| Chain sequence(s) |
A: FSNEDIYDNIDPDTISFPPKIATTDLFLPLFFHFGSTRQFMDKLHEVISGDYEPSQAEKLVQDLCDETGIRKNFSTSILTCLSGDLMVFPRYFLNMFKDNVNPPPNVPGIWTHDDDESLKSNDQEQIRKLVKKHGTGRMEMRKRFFEK C: KMIDFATLSKLKKKYQIILD B: DFSNEDIYDNIDPDTISFPPKIATTDLFLPLFFHFGSTRQFMDKLHEVISGDYEPSQAEKLVQDLCDETGIRKNFSTSILTCLSGDLMVFPRYFLNMFKDNVNPPPNVPGIWTHDDDESLKSNDQEQIRKLVKKHGTGRMEMRKRFFE |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 677 | F | A | 1.1210 | |
| 678 | S | A | -0.0378 | |
| 679 | N | A | -0.7388 | |
| 680 | E | A | -0.3835 | |
| 681 | D | A | -0.8081 | |
| 682 | I | A | 0.6149 | |
| 683 | Y | A | -0.1424 | |
| 684 | D | A | -1.1001 | |
| 685 | N | A | -1.3332 | |
| 686 | I | A | -1.2858 | |
| 687 | D | A | -2.4275 | |
| 688 | P | A | -2.5677 | |
| 689 | D | A | -2.6326 | |
| 690 | T | A | -1.6334 | |
| 691 | I | A | 0.0000 | |
| 692 | S | A | -1.0342 | |
| 693 | F | A | -0.6053 | |
| 694 | P | A | -0.3732 | |
| 695 | P | A | 0.0000 | |
| 696 | K | A | -1.7582 | |
| 697 | I | A | -1.2515 | |
| 698 | A | A | 0.0000 | |
| 699 | T | A | -0.3881 | |
| 700 | T | A | -0.2981 | |
| 701 | D | A | -1.0269 | |
| 702 | L | A | 0.0000 | |
| 703 | F | A | 0.0000 | |
| 704 | L | A | -0.2397 | |
| 705 | P | A | 0.1334 | |
| 706 | L | A | 0.0227 | |
| 707 | F | A | 0.0000 | |
| 708 | F | A | 0.3904 | |
| 709 | H | A | -0.5599 | |
| 710 | F | A | -0.6366 | |
| 711 | G | A | -0.9291 | |
| 712 | S | A | -1.3559 | |
| 713 | T | A | 0.0000 | |
| 714 | R | A | -3.1164 | |
| 715 | Q | A | -2.6702 | |
| 716 | F | A | 0.0000 | |
| 717 | M | A | 0.0000 | |
| 718 | D | A | -3.5124 | |
| 719 | K | A | -3.1763 | |
| 720 | L | A | 0.0000 | |
| 721 | H | A | -2.4131 | |
| 722 | E | A | -3.2018 | |
| 723 | V | A | 0.0000 | |
| 724 | I | A | 0.0000 | |
| 725 | S | A | -1.6970 | |
| 726 | G | A | -1.9901 | |
| 727 | D | A | -2.6229 | |
| 728 | Y | A | -2.5571 | |
| 729 | E | A | -2.8424 | |
| 730 | P | A | -1.8719 | |
| 731 | S | A | -1.6808 | |
| 732 | Q | A | -2.4785 | |
| 733 | A | A | 0.0000 | |
| 734 | E | A | -2.4755 | |
| 735 | K | A | -2.7082 | |
| 736 | L | A | 0.0000 | |
| 737 | V | A | 0.0000 | |
| 738 | Q | A | -2.5767 | |
| 739 | D | A | -2.3854 | |
| 740 | L | A | 0.0000 | |
| 741 | C | A | -2.1073 | |
| 742 | D | A | -2.8740 | |
| 743 | E | A | -3.0203 | |
| 744 | T | A | 0.0000 | |
| 745 | G | A | 0.0000 | |
| 746 | I | A | 0.0000 | |
| 747 | R | A | -1.6157 | |
| 748 | K | A | -1.8545 | |
| 749 | N | A | -2.1650 | |
| 750 | F | A | 0.0000 | |
| 751 | S | A | 0.0000 | |
| 752 | T | A | 0.0000 | |
| 753 | S | A | -0.6704 | |
| 754 | I | A | 0.0000 | |
| 755 | L | A | 0.0000 | |
| 756 | T | A | -0.1108 | |
| 757 | C | A | -0.1959 | |
| 758 | L | A | 0.0000 | |
| 759 | S | A | 0.0000 | |
| 760 | G | A | 0.0000 | |
| 761 | D | A | -0.3255 | |
| 762 | L | A | 0.0000 | |
| 763 | M | A | 0.4150 | |
| 764 | V | A | 0.0000 | |
| 765 | F | A | 0.0000 | |
| 766 | P | A | -0.3212 | |
| 767 | R | A | 0.0000 | |
| 768 | Y | A | 0.0000 | |
| 769 | F | A | 0.0000 | |
| 770 | L | A | 0.0000 | |
| 771 | N | A | -1.6971 | |
| 772 | M | A | 0.0000 | |
| 773 | F | A | 0.0000 | |
