Project name: bd9d1b17269a686

Chain sequence(s)	A: MEFGLSWLFLVAILKGVQCEVQLLESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASIRSGGGRTYYSDNVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAIIGLMVGGVVIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEALGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVICFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK; C: MDMRVPAQLLGLLMLWVSGSSGDVVMTQSPLSLPVTPGEPASISCKSSQSLLDSDGKTYLNWLLQKPGQSPQRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC; B: MEFGLSWLFLVAILKGVQCEVQLLESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASIRSGGGRTYYSDNVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAIIGLMVGGVVIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEALGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVICFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK; D: MDMRVPAQLLGLLMLWVSGSSGDVVMTQSPLSLPVTPGEPASISCKSSQSLLDSDGKTYLNWLLQKPGQSPQRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.3752
• Maximal score value: 4.1943
• Average score: -0.6273
• Total score value: -890.7537

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	1.5333
2	E	A	-0.1416
3	F	A	1.4100
4	G	A	1.0094
5	L	A	1.8428
6	S	A	1.5420
7	W	A	2.3554
8	L	A	2.9541
9	F	A	3.7945
10	L	A	4.1943
11	V	A	3.9746
12	A	A	3.1466
13	I	A	3.3266
14	L	A	2.1837
15	K	A	-0.1985
16	G	A	0.2139
17	V	A	1.8531
18	Q	A	1.7165
19	C	A	1.1945
20	E	A	-0.0730
21	V	A	0.0000
22	Q	A	-0.1011
23	L	A	0.0000
24	L	A	0.9975
25	E	A	0.1110
26	S	A	-0.4212
27	G	A	-0.5439
28	G	A	-0.1908
29	G	A	-0.0187
30	L	A	0.5529
31	V	A	-0.2146
32	Q	A	-1.1782
33	P	A	-1.7295
34	G	A	-1.4041
35	G	A	-0.9104
36	S	A	-1.1907
37	L	A	-0.8887
38	R	A	-1.9420
39	L	A	0.0000
40	S	A	-0.3523
41	C	A	0.0000
42	A	A	-0.1781
43	A	A	0.0000
44	S	A	-0.4962
45	G	A	-0.5517
46	F	A	-0.1108
47	T	A	-0.5390
48	F	A	0.0000
49	S	A	-1.7625
50	N	A	-1.3499
51	Y	A	-0.3934
52	G	A	-1.0146
53	M	A	0.0000
54	S	A	0.0000
55	W	A	0.0000
56	V	A	0.0000
57	R	A	-0.6797
58	Q	A	-0.9799
59	A	A	-1.2540
60	P	A	-1.3325
61	G	A	-1.6168
62	K	A	-2.4828
63	G	A	-1.7643
64	L	A	0.0000
65	E	A	-1.2583
66	W	A	0.0000
67	V	A	0.0000
68	A	A	0.0000
69	S	A	-0.4679
70	I	A	0.0000
71	R	A	-2.9922
72	S	A	-2.5872
73	G	A	-2.1974
74	G	A	-2.0205
75	G	A	-2.5078
76	R	A	-2.7447
77	T	A	-1.3716
78	Y	A	-0.2894
79	Y	A	-0.7008
80	S	A	-1.5735
81	D	A	-2.6999
82	N	A	-2.6590
83	V	A	0.0000
84	K	A	-2.6982
85	G	A	-2.0737
86	R	A	-1.8686
