| Chain sequence(s) |
A: GTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSSFLGRTDCSPIQFESSAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDDPLLALLAVPDMSSLACGYLRNNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMMIEECGGLDKIEALQNHENESVYKASLSLIEKYFS C: KKS B: PVKKPKIRR |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 72 | G | A | -0.4781 | |
| 73 | T | A | -0.2055 | |
| 74 | V | A | -0.5649 | |
| 75 | N | A | -1.4122 | |
| 76 | W | A | -0.5249 | |
| 77 | S | A | -0.8907 | |
| 78 | V | A | 0.0000 | |
| 79 | D | A | -2.8288 | |
| 80 | D | A | -2.9706 | |
| 81 | I | A | 0.0000 | |
| 82 | V | A | -1.9412 | |
| 83 | K | A | -3.1618 | |
| 84 | G | A | -2.7778 | |
| 85 | I | A | 0.0000 | |
| 86 | N | A | -2.0800 | |
| 87 | S | A | -1.7317 | |
| 88 | S | A | -1.0976 | |
| 89 | N | A | -1.4634 | |
| 90 | V | A | -1.2514 | |
| 91 | E | A | -2.4999 | |
| 92 | N | A | -2.8271 | |
| 93 | Q | A | -2.0460 | |
| 94 | L | A | -1.3854 | |
| 95 | Q | A | -2.0848 | |
| 96 | A | A | 0.0000 | |
| 97 | T | A | 0.0000 | |
| 98 | Q | A | -1.4313 | |
| 99 | A | A | -1.3601 | |
| 100 | A | A | 0.0000 | |
| 101 | R | A | -1.3231 | |
| 102 | K | A | -2.1476 | |
| 103 | L | A | -1.3123 | |
| 104 | L | A | 0.0000 | |
| 105 | S | A | 0.0000 | |
| 106 | R | A | -2.9947 | |
| 107 | E | A | -3.6468 | |
| 108 | K | A | -3.4236 | |
| 109 | Q | A | -2.6416 | |
| 110 | P | A | -2.2071 | |
| 111 | P | A | 0.0000 | |
| 112 | I | A | 0.0000 | |
| 113 | D | A | -1.9922 | |
| 114 | N | A | -1.7712 | |
| 115 | I | A | 0.0000 | |
| 116 | I | A | -1.2033 | |
| 117 | R | A | -2.2139 | |
| 118 | A | A | -1.5615 | |
| 119 | G | A | -1.0492 | |
| 120 | L | A | 0.0000 | |
| 121 | I | A | 0.0000 | |
| 122 | P | A | -0.8597 | |
| 123 | K | A | -0.9316 | |
| 124 | F | A | 0.0000 | |
| 125 | V | A | -0.3822 | |
| 126 | S | A | -0.6733 | |
| 127 | F | A | 0.0000 | |
| 128 | L | A | 0.0000 | |
| 129 | G | A | -1.0797 | |
| 130 | R | A | -1.4690 | |
| 131 | T | A | -1.3940 | |
| 132 | D | A | -2.0941 | |
| 133 | C | A | -1.1891 | |
| 134 | S | A | -0.7974 | |
| 135 | P | A | -0.5663 | |
| 136 | I | A | 0.0000 | |
| 137 | Q | A | 0.0000 | |
| 138 | F | A | -0.0609 | |
| 139 | E | A | 0.0000 | |
| 140 | S | A | 0.0000 | |
| 141 | A | A | 0.0000 | |
| 142 | W | A | 0.0000 | |
| 143 | A | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | T | A | 0.0000 | |
| 146 | N | A | 0.0000 | |
| 147 | I | A | 0.0000 | |
| 148 | A | A | 0.0000 | |
| 149 | S | A | -0.3335 | |
| 150 | G | A | -1.0115 | |
