Project name: 94bf5749af9c683

Chain sequence(s)	A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAQTPPAPKEPPSSGEPPKSGDRSGYSSPGEPGTPGSRSRTPSLPTPPEREPKKVAVVREPPKSPESAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTEPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.1457
• Maximal score value: 2.5207
• Average score: -1.0864
• Total score value: -479.0806

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-1.4246
2	A	A	-1.8251
3	E	A	-2.4598
4	P	A	-2.2432
5	R	A	-2.4355
6	Q	A	0.0000
7	E	A	-2.5682
8	F	A	0.0000
9	E	A	-0.4132
10	V	A	0.4513
11	M	A	0.0000
12	E	A	-1.9112
13	D	A	-2.2433
14	H	A	-1.4228
15	A	A	-0.5184
16	G	A	0.3006
17	T	A	0.2302
18	Y	A	1.1015
19	G	A	0.4974
20	L	A	1.0869
21	G	A	-1.0005
22	D	A	-3.1775
23	R	A	-3.9702
24	K	A	-3.9794
25	D	A	-3.4274
26	Q	A	-2.6907
27	G	A	-1.7207
28	G	A	-1.1703
29	Y	A	0.2773
30	T	A	0.4075
31	M	A	0.3484
32	H	A	-1.5461
33	Q	A	-3.2352
34	D	A	-3.7639
35	Q	A	-4.1457
36	E	A	-3.6889
37	G	A	-3.1576
38	D	A	-3.8347
39	T	A	-3.3228
40	D	A	-2.7900
41	A	A	-1.8307
42	G	A	-1.8397
43	L	A	0.0000
44	K	A	-1.8649
45	E	A	-1.2754
46	S	A	0.0000
47	P	A	0.0000
48	L	A	0.0000
49	Q	A	-1.0937
50	T	A	-0.7099
51	P	A	-1.6070
52	T	A	-1.8096
53	E	A	-3.1599
54	D	A	-3.2528
55	G	A	-2.7064
56	S	A	-2.2517
57	E	A	0.0000
58	E	A	-2.1399
59	P	A	-2.2830
60	G	A	-2.1010
61	S	A	-2.1945
62	E	A	-2.4816
63	T	A	-2.4533
64	S	A	-1.9872
65	D	A	-2.6845
66	A	A	0.0000
67	K	A	-3.2629
68	S	A	0.0000
69	T	A	-2.2774
70	P	A	0.0000
71	T	A	-1.0448
72	A	A	-1.1295
73	E	A	-2.1952
74	D	A	-1.4501
75	V	A	0.7228
76	T	A	-0.1477
77	A	A	-0.4353
78	P	A	0.0000
79	L	A	-0.4034
80	V	A	-1.4853
81	D	A	-2.9140
82	E	A	-2.9802
83	G	A	-2.2970
84	A	A	-2.0606
85	P	A	-1.4879
86	G	A	-1.2859
87	K	A	-2.4718
88	Q	A	-2.2678
89	A	A	-1.7351
90	A	A	-0.9594
91	A	A	-1.1613
92	Q	A	-1.8799
93	P	A	-1.6482
94	H	A	-1.5364
95	T	A	-1.3476
96	E	A	-1.5685
97	I	A	0.4404
98	P	A	-0.9776
99	E	A	-2.2223
100	G	A	-1.8749
101	T	A	-1.7651
102	T	A	-2.2521
103	A	A	0.0000
104	E	A	-3.2319
105	E	A	-2.9156
106	A	A	-2.0108
107	G	A	-1.3000
108	I	A	0.1072
109	G	A	-1.0731
110	D	A	-1.6381
111	T	A	0.0000
112	P	A	-0.6249
113	S	A	-0.8226
114	L	A	-0.7355
115	E	A	-1.8802
116	D	A	-2.5478
117	E	A	-2.5977
118	A	A	-1.7785
119	A	A	-1.2633
120	G	A	-0.9616
121	H	A	-1.3105
122	V	A	-0.8783
123	T	A	-1.5029
124	Q	A	-2.2575
125	A	A	0.0000
126	R	A	-1.8977
127	M	A	-1.4034
128	V	A	-0.3849
129	S	A	-1.0998
130	K	A	-1.4909
131	S	A	-1.2013
132	K	A	-1.3649
133	D	A	-1.4661