87	F	A	0.0000
88	T	A	-0.9298
89	I	A	0.0000
90	S	A	-1.2209
91	R	A	-2.0741
92	D	A	-2.3053
93	N	A	-2.7893
94	S	A	-2.1394
95	K	A	-2.8071
96	N	A	-2.3754
97	T	A	0.0000
98	L	A	0.0000
99	Y	A	-0.6167
100	L	A	0.0000
101	Q	A	-1.2861
102	M	A	0.0000
103	N	A	-1.3988
104	S	A	-1.2059
105	L	A	0.0000
106	R	A	-2.7174
107	A	A	-1.9365
108	E	A	-2.3922
109	D	A	0.0000
110	T	A	-0.6159
111	A	A	0.0000
112	V	A	0.4138
113	Y	A	0.0000
114	Y	A	0.0000
115	C	A	0.0000
116	A	A	0.0000
117	I	A	0.0000
118	I	A	1.0469
119	G	A	0.5454
120	L	A	0.4027
121	M	A	0.8528
122	V	A	0.5422
123	G	A	-0.0682
124	G	A	0.0000
125	V	A	0.0000
126	V	A	0.6431
127	I	A	0.0000
128	W	A	0.0000
129	G	A	0.0000
130	Q	A	-1.2535
131	G	A	0.0000
132	T	A	0.0000
133	L	A	0.9338
134	V	A	0.0000
135	T	A	-0.1076
136	V	A	0.0000
137	S	A	-0.9289
138	S	A	-0.7359
139	A	A	-0.5255
140	S	A	-0.5576
141	T	A	-0.7947
142	K	A	-1.4315
143	G	A	-1.4243
144	P	A	-0.6584
145	S	A	-0.0978
146	V	A	-0.4077
147	F	A	-0.3779
148	P	A	-0.9793
149	L	A	0.0000
150	A	A	0.0000
151	P	A	0.0000
152	S	A	-0.8874
153	S	A	-0.6975
154	K	A	-1.1540
155	S	A	-0.9806
156	T	A	-0.9292
157	S	A	-0.8152
158	G	A	-0.8673
159	G	A	-0.9087
160	T	A	-0.6987
161	A	A	0.0000
162	A	A	0.0000
163	L	A	0.0000
164	G	A	0.0000
165	C	A	0.0000
166	L	A	0.0000
167	V	A	0.0000
168	K	A	0.0000
169	D	A	-0.4823
170	Y	A	0.0000
171	F	A	0.0000
172	P	A	-0.6941
173	E	A	-0.9794
174	P	A	-0.9384
175	V	A	-0.7755
176	T	A	-0.6333
177	V	A	-0.2770
178	S	A	-0.4839
179	W	A	0.0000
180	N	A	-0.7962
181	S	A	-0.7334
182	G	A	-0.6092
183	A	A	-0.2757
184	L	A	-0.0256
185	T	A	-0.1999
186	S	A	-0.1865
187	G	A	-0.2174
188	V	A	0.1698
189	H	A	-0.1105
190	T	A	0.0069
191	F	A	0.0000
192	P	A	-0.3792
193	A	A	0.0402
194	V	A	0.2943
195	L	A	0.7331
196	Q	A	0.1121
197	S	A	-0.1355
198	S	A	-0.2506
199	G	A	-0.0618
200	L	A	-0.0488
201	Y	A	0.3121
202	S	A	0.1238
203	L	A	0.0000
204	S	A	0.0000
205	S	A	0.0000
206	V	A	0.0000
207	V	A	0.0000
208	T	A	-0.1510
209	V	A	0.0000
210	P	A	-0.5448
211	S	A	-0.5793
212	S	A	-0.5586
213	S	A	-0.6967
214	L	A	-0.8648
215	G	A	-1.0536
216	T	A	-0.8748
217	Q	A	-1.5081
218	T	A	-1.1726
219	Y	A	0.0000
220	I	A	-1.3429
221	C	A	0.0000
222	N	A	-1.6944
223	V	A	0.0000
224	N	A	-1.9280
225	H	A	0.0000
226	K	A	-2.6881
227	P	A	-1.6632
228	S	A	-1.9450
229	N	A	-2.4580
230	T	A	-2.1045
231	K	A	-2.6891
232	V	A	-1.6145
233	D	A	-2.6657
234	K	A	-2.1829
235	K	A	-2.2900
236	V	A	0.0000
237	E	A	-2.7132
238	P	A	-1.6567
239	K	A	-1.8141