| 774 | K | A | -2.6712 | |
| 775 | D | A | -3.0280 | |
| 776 | N | A | -2.7254 | |
| 777 | V | A | -1.4511 | |
| 778 | N | A | -0.8625 | |
| 779 | P | A | -0.9478 | |
| 780 | P | A | 0.0000 | |
| 781 | P | A | -1.4195 | |
| 782 | N | A | -1.4346 | |
| 783 | V | A | 0.0000 | |
| 784 | P | A | -0.3983 | |
| 785 | G | A | 0.0000 | |
| 786 | I | A | 0.0000 | |
| 787 | W | A | 0.0000 | |
| 788 | T | A | -1.7169 | |
| 789 | H | A | -2.5564 | |
| 790 | D | A | -3.1705 | |
| 791 | D | A | 0.0000 | |
| 792 | D | A | -2.5535 | |
| 793 | E | A | -3.5250 | |
| 794 | S | A | -2.8093 | |
| 795 | L | A | 0.0000 | |
| 796 | K | A | -2.6930 | |
| 797 | S | A | -2.6208 | |
| 798 | N | A | -2.6798 | |
| 799 | D | A | -3.3214 | |
| 800 | Q | A | -3.5296 | |
| 801 | E | A | -3.9391 | |
| 802 | Q | A | -3.4907 | |
| 803 | I | A | -2.9543 | |
| 804 | R | A | -3.8978 | |
| 805 | K | A | -3.5336 | |
| 806 | L | A | 0.0000 | |
| 807 | V | A | -2.0740 | |
| 808 | K | A | -2.6351 | |
| 809 | K | A | -1.8447 | |
| 810 | H | A | 0.0000 | |
| 811 | G | A | -0.9804 | |
| 812 | T | A | -1.1074 | |
| 813 | G | A | -0.8733 | |
| 814 | R | A | 0.0000 | |
| 815 | M | A | 0.0000 | |
| 816 | E | A | -1.9675 | |
| 817 | M | A | -1.3947 | |
| 818 | R | A | 0.0000 | |
| 819 | K | A | -2.5229 | |
| 820 | R | A | -2.9822 | |
| 821 | F | A | -1.4853 | |
| 822 | F | A | -1.4869 | |
| 823 | E | A | -2.8613 | |
| 824 | K | A | -2.6478 | |
| 676 | D | B | -0.8884 | |
| 677 | F | B | 0.3681 | |
| 678 | S | B | -0.5818 | |
| 679 | N | B | -1.1951 | |
| 680 | E | B | -1.1375 | |
| 681 | D | B | -1.4616 | |
| 682 | I | B | 0.3105 | |
| 683 | Y | B | -0.4444 | |
| 684 | D | B | -1.4374 | |
| 685 | N | B | -1.5655 | |
| 686 | I | B | -1.1758 | |
| 687 | D | B | -2.2402 | |
| 688 | P | B | -2.3704 | |
| 689 | D | B | -2.6461 | |
| 690 | T | B | -1.5713 | |
| 691 | I | B | 0.0000 | |
| 692 | S | B | -1.0688 | |
| 693 | F | B | -0.8105 | |
| 694 | P | B | -0.4226 | |
| 695 | P | B | 0.0000 | |
| 696 | K | B | -1.9178 | |
| 697 | I | B | -1.3295 | |
| 698 | A | B | 0.0000 | |
| 699 | T | B | -0.7525 | |
| 700 | T | B | -0.8453 | |
| 701 | D | B | -1.9346 | |
| 702 | L | B | -1.1220 | |
| 703 | F | B | 0.0000 | |
| 704 | L | B | -0.4409 | |
| 705 | P | B | 0.1301 | |
| 706 | L | B | 0.0318 | |
| 707 | F | B | 0.0000 | |
| 708 | F | B | 0.2074 | |
| 709 | H | B | -0.6663 | |
| 710 | F | B | -0.8019 | |
| 711 | G | B | -1.0944 | |
| 712 | S | B | -1.5577 | |
| 713 | T | B | 0.0000 | |
| 714 | R | B | -3.4554 | |
| 715 | Q | B | -3.0506 | |
| 716 | F | B | 0.0000 | |
| 717 | M | B | 0.0000 | |
| 718 | D | B | -3.4979 | |
| 719 | K | B | -2.7978 | |
| 720 | L | B | 0.0000 | |
| 721 | H | B | -2.3445 | |
| 722 | E | B | -2.9838 | |
| 723 | V | B | 0.0000 | |
| 724 | I | B | 0.0000 | |
| 725 | S | B | -1.3783 | |
| 726 | G | B | -1.7273 | |
| 727 | D | B | -2.3275 | |
| 728 | Y | B | -2.3383 | |
| 729 | E | B | -2.5624 | |
| 730 | P | B | -1.1471 | |
| 731 | S | B | -1.4801 | |
| 732 | Q | B | -2.2566 | |
| 733 | A | B | 0.0000 | |
| 734 | E | B | -2.9922 | |
