Chain sequence(s) |
A: MSVAHVALPVPLPRTFDYLLPEKAGCRVRVPFGKQERIGIVAAVLKPVLDDEPVFSTTVWRLLMWAAEYYHHPIGDVLFHALPVMLRQGKPASATRLNTEQATAVGAIHSAADDRFSAWLLAGITGSGKTEVYLSVLENVLAQGRQALVMVPEIGLTPQTIARFRQRFNAPVEVLHSGLNDSERLSAWLKAKNGEAAIVIGTRSSLFTPFKDLGVIVIDEEHDSSYKQQEGWRYHARDLAVWRAHSEQIPIILGSATPALETLHNVRQGKYRQLTLSQQHVLDLKGQPLQAGLSPALISRMRQHLQADNQVILFLNRRGFAPALLCHDCGWIAECPRCDSYYTLHQAQHHLRCHHCDSQRPIPRQCPSCGSTHLVPVGIGTEQLEQALAPLLDVDGALFSADFRSAERFAQLYTQVSGRKQGEVILQTHHPEHPLLQTLLYKGYDAFAEQALAERQTMQLPPWTSHVLIRAEDHNNQQAPLFLQQLRNLLQASPLADEKLWVLGPVPALARWQILLQHPSRVRLQHIVSGTLALINTLVKWVLDVDPIEG C: IPF |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
175 | I | C | 1.9469 | |
176 | P | C | 0.9720 | |
177 | F | C | 0.7226 | |
1 | M | A | 1.1264 | |
2 | S | A | 0.8054 | |
3 | V | A | 1.0568 | |
4 | A | A | 0.0000 | |
5 | H | A | -0.2835 | |
6 | V | A | 0.0000 | |
7 | A | A | 0.0000 | |
8 | L | A | 0.0000 | |
9 | P | A | -0.3885 | |
10 | V | A | 0.0000 | |
11 | P | A | -0.2831 | |
12 | L | A | 0.1216 | |
13 | P | A | -0.9685 | |
14 | R | A | -1.7273 | |
15 | T | A | -0.9912 | |
16 | F | A | -0.5166 | |
17 | D | A | -0.5728 | |
18 | Y | A | 0.0000 | |
19 | L | A | 0.8432 | |
20 | L | A | 0.8481 | |
21 | P | A | -0.5470 | |
22 | E | A | -1.7670 | |
27 | K | A | -1.9279 | |
28 | A | A | -0.6509 | |
29 | G | A | 0.0000 | |
30 | C | A | 0.0000 | |
31 | R | A | 0.0000 | |
32 | V | A | -0.2548 | |
33 | R | A | -1.8098 | |
34 | V | A | 0.0000 | |
35 | P | A | -1.9512 | |
36 | F | A | -1.6609 | |
37 | G | A | -1.8413 | |
38 | K | A | -2.8608 | |
39 | Q | A | -3.0699 | |
40 | E | A | -3.4025 | |
41 | R | A | -2.6083 | |
42 | I | A | -1.4904 | |
43 | G | A | 0.0000 | |
44 | I | A | 0.0000 | |
45 | V | A | 0.0000 | |
46 | A | A | 0.0480 | |
47 | A | A | 0.3683 | |
48 | V | A | 1.3427 | |
59 | L | A | 0.8687 | |
60 | K | A | -0.5745 | |
61 | P | A | 0.0662 | |
62 | V | A | 0.6713 | |
66 | L | A | -0.4570 | |
67 | D | A | -1.6971 | |
68 | D | A | -2.8897 | |
69 | E | A | -3.0176 | |
70 | P | A | -1.7581 | |
71 | V | A | 0.0000 | |
72 | F | A | 0.0000 | |
73 | S | A | -0.8487 | |
74 | T | A | -0.5689 | |
75 | T | A | -0.7777 | |
76 | V | A | 0.0000 | |
77 | W | A | -0.6735 | |
78 | R | A | -1.6557 | |
79 | L | A | 0.0000 | |
80 | L | A | 0.0000 | |
81 | M | A | -0.6013 | |
82 | W | A | -0.6328 | |
83 | A | A | 0.0000 | |
84 | A | A | 0.0000 | |
85 | E | A | -1.9084 | |
86 | Y | A | 0.0000 | |
87 | Y | A | 0.0000 | |
88 | H | A | -0.7701 | |