240	S	A	-1.4639
241	C	A	-1.2110
242	D	A	-2.8645
243	K	A	-3.2122
244	T	A	-2.2472
245	H	A	-2.5450
246	T	A	-1.7887
247	C	A	-0.6344
248	P	A	-0.6639
249	P	A	-0.0447
250	C	A	0.4217
251	P	A	-0.2519
252	A	A	-1.1153
253	P	A	-1.6038
254	E	A	-2.1252
255	A	A	-0.5525
256	L	A	0.5042
257	G	A	-0.0297
258	A	A	-0.4962
259	P	A	0.0000
260	S	A	0.0829
261	V	A	0.0000
262	F	A	1.3987
263	L	A	1.2064
264	F	A	1.6533
265	P	A	0.1594
266	P	A	0.0000
267	K	A	-2.2290
268	P	A	-1.4976
269	K	A	-1.5056
270	D	A	-1.4316
271	T	A	0.0000
272	L	A	0.0000
273	M	A	0.1069
274	I	A	1.1773
275	S	A	-0.2418
276	R	A	-1.7783
277	T	A	-0.8582
278	P	A	0.0000
279	E	A	-0.8194
280	V	A	0.0000
281	T	A	0.6680
282	C	A	0.0000
283	V	A	0.0000
284	V	A	0.0000
285	V	A	-0.9301
286	D	A	-1.7307
287	V	A	0.0000
288	S	A	-2.3242
289	H	A	-2.6752
290	E	A	-3.1476
291	D	A	-2.5883
292	P	A	-2.4161
293	E	A	-2.1921
294	V	A	-0.2089
295	I	A	1.7040
296	C	A	1.2141
297	F	A	0.6267
298	N	A	-0.4253
299	W	A	0.0000
300	Y	A	-1.1144
301	V	A	-0.9589
302	D	A	-1.7516
303	G	A	-0.7029
304	V	A	0.5218
305	E	A	-1.3412
306	V	A	-0.8895
307	H	A	-1.9754
308	N	A	-2.1263
309	A	A	-1.5535
310	K	A	-2.0444
311	T	A	-1.3097
312	K	A	-2.4722
313	P	A	-2.5087
314	R	A	-4.1678
315	E	A	-4.3752
316	E	A	-3.7244
317	Q	A	-2.2787
318	Y	A	-0.0297
319	N	A	-1.2646
320	S	A	-1.3777
321	T	A	-2.0659
322	Y	A	0.0000
323	R	A	-3.3383
324	V	A	0.0000
325	V	A	-0.9289
326	S	A	0.0000
327	V	A	0.0000
328	L	A	0.0000
329	T	A	-0.4658
330	V	A	0.0000
331	L	A	0.1377
332	H	A	-0.5779
333	Q	A	-1.5847
334	D	A	-1.6581
335	W	A	0.0000
336	L	A	-1.1789
337	N	A	-2.2690
338	G	A	-2.2256
339	K	A	-2.3791
340	E	A	-2.6994
341	Y	A	0.0000
342	K	A	-1.5651
343	C	A	0.0000
344	K	A	-0.7701
345	V	A	0.0000
346	S	A	-0.0673
347	N	A	0.0000
348	K	A	-2.1064
349	A	A	-1.6974
350	L	A	0.0000
351	P	A	-0.6155
352	A	A	-0.4254
353	P	A	-0.4203
354	I	A	-0.1990
355	E	A	-1.4306
356	K	A	-0.9592
357	T	A	-0.9728
358	I	A	-0.3849
359	S	A	-1.2500
360	K	A	0.0000
361	A	A	-0.9310
362	K	A	-2.1962
363	G	A	-1.7431
364	Q	A	-1.8393
365	P	A	-1.7438
366	R	A	-1.9135
367	E	A	-2.4100
368	P	A	0.0000
369	Q	A	-1.3221
370	V	A	0.0000
371	Y	A	0.0000
372	T	A	0.0000
373	L	A	0.0000
374	P	A	-0.4367
375	P	A	0.0000
376	S	A	-1.5512
377	R	A	-2.8294
378	E	A	-2.9088
379	E	A	0.0000
380	M	A	-1.9947
381	T	A	-1.8703
382	K	A	-2.8939
383	N	A	-2.9193
384	Q	A	-2.8754
385	V	A	0.0000
386	S	A	0.0000
387	L	A	0.0000
388	T	A	0.0000
389	C	A	0.0000
390	L	A	0.0000