| 735 | K | B | -3.1778 | |
| 736 | L | B | 0.0000 | |
| 737 | V | B | 0.0000 | |
| 738 | Q | B | -2.7020 | |
| 739 | D | B | -2.2658 | |
| 740 | L | B | 0.0000 | |
| 741 | C | B | -2.0314 | |
| 742 | D | B | -2.5308 | |
| 743 | E | B | -2.1846 | |
| 744 | T | B | 0.0000 | |
| 745 | G | B | 0.0000 | |
| 746 | I | B | 0.0000 | |
| 747 | R | B | -2.1042 | |
| 748 | K | B | -2.5455 | |
| 749 | N | B | -2.2717 | |
| 750 | F | B | 0.0000 | |
| 751 | S | B | 0.0000 | |
| 752 | T | B | -1.2650 | |
| 753 | S | B | -0.6630 | |
| 754 | I | B | 0.0000 | |
| 755 | L | B | 0.0000 | |
| 756 | T | B | 0.2184 | |
| 757 | C | B | -0.0990 | |
| 758 | L | B | 0.0000 | |
| 759 | S | B | 0.0000 | |
| 760 | G | B | 0.0000 | |
| 761 | D | B | -0.4331 | |
| 762 | L | B | 0.0000 | |
| 763 | M | B | 0.5052 | |
| 764 | V | B | 0.0000 | |
| 765 | F | B | 0.0000 | |
| 766 | P | B | 0.0000 | |
| 767 | R | B | 0.0000 | |
| 768 | Y | B | 0.0000 | |
| 769 | F | B | 0.0000 | |
| 770 | L | B | 0.0000 | |
| 771 | N | B | -1.5490 | |
| 772 | M | B | 0.0000 | |
| 773 | F | B | 0.0000 | |
| 774 | K | B | -2.6879 | |
| 775 | D | B | -2.9875 | |
| 776 | N | B | -2.7203 | |
| 777 | V | B | -1.4547 | |
| 778 | N | B | -0.9336 | |
| 779 | P | B | -0.9235 | |
| 780 | P | B | 0.0000 | |
| 781 | P | B | -1.3546 | |
| 782 | N | B | -1.4259 | |
| 783 | V | B | 0.0000 | |
| 784 | P | B | -0.7320 | |
| 785 | G | B | 0.0000 | |
| 786 | I | B | 0.0000 | |
| 787 | W | B | 0.0000 | |
| 788 | T | B | 0.0000 | |
| 789 | H | B | -1.9647 | |
| 790 | D | B | -2.8450 | |
| 791 | D | B | -2.5079 | |
| 792 | D | B | -2.3650 | |
| 793 | E | B | -3.4738 | |
| 794 | S | B | -3.4090 | |
| 795 | L | B | -2.8384 | |
| 796 | K | B | -2.9885 | |
| 797 | S | B | -2.7627 | |
| 798 | N | B | -3.1485 | |
| 799 | D | B | -3.2659 | |
| 800 | Q | B | -3.6446 | |
| 801 | E | B | -4.0572 | |
| 802 | Q | B | -3.6677 | |
| 803 | I | B | -3.5714 | |
| 804 | R | B | -4.0149 | |
| 805 | K | B | -3.8395 | |
| 806 | L | B | 0.0000 | |
| 807 | V | B | -2.0804 | |
| 808 | K | B | -2.7652 | |
| 809 | K | B | -2.0643 | |
| 810 | H | B | 0.0000 | |
| 811 | G | B | -1.4350 | |
| 812 | T | B | -1.0779 | |
| 813 | G | B | -1.0047 | |
| 814 | R | B | -1.1377 | |
| 815 | M | B | 0.0000 | |
| 816 | E | B | -1.7496 | |
| 817 | M | B | -1.3851 | |
| 818 | R | B | 0.0000 | |
| 819 | K | B | -2.5962 | |
| 820 | R | B | -2.6259 | |
| 821 | F | B | -0.5884 | |
| 822 | F | B | -1.1428 | |
| 823 | E | B | -2.1413 | |
| 461 | K | C | -1.8973 | |
| 462 | M | C | -0.8914 | |
| 463 | I | C | 0.0000 | |
| 464 | D | C | -1.2152 | |
| 465 | F | C | -0.3279 | |
| 466 | A | C | -0.7671 | |
| 467 | T | C | -1.1268 | |
| 468 | L | C | 0.0000 | |
| 469 | S | C | -1.6848 | |
| 470 | K | C | -3.0222 | |
| 471 | L | C | 0.0000 | |
| 472 | K | C | -3.0311 | |
| 473 | K | C | -3.4668 | |
| 474 | K | C | -3.1150 | |
| 475 | Y | C | -1.7386 | |
| 476 | Q | C | -1.7431 | |
| 477 | I | C | 0.0339 | |
| 478 | I | C | 0.5724 | |
| 479 | L | C | 0.0000 | |
| 480 | D | C | -1.4943 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine