Chain sequence(s) |
A: QSNSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYNAQNQLQ B: AIRKKLVIVGDGACGKTCLLIVNSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | Q | A | -1.4711 | |
2 | S | A | -1.1142 | |
3 | N | A | -1.2235 | |
4 | S | A | -0.8677 | |
5 | W | A | 0.0000 | |
6 | R | A | -1.5786 | |
7 | E | A | -2.1245 | |
8 | L | A | -0.6148 | |
9 | I | A | -1.5741 | |
10 | D | A | -2.6728 | |
11 | G | A | -2.3568 | |
12 | H | A | -2.3452 | |
13 | E | A | -3.0294 | |
14 | K | A | -2.7998 | |
15 | L | A | -1.7385 | |
16 | T | A | -1.8890 | |
17 | R | A | -2.5340 | |
18 | R | A | -2.8012 | |
19 | Q | A | -2.0362 | |
20 | C | A | -1.5678 | |
21 | H | A | -1.6742 | |
22 | Q | A | 0.0000 | |
23 | Q | A | 0.0000 | |
24 | E | A | -0.4854 | |
25 | A | A | 0.0000 | |
26 | V | A | 0.0000 | |
27 | W | A | -0.2448 | |
28 | E | A | 0.0000 | |
29 | L | A | 0.0000 | |
30 | L | A | 0.0000 | |
31 | H | A | -0.5827 | |
32 | T | A | 0.0000 | |
33 | E | A | 0.0000 | |
34 | A | A | -0.7073 | |
35 | S | A | -0.8083 | |
36 | Y | A | -1.0244 | |
37 | I | A | 0.0000 | |
38 | R | A | -2.7646 | |
39 | K | A | -1.7972 | |
40 | L | A | 0.0000 | |
41 | R | A | -3.1533 | |
42 | V | A | 0.0000 | |
43 | I | A | 0.0000 | |
44 | I | A | -0.8566 | |
45 | N | A | -1.6446 | |
46 | L | A | 0.0000 | |
47 | F | A | 0.0000 | |
48 | L | A | -0.3275 | |
49 | C | A | 0.0176 | |
50 | C | A | -0.0978 | |
51 | L | A | 0.0000 | |
52 | L | A | -0.5322 | |
53 | N | A | -1.0516 | |
54 | L | A | -0.5680 | |
55 | Q | A | -1.8255 | |
56 | E | A | -2.0887 | |
57 | S | A | -1.1336 | |
58 | G | A | -0.5937 | |
59 | L | A | -0.4642 | |
60 | L | A | 0.0000 | |
61 | C | A | -0.4507 | |
62 | E | A | -1.4590 | |
63 | V | A | -0.2157 | |
64 | E | A | -1.3859 | |
65 | A | A | 0.0000 | |
66 | E | A | -2.1000 | |
67 | R | A | -2.0790 | |
68 | L | A | 0.0000 | |
69 | F | A | 0.0000 | |
70 | S | A | -1.4585 | |
71 | N | A | -1.5594 | |
72 | I | A | 0.0000 | |
73 | P | A | -1.1994 | |
74 | E | A | -1.7458 | |
75 | I | A | 0.0000 | |
76 | A | A | -2.1119 | |
77 | Q | A | -2.5207 | |
78 | L | A | -1.6624 | |
79 | H | A | 0.0000 | |
80 | R | A | -3.0641 | |
81 | R | A | -2.7255 | |
82 | L | A | 0.0000 | |
83 | W | A | -1.0139 | |
84 | A | A | -0.8335 | |
85 | S | A | -1.0880 | |
86 | V | A | 0.0000 | |
87 | M | A | 0.3643 | |
88 | A | A | 0.1162 | |
89 | P | A | -0.7849 | |
90 | V | A | 0.0000 | |
91 | L | A | -0.1029 | |
92 | E | A | -1.8062 | |
93 | K | A | -1.6325 | |
94 | A | A | -1.6152 | |
95 | R | A | -2.9414 | |
96 | R | A | -2.9722 | |
97 | T | A | -1.7566 | |
98 | R | A | -1.6165 | |
99 | A | A | -0.8317 | |
100 | L | A | 0.0000 | |
101 | L | A | 0.6168 | |
102 | Q | A | -0.2827 | |
103 | P | A | 0.0000 | |
104 | G | A | 0.0000 | |
105 | D | A | -2.5635 | |
106 | F | A | 0.0000 | |
107 | L | A | 0.0000 | |
108 | K | A | -2.6754 | |