391	V	A	0.0000
392	K	A	0.0000
393	G	A	-0.9106
394	F	A	0.0000
395	Y	A	-0.8624
396	P	A	0.0000
397	S	A	-0.3146
398	D	A	-0.8424
399	I	A	-0.5463
400	A	A	-0.5911
401	V	A	0.0000
402	E	A	-1.0522
403	W	A	0.0000
404	E	A	-1.7570
405	S	A	0.0000
406	N	A	-1.8586
407	G	A	-1.9018
408	Q	A	-2.3492
409	P	A	-2.0181
410	E	A	-1.9774
411	N	A	-2.3468
412	N	A	-2.0765
413	Y	A	-1.2710
414	K	A	-1.2309
415	T	A	-0.4324
416	T	A	0.0000
417	P	A	-0.2256
418	P	A	0.0488
419	V	A	0.0000
420	L	A	0.4619
421	D	A	-0.5601
422	S	A	-1.1235
423	D	A	-1.8419
424	G	A	-0.8566
425	S	A	0.0000
426	F	A	0.1334
427	F	A	0.0000
428	L	A	0.0000
429	Y	A	0.0000
430	S	A	0.0000
431	K	A	0.0000
432	L	A	0.0000
433	T	A	-1.2392
434	V	A	0.0000
435	D	A	-2.9382
436	K	A	-2.7802
437	S	A	-2.2024
438	R	A	-1.9779
439	W	A	0.0000
440	Q	A	-2.2516
441	Q	A	-2.2523
442	G	A	-1.4153
443	N	A	-0.6880
444	V	A	0.5696
445	F	A	0.0000
446	S	A	-0.7743
447	C	A	0.0000
448	S	A	0.0000
449	V	A	0.0000
450	M	A	0.0000
451	H	A	0.0000
452	E	A	-1.0542
453	A	A	-1.5078
454	L	A	-1.4822
455	H	A	-1.8309
456	N	A	-1.7485
457	H	A	-1.2508
458	Y	A	-0.6295
459	T	A	-0.9365
460	Q	A	-1.4987
461	K	A	-1.3082
462	S	A	-0.4644
463	L	A	0.0000
464	S	A	-0.0156
465	L	A	-0.5799
466	S	A	-0.7270
467	P	A	-0.9791
468	G	A	-1.6594
469	K	A	-2.4559
470	M	B	0.8073
471	E	B	-0.2518
472	F	B	1.3759
473	G	B	0.9972
474	L	B	1.8784
475	S	B	1.6431
476	W	B	2.4921
477	L	B	3.3437
478	F	B	3.8378
479	L	B	4.0152
480	V	B	3.8035
481	A	B	2.6275
482	I	B	2.6338
483	L	B	1.5024
484	K	B	-0.5957
485	G	B	-0.0757
486	V	B	0.7429
487	Q	B	-0.5871
488	C	B	-0.3661
489	E	B	-1.5746
490	V	B	-0.5668
491	Q	B	-0.6294
492	L	B	0.0000
493	L	B	1.1443
494	E	B	0.1589
495	S	B	-0.5082
496	G	B	-0.5710
497	G	B	-0.5533
498	G	B	-0.1207
499	L	B	0.8363
500	V	B	-0.0718
501	Q	B	-1.1677
502	P	B	-1.7780
503	G	B	-1.4558
504	G	B	-0.9431
505	S	B	-0.9976
506	L	B	-0.8193
507	R	B	-1.8964
508	L	B	0.0000
509	S	B	-0.4099
510	C	B	0.0000
511	A	B	-0.2833
512	A	B	0.0000
513	S	B	-0.5208
514	G	B	-0.9060
515	F	B	-0.2543
516	T	B	-0.2874
517	F	B	0.0000
518	S	B	-1.0219
519	N	B	-0.1824
520	Y	B	0.2326
521	G	B	-0.4040
522	M	B	0.0000
523	S	B	0.0000
524	W	B	0.0000
525	V	B	0.0000
526	R	B	0.0000
527	Q	B	-1.2228
528	A	B	0.0000
529	P	B	-1.3505
530	G	B	-1.6533
531	K	B	-2.5770
532	G	B	-1.8860
533	L	B	0.0000
534	E	B	-1.6118
535	W	B	0.0000
536	V	B	0.0000
537	A	B	0.0000
538	S	B	0.0000
539	I	B	0.0000
540	R	B	-1.2364
541	S	B	0.0000
542	G	B	-1.4566