89 | H | A | -0.6255 | |
90 | P | A | -0.7883 | |
91 | I | A | -0.6084 | |
92 | G | A | 0.0000 | |
93 | D | A | -0.7186 | |
94 | V | A | 0.0000 | |
95 | L | A | 0.0000 | |
96 | F | A | 0.0000 | |
97 | H | A | -0.4562 | |
98 | A | A | -0.1878 | |
99 | L | A | 0.0000 | |
100 | P | A | 0.0000 | |
101 | V | A | 0.1230 | |
102 | M | A | -0.5596 | |
103 | L | A | 0.0000 | |
104 | R | A | -0.9664 | |
105 | Q | A | -1.7153 | |
106 | G | A | -1.3644 | |
107 | K | A | -1.2748 | |
108 | P | A | -0.7892 | |
109 | A | A | -0.7698 | |
110 | S | A | -0.4711 | |
111 | A | A | -0.3370 | |
112 | T | A | -0.0985 | |
197 | R | A | -1.8893 | |
198 | L | A | -1.1452 | |
199 | N | A | -1.7241 | |
200 | T | A | -1.0194 | |
201 | E | A | -1.3164 | |
202 | Q | A | 0.0000 | |
203 | A | A | -0.8240 | |
204 | T | A | -0.6708 | |
205 | A | A | 0.0000 | |
206 | V | A | 0.0000 | |
207 | G | A | -0.7518 | |
208 | A | A | -0.4189 | |
209 | I | A | 0.0000 | |
210 | H | A | -1.2985 | |
211 | S | A | -1.1600 | |
212 | A | A | -1.3926 | |
213 | A | A | -1.9590 | |
214 | D | A | -2.9945 | |
215 | R | A | -3.1666 | |
216 | F | A | -1.7267 | |
217 | S | A | -1.3817 | |
218 | A | A | 0.0000 | |
219 | W | A | 0.0000 | |
220 | L | A | 0.0000 | |
221 | L | A | 0.0000 | |
222 | A | A | 0.1174 | |
223 | G | A | 0.0000 | |
224 | I | A | 1.6411 | |
225 | T | A | 0.2728 | |
226 | G | A | -0.1535 | |
227 | S | A | 0.1756 | |
228 | G | A | -0.0450 | |
229 | K | A | 0.0000 | |
230 | T | A | -0.3079 | |
231 | E | A | -0.4720 | |
232 | V | A | 0.0000 | |
233 | Y | A | 0.0000 | |
234 | L | A | 0.0000 | |
235 | S | A | -1.2025 | |
236 | V | A | 0.0000 | |
237 | L | A | 0.0000 | |
238 | E | A | -2.5442 | |
239 | N | A | -1.8007 | |
240 | V | A | 0.0000 | |
241 | L | A | -1.5198 | |
242 | A | A | -1.3200 | |
243 | Q | A | -1.7264 | |
244 | G | A | -1.9539 | |
245 | R | A | -2.7489 | |
246 | Q | A | 0.0000 | |
247 | A | A | 0.0000 | |
248 | L | A | 0.0000 | |
249 | V | A | 0.0000 | |
250 | M | A | 0.0000 | |
251 | V | A | 0.0000 | |
252 | P | A | 0.0000 | |
253 | E | A | -1.0772 | |
254 | I | A | 1.0468 | |
255 | G | A | 0.0113 | |
256 | L | A | -0.0397 | |
257 | T | A | -0.2922 | |
258 | P | A | -1.0481 | |
259 | Q | A | -1.7242 | |
260 | T | A | -1.3660 | |
261 | I | A | -1.3697 | |
262 | A | A | -2.2555 | |
263 | R | A | -3.2928 | |
264 | F | A | 0.0000 | |
265 | R | A | -3.2109 | |
266 | Q | A | -3.3863 | |
267 | R | A | -3.4464 | |
268 | F | A | 0.0000 | |