109 | G | A | -1.9013 | |
110 | F | A | 0.0000 | |
111 | K | A | -1.0153 | |
112 | M | A | 0.5233 | |
113 | F | A | 1.2985 | |
114 | G | A | 0.3658 | |
115 | S | A | 0.1757 | |
116 | L | A | 0.0000 | |
117 | F | A | -0.3591 | |
118 | K | A | -1.7948 | |
119 | P | A | -1.4713 | |
120 | Y | A | 0.0000 | |
121 | I | A | -0.8896 | |
122 | R | A | -1.8738 | |
123 | Y | A | 0.0000 | |
124 | C | A | 0.0000 | |
125 | M | A | -0.6153 | |
126 | E | A | 0.0000 | |
127 | E | A | 0.0000 | |
128 | E | A | -1.3535 | |
129 | G | A | 0.0000 | |
130 | C | A | 0.0000 | |
131 | M | A | -1.4033 | |
132 | E | A | -2.2568 | |
133 | Y | A | -1.5538 | |
134 | M | A | 0.0000 | |
135 | R | A | -2.4395 | |
136 | G | A | -2.0854 | |
137 | L | A | -1.8206 | |
138 | L | A | -2.2426 | |
139 | R | A | -3.4636 | |
140 | D | A | -3.4207 | |
141 | N | A | -2.3727 | |
142 | D | A | -2.6486 | |
143 | L | A | -0.9275 | |
144 | F | A | 0.0000 | |
145 | R | A | -1.8560 | |
146 | A | A | -0.4882 | |
147 | Y | A | 0.0000 | |
148 | I | A | 0.0000 | |
149 | T | A | -0.5793 | |
150 | W | A | -0.2774 | |
151 | A | A | 0.0000 | |
152 | E | A | -2.1088 | |
153 | K | A | -2.5724 | |
154 | H | A | -1.7734 | |
155 | P | A | -1.8561 | |
156 | Q | A | -2.5447 | |
157 | C | A | 0.0000 | |
158 | Q | A | -2.7244 | |
159 | R | A | -2.5117 | |
160 | L | A | -2.0085 | |
161 | K | A | -1.8221 | |
162 | L | A | 0.0000 | |
163 | S | A | -0.7731 | |
164 | D | A | -0.7205 | |
165 | M | A | 0.0000 | |
166 | L | A | 0.0000 | |
167 | A | A | 0.0000 | |
168 | K | A | -0.3722 | |
169 | P | A | 0.0000 | |
170 | H | A | 0.0000 | |
171 | Q | A | -0.3976 | |
172 | R | A | 0.0000 | |
173 | L | A | 0.0000 | |
174 | T | A | 0.0000 | |
175 | K | A | -0.4656 | |
176 | Y | A | 0.0000 | |
177 | P | A | 0.0000 | |
178 | L | A | -0.2845 | |
179 | L | A | 0.0000 | |
180 | L | A | 0.0000 | |
181 | K | A | -1.4809 | |
182 | S | A | -1.2144 | |
183 | V | A | 0.0000 | |
184 | L | A | -1.6801 | |
185 | R | A | -2.7350 | |
186 | K | A | -2.8054 | |
187 | T | A | 0.0000 | |
188 | E | A | -3.0572 | |
189 | E | A | -2.2664 | |
190 | P | A | -2.2915 | |
191 | R | A | -3.0997 | |
192 | A | A | 0.0000 | |
193 | K | A | -2.7534 | |
194 | E | A | -2.4411 | |
195 | A | A | -1.8177 | |
196 | V | A | 0.0000 | |
197 | V | A | 0.0800 | |
198 | A | A | -0.4094 | |
199 | M | A | 0.0000 | |
200 | I | A | 0.0000 | |
201 | G | A | -1.0831 | |
202 | S | A | -1.0887 | |
203 | V | A | 0.0000 | |
204 | E | A | -2.8594 | |
205 | R | A | -2.9754 | |
206 | F | A | 0.0000 | |
207 | I | A | 0.0000 | |
208 | H | A | -2.4226 | |
209 | H | A | -1.7060 | |
210 | V | A | 0.0000 | |
211 | N | A | -1.4547 | |
212 | A | A | -1.0297 | |
213 | C | A | -0.8740 | |
214 | M | A | 0.0000 | |
215 | R | A | -1.7683 | |
216 | Q | A | -1.8625 | |
217 | R | A | -1.7005 | |
218 | Q | A | 0.0000 | |
