Project name: 426cTM4 5fa2

Chain sequence(s)	A: EAKTTLFCASDAKAYEKECHNVWATHACVPTDPNPQEVVLEQVTENFNMWKNDMVDQMQEDVISIWDQCLKPCVKLTNTSTLTQACPKVTFDPIPIHYCAPAGYAILKCNNKTFNGKGPCNNVSTVQCTHGIKPVVSTQLLLNGSLAEEEIVIRSKNLRDNAKIIIVQLQKSVEIVCTRPNNGDIRQAYCQISGRNWSEAVNQVKKKLKEHFPHKNISFQSSSGGDLEITTHSFNCGGEFFYCNTSGLFQDTISNATIMLPCRIKQIINMWQEVGKAIYAPPIKGQITCKSDITGLLLLRDGGDTTDNTEIFRPSGGDMRDNWRSELYKYKVVEIK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.0952
• Maximal score value: 1.6719
• Average score: -0.8287
• Total score value: -278.4293

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
47	E	A	-2.3756
48	A	A	-1.7439
49	K	A	-2.2892
50	T	A	-1.1199
51	T	A	-0.2494
52	L	A	0.0000
53	F	A	1.1558
54	C	A	0.0000
55	A	A	0.0000
56	S	A	0.0000
57	D	A	-1.9683
58	A	A	-0.9770
59	K	A	-1.1005
60	A	A	-0.3174
61	Y	A	0.4851
62	E	A	-0.8918
63	K	A	-1.5447
64	E	A	0.0000
65	C	A	0.0000
66	H	A	0.0000
67	N	A	0.0000
68	V	A	-0.1794
69	W	A	-0.4534
70	A	A	0.0000
71	T	A	-0.3684
72	H	A	-0.5840
73	A	A	0.0348
74	C	A	0.0000
75	V	A	0.8589
76	P	A	-0.4220
77	T	A	-1.0322
78	D	A	-1.6233
79	P	A	-1.6013
80	N	A	-2.1756
81	P	A	-2.2371
82	Q	A	-2.1737
83	E	A	-1.0787
84	V	A	1.4265
85	V	A	1.6719
86	L	A	0.1999
87	E	A	-1.7188
88	Q	A	-2.0213
89	V	A	-1.1677
90	T	A	-1.7033
91	E	A	-1.6986
92	N	A	-2.3441
93	F	A	0.0000
94	N	A	-2.0218
95	M	A	0.0000
96	W	A	0.0000
97	K	A	-2.3262
98	N	A	-1.7427
99	D	A	-1.6441
100	M	A	0.0000
101	V	A	0.0000
102	D	A	-1.9347
103	Q	A	-1.3531
104	M	A	0.0000
105	Q	A	0.0000
106	E	A	-2.2165
107	D	A	-1.4666
108	V	A	0.0000
109	I	A	-1.1650
110	S	A	-1.2994
111	I	A	0.0000
112	W	A	0.0000
113	D	A	-2.2413
114	Q	A	-1.4885
115	C	A	0.0000
116	L	A	0.0000
117	K	A	-1.2792
118	P	A	0.0000
119	C	A	0.1676
120	V	A	0.5208
121	K	A	-0.0041
122	L	A	0.0611
123	T	A	-0.6088
124	N	A	-1.1006
198	T	A	-0.7180
199	S	A	-0.4369
200	T	A	-0.0781
201	L	A	0.4650
202	T	A	0.2215
203	Q	A	-0.2867
204	A	A	-0.2519
205	C	A	-0.2781
206	P	A	-0.5773
207	K	A	-0.6753
208	V	A	-0.5401
209	T	A	-0.9238
210	F	A	0.0000
211	D	A	-1.8305
212	P	A	-1.0478
213	I	A	-0.7809
214	P	A	-0.7496
215	I	A	0.0000
216	H	A	-0.5045
217	Y	A	0.0000
218	C	A	0.0000
219	A	A	0.0000
220	P	A	-0.0228
221	A	A	0.0291
222	G	A	-0.1172
223	Y	A	-0.3515
224	A	A	-0.1641
225	I	A	0.0000
226	L	A	0.0000
227	K	A	-0.5147
228	C	A	0.0000
229	N	A	-1.4625
230	N	A	-2.6351
231	K	A	-3.3962
232	T	A	-2.3273
233	F	A	0.0000
234	N	A	-1.9487
235	G	A	0.0000
236	K	A	-2.3079
237	G	A	-1.6301
238	P	A	-1.8909
239	C	A	0.0000
240	N	A	-2.6797
241	N	A	-2.4699
242	V	A	0.0000
243	S	A	0.0000
244	T	A	0.3784
245	V	A	-0.5351
246	Q	A	-1.1776
247	C	A	-0.7804
248	T	A	0.0000
249	H	A	-0.6566
250	G	A	-0.7629
251	I	A	0.0000
252	K	A	-0.9865
253	P	A	0.0000
254	V	A	-0.3380
255	V	A	0.0000
256	S	A	0.0000
257	T	A	0.0000
258	Q	A	0.0000
259	L	A	0.0000
260	L	A	0.0000
261	L	A	0.0000
262	N	A	-1.3129
263	G	A	-0.6745
264	S	A	-0.6328
265	L	A	-0.9459
266	A	A	0.0000
267	E	A	-3.7364
268	E	A	-4.0952
269	E	A	-3.6853
270	I	A	0.0000