269 | N | A | -2.3029 | |
270 | A | A | -1.4884 | |
271 | P | A | -1.2453 | |
272 | V | A | 0.0000 | |
273 | E | A | -0.8630 | |
274 | V | A | 0.0000 | |
275 | L | A | 0.0000 | |
276 | H | A | -0.8728 | |
277 | S | A | -0.8426 | |
278 | G | A | -1.1265 | |
279 | L | A | -1.3919 | |
280 | N | A | -2.1951 | |
281 | D | A | -1.9433 | |
282 | S | A | -1.4423 | |
283 | E | A | -1.9412 | |
284 | R | A | -1.6071 | |
285 | L | A | 0.0000 | |
286 | S | A | -0.9897 | |
287 | A | A | 0.0000 | |
288 | W | A | 0.0000 | |
289 | L | A | 0.0000 | |
290 | K | A | -1.9776 | |
291 | A | A | 0.0000 | |
292 | K | A | -2.3125 | |
293 | N | A | -2.4199 | |
294 | G | A | -2.9069 | |
295 | E | A | -2.6390 | |
296 | A | A | 0.0000 | |
297 | A | A | -1.4563 | |
298 | I | A | 0.0000 | |
299 | V | A | 0.0000 | |
300 | I | A | 0.0000 | |
301 | G | A | 0.0000 | |
302 | T | A | -0.5798 | |
303 | R | A | -0.6954 | |
304 | S | A | -0.5210 | |
305 | S | A | 0.0000 | |
306 | L | A | 0.0000 | |
307 | F | A | 0.0000 | |
308 | T | A | 0.0000 | |
309 | P | A | 0.0000 | |
310 | F | A | -2.1293 | |
311 | K | A | -3.4711 | |
312 | D | A | -3.3024 | |
313 | L | A | 0.0000 | |
314 | G | A | -1.9388 | |
315 | V | A | 0.0000 | |
316 | I | A | 0.0000 | |
317 | V | A | 0.0000 | |
318 | I | A | 0.0000 | |
319 | D | A | -1.0008 | |
320 | E | A | -1.4361 | |
321 | E | A | 0.0000 | |
322 | H | A | -0.9094 | |
323 | D | A | -1.1833 | |
324 | S | A | -0.9002 | |
325 | S | A | -0.7519 | |
326 | Y | A | 0.0000 | |
327 | K | A | 0.0000 | |
328 | Q | A | 0.0000 | |
329 | Q | A | -2.1189 | |
330 | E | A | -2.4679 | |
331 | G | A | -1.6290 | |
332 | W | A | 0.0000 | |
333 | R | A | -1.1703 | |
334 | Y | A | 0.0000 | |
335 | H | A | -0.5064 | |
336 | A | A | 0.0000 | |
337 | R | A | 0.0000 | |
338 | D | A | -0.3720 | |
339 | L | A | 0.0000 | |
340 | A | A | 0.0000 | |
341 | V | A | 0.0000 | |
342 | W | A | 0.0000 | |
343 | R | A | 0.0000 | |
344 | A | A | 0.0000 | |
345 | H | A | -1.0866 | |
346 | S | A | -1.2006 | |
347 | E | A | -1.4755 | |
348 | Q | A | -2.3560 | |
349 | I | A | 0.0000 | |
350 | P | A | 0.0000 | |
351 | I | A | 0.0000 | |
352 | I | A | 0.0000 | |
353 | L | A | 0.0000 | |
354 | G | A | 0.0000 | |
355 | S | A | 0.0000 | |
356 | A | A | 0.1390 | |
357 | T | A | 0.0000 | |
358 | P | A | 0.0000 | |
359 | A | A | 0.0000 | |
360 | L | A | 0.0000 | |
361 | E | A | -0.3161 | |
362 | T | A | 0.0000 | |
363 | L | A | 0.0000 | |
364 | H | A | 0.0000 | |
