Project name: human acid-beta-glucosidase

Chain sequence(s)	A: ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQQANHTGTGLLLTLQPEQQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDDRGMQYSHSIITNLLYHVVGWTDWNLALNPEEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWHRQ
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -2.9196
• Maximal score value: 2.594
• Average score: -0.4608
• Total score value: -229.0334

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	A	A	-1.3031
2	R	A	-1.5441
3	P	A	-1.0026
4	C	A	-0.4874
5	I	A	0.3700
6	P	A	-0.4802
7	K	A	-0.7660
8	S	A	-0.3035
9	F	A	0.3887
10	G	A	-0.0423
11	Y	A	0.2398
12	S	A	-0.3850
13	S	A	0.0000
14	V	A	-0.3794
15	V	A	0.0000
16	C	A	0.0000
17	V	A	0.0000
18	C	A	0.0000
19	N	A	-0.6515
20	A	A	-0.5231
21	T	A	-0.0390
22	Y	A	-0.0042
23	C	A	0.0000
24	D	A	-0.5044
25	S	A	-1.1695
26	F	A	-1.5017
27	D	A	-2.3123
28	P	A	-1.3128
29	P	A	-0.5369
30	T	A	0.3999
31	F	A	1.8548
32	P	A	1.0848
33	A	A	0.5381
34	L	A	0.5181
35	G	A	-0.2104
36	T	A	0.2523
37	F	A	0.0000
38	S	A	0.0000
39	R	A	-0.0393
40	Y	A	-0.2590
41	E	A	0.0000
42	S	A	0.0000
43	T	A	0.0000
44	R	A	-1.7146
45	S	A	-1.1828
46	G	A	-1.4086
47	R	A	-2.1961
48	R	A	0.0000
49	M	A	0.0000
50	E	A	-1.4253
51	L	A	0.0376
52	S	A	0.2440
53	M	A	0.6846
54	G	A	-0.1432
55	P	A	-0.4549
56	I	A	0.0000
57	Q	A	-1.7539
58	A	A	-1.2533
59	N	A	-1.8897
60	H	A	-1.4959
61	T	A	-0.9420
62	G	A	-0.6192
63	T	A	-0.4000
64	G	A	-0.6693
65	L	A	0.0000
66	L	A	-0.1075
67	L	A	0.0000
68	T	A	0.3593
69	L	A	0.0000
70	Q	A	-1.2236
71	P	A	0.0000
72	E	A	-2.8427
73	Q	A	-2.7158
74	K	A	-2.5593
75	F	A	-1.0386
76	Q	A	-1.0434
77	K	A	-2.3232
78	V	A	0.0000
79	K	A	-1.2631
80	G	A	0.0000
81	F	A	0.0000
82	G	A	0.0000
83	G	A	0.0000
84	A	A	0.0000
85	M	A	0.0000
86	T	A	0.0000
87	D	A	0.0000
88	A	A	0.0000
89	A	A	0.0000
90	A	A	0.0000
91	L	A	0.7377
92	N	A	0.0000
93	I	A	0.0000
94	L	A	0.4603
95	A	A	0.5634
96	L	A	0.0000
97	S	A	-0.1911
98	P	A	-0.4303
99	P	A	-0.5036
100	A	A	0.0000
101	Q	A	0.0000
102	N	A	-0.5973
103	L	A	-0.3078
104	L	A	0.0000
105	L	A	0.0000
106	K	A	-0.9381
107	S	A	0.0000
108	Y	A	0.0000
109	F	A	0.0000
110	S	A	0.0000
111	E	A	-1.7295
112	E	A	-1.7699
113	G	A	0.0000
114	I	A	0.0000
115	G	A	0.0000
116	Y	A	0.0000
117	N	A	0.0000
118	I	A	0.0000
119	I	A	0.0000
120	R	A	0.0000
121	V	A	0.0000
122	P	A	0.0000
123	M	A	0.0000
124	A	A	0.0000
125	S	A	0.0000
126	C	A	0.0000
127	D	A	0.0000
128	F	A	0.0000
129	S	A	0.0000
130	I	A	1.7633
131	R	A	0.1803
132	T	A	0.0208
133	Y	A	0.0000
134	T	A	0.0000
135	Y	A	0.0000
136	A	A	0.0000
137	D	A	-1.9520
138	T	A	-1.6228
139	P	A	-1.6223
140	D	A	-2.1384
141	D	A	0.0000
142	F	A	-0.8754
143	Q	A	-1.7286
144	L	A	0.0000
145	H	A	-1.9346
146	N	A	-2.0757
147	F	A	-1.2279
148	S	A	-0.8829
149	L	A	-0.6374
150	P	A	-1.1390
