Project name: 884394f916b139e

Chain sequence(s)	A: IDFPFAHEDVVQKTVDDVRRTLSNMSAAADQGVHDVNHSSKTLAERYKDDITALAVLPPRVDEFAKSFNDILWAGRTSATHGVSRITDFVDVTVVGIVEDIKTPEDRDAVIELNAIAGQKSKPVDGFPGATRRLDGIWNTSSTDAANIAKVKTVKELTTAFSPAKAGYKKVQEALRAYASSITKLAAIDFPFAHEDVVQKTVDDVRRTLSNMSAAADQGVHDVNHSSKTLAERYKDDITALAVLPPRVDEFAKSFNDILWAGRTSATHGVSRITDFVDVTVVGIVEDIKTPEDRDAVIELNAIAGQKSKPVDGFPGATRRLDGIWNTSSTDAANIAKVKTVKELTTAFSPAKAGYKKVQEALRAYASSITKLAA
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.9866
• Maximal score value: 1.1877
• Average score: -1.1938
• Total score value: -444.0839

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
5	I	A	0.8376
6	D	A	-1.0344
7	F	A	0.0000
8	P	A	-0.8119
9	F	A	0.0000
10	A	A	-1.4166
11	H	A	-2.2732
12	E	A	-3.3918
13	D	A	-3.4074
14	V	A	-2.0367
15	V	A	0.0000
16	Q	A	-3.4929
17	K	A	-3.2751
18	T	A	-2.2717
19	V	A	-2.0169
20	D	A	-2.3616
21	D	A	-2.0461
22	V	A	0.0000
23	R	A	-1.7543
24	T	A	-1.2796
25	L	A	0.0000
26	S	A	-1.1533
27	N	A	-1.6489
28	M	A	0.0000
29	S	A	0.0000
30	A	A	-0.8744
31	A	A	-0.7295
32	A	A	0.0000
33	D	A	0.0000
34	Q	A	-1.8459
35	G	A	-1.4263
36	V	A	0.0000
37	H	A	-2.0847
38	D	A	-2.6266
39	V	A	0.0000
40	N	A	-1.9677
41	H	A	-2.3826
42	S	A	-1.9117
43	S	A	0.0000
44	K	A	-2.9177
45	T	A	-2.3657
46	L	A	0.0000
47	A	A	0.0000
48	E	A	-3.9866
49	R	A	-3.7132
50	Y	A	0.0000
51	K	A	-3.9812
52	D	A	-3.3158
53	D	A	-2.1877
54	I	A	0.0000
55	T	A	-1.2931
56	A	A	0.0000
57	L	A	0.0000
58	A	A	-0.3072
59	V	A	1.1877
60	L	A	0.0000
61	P	A	0.0000
62	P	A	-1.0076
63	R	A	-1.3513
64	V	A	0.0000
65	D	A	-2.4180
66	E	A	-2.8672
67	F	A	0.0000
68	A	A	0.0000
69	K	A	-3.0588
70	S	A	-2.1242
71	F	A	0.0000
72	N	A	-1.7763
73	D	A	-2.4087
74	I	A	-1.3505
75	L	A	0.0000
76	W	A	-0.4023
77	A	A	-0.9503
78	G	A	0.0000
79	R	A	-0.9334
80	T	A	-0.6343
81	S	A	-0.9874
82	A	A	0.0000
83	T	A	-1.1447
84	H	A	-1.5354
85	G	A	-1.1168
86	V	A	0.0000
87	S	A	-1.0971
88	R	A	0.0000
89	I	A	0.0000
90	T	A	-1.2565
91	D	A	-1.5969
92	F	A	0.0000
93	V	A	0.0000
94	D	A	-1.4796
95	V	A	-0.0590
96	T	A	0.0000
97	V	A	0.0000
98	V	A	-0.7611
99	G	A	-0.8390
100	I	A	-1.1700
101	V	A	0.0000
102	E	A	-2.3111
103	D	A	-2.7638
104	I	A	-2.6017