365 | N | A | -1.8652 | |
366 | V | A | -2.0826 | |
367 | R | A | -2.5475 | |
368 | Q | A | -2.3680 | |
369 | G | A | -2.3204 | |
370 | K | A | -2.7150 | |
371 | Y | A | 0.0000 | |
372 | R | A | -2.7267 | |
373 | Q | A | -1.3732 | |
374 | L | A | -0.6449 | |
375 | T | A | -0.2683 | |
376 | L | A | 0.0000 | |
377 | S | A | 0.0216 | |
387 | Q | A | -1.8377 | |
388 | Q | A | -0.9525 | |
389 | H | A | -0.4028 | |
390 | V | A | 0.0603 | |
391 | L | A | -0.1799 | |
392 | D | A | -1.4446 | |
393 | L | A | 0.0000 | |
394 | K | A | -1.4735 | |
395 | G | A | -1.5692 | |
396 | Q | A | -1.2940 | |
397 | P | A | -0.6227 | |
398 | L | A | -0.3574 | |
399 | Q | A | -0.6652 | |
400 | A | A | -1.0527 | |
401 | G | A | -0.4357 | |
402 | L | A | 0.0000 | |
403 | S | A | 0.0000 | |
404 | P | A | -0.3052 | |
405 | A | A | -0.2604 | |
406 | L | A | 0.0000 | |
407 | I | A | -0.6954 | |
408 | S | A | -1.1266 | |
409 | R | A | -1.2783 | |
410 | M | A | -1.1685 | |
411 | R | A | -2.5436 | |
412 | Q | A | -2.5910 | |
413 | H | A | -2.1937 | |
414 | L | A | -1.7692 | |
415 | Q | A | -2.4686 | |
416 | A | A | -2.0368 | |
417 | D | A | -2.7461 | |
418 | N | A | -2.2435 | |
419 | Q | A | -1.1637 | |
420 | V | A | 0.4502 | |
421 | I | A | 2.3107 | |
422 | L | A | 1.9568 | |
423 | F | A | 1.2867 | |
424 | L | A | 0.0490 | |
425 | N | A | -1.2768 | |
426 | R | A | -2.6727 | |
427 | R | A | -2.9803 | |
428 | G | A | -1.4499 | |
429 | F | A | -0.7371 | |
430 | A | A | -0.1928 | |
431 | P | A | 0.0395 | |
432 | A | A | 0.0000 | |
433 | L | A | 0.0000 | |
434 | L | A | 0.0000 | |
435 | C | A | 0.0000 | |
436 | H | A | 0.0000 | |
437 | D | A | -1.4647 | |
438 | C | A | -0.3748 | |
439 | G | A | 0.0000 | |
440 | W | A | 0.0803 | |
441 | I | A | 0.0429 | |
442 | A | A | 0.0000 | |
443 | E | A | -2.1211 | |
444 | C | A | 0.0000 | |
445 | P | A | -1.9865 | |
446 | R | A | -2.7500 | |
447 | C | A | -2.2200 | |
448 | D | A | -2.6506 | |
449 | S | A | -1.5511 | |
450 | Y | A | -0.7987 | |
451 | Y | A | 0.0000 | |
452 | T | A | 0.0000 | |
453 | L | A | 0.0000 | |
454 | H | A | -1.4471 | |
455 | Q | A | -2.0014 | |
456 | A | A | -1.4592 | |
457 | Q | A | -2.0834 | |
458 | H | A | -2.1247 | |
459 | H | A | 0.0000 | |
460 | L | A | 0.0000 | |
461 | R | A | -1.5369 | |
462 | C | A | 0.0000 | |
463 | H | A | -0.7860 | |
464 | H | A | -1.0181 | |
465 | C | A | -1.6230 | |
466 | D | A | -2.3785 | |
467 | S | A | -2.0834 | |
468 | Q | A | -2.0889 | |