| 151 | T | A | -1.1267 | |
| 152 | S | A | -1.6565 | |
| 153 | E | A | -2.6966 | |
| 154 | Q | A | -1.9505 | |
| 155 | T | A | 0.0000 | |
| 156 | K | A | -2.8198 | |
| 157 | A | A | -2.1553 | |
| 158 | V | A | 0.0000 | |
| 159 | V | A | -1.4885 | |
| 160 | D | A | -2.2968 | |
| 161 | G | A | -1.3907 | |
| 162 | G | A | -0.9912 | |
| 163 | A | A | 0.0000 | |
| 164 | I | A | 0.0000 | |
| 165 | P | A | -0.0398 | |
| 166 | A | A | -0.1109 | |
| 167 | F | A | 0.0000 | |
| 168 | I | A | 0.0156 | |
| 169 | S | A | -0.2368 | |
| 170 | L | A | 0.0000 | |
| 171 | L | A | 0.0000 | |
| 172 | A | A | -0.0495 | |
| 173 | S | A | -0.3459 | |
| 174 | P | A | -0.4994 | |
| 175 | H | A | -0.6163 | |
| 176 | A | A | -0.3817 | |
| 177 | H | A | -0.5688 | |
| 178 | I | A | 0.0000 | |
| 179 | S | A | 0.0000 | |
| 180 | E | A | 0.0000 | |
| 181 | Q | A | 0.0000 | |
| 182 | A | A | 0.0000 | |
| 183 | V | A | 0.0000 | |
| 184 | W | A | -0.0142 | |
| 185 | A | A | 0.0000 | |
| 186 | L | A | 0.0000 | |
| 187 | G | A | 0.0000 | |
| 188 | N | A | 0.0000 | |
| 189 | I | A | 0.0000 | |
| 190 | A | A | 0.0000 | |
| 191 | G | A | -0.1155 | |
| 192 | D | A | -0.6012 | |
| 193 | G | A | -0.2196 | |
| 194 | S | A | 0.0000 | |
| 195 | V | A | 1.2697 | |
| 196 | F | A | 0.0000 | |
| 197 | R | A | 0.0000 | |
| 198 | D | A | -0.1039 | |
| 199 | L | A | 0.2095 | |
| 200 | V | A | 0.0000 | |
| 201 | I | A | -0.6523 | |
| 202 | K | A | -1.2205 | |
| 203 | Y | A | 0.1571 | |
| 204 | G | A | -0.6748 | |
| 205 | A | A | 0.0000 | |
| 206 | V | A | 0.0000 | |
| 207 | D | A | -1.7960 | |
| 208 | P | A | -0.7874 | |
| 209 | L | A | 0.0000 | |
| 210 | L | A | -0.3407 | |
| 211 | A | A | -0.1075 | |
| 212 | L | A | 0.3300 | |
| 213 | L | A | 0.0000 | |
| 214 | A | A | 0.1097 | |
| 215 | V | A | -0.1569 | |
| 216 | P | A | -0.9117 | |
| 217 | D | A | -1.7406 | |
| 218 | M | A | 0.0000 | |
| 219 | S | A | -0.9092 | |
| 220 | S | A | -0.6108 | |
| 221 | L | A | 0.0275 | |
| 222 | A | A | 0.2520 | |
| 223 | C | A | 0.1092 | |
| 224 | G | A | -0.2546 | |
| 225 | Y | A | 0.1732 | |
| 226 | L | A | 0.0000 | |
| 227 | R | A | -0.8807 | |
| 228 | N | A | -0.4578 | |
| 229 | L | A | 0.0000 | |
| 230 | T | A | 0.0000 | |
| 231 | W | A | 0.0000 | |
| 232 | T | A | 0.0000 | |
| 233 | L | A | 0.0000 | |
| 234 | S | A | 0.0000 | |
| 235 | N | A | 0.0000 | |
| 236 | L | A | 0.0000 | |
| 237 | C | A | 0.0000 | |
| 238 | R | A | -0.9070 | |
| 239 | N | A | -1.4594 | |
| 240 | K | A | -1.5908 | |
