1060L |
1061 | S | A | -0.4028 | |
1062 | D | A | -0.9582 | |
1063 | S | A | -1.1403 | |
1064 | E | A | -2.0124 | |
1065 | S | A | -1.7829 | |
1066 | T | A | 0.0000 | |
1067 | S | A | -1.8915 | |
1068 | S | A | -2.8707 | |
1069 | D | A | -2.9921 | |
1070 | N | A | -3.0033 | |
1071 | S | A | -1.9750 | |
1072 | G | A | -1.9117 | |
1073 | R | A | -3.5707 | |
1074 | R | A | -3.8430 | |
1075 | R | A | -3.8263 | |
1076 | K | A | -3.1661 | |
1077 | G | A | -1.6458 | |
1078 | P | A | -1.0515 | |
1079 | F | A | -0.6165 | |
1080 | K | A | -0.2067 | |
1081 | T | A | -0.2030 | |
1082 | I | A | 0.0000 | |
1083 | K | A | -1.2474 | |
1084 | F | A | 0.0000 | |
1085 | G | A | 0.0000 | |
1086 | T | A | 0.0000 | |
1087 | N | A | -0.7619 | |
1088 | I | A | 0.0000 | |
1089 | D | A | -0.2733 | |
1090 | L | A | 0.0000 | |
1091 | S | A | -1.1599 | |
1092 | D | A | -2.5295 | |
1093 | D | A | -3.7874 | |
1094 | K | A | -3.5657 | |
1095 | K | A | -2.8447 | |
1096 | W | A | 0.0000 | |
1097 | K | A | -3.0568 | |
1098 | L | A | -0.9111 | |
1099 | Q | A | 0.0000 | |
1100 | L | A | -1.3752 | |
1101 | H | A | -1.4419 | |
1102 | E | A | 0.0000 | |
1103 | L | A | 0.0000 | |
1104 | T | A | -0.5673 | |
1105 | K | A | -1.4500 | |
1106 | L | A | 0.0000 | |
1107 | P | A | 0.0000 | |
1108 | A | A | 0.3391 | |
1109 | F | A | 0.3197 | |
1110 | V | A | 0.0000 | |
1111 | R | A | 0.1381 | |
1112 | V | A | 0.8148 | |
1113 | V | A | 1.6196 | |
1114 | S | A | 0.7081 | |
1115 | A | A | 0.3030 | |
1116 | G | A | 0.1157 | |
1117 | N | A | 0.0000 | |
1118 | L | A | 0.0000 | |
1119 | L | A | 0.0000 | |
1120 | S | A | 0.2908 | |
1121 | H | A | -0.3569 | |
1122 | V | A | 0.0000 | |
1123 | G | A | -1.2010 | |
1124 | H | A | -1.1427 | |
1125 | T | A | -0.1977 | |
1126 | I | A | 0.0000 | |
1127 | L | A | 1.1483 | |
1128 | G | A | 0.0000 | |
1129 | M | A | 0.0000 | |
1130 | N | A | 0.4810 | |
1131 | T | A | 0.2567 | |
1132 | V | A | 0.0000 | |
1133 | Q | A | -0.2965 | |
1134 | L | A | 0.0000 | |
1135 | Y | A | -0.1215 | |
1136 | M | A | 0.0000 | |
1137 | K | A | 0.0000 | |
1138 | V | A | 0.0000 | |
1139 | P | A | 0.4444 | |
1140 | G | A | 0.2608 | |
1141 | S | A | 0.0000 | |
1142 | R | A | 0.0000 | |
1143 | T | A | -0.1705 | |
1144 | P | A | -0.2773 | |
1145 | G | A | 0.0000 | |
1146 | H | A | -0.2216 | |
1147 | Q | A | -0.4961 | |
1148 | E | A | -0.4872 | |
1149 | N | A | -0.4016 | |
1150 | N | A | 0.0000 | |
1151 | N | A | 0.0000 | |
1152 | F | A | 0.0000 | |
1153 | C | A | 0.0000 | |
1154 | S | A | 0.0000 | |
1155 | V | A | 0.0000 | |
1156 | N | A | 0.0000 | |
1157 | I | A | 0.0000 | |
1158 | N | A | 0.0000 | |
1159 | I | A | 0.0000 | |
1160 | G | A | 0.0000 | |
1161 | P | A | -0.5705 | |
1162 | G | A | -0.3920 | |
1163 | D | A | -0.5159 | |
1164 | C | A | 0.0000 | |
1165 | E | A | 0.0658 | |
1166 | W | A | 0.0000 | |
1167 | F | A | 0.0000 | |
1168 | V | A | 0.0000 | |
1169 | V | A | 0.0000 | |
1170 | P | A | -0.5399 | |
1171 | E | A | -0.7214 | |