105	K	A	-2.8357
106	T	A	-2.5774
107	P	A	-2.6624
108	E	A	-3.6395
109	D	A	-3.3617
110	R	A	-3.2329
111	D	A	-3.0330
113	A	A	0.0000
114	V	A	-0.4685
115	I	A	0.0491
116	E	A	-0.8470
117	L	A	0.0000
118	N	A	-1.1225
119	A	A	-0.8468
120	I	A	0.0000
121	A	A	-1.5588
122	G	A	-1.8581
123	Q	A	-2.4214
124	K	A	-3.0177
125	S	A	-2.4925
126	K	A	-2.6401
127	P	A	-2.1307
128	V	A	0.0000
129	D	A	-2.2556
130	G	A	-0.8579
131	F	A	0.0000
132	P	A	-1.5172
133	G	A	0.0000
134	A	A	0.0000
135	T	A	-1.9523
136	R	A	-2.4207
137	R	A	-1.6477
138	L	A	0.0000
139	D	A	-2.3480
140	G	A	-1.7271
141	I	A	0.0000
142	W	A	0.0000
143	N	A	-2.0331
144	T	A	-0.8484
145	S	A	0.0000
146	S	A	-1.4516
147	T	A	-0.9187
148	D	A	0.0000
149	A	A	0.0000
150	A	A	-0.9815
151	N	A	-1.3858
152	I	A	0.0000
153	A	A	0.0000
154	K	A	-1.6205
155	V	A	-0.7031
164	K	A	-2.6315
165	T	A	-2.0580
166	V	A	-1.9864
167	K	A	-3.2294
168	E	A	-3.0145
169	L	A	0.0000
170	T	A	-1.4294
171	T	A	-1.2019
172	A	A	-0.7292
173	F	A	0.0000
174	S	A	-0.6732
175	P	A	-0.8200
176	A	A	0.0000
177	K	A	-1.5837
178	A	A	-1.5289
179	G	A	0.0000
180	Y	A	0.0000
181	K	A	-2.6693
182	K	A	-3.2578
183	V	A	0.0000
184	Q	A	0.0000
185	E	A	-3.3393
186	A	A	0.0000
187	L	A	0.0000
188	R	A	-2.9118
189	A	A	-1.6039
190	Y	A	0.0000
191	A	A	0.0000
192	S	A	-1.1464
193	S	A	-1.1518
194	I	A	0.0000
195	T	A	-0.8707
196	K	A	-1.6160
197	L	A	-0.7273
198	A	A	-0.5145
199	A	A	-0.4129
5	I	A	0.8378
6	D	A	-1.0346
7	F	A	0.0000
8	P	A	-0.8119
9	F	A	0.0000
10	A	A	-1.4166
11	H	A	-2.2732
12	E	A	-3.3918
13	D	A	-3.4074
14	V	A	-2.0367
15	V	A	0.0000
16	Q	A	-3.4929
17	K	A	-3.2751
18	T	A	-2.2718
19	V	A	-2.0168
20	D	A	-2.3616
21	D	A	-2.0462
22	V	A	0.0000
23	R	A	-1.7543
24	T	A	-1.2796
25	L	A	0.0000
26	S	A	-1.1533
27	N	A	-1.6489
28	M	A	0.0000
29	S	A	0.0000
30	A	A	-0.8744
31	A	A	-0.7296
32	A	A	0.0000
33	D	A	0.0000
34	Q	A	-1.8459
35	G	A	-1.4263
36	V	A	0.0000
37	H	A	-2.0846
38	D	A	-2.6266
39	V	A	0.0000
40	N	A	-1.9677
41	H	A	-2.3825
42	S	A	-1.9117
43	S	A	0.0000
44	K	A	-2.9177
45	T	A	-2.3657
46	L	A	0.0000
47	A	A	0.0000
48	E	A	-3.9866
49	R	A	-3.7132
50	Y	A	0.0000
51	K	A	-3.9813
52	D	A	-3.3158
53	D	A	-2.1881
54	I	A	0.0000