| 241 | N | A | -1.5801 | |
| 242 | P | A | -1.1665 | |
| 243 | A | A | -0.9354 | |
| 244 | P | A | 0.0000 | |
| 245 | P | A | -0.1811 | |
| 246 | I | A | 0.5230 | |
| 247 | D | A | -1.6304 | |
| 248 | A | A | 0.0000 | |
| 249 | V | A | 0.0000 | |
| 250 | E | A | -2.2323 | |
| 251 | Q | A | -1.9569 | |
| 252 | I | A | 0.0000 | |
| 253 | L | A | 0.0000 | |
| 254 | P | A | -0.8547 | |
| 255 | T | A | -0.5923 | |
| 256 | L | A | 0.0000 | |
| 257 | V | A | -0.5463 | |
| 258 | R | A | -1.1077 | |
| 259 | L | A | 0.0000 | |
| 260 | L | A | 0.0000 | |
| 261 | H | A | -1.7608 | |
| 262 | H | A | -1.9616 | |
| 263 | D | A | -2.4859 | |
| 264 | D | A | -1.8042 | |
| 265 | P | A | -1.8424 | |
| 266 | E | A | -2.1317 | |
| 267 | V | A | 0.0000 | |
| 268 | L | A | 0.0000 | |
| 269 | A | A | -0.8963 | |
| 270 | D | A | -0.7458 | |
| 271 | T | A | 0.0000 | |
| 272 | C | A | 0.0000 | |
| 273 | W | A | 0.0855 | |
| 274 | A | A | 0.0000 | |
| 275 | I | A | 0.0000 | |
| 276 | S | A | 0.0000 | |
| 277 | Y | A | -0.5481 | |
| 278 | L | A | 0.0000 | |
| 279 | T | A | 0.0000 | |
| 280 | D | A | -1.3554 | |
| 281 | G | A | -1.4304 | |
| 282 | P | A | -1.5818 | |
| 283 | N | A | -2.0212 | |
| 284 | E | A | -2.4011 | |
| 285 | R | A | -1.2726 | |
| 286 | I | A | 0.0000 | |
| 287 | G | A | -1.6651 | |
| 288 | M | A | -1.1538 | |
| 289 | V | A | 0.0000 | |
| 290 | V | A | 0.0000 | |
| 291 | K | A | -1.7961 | |
| 292 | T | A | -1.0463 | |
| 293 | G | A | -1.0005 | |
| 294 | V | A | 0.0000 | |
| 295 | V | A | 0.0000 | |
| 296 | P | A | -1.0960 | |
| 297 | Q | A | -1.1040 | |
| 298 | L | A | 0.0000 | |
| 299 | V | A | 0.0000 | |
| 300 | K | A | -1.9493 | |
| 301 | L | A | 0.0000 | |
| 302 | L | A | 0.0000 | |
| 303 | G | A | -1.1193 | |
| 304 | A | A | -1.0227 | |
| 305 | S | A | -0.8496 | |
| 306 | E | A | -1.3186 | |
| 307 | L | A | -0.6007 | |
| 308 | P | A | -0.7589 | |
| 309 | I | A | 0.0000 | |
| 310 | V | A | 0.0000 | |
| 311 | T | A | -0.6245 | |
| 312 | P | A | 0.0000 | |
| 313 | A | A | 0.0000 | |
| 314 | L | A | 0.0000 | |
| 315 | R | A | -0.6833 | |
| 316 | A | A | 0.0000 | |
| 317 | I | A | 0.0000 | |
| 318 | G | A | 0.0000 | |
| 319 | N | A | 0.0000 | |
| 320 | I | A | 0.0000 | |
| 321 | V | A | 0.0000 | |
| 322 | T | A | -1.0684 | |
| 323 | G | A | 0.0000 | |
| 324 | T | A | -1.7624 | |
| 325 | D | A | -2.2069 | |
| 326 | E | A | -2.4858 | |
| 327 | Q | A | -1.6321 | |
| 328 | T | A | 0.0000 | |
| 329 | Q | A | -1.7881 | |
| 330 | V | A | -1.2763 | |
| 331 | V | A | 0.0000 | |
