Chain sequence(s) |
A: SSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTGATVRAACDWAGIKQEDGIPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNKKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRNSLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRD B: DSSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTGATVRAACDWAGIKQVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNKKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRNSLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRD |
Distance of aggregation | 10 Å |
Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
56 | S | A | -0.3741 | |
57 | S | A | -0.1625 | |
58 | P | A | -0.1971 | |
59 | G | A | 0.0000 | |
60 | I | A | -0.1346 | |
61 | W | A | 0.0000 | |
62 | Q | A | -0.5521 | |
63 | L | A | 0.0000 | |
64 | D | A | -1.1106 | |
65 | C | A | -0.9152 | |
66 | T | A | 0.0000 | |
67 | H | A | -1.9020 | |
68 | L | A | -1.6773 | |
69 | E | A | -2.4056 | |
70 | G | A | -2.0476 | |
71 | K | A | -2.2899 | |
72 | V | A | -1.5582 | |
73 | I | A | 0.0000 | |
74 | L | A | 0.0000 | |
75 | V | A | 0.0000 | |
76 | A | A | 0.0000 | |
77 | V | A | 0.0000 | |
78 | H | A | 0.0000 | |
79 | V | A | 0.6019 | |
80 | A | A | 0.2534 | |
81 | S | A | 0.0000 | |
82 | G | A | 0.0565 | |
83 | Y | A | 0.0000 | |
84 | I | A | 0.0000 | |
85 | E | A | 0.0000 | |
86 | A | A | 0.0000 | |
87 | E | A | -0.3756 | |
88 | V | A | -0.7021 | |
89 | I | A | 0.0000 | |
90 | P | A | -0.8865 | |
91 | A | A | -1.3988 | |
92 | E | A | -2.4011 | |
93 | T | A | -1.5777 | |
94 | G | A | -1.5205 | |
95 | Q | A | -1.6529 | |
96 | E | A | -1.2057 | |
97 | T | A | 0.0000 | |
98 | A | A | -0.6844 | |
99 | Y | A | -0.1697 | |
100 | F | A | 0.0000 | |
101 | L | A | 0.0000 | |
102 | L | A | 0.3247 | |
103 | K | A | 0.0000 | |
104 | L | A | 0.0000 | |
105 | A | A | 0.0000 | |
106 | G | A | 0.0000 | |
107 | R | A | 0.0000 | |
108 | W | A | 0.0000 | |
109 | P | A | -0.2837 | |
110 | V | A | -0.4303 | |
111 | K | A | -1.2641 | |
112 | T | A | -1.5307 | |
113 | I | A | 0.0000 | |
114 | H | A | -1.9664 | |
115 | T | A | -2.2015 | |
116 | D | A | -2.7352 | |
117 | N | A | -2.5103 | |
118 | G | A | -1.7539 | |
119 | S | A | -1.2111 | |
120 | N | A | -1.5315 | |
121 | F | A | 0.0000 | |
122 | T | A | -1.2492 | |
123 | G | A | -1.0397 | |
124 | A | A | -0.8159 | |
125 | T | A | -0.8635 | |
126 | V | A | 0.0000 | |
127 | R | A | -2.5117 | |
128 | A | A | -1.3192 | |
129 | A | A | -1.0584 | |
130 | C | A | 0.0000 | |
131 | D | A | -2.4632 | |
132 | W | A | -0.8934 | |
133 | A | A | -0.8073 | |
134 | G | A | -1.5168 | |
135 | I | A | 0.0000 | |
136 | K | A | -3.0874 | |
137 | Q | A | -2.9527 | |
138 | E | A | -3.2412 | |
139 | D | A | -2.9411 | |
140 | G | A | -1.5601 | |
141 | I | A | 0.6215 | |
145 | P | A | -0.8794 | |