469 | R | A | -1.5860 | |
470 | P | A | -1.3240 | |
471 | I | A | -1.1369 | |
472 | P | A | -1.2474 | |
473 | R | A | -2.4281 | |
474 | Q | A | -2.0190 | |
475 | C | A | 0.0000 | |
476 | P | A | -0.6597 | |
477 | S | A | -0.0428 | |
478 | C | A | 0.1907 | |
479 | G | A | -0.7802 | |
480 | S | A | -1.0677 | |
481 | T | A | -1.4577 | |
482 | H | A | -1.6026 | |
483 | L | A | -0.8185 | |
484 | V | A | 0.0020 | |
485 | P | A | 0.0438 | |
486 | V | A | 0.0000 | |
487 | G | A | -0.3383 | |
488 | I | A | -0.6921 | |
489 | G | A | -1.6005 | |
490 | T | A | -2.2712 | |
491 | E | A | -2.9377 | |
492 | Q | A | -2.9265 | |
493 | L | A | -2.0893 | |
494 | E | A | -2.8551 | |
495 | Q | A | -2.5775 | |
496 | A | A | -1.6011 | |
497 | L | A | -0.9725 | |
498 | A | A | -0.6937 | |
499 | P | A | -0.4488 | |
500 | L | A | -0.2669 | |
556 | L | A | 0.4631 | |
557 | D | A | -0.1103 | |
558 | V | A | 0.0000 | |
559 | D | A | 0.0000 | |
560 | G | A | 0.0000 | |
561 | A | A | 0.0000 | |
562 | L | A | 0.0000 | |
563 | F | A | 0.0000 | |
564 | S | A | 0.1158 | |
565 | A | A | 0.1488 | |
566 | D | A | 0.0000 | |
567 | F | A | 0.2514 | |
568 | R | A | -0.1603 | |
569 | S | A | 0.0000 | |
570 | A | A | 0.0156 | |
571 | E | A | 0.0000 | |
572 | R | A | -0.3640 | |
573 | F | A | 0.1218 | |
574 | A | A | 0.0000 | |
575 | Q | A | -0.0292 | |
576 | L | A | 0.5218 | |
577 | Y | A | 0.1490 | |
578 | T | A | 0.0020 | |
579 | Q | A | -0.2688 | |
580 | V | A | -0.6167 | |
581 | S | A | -1.0797 | |
582 | G | A | -1.2603 | |
583 | R | A | -2.2073 | |
589 | K | A | -2.4822 | |
590 | Q | A | -2.6252 | |
591 | G | A | -2.4690 | |
592 | E | A | -1.8562 | |
593 | V | A | -0.3626 | |
594 | I | A | 0.2113 | |
595 | L | A | 0.0000 | |
596 | Q | A | 0.0000 | |
597 | T | A | 0.0000 | |
598 | H | A | 0.0000 | |
599 | H | A | -1.0728 | |
600 | P | A | -1.3416 | |
601 | E | A | -2.1873 | |
602 | H | A | -1.2906 | |
603 | P | A | -0.9273 | |
604 | L | A | -0.5590 | |
605 | L | A | 0.0000 | |
606 | Q | A | -0.8448 | |
607 | T | A | 0.0000 | |
608 | L | A | 0.0000 | |
609 | L | A | 0.0000 | |
610 | Y | A | 0.3522 | |
611 | K | A | -1.4828 | |
612 | G | A | -1.1624 | |
613 | Y | A | 0.0000 | |
614 | D | A | -2.6479 | |
615 | A | A | -1.9333 | |
616 | F | A | 0.0000 | |
617 | A | A | 0.0000 | |
618 | E | A | -2.7728 | |
619 | Q | A | -1.7956 | |
620 | A | A | 0.0000 | |
621 | L | A | 0.0000 | |
622 | A | A | -1.2544 | |
623 | E | A | -1.4826 | |
624 | R | A | 0.0000 | |