219 | E | A | 0.0000 | |
220 | R | A | -2.5639 | |
221 | Q | A | -1.7730 | |
222 | R | A | -1.3537 | |
223 | L | A | 0.0000 | |
224 | A | A | -0.8184 | |
225 | A | A | -0.4283 | |
226 | V | A | -0.1633 | |
227 | V | A | 0.1569 | |
228 | S | A | -0.2439 | |
229 | R | A | -1.2060 | |
230 | I | A | -0.6220 | |
231 | D | A | -0.8891 | |
232 | A | A | 0.3417 | |
233 | Y | A | 0.8074 | |
234 | E | A | -0.3119 | |
235 | V | A | 0.0000 | |
236 | V | A | 0.3823 | |
237 | E | A | -1.0715 | |
238 | S | A | -1.3746 | |
239 | S | A | -1.3361 | |
240 | S | A | -2.0618 | |
241 | D | A | -3.2880 | |
242 | E | A | -3.2606 | |
243 | V | A | 0.0000 | |
244 | D | A | -2.6319 | |
245 | K | A | -3.0999 | |
246 | L | A | 0.0000 | |
247 | L | A | 0.0000 | |
248 | K | A | -1.3414 | |
249 | E | A | -1.1121 | |
250 | F | A | 0.0000 | |
251 | L | A | 0.3469 | |
252 | H | A | -0.9927 | |
253 | L | A | 0.0000 | |
254 | D | A | -2.1503 | |
255 | L | A | 0.0000 | |
256 | T | A | -0.4690 | |
257 | A | A | 0.3978 | |
258 | P | A | 0.5012 | |
259 | I | A | 2.0060 | |
260 | P | A | 0.7067 | |
261 | G | A | 0.6594 | |
262 | A | A | 0.6383 | |
263 | S | A | 0.3000 | |
264 | P | A | -0.5017 | |
265 | E | A | 0.0000 | |
266 | E | A | -1.8062 | |
267 | T | A | -1.5288 | |
268 | R | A | -1.8817 | |
269 | Q | A | -1.9308 | |
270 | L | A | 0.0000 | |
271 | L | A | 0.3362 | |
272 | L | A | 0.6859 | |
273 | E | A | 0.1913 | |
274 | G | A | 0.0000 | |
275 | S | A | -0.7641 | |
276 | L | A | 0.0000 | |
277 | R | A | -2.9182 | |
278 | M | A | 0.0000 | |
279 | K | A | -3.7081 | |
280 | E | A | -3.5893 | |
281 | G | A | -3.0562 | |
282 | K | A | -3.5388 | |
283 | D | A | -3.6125 | |
284 | S | A | -3.1165 | |
285 | K | A | -4.0682 | |
286 | M | A | -2.5283 | |
287 | D | A | -2.8232 | |
288 | V | A | 0.0000 | |
289 | Y | A | -0.3096 | |
290 | C | A | 0.0000 | |
291 | F | A | 0.0000 | |
292 | L | A | 0.0000 | |
293 | F | A | 0.0000 | |
294 | T | A | -0.4986 | |
295 | D | A | 0.0000 | |
296 | L | A | 0.0000 | |
297 | L | A | 0.0000 | |
298 | L | A | 0.0000 | |
299 | V | A | 0.0000 | |
300 | T | A | -0.4426 | |
301 | K | A | -1.0713 | |
302 | A | A | -1.2509 | |
303 | V | A | -2.1955 | |
304 | K | A | -2.6940 | |
305 | K | A | -3.1567 | |
306 | A | A | -3.0502 | |
307 | E | A | -3.7521 | |
308 | R | A | -3.0617 | |
309 | T | A | -1.6015 | |
310 | R | A | -1.8231 | |
311 | V | A | -0.5011 | |
312 | I | A | 0.0000 | |
313 | R | A | -0.8742 | |
314 | P | A | -0.3282 | |
315 | P | A | 0.0000 | |
316 | L | A | 0.0000 | |
317 | L | A | 0.0000 | |
318 | V | A | 0.0000 | |
319 | D | A | -1.5571 | |
320 | K | A | -0.8565 | |
321 | I | A | 0.0000 | |
322 | V | A | 0.3984 | |
323 | C | A | 0.0000 | |
324 | R | A | -1.9750 | |
325 | E | A | -3.0877 | |
326 | L | A | -2.2255 | |
327 | R | A | -2.8434 | |
328 | D | A | -2.3316 | |
329 | P | A | -1.9100 | |