151	E	A	-2.4453
152	E	A	0.0000
153	D	A	0.0000
154	T	A	-1.5511
155	K	A	-2.3429
156	L	A	0.0000
157	K	A	0.0000
158	I	A	0.0000
159	P	A	-0.8207
160	L	A	0.0000
161	I	A	0.0000
162	H	A	-1.0185
163	R	A	-0.9870
164	A	A	0.0000
165	L	A	-0.3831
166	Q	A	-1.2271
167	L	A	-0.7910
168	A	A	-0.8538
169	Q	A	-1.3345
170	R	A	-1.0168
171	P	A	-0.6516
172	V	A	-0.1985
173	S	A	-0.1178
174	L	A	0.0000
175	L	A	0.0000
176	A	A	0.0000
177	S	A	0.0000
178	P	A	0.0000
179	W	A	0.0000
180	T	A	0.0000
181	S	A	0.0000
182	P	A	0.0000
183	T	A	-0.7390
184	W	A	-0.8917
185	L	A	0.0000
186	K	A	0.0000
187	T	A	-1.0915
188	N	A	-1.3225
189	G	A	-0.8195
190	A	A	-0.5862
191	V	A	-0.2066
192	N	A	-0.6490
193	G	A	-0.9641
194	K	A	-1.4778
195	G	A	0.0000
196	S	A	-0.9410
197	L	A	0.0000
198	K	A	-1.2480
199	G	A	-1.2672
200	Q	A	-1.8847
201	P	A	-1.5897
202	G	A	-1.0972
203	D	A	-0.4644
204	I	A	1.1640
205	Y	A	0.1179
206	H	A	0.0000
207	Q	A	-0.4571
208	T	A	0.0000
209	W	A	0.0000
210	A	A	0.0000
211	R	A	-1.1263
212	Y	A	0.0000
213	F	A	0.0000
214	V	A	-0.7682
215	K	A	-0.8735
216	F	A	0.0000
217	L	A	0.0000
218	D	A	-1.7824
219	A	A	-1.4653
220	Y	A	0.0000
221	A	A	-2.3133
222	E	A	-2.8652
223	H	A	-2.3483
224	K	A	-2.8378
225	L	A	0.0000
226	Q	A	-1.9086
227	F	A	0.0000
228	W	A	-0.6023
229	A	A	0.0000
230	V	A	0.0000
231	T	A	0.0000
232	A	A	0.0000
233	E	A	0.0000
234	N	A	0.0000
235	E	A	-0.2740
236	P	A	0.0000
237	S	A	0.0614
238	A	A	0.0000
239	G	A	0.0000
240	L	A	0.3015
241	L	A	0.7133
242	S	A	-0.3807
243	G	A	-0.6353
244	Y	A	-0.1819
245	P	A	-0.2503
246	F	A	0.0000
247	Q	A	0.0000
248	C	A	0.0000
249	L	A	0.0000
250	G	A	0.0000
251	F	A	0.0000
252	T	A	-0.7020
253	P	A	-1.3165
254	E	A	-2.0106
255	H	A	-1.5277
256	Q	A	0.0000
257	R	A	-1.9778
258	D	A	-2.4773
259	F	A	0.0000
260	I	A	0.0000
261	A	A	-2.2164
262	R	A	-2.7255
263	D	A	0.0000
264	L	A	0.0000
265	G	A	0.0000
266	P	A	-1.2954
267	T	A	-1.0926
268	L	A	0.0000
269	A	A	-1.2064
270	N	A	-1.5365
271	S	A	-1.3187
272	T	A	-0.9951
273	H	A	-1.5781
274	H	A	-2.1283
275	N	A	-2.0223
276	V	A	-1.5720
277	R	A	-1.7365
278	L	A	0.0000
279	L	A	0.0000
280	M	A	0.0000
281	L	A	0.0000
282	D	A	0.0000
283	D	A	0.0000
284	Q	A	-0.0185
285	R	A	0.0000
286	L	A	1.3999
287	L	A	0.5552
288	L	A	0.0000
289	P	A	0.0000
290	H	A	-1.0726
291	W	A	0.0000
292	A	A	0.0000
293	K	A	-1.3036
294	V	A	-1.2088
295	V	A	0.0000
296	L	A	0.0000
297	T	A	-0.7341
298	D	A	-1.4918
299	P	A	-1.6904
300	E	A	-2.9196
301	A	A	0.0000
302	A	A	-1.5094
303	K	A	-2.2058
304	Y	A	-1.1453
305	V	A	0.0000
306	H	A	-0.9928
307	G	A	0.0000
308	I	A	0.0000
309	A	A	0.0000
310	V	A	0.0000
311	H	A	0.0000
312	W	A	0.7188
313	Y	A	0.9033
314	L	A	0.0000
315	D	A	0.8929
316	F	A	2.5766
317	L	A	2.5940
318	A	A	0.0000
319	P	A	-0.1768
320	A	A	-0.6422
321	K	A	-2.2435
322	A	A	-1.1523
323	T	A	0.0000