146 | Q | A | -1.5816 | |
147 | S | A | -0.9013 | |
148 | Q | A | -1.4070 | |
149 | G | A | -1.3194 | |
150 | V | A | -0.4475 | |
151 | V | A | 0.0000 | |
152 | E | A | -1.8431 | |
153 | S | A | -1.4112 | |
154 | M | A | -1.5000 | |
155 | N | A | -1.9501 | |
156 | K | A | -2.7958 | |
157 | E | A | -2.5439 | |
158 | L | A | 0.0000 | |
159 | K | A | -2.4633 | |
160 | K | A | -3.0029 | |
161 | I | A | 0.0000 | |
162 | I | A | 0.0000 | |
163 | G | A | -2.5447 | |
164 | Q | A | -2.7260 | |
165 | V | A | -2.5500 | |
166 | R | A | -3.6358 | |
167 | D | A | -3.7287 | |
168 | Q | A | -3.2723 | |
169 | A | A | -2.9462 | |
170 | E | A | -3.2019 | |
171 | H | A | -2.6483 | |
172 | L | A | -1.9706 | |
173 | K | A | -1.5282 | |
174 | T | A | -1.4250 | |
175 | A | A | 0.0000 | |
176 | V | A | 0.0000 | |
177 | Q | A | 0.0000 | |
178 | M | A | 0.0000 | |
179 | A | A | 0.0000 | |
180 | V | A | 0.0000 | |
181 | F | A | -0.0086 | |
182 | I | A | -0.3210 | |
183 | H | A | -0.9705 | |
184 | N | A | 0.0000 | |
185 | K | A | -1.7348 | |
186 | K | A | -3.0868 | |
187 | R | A | -3.7245 | |
188 | K | A | -3.2813 | |
189 | G | A | -2.0898 | |
190 | G | A | -0.9257 | |
191 | I | A | -0.2666 | |
192 | G | A | -0.9025 | |
193 | G | A | -1.7311 | |
194 | Y | A | -1.7401 | |
195 | S | A | 0.0000 | |
196 | A | A | 0.0000 | |
197 | G | A | -1.0348 | |
198 | E | A | -1.1444 | |
199 | R | A | -0.9970 | |
200 | I | A | 0.0000 | |
201 | V | A | 0.0000 | |
202 | D | A | -1.2680 | |
203 | I | A | -0.4457 | |
204 | I | A | 0.0000 | |
205 | A | A | 0.0000 | |
206 | T | A | -0.9071 | |
207 | D | A | -1.4196 | |
208 | I | A | -1.0143 | |
209 | Q | A | -1.4936 | |
210 | T | A | -1.7938 | |
211 | K | A | -3.0560 | |
212 | E | A | -2.8793 | |
213 | L | A | -1.2880 | |
214 | Q | A | -2.4991 | |
215 | K | A | -2.9524 | |
216 | Q | A | -2.2450 | |
217 | I | A | -0.8014 | |
218 | T | A | -1.5149 | |
219 | K | A | -2.3656 | |
220 | I | A | 0.0000 | |
221 | Q | A | -1.2651 | |
222 | N | A | -2.2194 | |
223 | F | A | -1.4213 | |
224 | R | A | -1.5579 | |
225 | V | A | 0.0000 | |
226 | Y | A | -0.6843 | |
227 | Y | A | 0.0000 | |
228 | R | A | -1.5157 | |
229 | D | A | -1.4877 | |
230 | S | A | -2.0247 | |
231 | R | A | -2.6515 | |
232 | N | A | -2.1216 | |
233 | S | A | -0.7839 | |
234 | L | A | 0.7122 | |
235 | W | A | 0.4927 | |
236 | K | A | -0.6490 | |
237 | G | A | -1.0580 | |
238 | P | A | -0.9158 | |
239 | A | A | 0.0000 | |
240 | K | A | -1.1924 | |
241 | L | A | 0.0000 | |
242 | L | A | 0.3322 | |
243 | W | A | 0.5985 | |
244 | K | A | -1.5165 | |
245 | G | A | -1.9074 | |
246 | E | A | -2.7446 | |
247 | G | A | -2.3861 | |
248 | A | A | -1.5172 | |
249 | V | A | 0.0000 | |
250 | V | A | 0.8727 | |
251 | I | A | 0.0000 | |
252 | Q | A | -0.7985 | |
253 | D | A | -1.8581 | |
254 | N | A | -2.0716 | |
