Chain sequence(s) |
A: MQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTNYSVTDLNVQRKAIHELIQVMAELSPAAKT B: MQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTNYSVTDLNVQRKAIHELIQVMAELSPAAKT |
Distance of aggregation | 10 Å |
Dynamic mode | No |
Mutated residues | EA38A, EB38A |
Energy difference between WT (input) and mutated protein (by FoldX) | 0.505198 kcal/mol
Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
0 | M | A | -0.0315 | |
1 | Q | A | -1.7773 | |
2 | D | A | -2.4148 | |
3 | P | A | -1.6213 | |
4 | Y | A | 0.0000 | |
5 | V | A | -1.7585 | |
6 | K | A | -2.3813 | |
7 | E | A | 0.0000 | |
8 | A | A | 0.0000 | |
9 | E | A | -2.4722 | |
10 | N | A | -2.0458 | |
11 | L | A | 0.0000 | |
12 | K | A | -2.2370 | |
13 | K | A | -2.5822 | |
14 | Y | A | -0.7415 | |
15 | F | A | -1.0450 | |
16 | N | A | -2.0643 | |
17 | A | A | 0.0000 | |
18 | G | A | -2.2078 | |
19 | H | A | -2.2075 | |
20 | S | A | -1.8117 | |
21 | D | A | -2.5827 | |
22 | V | A | 0.0000 | |
23 | A | A | -1.9920 | |
24 | D | A | -2.9673 | |
25 | N | A | -2.5524 | |
26 | G | A | -1.5691 | |
27 | T | A | -0.8740 | |
28 | L | A | 0.0000 | |
29 | F | A | 0.0000 | |
30 | L | A | -0.7491 | |
31 | G | A | -0.9281 | |
32 | I | A | 0.0000 | |
33 | L | A | 0.0000 | |
34 | K | A | -2.5437 | |
35 | N | A | -2.0729 | |
36 | W | A | 0.0000 | |
37 | K | A | -2.9593 | |
38 | A | A | -1.9025 | mutated: EA38A |
39 | E | A | -2.5964 | |
40 | S | A | -1.5292 | |
41 | D | A | -1.3650 | |
42 | R | A | -1.9561 | |
43 | K | A | 0.0000 | |
44 | I | A | 0.0000 | |
45 | M | A | 0.0000 | |
46 | Q | A | 0.0000 | |
47 | S | A | 0.0000 | |
48 | Q | A | 0.0000 | |
49 | I | A | 0.0000 | |
50 | V | A | 0.0000 | |
51 | S | A | -0.5647 | |
52 | F | A | 0.0000 | |
53 | Y | A | 0.0000 | |
54 | F | A | -1.2636 | |
55 | K | A | -2.1636 | |
56 | L | A | 0.0000 | |
57 | F | A | 0.0000 | |
58 | K | A | -3.3042 | |
59 | N | A | -2.9678 | |
60 | F | A | -2.6062 | |
61 | K | A | -3.3022 | |
62 | D | A | -3.3442 | |
63 | D | A | -2.7343 | |
64 | Q | A | -2.5922 | |
65 | S | A | -1.5229 | |
66 | I | A | 0.0000 | |
67 | Q | A | -2.4918 | |
68 | K | A | -2.6397 | |
69 | S | A | 0.0000 | |
70 | V | A | 0.0000 | |
71 | E | A | -3.2260 | |
72 | T | A | -2.3700 | |
73 | I | A | 0.0000 | |
74 | K | A | -2.2772 | |
75 | E | A | -2.5241 | |
76 | D | A | -1.7159 | |
77 | M | A | 0.0000 | |
78 | N | A | -1.4704 | |
79 | V | A | -0.6377 | |
80 | K | A | -0.9550 | |
81 | F | A | 0.0000 | |
82 | F | A | 0.0000 | |
83 | N | A | -1.6691 | |
84 | S | A | -1.7709 | |
85 | N | A | -2.6003 | |
86 | K | A | -3.3650 | |
87 | K | A | -3.3666 | |
88 | K | A | 0.0000 | |
89 | R | A | -2.9084 | |
90 | D | A | -3.2530 | |
91 | D | A | 0.0000 | |
92 | F | A | 0.0000 | |
93 | E | A | -2.6423 | |
94 | K | A | -2.7504 | |
95 | L | A | 0.0000 | |
96 | T | A | -1.6713 | |
97 | N | A | -1.9136 | |
98 | Y | A | -0.9640 | |
99 | S | A | -0.5057 | |
100 | V | A | -0.5267 | |
101 | T | A | -0.4380 | |
102 | D | A | -0.5760 | |
103 | L | A | 0.4460 | |
104 | N | A | -0.9868 | |
105 | V | A | -0.3975 | |
106 | Q | A | 0.0000 | |
107 | R | A | -1.2192 | |
108 | K | A | -1.3070 | |
109 | A | A | 0.0000 | |
110 | I | A | 0.0000 | |
111 | H | A | -1.3980 | |
112 | E | A | 0.0000 | |
113 | L | A | 0.0000 | |
114 | I | A | -0.9247 | |
115 | Q | A | -1.3184 | |
116 | V | A | 0.0000 | |
117 | M | A | 0.0000 | |
118 | A | A | -1.1178 | |