324	L	A	0.0000
325	G	A	-1.8724
326	E	A	-2.3516
327	T	A	0.0000
328	H	A	-1.8253
329	R	A	-2.5032
330	L	A	-1.0464
331	F	A	-1.0033
332	P	A	-1.4652
333	N	A	-1.5280
334	T	A	-0.6169
335	M	A	-0.5391
336	L	A	0.0000
337	F	A	0.0000
338	A	A	0.0000
339	S	A	0.0000
340	E	A	0.0000
341	A	A	0.0000
342	C	A	0.0000
343	V	A	0.0000
344	G	A	0.0000
345	S	A	0.4052
346	K	A	0.7286
347	F	A	2.0354
348	W	A	1.6048
349	E	A	0.2404
350	Q	A	-1.0121
351	S	A	-0.9720
352	V	A	0.0000
353	R	A	-0.7497
354	L	A	-0.0050
355	G	A	0.0000
356	S	A	0.0000
357	W	A	0.0000
358	D	A	-1.4608
359	R	A	0.0000
360	G	A	0.0000
361	M	A	0.0000
362	Q	A	-0.8395
363	Y	A	0.0000
364	S	A	0.0000
365	H	A	-0.5008
366	S	A	0.0000
367	I	A	0.0000
368	I	A	0.0000
369	T	A	-0.0788
370	N	A	0.0000
371	L	A	0.0000
372	L	A	0.4907
373	Y	A	-0.0484
374	H	A	-0.1348
375	V	A	0.0000
376	V	A	-0.5272
377	G	A	0.0000
378	W	A	0.0000
379	T	A	0.0000
380	D	A	0.0000
381	W	A	0.0000
382	N	A	0.0000
383	L	A	0.0000
384	A	A	0.0000
385	L	A	0.0000
386	N	A	-0.6568
387	P	A	-1.0189
388	E	A	-2.4227
389	G	A	0.0000
390	G	A	0.0000
391	P	A	-0.1637
392	N	A	-0.1403
393	W	A	0.6240
394	V	A	0.0890
395	R	A	-1.4079
396	N	A	-1.5773
397	F	A	-0.6156
398	V	A	0.0000
399	D	A	0.0000
400	S	A	0.0000
401	P	A	0.0000
402	I	A	0.0000
403	I	A	0.0000
404	V	A	0.0000
405	D	A	-0.4618
406	I	A	0.5926
407	T	A	-0.2753
408	K	A	-1.3014
409	D	A	-0.8508
410	T	A	0.0000
411	F	A	0.0000
412	Y	A	0.0000
413	K	A	0.0000
414	Q	A	0.0000
415	P	A	0.0000
416	M	A	0.0000
417	F	A	0.0000
418	Y	A	0.0000
419	H	A	0.0000
420	L	A	0.0000
421	G	A	0.0000
422	H	A	0.0000
423	F	A	0.0000
424	S	A	0.0000
425	K	A	-0.4846
426	F	A	0.0000
427	I	A	0.0000
428	P	A	-1.2297
429	E	A	-1.9690
430	G	A	-1.7425
431	S	A	0.0000
432	Q	A	-1.5663
433	R	A	-1.0005
434	V	A	0.0000
435	G	A	0.0000
436	L	A	0.6720
437	V	A	1.4011
438	A	A	0.0248
439	S	A	-0.7315
440	Q	A	-2.0491
441	K	A	-2.8510
442	N	A	-2.3733
443	D	A	-2.3656
444	L	A	-1.2351
445	D	A	-0.7722
446	A	A	0.0243
447	V	A	0.0000
448	A	A	0.0000
449	L	A	0.0000
450	M	A	-0.8921
451	H	A	-1.3376
452	P	A	-1.6634
453	D	A	-2.0622
454	G	A	-1.3956
455	S	A	0.0000
456	A	A	0.0000
457	V	A	0.0000
458	V	A	0.0000
459	V	A	0.0000
460	V	A	0.0000
461	L	A	0.0000
462	N	A	0.0000
463	R	A	-1.6664
464	S	A	-1.5466
465	S	A	-1.5283
466	K	A	-2.9130
467	D	A	-2.5051
468	V	A	-1.3629
469	P	A	-0.6163
470	L	A	0.0000
471	T	A	0.0000
472	I	A	0.0000
473	K	A	-0.4623
474	D	A	0.0000
475	P	A	-0.3509
476	A	A	-0.2966
477	V	A	-0.2476
478	G	A	-0.8209
479	F	A	-0.9421
480	L	A	0.0000
481	E	A	-0.9248
482	T	A	0.0585
483	I	A	0.2568
484	S	A	0.0000
485	P	A	-1.2064
486	G	A	-1.6472
487	Y	A	-1.0841
488	S	A	0.0000
489	I	A	0.0000
490	H	A	0.0000
491	T	A	0.0000
492	Y	A	0.0000
493	L	A	0.0000
494	W	A	0.0000
495	H	A	-0.3794
496	R	A	-0.9245
497	Q	A	-1.1367