255 | S | A | -1.3890 | |
256 | D | A | -1.2695 | |
257 | I | A | 0.5000 | |
258 | K | A | 0.6308 | |
259 | V | A | 1.6182 | |
260 | V | A | 0.0000 | |
261 | P | A | -1.5858 | |
262 | R | A | -3.2847 | |
263 | R | A | -3.1717 | |
264 | K | A | -2.2340 | |
265 | A | A | -1.8907 | |
266 | K | A | -2.1320 | |
267 | I | A | -0.9893 | |
268 | I | A | -0.9350 | |
269 | R | A | -2.5071 | |
270 | D | A | -2.5872 | |
55 | D | B | -2.7348 | |
56 | S | B | -1.4745 | |
57 | S | B | -1.2317 | |
58 | P | B | -0.5733 | |
59 | G | B | 0.0000 | |
60 | I | B | -0.3955 | |
61 | W | B | 0.0000 | |
62 | Q | B | -0.3058 | |
63 | L | B | 0.0000 | |
64 | D | B | -1.1297 | |
65 | C | B | -0.7643 | |
66 | T | B | -1.1741 | |
67 | H | B | -1.4163 | |
68 | L | B | -1.0603 | |
69 | E | B | -1.4492 | |
70 | G | B | -1.3714 | |
71 | K | B | -1.5971 | |
72 | V | B | 0.0000 | |
73 | I | B | 0.0000 | |
74 | L | B | 0.0000 | |
75 | V | B | 0.0000 | |
76 | A | B | 0.0000 | |
77 | V | B | 0.0000 | |
78 | H | B | 0.0000 | |
79 | V | B | 1.2219 | |
80 | A | B | 0.4658 | |
81 | S | B | 0.0000 | |
82 | G | B | 0.3294 | |
83 | Y | B | 0.0000 | |
84 | I | B | 0.0000 | |
85 | E | B | 0.0000 | |
86 | A | B | 0.0000 | |
87 | E | B | -0.3592 | |
88 | V | B | 0.0000 | |
89 | I | B | 0.0000 | |
90 | P | B | -0.7044 | |
91 | A | B | -0.8914 | |
92 | E | B | -1.2836 | |
93 | T | B | -1.0665 | |
94 | G | B | -1.2416 | |
95 | Q | B | -1.5127 | |
96 | E | B | -1.1919 | |
97 | T | B | 0.0000 | |
98 | A | B | -0.7801 | |
99 | Y | B | -0.3469 | |
100 | F | B | 0.0000 | |
101 | L | B | 0.0000 | |
102 | L | B | 0.0000 | |
103 | K | B | -0.2512 | |
104 | L | B | 0.0000 | |
105 | A | B | 0.0000 | |
106 | G | B | 0.0000 | |
107 | R | B | 0.0000 | |
108 | W | B | 0.0000 | |
109 | P | B | -0.4908 | |
110 | V | B | 0.0000 | |
111 | K | B | -2.3500 | |
112 | T | B | 0.0000 | |
113 | I | B | 0.0000 | |
114 | H | B | -1.6772 | |
115 | T | B | -1.8258 | |
116 | D | B | -2.6644 | |
117 | N | B | -2.3846 | |
118 | G | B | -1.5893 | |
119 | S | B | -1.0073 | |
120 | N | B | 0.0000 | |
121 | F | B | 0.0000 | |
122 | T | B | -1.3531 | |
123 | G | B | -0.9253 | |
124 | A | B | -0.9021 | |
125 | T | B | -1.0204 | |
126 | V | B | 0.0000 | |
127 | R | B | -2.6900 | |
128 | A | B | -1.4663 | |
129 | A | B | -1.1400 | |
130 | C | B | 0.0000 | |
131 | D | B | -2.7297 | |
132 | W | B | -0.8422 | |
133 | A | B | -1.1349 | |
134 | G | B | -1.9202 | |
135 | I | B | 0.0000 | |
136 | K | B | -3.7682 | |
137 | Q | B | -3.1600 | |
150 | V | B | 1.3031 | |
151 | V | B | -0.1608 | |
152 | E | B | -1.6593 | |
153 | S | B | -1.0121 | |
154 | M | B | -1.3092 | |
155 | N | B | -2.1624 | |
156 | K | B | -3.3825 | |
157 | E | B | -2.9358 | |
158 | L | B | 0.0000 | |
159 | K | B | -3.2086 | |
160 | K | B | -3.4225 | |
161 | I | B | 0.0000 | |