| 332 | I | A | 0.0000 | |
| 333 | D | A | -1.8440 | |
| 334 | A | A | -1.2548 | |
| 335 | G | A | -0.9626 | |
| 336 | A | A | 0.0000 | |
| 337 | L | A | 0.0000 | |
| 338 | A | A | -0.1000 | |
| 339 | V | A | -0.2145 | |
| 340 | F | A | 0.0000 | |
| 341 | P | A | -0.1260 | |
| 342 | S | A | -0.3123 | |
| 343 | L | A | 0.0000 | |
| 344 | L | A | 0.0000 | |
| 345 | T | A | -0.5281 | |
| 346 | N | A | -1.1548 | |
| 347 | P | A | -1.2660 | |
| 348 | K | A | -2.0141 | |
| 349 | T | A | -2.0159 | |
| 350 | N | A | -2.3791 | |
| 351 | I | A | 0.0000 | |
| 352 | Q | A | -1.6618 | |
| 353 | K | A | -1.8241 | |
| 354 | E | A | -1.2318 | |
| 355 | A | A | 0.0000 | |
| 356 | T | A | 0.0000 | |
| 357 | W | A | -0.4787 | |
| 358 | T | A | 0.0000 | |
| 359 | M | A | 0.0000 | |
| 360 | S | A | 0.0000 | |
| 361 | N | A | 0.0000 | |
| 362 | I | A | 0.0000 | |
| 363 | T | A | 0.0000 | |
| 364 | A | A | -0.8796 | |
| 365 | G | A | -1.6549 | |
| 366 | R | A | -2.2339 | |
| 367 | Q | A | -2.2737 | |
| 368 | D | A | -2.4758 | |
| 369 | Q | A | 0.0000 | |
| 370 | I | A | 0.0000 | |
| 371 | Q | A | -1.9439 | |
| 372 | Q | A | -1.8978 | |
| 373 | V | A | 0.0000 | |
| 374 | V | A | -1.0252 | |
| 375 | N | A | -1.7008 | |
| 376 | H | A | -1.1973 | |
| 377 | G | A | -0.8162 | |
| 378 | L | A | 0.0000 | |
| 379 | V | A | 0.0000 | |
| 380 | P | A | 0.0234 | |
| 381 | F | A | 0.4103 | |
| 382 | L | A | 0.0000 | |
| 383 | V | A | -0.1329 | |
| 384 | S | A | -0.3906 | |
| 385 | V | A | 0.0000 | |
| 386 | L | A | 0.0000 | |
| 387 | S | A | -1.3024 | |
| 388 | K | A | -1.8241 | |
| 389 | A | A | -1.4274 | |
| 390 | D | A | -1.4662 | |
| 391 | F | A | -0.8427 | |
| 392 | K | A | -2.0595 | |
| 393 | T | A | 0.0000 | |
| 394 | Q | A | -1.1974 | |
| 395 | K | A | -1.2976 | |
| 396 | E | A | -0.8260 | |
| 397 | A | A | 0.0000 | |
| 398 | V | A | 0.0000 | |
| 399 | W | A | -0.2549 | |
| 400 | A | A | 0.0000 | |
| 401 | V | A | 0.0000 | |
| 402 | T | A | 0.0000 | |
| 403 | N | A | -0.4914 | |
| 404 | Y | A | 0.0000 | |
| 405 | T | A | 0.0000 | |
| 406 | S | A | -0.7077 | |
| 407 | G | A | -0.6844 | |
| 408 | G | A | -1.1163 | |
| 409 | T | A | -0.9701 | |
| 410 | V | A | -0.8602 | |
| 411 | E | A | -1.2347 | |
| 412 | Q | A | 0.0000 | |
| 413 | I | A | 0.0000 | |
| 414 | V | A | 0.2068 | |
| 415 | Y | A | 0.0713 | |
| 416 | L | A | 0.0000 | |
| 417 | V | A | -0.1518 | |
| 418 | H | A | -0.5105 | |
| 419 | C | A | -0.0510 | |
| 420 | G | A | -0.5101 | |
| 421 | I | A | 0.0000 | |