625 | Q | A | -1.0137 | |
626 | T | A | -0.5737 | |
627 | M | A | 0.0355 | |
628 | Q | A | -0.6756 | |
629 | L | A | 0.0000 | |
630 | P | A | -0.2376 | |
631 | P | A | -0.3415 | |
632 | W | A | -0.2138 | |
633 | T | A | 0.0000 | |
634 | S | A | -0.4416 | |
635 | H | A | 0.0000 | |
636 | V | A | 0.0000 | |
637 | L | A | 0.0000 | |
638 | I | A | 0.0000 | |
639 | R | A | -0.5799 | |
640 | A | A | 0.0000 | |
641 | E | A | -2.8203 | |
642 | D | A | -2.9165 | |
643 | H | A | -2.8359 | |
644 | N | A | -3.3312 | |
645 | N | A | -3.6930 | |
646 | Q | A | -3.1290 | |
647 | Q | A | -2.0283 | |
648 | A | A | 0.0000 | |
649 | P | A | 0.0000 | |
650 | L | A | -0.2633 | |
651 | F | A | -0.2374 | |
652 | L | A | 0.0000 | |
653 | Q | A | -1.6117 | |
654 | Q | A | -1.7919 | |
655 | L | A | 0.0000 | |
656 | R | A | -1.8971 | |
657 | N | A | -2.2381 | |
658 | L | A | -0.7419 | |
659 | L | A | 0.0000 | |
660 | Q | A | -1.2307 | |
661 | A | A | -0.5088 | |
662 | S | A | -0.4018 | |
663 | P | A | -0.4638 | |
664 | L | A | -0.9944 | |
665 | A | A | -1.6856 | |
666 | D | A | -2.7432 | |
667 | E | A | -3.2146 | |
668 | K | A | -2.8278 | |
669 | L | A | -1.4989 | |
670 | W | A | -0.4442 | |
671 | V | A | 0.1427 | |
672 | L | A | -0.0752 | |
673 | G | A | -0.6440 | |
674 | P | A | -0.4788 | |
675 | V | A | 0.0000 | |
676 | P | A | -0.7853 | |
677 | A | A | 0.0000 | |
678 | L | A | -0.0809 | |
679 | A | A | -0.2517 | |
687 | R | A | -2.9530 | |
688 | W | A | -1.4555 | |
689 | Q | A | -0.4923 | |
690 | I | A | 0.0000 | |
691 | L | A | 0.1208 | |
692 | L | A | 0.0000 | |
693 | Q | A | 0.0000 | |
694 | H | A | 0.0000 | |
695 | P | A | -0.6317 | |
696 | S | A | -0.3757 | |
697 | R | A | -0.4129 | |
698 | V | A | -0.1877 | |
699 | R | A | -1.1670 | |
700 | L | A | 0.0000 | |
701 | Q | A | -1.3848 | |
702 | H | A | -1.6748 | |
703 | I | A | 0.0000 | |
704 | V | A | 0.0000 | |
705 | S | A | -0.8573 | |
706 | G | A | -0.1572 | |
707 | T | A | 0.0000 | |
708 | L | A | 0.6311 | |
709 | A | A | 0.9209 | |
710 | L | A | 1.6743 | |
711 | I | A | 0.8808 | |
712 | N | A | -0.4985 | |
713 | T | A | 0.1392 | |
714 | L | A | 0.5994 | |
720 | V | A | 0.4455 | |
721 | K | A | -1.1969 | |
722 | W | A | -0.1617 | |
723 | V | A | 0.3483 | |
724 | L | A | 0.3915 | |
725 | D | A | 0.0000 | |
726 | V | A | 0.0000 | |
727 | D | A | -0.6892 | |
728 | P | A | -0.5461 | |
729 | I | A | -0.4329 | |
730 | E | A | -0.6632 | |
731 | G | A | -0.8973 |