543	G	B	-1.5932
544	G	B	-2.0962
545	R	B	-2.1463
546	T	B	-0.7214
547	Y	B	0.3134
548	Y	B	-0.0582
549	S	B	-1.0733
550	D	B	-1.9392
551	N	B	-2.1771
552	V	B	0.0000
553	K	B	-1.3473
554	G	B	0.3580
555	R	B	-0.0517
556	F	B	0.0000
557	T	B	-0.4078
558	I	B	0.0000
559	S	B	-0.8181
560	R	B	-1.3932
561	D	B	-2.0381
562	N	B	-2.4671
563	S	B	-1.9855
564	K	B	-2.7214
565	N	B	-2.2060
566	T	B	0.0000
567	L	B	0.0000
568	Y	B	-0.6002
569	L	B	0.0000
570	Q	B	-1.1481
571	M	B	0.0000
572	N	B	-0.8019
573	S	B	-1.0494
574	L	B	0.0000
575	R	B	-2.8596
576	A	B	-2.0631
577	E	B	-2.4594
578	D	B	0.0000
579	T	B	-0.9002
580	A	B	0.0000
581	V	B	-0.0500
582	Y	B	0.0000
583	Y	B	0.0000
584	C	B	0.0000
585	A	B	0.0000
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1299	H	D	-0.3074
1300	F	D	0.6369
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1307	G	D	0.0000
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1324	F	D	0.0000
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1326	P	D	0.0000
1327	S	D	-1.8237
1328	D	D	-3.1839
1329	E	D	-3.3742
1330	Q	D	0.0000
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1358	N	D	-1.5097
1359	A	D	-0.2211
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1364	N	D	-0.8210
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1367	E	D	-2.1322
1368	S	D	-1.1266
1369	V	D	-0.9445
1370	T	D	-1.1296
1371	E	D	-2.2267
1372	Q	D	-1.8831
1373	D	D	-2.1594
1374	S	D	-1.8195
1375	K	D	-2.5582
1376	D	D	-2.1018
1377	S	D	0.0000
1378	T	D	0.0000
1379	Y	D	0.0000
1380	S	D	0.0000
1381	L	D	0.0000
1382	S	D	0.0000
1383	S	D	0.0000
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1385	L	D	0.0000
1386	T	D	-0.3834
1387	L	D	-0.4332
1388	S	D	-1.0748
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1390	A	D	-1.6529
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1392	Y	D	0.0000
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1394	K	D	-3.4674
1395	H	D	-3.0254
1396	K	D	-3.1514
1397	V	D	-2.1392
1398	Y	D	0.0000
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1400	C	D	0.0000
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1402	V	D	0.0000
1403	T	D	-1.2104
1404	H	D	0.0000
1405	Q	D	-1.7632
1406	G	D	-0.5865
1407	L	D	-0.2839
1408	S	D	-0.4969
1409	S	D	-0.6592
1410	P	D	-0.5596
1411	V	D	-0.2351
1412	T	D	-0.6799
1413	K	D	-1.0206
1414	S	D	-0.8528
1415	F	D	-1.0094
1416	N	D	-2.0893
1417	R	D	-2.3476
1418	G	D	-2.1788
1419	E	D	-2.0736
1420	C	D	-0.7477