271	V	A	0.0000
272	I	A	0.0000
273	R	A	0.0000
274	S	A	-1.4739
275	K	A	-2.1383
276	N	A	-2.4077
277	L	A	-1.8126
278	R	A	-2.7903
279	D	A	-2.3474
280	N	A	-1.9096
281	A	A	-1.1449
282	K	A	-1.4932
283	I	A	-0.6302
284	I	A	0.0000
285	I	A	0.0000
286	V	A	0.0000
287	Q	A	0.0000
288	L	A	0.0000
289	Q	A	-2.4911
290	K	A	-2.8730
291	S	A	-1.5809
292	V	A	0.0000
293	E	A	-2.1409
294	I	A	0.0000
295	V	A	-0.8751
296	C	A	0.0000
297	T	A	0.0000
298	R	A	0.0000
299	P	A	-1.9735
300	N	A	-2.7514
301	N	A	-2.6795
324	G	A	-1.6387
325	D	A	-1.9068
326	I	A	-1.3023
327	R	A	-1.5221
328	Q	A	-1.5312
329	A	A	0.0000
330	Y	A	-0.0218
331	C	A	0.0000
332	Q	A	-0.4398
333	I	A	0.0000
334	S	A	-1.3944
335	G	A	0.0000
336	R	A	-3.1220
337	N	A	-2.6393
338	W	A	0.0000
339	S	A	-2.5879
340	E	A	-3.4006
341	A	A	-2.4843
342	V	A	0.0000
343	N	A	-2.8894
344	Q	A	-3.1240
345	V	A	0.0000
346	K	A	-2.6942
347	K	A	-3.5177
348	K	A	-2.7917
349	L	A	0.0000
350	K	A	-3.4028
351	E	A	-3.1888
352	H	A	-2.1532
353	F	A	0.0000
354	P	A	-1.9719
355	H	A	-2.2439
356	K	A	-2.6409
357	N	A	-2.6425
358	I	A	0.0000
359	S	A	0.0000
360	F	A	0.0000
361	Q	A	-1.0655
362	S	A	-0.7547
363	S	A	-0.4255
364	S	A	-0.6955
365	G	A	-0.9255
366	G	A	-1.1283
367	D	A	-1.2850
368	L	A	-0.1675
369	E	A	-0.2284
370	I	A	-0.3633
371	T	A	-0.4711
372	T	A	0.0000
373	H	A	0.0000
374	S	A	0.0000
375	F	A	0.0000
376	N	A	-0.3802
377	C	A	0.0000
378	G	A	-0.6583
379	G	A	-0.4274
380	E	A	0.0000
381	F	A	0.0000
382	F	A	0.0000
383	Y	A	0.0000
384	C	A	0.0000
385	N	A	-0.8544
386	T	A	0.0000
387	S	A	-0.7756
388	G	A	-0.6781
389	L	A	0.0000
390	F	A	0.0000
391	Q	A	-1.6562
392	D	A	-2.2391
393	T	A	-1.1912
394	I	A	-1.2602
395	S	A	-1.2884
396	N	A	-2.4708
412	A	A	-0.9920
413	T	A	-0.5514
414	I	A	0.0007
415	M	A	0.8008
416	L	A	0.0000
417	P	A	-0.4545
418	C	A	0.0000
419	R	A	-1.6835
420	I	A	0.0000
421	K	A	-0.5808
422	Q	A	0.1776
423	I	A	1.2645
424	I	A	0.0000
425	N	A	-0.2951
426	M	A	-0.2487
427	W	A	-0.7818
428	Q	A	-1.3068
429	E	A	-1.1712
430	V	A	0.4339
431	G	A	-0.5243
432	K	A	-0.5570
433	A	A	0.0000
434	I	A	0.7905
435	Y	A	0.2684
436	A	A	0.2165
437	P	A	-0.1353
438	P	A	-0.2528
439	I	A	-0.1993
440	K	A	-1.9695
441	G	A	-2.1210
442	Q	A	-2.2996
443	I	A	0.0000
444	T	A	-0.6462
445	C	A	-0.9948
446	K	A	-2.0975
447	S	A	-1.7884
448	D	A	-2.2815
449	I	A	0.0000
450	T	A	0.0000
451	G	A	0.0000
452	L	A	0.0000
453	L	A	0.0000
454	L	A	0.0000
455	L	A	-0.1300
456	R	A	-0.8613
457	D	A	-1.1326
458	G	A	-1.6630
459	G	A	-1.7753
460	D	A	-2.6213
461	T	A	-2.1876
462	T	A	-1.9531
463	D	A	-2.9324
464	N	A	-3.0024
465	T	A	-2.1754
466	E	A	0.0000
467	I	A	-0.3359
468	F	A	0.0000
469	R	A	-0.4652
470	P	A	0.0000
471	S	A	-0.2762
472	G	A	-0.5278
473	G	A	-1.1767
474	D	A	-1.8535
475	M	A	0.0000
476	R	A	-1.5628
477	D	A	-0.9634
478	N	A	0.0000
479	W	A	0.0000
480	R	A	-0.8064
481	S	A	-0.2605
482	E	A	0.0000
483	L	A	0.0000
484	Y	A	0.0000
485	K	A	-1.1116
486	Y	A	0.0000
487	K	A	-1.2390
488	V	A	-0.7972
489	V	A	-1.0353
490	E	A	-1.2444
491	I	A	0.3711
492	K	A	-1.2791