1172 | G | A | -0.3311 | |
1173 | Y | A | 0.0000 | |
1174 | W | A | 0.0000 | |
1175 | G | A | 0.0000 | |
1176 | V | A | -0.3466 | |
1177 | L | A | 0.0000 | |
1178 | N | A | -1.1591 | |
1179 | D | A | -2.0117 | |
1180 | F | A | -1.5649 | |
1181 | C | A | 0.0000 | |
1182 | E | A | -3.0390 | |
1183 | K | A | -3.1805 | |
1184 | N | A | -2.5518 | |
1185 | N | A | -2.8870 | |
1186 | L | A | 0.0000 | |
1187 | N | A | -1.2856 | |
1188 | F | A | 0.0000 | |
1189 | L | A | 0.3005 | |
1190 | M | A | 0.9502 | |
1191 | G | A | -0.2231 | |
1192 | S | A | -0.3760 | |
1193 | W | A | 0.0000 | |
1194 | W | A | 0.0000 | |
1195 | P | A | 0.0000 | |
1196 | N | A | 0.0000 | |
1197 | L | A | 0.0000 | |
1198 | E | A | -1.9555 | |
1199 | D | A | -1.6897 | |
1200 | L | A | 0.0000 | |
1201 | Y | A | -2.2360 | |
1202 | E | A | -2.5645 | |
1203 | A | A | -1.4010 | |
1204 | N | A | -2.0426 | |
1205 | V | A | 0.0000 | |
1206 | P | A | 0.0000 | |
1207 | V | A | 0.0000 | |
1208 | Y | A | -0.5935 | |
1209 | R | A | -0.7422 | |
1210 | F | A | 0.1204 | |
1211 | I | A | 0.3722 | |
1212 | Q | A | 0.0000 | |
1213 | R | A | -1.1318 | |
1214 | P | A | -0.8931 | |
1215 | G | A | 0.0000 | |
1216 | D | A | 0.0000 | |
1217 | L | A | 0.0000 | |
1218 | V | A | 0.0000 | |
1219 | W | A | 0.0000 | |
1220 | I | A | 0.0000 | |
1221 | N | A | 0.0000 | |
1222 | A | A | 0.0000 | |
1223 | G | A | 0.0000 | |
1224 | T | A | 0.0000 | |
1225 | V | A | 0.0000 | |
1226 | H | A | 0.0000 | |
1227 | W | A | 0.0000 | |
1228 | V | A | 0.0000 | |
1229 | Q | A | 0.0000 | |
1230 | A | A | 0.0000 | |
1231 | I | A | 1.0353 | |
1232 | G | A | 0.3405 | |
1233 | W | A | 0.3876 | |
1234 | C | A | 0.0000 | |
1235 | N | A | 0.0000 | |
1236 | N | A | 0.0000 | |
1237 | I | A | 0.0000 | |
1238 | A | A | 0.0000 | |
1239 | W | A | 0.0000 | |
1240 | N | A | 0.0000 | |
1241 | V | A | 0.0000 | |
1242 | G | A | 0.0000 | |
1243 | P | A | 0.0000 | |
1244 | L | A | 0.3574 | |
1245 | T | A | -0.1816 | |
1246 | A | A | 0.0000 | |
1247 | C | A | -0.0751 | |
1248 | Q | A | 0.0000 | |
1249 | Y | A | 0.0000 | |
1250 | K | A | -1.1267 | |
1251 | L | A | -0.7431 | |
1252 | A | A | 0.0000 | |
1253 | V | A | -0.9504 | |
1254 | E | A | -2.3140 | |
1255 | R | A | 0.0000 | |
1256 | Y | A | 0.0000 | |
1257 | E | A | -0.9914 | |
1258 | W | A | 0.0000 | |
1259 | N | A | 0.0000 | |
1260 | K | A | -0.5242 | |
1261 | L | A | 0.6014 | |
1262 | Q | A | -0.2526 | |
1263 | S | A | -0.0707 | |
1264 | V | A | -0.0054 | |
1265 | K | A | -0.6121 | |
1266 | S | A | 0.0000 | |
1267 | I | A | 0.9488 | |
1268 | V | A | 0.0000 | |
1269 | P | A | 0.0000 | |
1270 | M | A | 0.0000 | |
1271 | V | A | 0.0000 | |
1272 | H | A | 0.0000 | |
1273 | L | A | 0.0000 | |
1274 | S | A | 0.0000 | |
1275 | W | A | 0.0000 | |
1276 | N | A | -0.8354 | |
1277 | M | A | 0.0000 | |
1278 | A | A | 0.0000 | |
1279 | R | A | -2.0653 | |
1280 | N | A | -2.0205 | |
1281 | I | A | -1.3633 | |
1282 | K | A | -2.1224 | |
1283 | V | A | 0.0000 | |