134	G	A	0.3841
135	T	A	0.3275
136	G	A	-0.5587
137	S	A	-1.3794
138	D	A	-2.8650
139	D	A	-2.4476
140	K	A	-2.4873
141	K	A	0.0000
142	A	A	-2.7509
143	K	A	-3.3317
144	G	A	-1.9247
145	A	A	-1.6929
146	D	A	-2.8683
147	G	A	-2.6663
148	K	A	-2.7418
149	T	A	-2.2831
150	K	A	-2.2493
151	I	A	-1.1833
152	A	A	0.0000
153	T	A	0.0000
154	P	A	-0.6257
155	R	A	-1.2778
156	G	A	-0.9532
157	A	A	-0.4358
158	A	A	-0.6389
159	P	A	-0.7335
160	P	A	-1.1564
161	G	A	0.0000
162	Q	A	0.0000
163	K	A	-2.3369
164	G	A	-1.2009
165	Q	A	-0.8288
166	A	A	0.0000
167	N	A	-0.7132
168	A	A	-0.2757
169	T	A	-0.4006
170	R	A	-0.7130
171	I	A	-0.2880
172	P	A	-0.4058
173	A	A	-0.3527
174	Q	A	-0.8388
175	T	A	-0.8149
176	P	A	-1.3853
177	P	A	-1.0077
178	A	A	-1.0575
179	P	A	-1.8437
180	K	A	-2.9694
181	E	A	-3.0779
182	P	A	-1.8688
183	P	A	-1.2665
184	S	A	-0.9502
185	S	A	-1.0543
186	G	A	-1.5757
187	E	A	-2.1770
188	P	A	-1.4039
189	P	A	-1.0774
190	K	A	0.0000
191	S	A	-0.8048
192	G	A	-1.6796
193	D	A	-2.6801
194	R	A	-2.6719
195	S	A	-1.7746
196	G	A	0.0000
197	Y	A	0.0000
198	S	A	0.0000
199	S	A	0.0000
200	P	A	-1.4212
201	G	A	-1.2258
202	E	A	-1.5150
203	P	A	-1.0991
204	G	A	-0.8957
205	T	A	-1.3561
206	P	A	-1.2513
207	G	A	-1.3558
208	S	A	-1.4529
209	R	A	-2.2053
210	S	A	0.0000
211	R	A	-1.5174
212	T	A	-1.0167
213	P	A	-0.7589
214	S	A	-0.5424
215	L	A	-0.1691
216	P	A	-0.3886
217	T	A	-0.7280
218	P	A	-1.0606
219	P	A	-1.6754
220	E	A	-2.6447
221	R	A	-3.8728
222	E	A	-3.7408
223	P	A	-2.8319
224	K	A	-3.6060
225	K	A	-2.9707
226	V	A	-0.6354
227	A	A	0.3522
228	V	A	1.1455
229	V	A	-0.2200
230	R	A	-1.5764
231	E	A	-1.4709
232	P	A	-1.2490
233	P	A	-1.2349
234	K	A	-1.8813
235	S	A	-1.2012
236	P	A	0.0000
237	E	A	-1.8927
238	S	A	0.0000
239	A	A	-1.5023
240	K	A	-2.3907
241	S	A	-2.4364
242	R	A	-2.3182
243	L	A	0.0876
244	Q	A	0.1860
245	T	A	0.0836
246	A	A	-0.0975
247	P	A	-0.2112
248	V	A	0.6549
249	P	A	-0.2584
250	M	A	-0.1782
251	P	A	-0.6498
252	D	A	-0.8092
253	L	A	0.0000
254	K	A	-0.4879
255	N	A	-1.0698
256	V	A	-1.5167
257	K	A	-2.2923
258	S	A	-1.8470
259	K	A	-2.6574
260	I	A	0.0000
261	G	A	-3.0012
262	S	A	-2.3921
263	T	A	-1.6686
264	E	A	-2.8674
265	N	A	-2.7678
266	L	A	-2.0548
267	K	A	-2.5560
268	H	A	-1.6773
269	Q	A	-1.2548
270	P	A	-0.9701
271	G	A	-1.0383
272	G	A	-1.0938
273	G	A	-0.9631
274	K	A	-0.9365
275	V	A	0.9663
276	Q	A	0.0924
277	I	A	1.2531
278	I	A	-0.3084
279	N	A	-2.0214
280	K	A	-2.8159
281	K	A	-2.5385
282	L	A	-1.6051
283	D	A	-1.7111
284	L	A	-0.2898
285	S	A	0.0000
286	N	A	-1.0701