119 | E | A | -1.4803 | |
120 | L | A | 0.0000 | |
121 | S | A | -0.7164 | |
122 | P | A | -0.7586 | |
123 | A | A | -0.9699 | |
124 | A | A | -1.0780 | |
125 | K | A | -1.6985 | |
126 | T | A | -0.8818 | |
0 | M | B | -0.0072 | |
1 | Q | B | -1.9368 | |
2 | D | B | -2.5378 | |
3 | P | B | -1.7621 | |
4 | Y | B | 0.0000 | |
5 | V | B | 0.0000 | |
6 | K | B | -2.7778 | |
7 | E | B | 0.0000 | |
8 | A | B | 0.0000 | |
9 | E | B | -2.4385 | |
10 | N | B | -1.9329 | |
11 | L | B | 0.0000 | |
12 | K | B | 0.0000 | |
13 | K | B | -2.4262 | |
14 | Y | B | -0.6126 | |
15 | F | B | -0.9005 | |
16 | N | B | -2.2207 | |
17 | A | B | 0.0000 | |
18 | G | B | -2.1382 | |
19 | H | B | -2.2786 | |
20 | S | B | -1.7219 | |
21 | D | B | -2.7001 | |
22 | V | B | 0.0000 | |
23 | A | B | -2.0232 | |
24 | D | B | -2.9867 | |
25 | N | B | -2.5578 | |
26 | G | B | -1.5697 | |
27 | T | B | -0.8898 | |
28 | L | B | 0.0000 | |
29 | F | B | 0.0000 | |
30 | L | B | -0.8471 | |
31 | G | B | -0.9524 | |
32 | I | B | 0.0000 | |
33 | L | B | 0.0000 | |
34 | K | B | -2.4108 | |
35 | N | B | -2.1581 | |
36 | W | B | 0.0000 | |
37 | K | B | -2.3503 | |
38 | A | B | -1.1346 | mutated: EB38A |
39 | E | B | -1.2470 | |
40 | S | B | -1.1259 | |
41 | D | B | -0.9745 | |
42 | R | B | 0.0000 | |
43 | K | B | 0.0000 | |
44 | I | B | 0.0000 | |
45 | M | B | 0.0000 | |
46 | Q | B | 0.0000 | |
47 | S | B | 0.0000 | |
48 | Q | B | 0.0000 | |
49 | I | B | 0.0000 | |
50 | V | B | 0.0000 | |
51 | S | B | -0.5315 | |
52 | F | B | 0.0000 | |
53 | Y | B | 0.0000 | |
54 | F | B | -1.1716 | |
55 | K | B | -2.0312 | |
56 | L | B | 0.0000 | |
57 | F | B | 0.0000 | |
58 | K | B | -3.3595 | |
59 | N | B | -2.8572 | |
60 | F | B | -2.7459 | |
61 | K | B | -3.9592 | |
62 | D | B | -3.5430 | |
63 | D | B | -2.8053 | |
64 | Q | B | -2.6512 | |
65 | S | B | -1.5488 | |
66 | I | B | 0.0000 | |
67 | Q | B | -2.8434 | |
68 | K | B | -2.7945 | |
69 | S | B | 0.0000 | |
70 | V | B | 0.0000 | |
71 | E | B | -3.4863 | |
72 | T | B | -2.5678 | |
73 | I | B | 0.0000 | |
74 | K | B | -2.5175 | |
75 | E | B | -2.6210 | |
76 | D | B | -1.7481 | |
77 | M | B | 0.0000 | |
78 | N | B | -1.4658 | |
79 | V | B | -0.5419 | |
80 | K | B | -0.8744 | |
81 | F | B | 0.0000 | |
82 | F | B | 0.0000 | |
83 | N | B | -1.6402 | |
84 | S | B | -1.7046 | |
85 | N | B | -2.6248 | |
86 | K | B | -3.3720 | |
87 | K | B | -3.2957 | |
88 | K | B | 0.0000 | |
89 | R | B | -3.0062 | |
90 | D | B | -3.5639 | |
91 | D | B | 0.0000 | |
92 | F | B | 0.0000 | |
93 | E | B | -2.7496 | |
94 | K | B | -2.7633 | |
95 | L | B | 0.0000 | |
96 | T | B | -1.6761 | |
97 | N | B | -1.8795 | |
98 | Y | B | -0.9596 | |
99 | S | B | -0.4985 | |
100 | V | B | -0.5618 | |
101 | T | B | -0.4697 | |
102 | D | B | -0.5571 | |
103 | L | B | 0.4916 | |
104 | N | B | -0.8383 | |
105 | V | B | -0.3817 | |
106 | Q | B | -0.3191 | |
107 | R | B | -1.2169 | |
108 | K | B | -1.2908 | |
109 | A | B | 0.0000 | |
110 | I | B | 0.0000 | |
111 | H | B | -1.3984 | |
112 | E | B | 0.0000 | |
113 | L | B | 0.0000 | |
114 | I | B | -0.7786 | |
115 | Q | B | -1.0328 | |
116 | V | B | 0.0000 | |
117 | M | B | 0.0000 | |
118 | A | B | -1.0551 | |
119 | E | B | -1.8960 | |
120 | L | B | 0.0000 | |
121 | S | B | -0.9923 | |
122 | P | B | -1.4536 | |
123 | A | B | -1.2912 | |
124 | A | B | -0.8173 | |
125 | K | B | -1.7182 | |
126 | T | B | -1.6589 |