1284 | S | A | -1.1877 | |
1285 | D | A | -1.7594 | |
1286 | P | A | -1.6481 | |
1287 | K | A | -2.2106 | |
1288 | L | A | 0.0000 | |
1289 | F | A | -1.1230 | |
1290 | E | A | -0.9358 | |
1291 | M | A | -0.5709 | |
1292 | I | A | 0.0000 | |
1293 | K | A | 0.0000 | |
1294 | Y | A | 0.6434 | |
1295 | C | A | 0.0000 | |
1296 | L | A | 0.0000 | |
1297 | L | A | 0.0000 | |
1298 | R | A | -1.0347 | |
1299 | T | A | -0.6546 | |
1300 | L | A | 0.0000 | |
1301 | K | A | -1.2981 | |
1302 | Q | A | -1.6764 | |
1303 | C | A | 0.0000 | |
1304 | Q | A | 0.0000 | |
1305 | T | A | -0.4183 | |
1306 | L | A | -0.2121 | |
1307 | R | A | -0.2582 | |
1308 | E | A | -0.0807 | |
1309 | A | A | 0.3858 | |
1310 | L | A | 0.0000 | |
1311 | I | A | 1.2183 | |
1312 | A | A | 0.5370 | |
1313 | A | A | -0.1260 | |
1314 | G | A | -0.4188 | |
1315 | K | A | -1.0100 | |
1316 | E | A | -1.0428 | |
1317 | I | A | 0.3232 | |
1318 | I | A | 1.1570 | |
1319 | W | A | 0.9811 | |
1320 | H | A | 0.3726 | |
1321 | G | A | 0.0000 | |
1322 | R | A | -1.2280 | |
1323 | T | A | -1.8300 | |
1324 | K | A | -2.8862 | |
1325 | E | A | -3.0248 | |
1326 | E | A | -2.0816 | |
1327 | P | A | -1.2951 | |
1328 | A | A | -0.4147 | |
1329 | H | A | -0.0520 | |
1330 | Y | A | 0.3371 | |
1331 | C | A | 0.0000 | |
1332 | S | A | 0.9296 | |
1333 | I | A | 1.5942 | |
1334 | C | A | 0.3237 | |
1335 | E | A | -0.0666 | |
1336 | V | A | 0.2053 | |
1337 | E | A | -0.1314 | |
1338 | V | A | 0.0000 | |
1339 | F | A | 0.2699 | |
1340 | D | A | 0.0000 | |
1341 | L | A | 0.0000 | |
1342 | L | A | 0.0000 | |
1343 | F | A | 0.0000 | |
1344 | V | A | 0.0000 | |
1345 | T | A | -1.4569 | |
1346 | N | A | -2.6789 | |
1347 | E | A | -2.4437 | |
1348 | S | A | 0.0000 | |
1349 | N | A | -2.0124 | |
1350 | S | A | -2.3818 | |
1351 | R | A | -3.1036 | |
1352 | K | A | -2.7659 | |
1353 | T | A | -1.2352 | |
1354 | Y | A | -0.3431 | |
1355 | I | A | 0.6754 | |
1356 | V | A | 0.0000 | |
1357 | H | A | 0.0000 | |
1358 | C | A | -0.4886 | |
1359 | Q | A | -1.5476 | |
1360 | D | A | -2.4546 | |
1361 | C | A | 0.0000 | |
1362 | A | A | 0.0000 | |
1363 | R | A | -3.1423 | |
1364 | K | A | -2.8865 | |
1365 | T | A | -2.0733 | |
1366 | S | A | 0.0000 | |
1367 | G | A | -2.5452 | |
1368 | N | A | -2.6754 | |
1369 | L | A | 0.0000 | |
1370 | E | A | -3.0621 | |
1371 | N | A | -2.5887 | |
1372 | F | A | 0.0000 | |
1373 | V | A | 0.0000 | |
1374 | V | A | 0.0000 | |
1375 | L | A | 0.0000 | |
1376 | E | A | 0.0000 | |
1377 | Q | A | 0.0000 | |
1378 | Y | A | 0.0000 | |
1379 | K | A | -2.2251 | |
1380 | M | A | 0.0000 | |
1381 | E | A | -2.9261 | |
1382 | D | A | -2.5916 | |
1383 | L | A | 0.0000 | |
1384 | M | A | -1.9463 | |
1385 | Q | A | -2.6496 | |
1386 | V | A | 0.0000 | |
1387 | Y | A | 0.0000 | |
1388 | D | A | -1.5755 | |
1389 | Q | A | -2.1110 | |
1390 | F | A | 0.0000 | |
1391 | T | A | -0.8951 | |
1392 | L | A | -0.6564 | |
1393 | A | A | -0.6924 | |
1394 | P | A | -0.5988 |