55	T	A	-1.2932
56	A	A	0.0000
57	L	A	0.0000
58	A	A	-0.3072
59	V	A	1.1877
60	L	A	0.0000
61	P	A	0.0000
62	P	A	-1.0076
63	R	A	-1.3511
64	V	A	0.0000
65	D	A	-2.4180
66	E	A	-2.8673
67	F	A	0.0000
68	A	A	0.0000
69	K	A	-3.0589
70	S	A	-2.1243
71	F	A	0.0000
72	N	A	-1.7762
73	D	A	-2.4087
74	I	A	-1.3505
75	L	A	0.0000
76	W	A	-0.4023
77	A	A	-0.9503
78	G	A	0.0000
79	R	A	-0.9333
80	T	A	-0.6343
81	S	A	-0.9874
82	A	A	0.0000
83	T	A	-1.1447
84	H	A	-1.5354
85	G	A	-1.1168
86	V	A	0.0000
87	S	A	-1.0971
88	R	A	0.0000
89	I	A	0.0000
90	T	A	-1.2567
91	D	A	-1.5970
92	F	A	0.0000
93	V	A	0.0000
94	D	A	-1.4797
95	V	A	-0.0589
96	T	A	0.0000
97	V	A	0.0000
98	V	A	-0.7611
99	G	A	-0.8388
100	I	A	-1.1701
101	V	A	0.0000
102	E	A	-2.3110
103	D	A	-2.7637
104	I	A	-2.6016
105	K	A	-2.8355
106	T	A	-2.5772
107	P	A	-2.6625
108	E	A	-3.6393
109	D	A	-3.3615
110	R	A	-3.2327
111	D	A	-3.0328
113	A	A	0.0000
114	V	A	-0.4686
115	I	A	0.0490
116	E	A	-0.8471
117	L	A	0.0000
118	N	A	-1.1224
119	A	A	-0.8466
120	I	A	0.0000
121	A	A	-1.5587
122	G	A	-1.8580
123	Q	A	-2.4213
124	K	A	-3.0177
125	S	A	-2.4925
126	K	A	-2.6401
127	P	A	-2.1307
128	V	A	0.0000
129	D	A	-2.2557
130	G	A	-0.8581
131	F	A	0.0000
132	P	A	-1.5171
133	G	A	0.0000
134	A	A	0.0000
135	T	A	-1.9523
136	R	A	-2.4207
137	R	A	-1.6478
138	L	A	0.0000
139	D	A	-2.3481
140	G	A	-1.7271
141	I	A	0.0000
142	W	A	0.0000
143	N	A	-2.0332
144	T	A	-0.8484
145	S	A	0.0000
146	S	A	-1.4516
147	T	A	-0.9187
148	D	A	0.0000
149	A	A	0.0000
150	A	A	-0.9815
151	N	A	-1.3858
152	I	A	0.0000
153	A	A	0.0000
154	K	A	-1.6204
155	V	A	-0.7031
164	K	A	-2.6315
165	T	A	-2.0580
166	V	A	-1.9864
167	K	A	-3.2294
168	E	A	-3.0145
169	L	A	0.0000
170	T	A	-1.4294
171	T	A	-1.2020
172	A	A	-0.7291
173	F	A	0.0000
174	S	A	-0.6732
175	P	A	-0.8200
176	A	A	0.0000
177	K	A	-1.5837
178	A	A	-1.5289
179	G	A	0.0000
180	Y	A	0.0000
181	K	A	-2.6693
182	K	A	-3.2578
183	V	A	0.0000
184	Q	A	0.0000
185	E	A	-3.3393
186	A	A	0.0000
187	L	A	0.0000
188	R	A	-2.9119
189	A	A	-1.6040
190	Y	A	0.0000
191	A	A	0.0000
192	S	A	-1.1463
193	S	A	-1.1517
194	I	A	0.0000
195	T	A	-0.8707
196	K	A	-1.6159
197	L	A	-0.7273
198	A	A	-0.5145
199	A	A	-0.4129