330 | G | A | -1.5239 | |
331 | S | A | 0.0000 | |
332 | F | A | 0.0000 | |
333 | L | A | -0.7374 | |
334 | L | A | 0.0000 | |
335 | I | A | 0.7228 | |
336 | Y | A | 0.5353 | |
337 | L | A | 0.3128 | |
338 | N | A | -0.4569 | |
339 | E | A | -1.0937 | |
340 | F | A | 0.5846 | |
341 | H | A | -0.4626 | |
342 | S | A | -0.2894 | |
343 | A | A | 0.3404 | |
344 | V | A | 1.3657 | |
345 | G | A | 0.7121 | |
346 | A | A | 0.7314 | |
347 | Y | A | -0.1998 | |
348 | T | A | -0.8348 | |
349 | F | A | 0.0000 | |
350 | Q | A | -1.3144 | |
351 | A | A | 0.0000 | |
352 | S | A | -0.8307 | |
353 | G | A | -1.3838 | |
354 | Q | A | -1.8765 | |
355 | A | A | -1.7923 | |
356 | L | A | -1.2407 | |
357 | C | A | 0.0000 | |
358 | R | A | -2.8981 | |
359 | G | A | -1.3441 | |
360 | W | A | 0.0000 | |
361 | V | A | -1.3835 | |
362 | D | A | -2.1199 | |
363 | T | A | -1.0310 | |
364 | I | A | 0.0000 | |
365 | Y | A | -0.5134 | |
366 | N | A | -1.6649 | |
367 | A | A | 0.0000 | |
368 | Q | A | -1.5355 | |
369 | N | A | -2.4570 | |
370 | Q | A | -2.2501 | |
371 | L | A | -1.5718 | |
372 | Q | A | -2.0739 | |
373 | A | B | -1.3506 | |
374 | I | B | -1.4147 | |
375 | R | B | -2.2888 | |
376 | K | B | -1.5606 | |
377 | K | B | -1.2824 | |
378 | L | B | 0.0000 | |
379 | V | B | 0.0000 | |
380 | I | B | 0.0000 | |
381 | V | B | 0.0000 | |
382 | G | B | 0.0000 | |
383 | D | B | -1.1162 | |
384 | G | B | -0.7185 | |
385 | A | B | -0.1443 | |
386 | C | B | 0.0000 | |
387 | G | B | -0.3986 | |
388 | K | B | 0.0000 | |
389 | T | B | 0.0375 | |
390 | C | B | -0.2325 | |
391 | L | B | 0.0000 | |
392 | L | B | 0.0000 | |
393 | I | B | 0.0000 | |
394 | V | B | 0.0000 | |
395 | N | B | -1.9560 | |
396 | S | B | -1.3644 | |
397 | K | B | -2.5265 | |
398 | D | B | -2.7782 | |
399 | Q | B | -2.3847 | |
400 | F | B | -1.4572 | |
401 | P | B | -1.1847 | |
402 | E | B | -1.9245 | |
403 | V | B | -0.7533 | |
404 | Y | B | -0.4430 | |
405 | V | B | 0.0523 | |
406 | P | B | 0.2400 | |
407 | T | B | 0.1798 | |
408 | V | B | 0.2440 | |
409 | F | B | 0.1139 | |
410 | E | B | -0.6033 | |
411 | N | B | -0.6849 | |
412 | Y | B | -0.2692 | |
413 | V | B | -0.4464 | |
414 | A | B | 0.0000 | |
415 | D | B | -2.5094 | |
416 | I | B | -2.4094 | |
417 | E | B | -3.5918 | |
418 | V | B | 0.0000 | |
419 | D | B | -3.0448 | |
420 | G | B | -2.5844 | |
421 | K | B | -3.0674 | |
422 | Q | B | -3.1696 | |
423 | V | B | 0.0000 | |
424 | E | B | -2.4620 | |
425 | L | B | 0.0000 | |
426 | A | B | 0.0000 | |
427 | L | B | 0.0000 | |
428 | W | B | -0.0201 | |
429 | D | B | -0.2320 | |
430 | T | B | 0.0000 | |
431 | A | B | -0.4704 | |
432 | G | B | -0.6267 | |
433 | Q | B | -1.4842 | |
434 | E | B | -1.8257 | |
435 | D | B | -2.5763 | |
436 | Y | B | -1.9362 | |
437 | D | B | -2.7555 | |
438 | R | B | -2.1660 | |
439 | L | B | 0.0000 | |