| 422 | I | A | 0.0000 | |
| 423 | E | A | -1.7143 | |
| 424 | P | A | -1.3588 | |
| 425 | L | A | 0.0000 | |
| 426 | M | A | 0.0000 | |
| 427 | N | A | -1.6997 | |
| 428 | L | A | 0.0000 | |
| 429 | L | A | 0.0000 | |
| 430 | T | A | -0.8960 | |
| 431 | A | A | -1.2853 | |
| 432 | K | A | -2.0822 | |
| 433 | D | A | -1.6825 | |
| 434 | T | A | -1.6713 | |
| 435 | K | A | -1.9743 | |
| 436 | I | A | 0.0000 | |
| 437 | I | A | 0.0000 | |
| 438 | L | A | -0.5479 | |
| 439 | V | A | 0.0000 | |
| 440 | I | A | 0.0000 | |
| 441 | L | A | 0.0000 | |
| 442 | D | A | -1.2172 | |
| 443 | A | A | 0.0000 | |
| 444 | I | A | 0.0000 | |
| 445 | S | A | -1.0527 | |
| 446 | N | A | -1.1398 | |
| 447 | I | A | 0.0000 | |
| 448 | F | A | 0.0000 | |
| 449 | Q | A | -2.0290 | |
| 450 | A | A | 0.0000 | |
| 451 | A | A | 0.0000 | |
| 452 | E | A | -2.9121 | |
| 453 | K | A | -2.3418 | |
| 454 | L | A | -0.9390 | |
| 455 | G | A | -2.1674 | |
| 456 | E | A | -3.0856 | |
| 457 | T | A | -2.6944 | |
| 458 | E | A | -2.8025 | |
| 459 | K | A | -2.6814 | |
| 460 | L | A | 0.0000 | |
| 461 | S | A | 0.0000 | |
| 462 | I | A | -0.4362 | |
| 463 | M | A | -0.9889 | |
| 464 | I | A | 0.0000 | |
| 465 | E | A | -2.4980 | |
| 466 | E | A | -2.4160 | |
| 467 | C | A | -1.6995 | |
| 468 | G | A | -1.9619 | |
| 469 | G | A | 0.0000 | |
| 470 | L | A | -1.8457 | |
| 471 | D | A | -2.9361 | |
| 472 | K | A | -2.0679 | |
| 473 | I | A | 0.0000 | |
| 474 | E | A | -2.2600 | |
| 475 | A | A | -1.6905 | |
| 476 | L | A | 0.0000 | |
| 477 | Q | A | -1.9795 | |
| 478 | N | A | -2.3093 | |
| 479 | H | A | -2.4074 | |
| 480 | E | A | -2.7443 | |
| 481 | N | A | -2.5379 | |
| 482 | E | A | -2.8805 | |
| 483 | S | A | -1.7349 | |
| 484 | V | A | 0.0000 | |
| 485 | Y | A | -1.7141 | |
| 486 | K | A | -1.8488 | |
| 487 | A | A | -1.1203 | |
| 488 | S | A | 0.0000 | |
| 489 | L | A | -1.0117 | |
| 490 | S | A | -1.1943 | |
| 491 | L | A | 0.0000 | |
| 492 | I | A | -1.4114 | |
| 493 | E | A | -2.3791 | |
| 494 | K | A | -2.3627 | |
| 495 | Y | A | -1.2198 | |
| 496 | F | A | -0.9819 | |
| 497 | S | A | -0.9544 | |
| 297 | P | B | 0.0166 | |
| 298 | V | B | 0.4839 | |
| 299 | K | B | -0.1609 | |
| 300 | K | B | -0.3964 | |
| 301 | P | B | -0.8764 | |
| 302 | K | B | -1.0507 | |
| 303 | I | B | -1.7214 | |
| 304 | R | B | -3.0509 | |
| 305 | R | B | -2.7896 | |
| 306 | K | C | -1.4602 | |
| 307 | K | C | -1.4014 | |
| 308 | S | C | -1.0211 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine