Project name: gqs-p75-2

Chain sequence(s)	H: VTLKESGGGVVQPGGSLRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSLISGDGGSTYYADSVKGRFTISRDNSKNSLYLQMNSLRTEDTALYYCAKPRGVGAALDYWGQGTLVTVS; L: PVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVYWYQQLPGTAPKLLIYSNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDSLNGLAFGGGTKLTVL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5374
• Maximal score value: 1.7904
• Average score: -0.6696
• Total score value: -151.3358

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	P	L	0.3087
3	V	L	1.3843
4	L	L	0.0000
5	T	L	0.0903
6	Q	L	0.0000
7	P	L	-0.6512
8	P	L	-0.9905
10	S	L	-1.1115
11	A	L	-0.8372
12	S	L	-0.5004
13	G	L	-0.4478
14	T	L	-0.4789
15	P	L	-1.1350
16	G	L	-1.8164
17	Q	L	-2.4689
18	R	L	-2.6797
19	V	L	0.0000
20	T	L	-0.7015
21	I	L	0.0000
22	S	L	-0.3985
23	C	L	0.0000
24	S	L	-0.3069
25	G	L	-0.2246
26	S	L	-0.6036
27	S	L	-0.9112
28	S	L	-0.9475
29	N	L	0.0000
30	I	L	0.0000
30A	G	L	-0.9018
30B	S	L	-0.6859
31	N	L	-0.3552
32	Y	L	0.4910
33	V	L	0.0000
34	Y	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	0.0000
39	L	L	-0.6384
40	P	L	-0.4853
41	G	L	-0.6504
42	T	L	-0.6250
43	A	L	-0.5495
44	P	L	0.0000
45	K	L	-0.8210
46	L	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	-0.5709
50	S	L	-0.3246
51	N	L	-1.1419
52	N	L	-2.0431
53	Q	L	-1.9917
54	R	L	-1.8547
55	P	L	-1.2499
56	S	L	-0.8587
57	G	L	-0.8397
58	V	L	-1.0336
59	P	L	-1.3285
60	D	L	-2.4578
61	R	L	-1.5819
62	F	L	0.0000
63	S	L	-1.2966
64	G	L	-1.0922
65	S	L	-1.0121
66	K	L	-1.1898
67	S	L	-0.8988
68	G	L	-0.9754
69	T	L	-0.8291
70	S	L	-0.7662
71	A	L	0.0000
72	S	L	-0.6096
73	L	L	0.0000
74	A	L	-0.6765
75	I	L	0.0000
76	S	L	-1.9675
77	G	L	-1.6184
78	L	L	0.0000
79	Q	L	-2.0240
80	S	L	-1.6074
81	E	L	-2.4234
82	D	L	0.0000
83	E	L	-1.9960
84	A	L	0.0000
85	D	L	-1.5738
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	A	L	0.0000
90	A	L	0.0000
91	W	L	-0.2160
92	D	L	0.0000
93	D	L	-1.7146
94	S	L	-0.9662
95	L	L	-0.7549
95A	N	L	-0.9240
95B	G	L	0.0000
96	L	L	0.0000
97	A	L	0.0000
98	F	L	0.0000
99	G	L	0.0000
100	G	L	-0.6954
101	G	L	-1.0244
102	T	L	0.0000
103	K	L	-2.2707
104	L	L	0.0000
105	T	L	-0.4077
106	V	L	-0.0561
107	L	L	1.4063
2	V	H	1.6656
3	T	H	0.2282
4	L	H	0.0000
5	K	H	-2.1816
6	E	H	-1.3693
7	S	H	-1.0739
8	G	H	-0.6011
9	G	H	0.2113
10	G	H	0.6706
11	V	H	1.5458
12	V	H	0.0000
13	Q	H	-1.2433
14	P	H	-1.3507
15	G	H	-1.2784
16	G	H	-1.1408
17	S	H	-1.5050
18	L	H	-1.1410
19	R	H	-2.2627
20	L	H	0.0000
21	S	H	-1.0609
22	C	H	0.0000
23	A	H	-1.2622
24	A	H	0.0000
25	S	H	-0.2929
26	G	H	0.3701
27	F	H	0.0645
28	T	H	-1.0470
29	F	H	0.0000
30	D	H	-3.4956
31	D	H	-2.8572
32	Y	H	-1.4649
33	A	H	-1.0270
34	M	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.6202
40	A	H	-0.9953
41	P	H	-0.7925
42	G	H	-1.4575
43	K	H	-2.2534
44	G	H	-1.2795
45	L	H	0.0000
46	E	H	-0.7490
47	W	H	0.0000
48	V	H	0.0000
49	S	H	0.0000
50	L	H	0.0000
51	I	H	0.0000
52	S	H	-1.1983
52A	G	H	-2.2372
53	D	H	-2.9646
54	G	H	-1.5798
55	G	H	-1.2628
56	S	H	-0.6477
57	T	H	-0.1127
58	Y	H	0.1941
59	Y	H	-0.7377
60	A	H	0.0000
61	D	H	-2.4523
62	S	H	-1.8964
63	V	H	0.0000
64	K	H	-2.7233
65	G	H	-2.2487
66	R	H	-2.4275
67	F	H	0.0000
68	T	H	-1.0528
69	I	H	0.0000
70	S	H	-0.6841
71	R	H	-1.7684
72	D	H	-2.7619
73	N	H	-3.5374
74	S	H	-2.3019
75	K	H	-2.7056
76	N	H	-2.4689
77	S	H	0.0000
78	L	H	0.0000
79	Y	H	-0.7297
80	L	H	0.0000
81	Q	H	-1.6425
82	M	H	0.0000
82A	N	H	-1.8957
82B	S	H	-1.3762
82C	L	H	0.0000
83	R	H	-1.7183
84	T	H	-1.5085
85	E	H	-2.0320
86	D	H	0.0000
87	T	H	-0.2149
88	A	H	0.0000
89	L	H	0.9134
90	Y	H	0.0000
91	Y	H	0.0000
92	C	H	0.0000
93	A	H	0.0000
94	K	H	0.0000
95	P	H	-0.5690
96	R	H	-1.3767
97	G	H	-0.4549
98	V	H	1.1662
99	G	H	0.2846
100	A	H	0.0000
100A	A	H	0.0000
100B	L	H	0.0000
101	D	H	-0.7635
102	Y	H	0.0424
103	W	H	-0.3145
104	G	H	0.0000
105	Q	H	-1.6615
106	G	H	-0.6177
107	T	H	0.1907
108	L	H	1.7904
109	V	H	0.0000
110	T	H	0.5292
111	V	H	0.0000
112	S	H	-0.6474