440 | R | B | 0.0000 | |
441 | P | B | -0.2917 | |
442 | L | B | 0.1491 | |
443 | S | B | -0.0787 | |
444 | Y | B | 0.0000 | |
445 | P | B | -0.8576 | |
446 | D | B | -1.9294 | |
447 | T | B | 0.0000 | |
448 | D | B | -1.4368 | |
449 | V | B | 0.0000 | |
450 | I | B | 0.0000 | |
451 | L | B | 0.0000 | |
452 | M | B | 0.0000 | |
453 | C | B | 0.0000 | |
454 | F | B | 0.0000 | |
455 | S | B | 0.0000 | |
456 | I | B | 0.0000 | |
457 | D | B | -1.6731 | |
458 | S | B | -1.6777 | |
459 | P | B | -2.0791 | |
460 | D | B | -2.6394 | |
461 | S | B | 0.0000 | |
462 | L | B | 0.0000 | |
463 | E | B | -3.1732 | |
464 | N | B | -2.8064 | |
465 | I | B | 0.0000 | |
466 | P | B | -2.1659 | |
467 | E | B | -3.2338 | |
468 | K | B | -2.7314 | |
469 | W | B | 0.0000 | |
470 | T | B | 0.0000 | |
471 | P | B | 0.0000 | |
472 | E | B | -1.0825 | |
473 | V | B | 0.0000 | |
474 | K | B | -1.0820 | |
475 | H | B | -0.5944 | |
476 | F | B | 0.1054 | |
477 | C | B | 0.0000 | |
478 | P | B | -0.9977 | |
479 | N | B | -1.4838 | |
480 | V | B | -0.9183 | |
481 | P | B | -0.5218 | |
482 | I | B | 0.0000 | |
483 | I | B | 0.0000 | |
484 | L | B | 0.0000 | |
485 | V | B | 0.0000 | |
486 | G | B | 0.0000 | |
487 | N | B | 0.0000 | |
488 | K | B | -1.5852 | |
489 | K | B | -1.9926 | |
490 | D | B | -2.0909 | |
491 | L | B | -1.7024 | |
492 | R | B | -2.1972 | |
493 | N | B | -2.6178 | |
494 | D | B | -2.9738 | |
495 | E | B | -3.8503 | |
496 | H | B | -3.4787 | |
497 | T | B | -3.2362 | |
498 | R | B | -4.2762 | |
499 | R | B | -4.7034 | |
500 | E | B | -4.2953 | |
501 | L | B | 0.0000 | |
502 | A | B | -3.1684 | |
503 | K | B | -3.1081 | |
504 | M | B | -1.5151 | |
505 | K | B | -2.5872 | |
506 | Q | B | -2.7358 | |
507 | E | B | -2.9891 | |
508 | P | B | 0.0000 | |
509 | V | B | 0.0000 | |
510 | K | B | -2.2980 | |
511 | P | B | -2.3216 | |
512 | E | B | -3.6642 | |
513 | E | B | -3.4368 | |
514 | G | B | 0.0000 | |
515 | R | B | -4.0244 | |
516 | D | B | -4.4236 | |
517 | M | B | -3.2856 | |
518 | A | B | 0.0000 | |
519 | N | B | -3.2043 | |
520 | R | B | -3.2475 | |
521 | I | B | 0.0000 | |
522 | G | B | -1.4562 | |
523 | A | B | -0.9600 | |
524 | F | B | 0.1503 | |
525 | G | B | -0.4796 | |
526 | Y | B | 0.0000 | |
527 | M | B | -0.3901 | |
528 | E | B | -0.8683 | |
529 | C | B | 0.0000 | |
530 | S | B | 0.0000 | |
531 | A | B | 0.0000 | |
532 | K | B | -2.6743 | |
533 | T | B | -2.1513 | |
534 | K | B | -2.9072 | |
535 | D | B | -3.3526 | |
536 | G | B | -2.4111 | |
537 | V | B | 0.0000 | |
538 | R | B | -3.3323 | |
539 | E | B | -2.6473 | |
540 | V | B | 0.0000 | |
541 | F | B | 0.0000 | |
542 | E | B | -2.1442 | |
543 | M | B | -0.7415 | |
544 | A | B | 0.0000 | |
545 | T | B | 0.0000 | |
546 | R | B | -1.3262 | |
547 | A | B | 0.0000 | |
548 | A | B | 0.0000 | |
549 | L | B | -0.8255 | |
550 | Q | B | -1.1103 |