287	V	A	0.9731
288	Q	A	-0.3122
289	S	A	0.0000
290	K	A	-0.5996
291	C	A	0.0000
292	G	A	0.0000
293	S	A	-0.8839
294	K	A	-1.1556
295	D	A	-1.5766
296	N	A	-1.6324
297	I	A	0.0000
298	K	A	-2.5212
299	H	A	0.0000
300	V	A	-0.9523
301	P	A	-0.9284
302	G	A	-0.3186
303	G	A	-0.6128
304	G	A	0.0560
305	S	A	1.3757
306	V	A	2.3058
307	Q	A	1.6319
308	I	A	2.5207
309	V	A	2.4763
310	Y	A	1.2375
311	K	A	-0.4018
312	P	A	0.0000
313	V	A	0.0000
314	D	A	-1.2030
315	L	A	-1.1582
316	S	A	-0.8094
317	K	A	-0.9009
318	V	A	-0.6945
319	T	A	0.0000
320	S	A	-2.1695
321	K	A	-2.1873
322	C	A	-0.8419
323	G	A	-1.4215
324	S	A	-0.9606
325	L	A	-0.9528
326	G	A	-0.9060
327	N	A	-0.5258
328	I	A	0.8841
329	H	A	-0.4589
330	H	A	-0.7972
331	K	A	-0.5266
332	P	A	0.0000
333	G	A	-0.9501
334	G	A	0.0000
335	G	A	-0.7843
336	Q	A	-0.6967
337	V	A	0.4879
338	E	A	0.1627
339	V	A	1.2921
340	K	A	-1.0117
341	S	A	-0.7992
342	E	A	0.0000
343	K	A	-2.5175
344	L	A	-1.3835
345	D	A	-2.0446
346	F	A	-0.3743
347	K	A	-2.6560
348	D	A	-3.2247
349	R	A	-3.0543
350	V	A	0.0000
351	Q	A	-1.0478
352	S	A	-0.6087
353	K	A	-0.9741
354	I	A	-0.3870
355	G	A	0.0000
356	S	A	0.0000
357	L	A	-0.6202
358	D	A	-1.8110
359	N	A	-1.8970
360	I	A	0.0000
361	T	A	-0.4215
362	H	A	-0.2918
363	V	A	0.9354
364	P	A	-0.2364
365	G	A	-0.6935
366	G	A	-1.1430
367	G	A	-1.3966
368	N	A	-1.7193
369	K	A	-1.5056
370	K	A	0.0000
371	I	A	0.0000
372	E	A	-0.8968
373	T	A	0.0000
374	H	A	-0.6827
375	K	A	-1.3638
376	L	A	-0.7203
377	T	A	-1.1804
378	F	A	0.0000
379	R	A	-2.4484
380	E	A	-2.7376
381	N	A	-2.1843
382	A	A	0.0000
383	K	A	-1.8308
384	A	A	0.0000
385	K	A	-0.9544
386	T	A	-0.1373
387	D	A	-0.0993
388	H	A	-0.2749
389	G	A	-1.2336
390	A	A	-1.3906
391	E	A	-2.2070
392	I	A	0.0000
393	V	A	0.3578
394	Y	A	-0.6578
395	K	A	-1.7075
396	S	A	-0.8655
397	P	A	-0.0332
398	V	A	0.6518
399	V	A	1.1698
400	S	A	-0.1356
401	G	A	-1.3354
402	D	A	-1.5520
403	T	A	-1.3160
404	E	A	-1.8982
405	P	A	-0.6819
406	R	A	0.0000
407	H	A	-1.3281
408	L	A	-0.9051
409	S	A	-0.9161
410	N	A	0.0000
411	V	A	-0.2307
412	S	A	0.0000
413	S	A	0.0000
414	T	A	-0.5517
415	G	A	0.0000
416	S	A	0.0000
417	I	A	0.0000
418	D	A	-0.2199
419	M	A	0.0000
420	V	A	0.0000
421	D	A	-0.8427
422	S	A	-0.7291
423	P	A	-1.0789
424	Q	A	-0.9329
425	L	A	0.6799
426	A	A	0.2449
427	T	A	-0.1852
428	L	A	0.0000
429	A	A	0.0000
430	D	A	-2.4072
431	E	A	-1.8680
432	V	A	0.3327
433	S	A	0.0184
434	A	A	0.3777
435	S	A	0.0604
436	L	A	0.7643
437	A	A	-0.8040
438	K	A	-2.4401
439	Q	A	-2.9263
440	G	A	-1.9353
441	L	A	-0.3808