162 | I | B | 0.0000 | |
163 | G | B | -2.4495 | |
164 | Q | B | -2.6532 | |
165 | V | B | 0.0000 | |
166 | R | B | -2.7810 | |
167 | D | B | -3.2467 | |
168 | Q | B | -2.9198 | |
169 | A | B | -2.4381 | |
170 | E | B | -2.9869 | |
171 | H | B | -2.2739 | |
172 | L | B | 0.0000 | |
173 | K | B | -1.2348 | |
174 | T | B | -1.1958 | |
175 | A | B | 0.0000 | |
176 | V | B | 0.0000 | |
177 | Q | B | 0.0000 | |
178 | M | B | 0.0000 | |
179 | A | B | 0.0000 | |
180 | V | B | 0.0000 | |
181 | F | B | 0.3141 | |
182 | I | B | 0.2123 | |
183 | H | B | 0.0000 | |
184 | N | B | 0.0000 | |
185 | K | B | -1.3528 | |
186 | K | B | -2.0423 | |
187 | R | B | -3.0616 | |
188 | K | B | -2.7129 | |
189 | G | B | -1.6456 | |
190 | G | B | -0.4894 | |
191 | I | B | 1.2199 | |
192 | G | B | -0.0292 | |
193 | G | B | -0.7456 | |
194 | Y | B | -1.0816 | |
195 | S | B | 0.0000 | |
196 | A | B | 0.0000 | |
197 | G | B | -0.8504 | |
198 | E | B | -0.8476 | |
199 | R | B | -0.5853 | |
200 | I | B | 0.0000 | |
201 | V | B | 0.0000 | |
202 | D | B | -0.7436 | |
203 | I | B | -0.2078 | |
204 | I | B | 0.0000 | |
205 | A | B | -0.9553 | |
206 | T | B | -1.1055 | |
207 | D | B | -1.3254 | |
208 | I | B | 0.0000 | |
209 | Q | B | -1.7669 | |
210 | T | B | -1.5381 | |
211 | K | B | -2.0622 | |
212 | E | B | -1.3805 | |
213 | L | B | -0.4179 | |
214 | Q | B | -1.6654 | |
215 | K | B | -1.4432 | |
216 | Q | B | -0.9809 | |
217 | I | B | -0.3915 | |
218 | T | B | -0.9513 | |
219 | K | B | -1.1048 | |
220 | I | B | -0.9146 | |
221 | Q | B | -1.3562 | |
222 | N | B | -2.1175 | |
223 | F | B | -1.6766 | |
224 | R | B | -1.4143 | |
225 | V | B | 0.0000 | |
226 | Y | B | -0.5803 | |
227 | Y | B | 0.0000 | |
228 | R | B | -2.0885 | |
229 | D | B | -2.9292 | |
230 | S | B | -2.3892 | |
231 | R | B | -2.8695 | |
232 | N | B | -2.3070 | |
233 | S | B | -1.3238 | |
234 | L | B | 0.2843 | |
235 | W | B | -0.5713 | |
236 | K | B | -1.2013 | |
237 | G | B | -1.4333 | |
238 | P | B | -1.1852 | |
239 | A | B | 0.0000 | |
240 | K | B | -0.8003 | |
241 | L | B | 0.0000 | |
242 | L | B | 0.5552 | |
243 | W | B | 0.4614 | |
244 | K | B | -1.6420 | |
245 | G | B | -2.2047 | |
246 | E | B | -2.6772 | |
247 | G | B | -2.5076 | |
248 | A | B | -1.6430 | |
249 | V | B | 0.0000 | |
250 | V | B | 0.8522 | |
251 | I | B | 0.0000 | |
252 | Q | B | -0.7049 | |
253 | D | B | -1.8406 | |
254 | N | B | -2.1298 | |
255 | S | B | -1.5301 | |
256 | D | B | -1.5571 | |
257 | I | B | 0.7266 | |
258 | K | B | 0.4287 | |
259 | V | B | 1.5487 | |
260 | V | B | 0.0000 | |
261 | P | B | -1.7834 | |
262 | R | B | -3.1038 | |
263 | R | B | -3.3740 | |
264 | K | B | -2.9333 | |
265 | A | B | 0.0000 | |
266 | K | B | -1.8227 | |
267 | I | B | -0.7157 | |
268 | I | B | -0.5503 | |
269 | R | B | -2.3139 | |
270 | D | B | -2.7354 |