| Chain sequence(s) |
A: AYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKV B: SAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRRCLLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKV |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 26 | A | A | -1.3741 | |
| 27 | Y | A | -1.2777 | |
| 28 | Q | A | -2.4043 | |
| 29 | R | A | -3.4386 | |
| 30 | F | A | 0.0000 | |
| 31 | E | A | -2.3643 | |
| 32 | P | A | 0.0000 | |
| 33 | R | A | -2.3213 | |
| 34 | A | A | -1.9955 | |
| 35 | Y | A | -1.2301 | |
| 36 | L | A | 0.0000 | |
| 37 | R | A | -2.3594 | |
| 38 | N | A | 0.0000 | |
| 39 | N | A | -0.9083 | |
| 40 | Y | A | 0.0000 | |
| 41 | A | A | -1.2445 | |
| 42 | P | A | -1.1100 | |
| 43 | P | A | -1.2148 | |
| 44 | R | A | 0.0000 | |
| 45 | G | A | 0.0000 | |
| 46 | D | A | -1.3921 | |
| 47 | L | A | 0.0000 | |
| 48 | C | A | -1.5655 | |
| 49 | N | A | -2.0795 | |
| 50 | P | A | -1.7532 | |
| 51 | N | A | -1.6836 | |
| 52 | G | A | 0.0000 | |
| 53 | V | A | 0.0000 | |
| 54 | G | A | 0.0000 | |
| 55 | P | A | 0.0000 | |
| 56 | W | A | -0.5600 | |
| 57 | K | A | 0.0000 | |
| 58 | L | A | 0.0000 | |
| 59 | R | A | -1.2535 | |
| 60 | C | A | 0.0000 | |
| 61 | L | A | 0.0000 | |
| 62 | A | A | 0.0000 | |
| 63 | Q | A | -1.5078 | |
| 64 | T | A | 0.0000 | |
| 65 | F | A | 0.0000 | |
| 66 | A | A | -0.9033 | |
| 67 | T | A | -1.0350 | |
| 68 | G | A | -1.4384 | |
| 69 | E | A | -1.8476 | |
| 70 | V | A | 0.0000 | |
| 71 | S | A | -1.5863 | |
| 72 | G | A | -1.9232 | |
| 73 | R | A | -2.7388 | |
| 74 | T | A | 0.0000 | |
| 75 | L | A | 0.0000 | |
| 76 | I | A | 0.0000 | |
| 77 | D | A | 0.0000 | |
| 78 | I | A | 0.0000 | |
| 79 | G | A | 0.2830 | |
| 80 | S | A | 0.0000 | |
| 81 | G | A | -0.0706 | |
| 82 | P | A | 0.0000 | |
| 83 | T | A | 0.0000 | |
| 84 | V | A | 0.0000 | |
| 85 | Y | A | 0.0000 | |
| 86 | Q | A | 0.0000 | |
| 87 | L | A | 0.0000 | |
| 88 | L | A | 0.0000 | |
| 89 | S | A | 0.0000 | |
| 90 | A | A | 0.0000 | |
| 91 | C | A | 0.0000 | |
| 92 | S | A | -0.8086 | |
| 93 | H | A | -1.3967 | |
| 94 | F | A | 0.0000 | |
| 95 | E | A | -2.9374 | |
| 96 | D | A | 0.0000 | |
| 97 | I | A | 0.0000 | |
| 98 | T | A | 0.0000 | |
| 99 | M | A | 0.0000 | |
| 100 | T | A | 0.0000 | |
| 101 | D | A | 0.0000 | |
| 102 | F | A | 1.0713 | |
| 103 | L | A | 0.0000 | |
| 104 | E | A | -1.7846 | |
| 105 | V | A | -1.0801 | |
| 106 | N | A | 0.0000 | |
| 107 | R | A | -1.4174 | |
| 108 | Q | A | -1.8479 | |
| 109 | E | A | 0.0000 | |
| 110 | L | A | 0.0000 | |
| 111 | G | A | -1.7609 | |
| 112 | R | A | -2.5057 | |
| 113 | W | A | 0.0000 | |
| 114 | L | A | 0.0000 | |
| 115 | Q | A | -2.9016 | |
| 116 | E | A | -3.5296 | |
| 117 | E | A | -3.4543 | |
| 118 | P | A | -1.9513 | |
| 119 | G | A | -1.4568 | |
| 120 | A | A | -1.8389 | |
| 121 | F | A | -1.3997 | |
| 122 | N | A | -1.1855 | |
| 123 | W | A | 0.0000 | |
| 124 | S | A | -0.3405 | |
| 125 | M | A | -0.1418 | |
| 126 | Y | A | 0.0000 | |
| 127 | S | A | 0.0000 | |
| 128 | Q | A | 0.0000 | |
| 129 | H | A | 0.0000 | |
| 130 | A | A | 0.0000 | |
| 131 | C | A | 0.0000 | |
| 132 | L | A | -0.9041 | |
| 133 | I | A | -0.8054 | |
| 134 | E | A | -1.3398 | |
| 135 | G | A | -1.7805 | |
| 136 | K | A | -2.3837 | |
| 137 | G | A | -1.6971 | |
| 138 | E | A | -2.2042 | |
| 139 | C | A | 0.0000 | |
| 140 | W | A | -0.9366 | |
| 141 | Q | A | -1.6421 | |
| 142 | D | A | -2.4904 | |
| 143 | K | A | 0.0000 | |
| 144 | E | A | 0.0000 | |
| 145 | R | A | -2.6798 | |
| 146 | Q | A | -1.9800 | |
| 147 | L | A | 0.0000 | |
| 148 | R | A | -1.8837 | |
| 149 | A | A | -1.4730 | |
| 150 | R | A | -1.9175 | |
| 151 | V | A | -1.3160 | |
| 152 | K | A | -2.1285 | |
| 153 | R | A | -1.0576 | |
| 154 | V | A | -0.7310 | |
| 155 | L | A | -0.0400 | |
| 156 | P | A | -0.1485 | |
| 157 | I | A | 0.0000 | |
| 158 | D | A | -0.7849 | |
| 159 | V | A | 0.0000 | |
| 160 | H | A | -1.9173 | |
| 161 | Q | A | -2.1581 | |
| 162 | P | A | -1.8735 | |
| 163 | Q | A | -1.9401 | |
| 164 | P | A | 0.0000 | |
| 165 | L | A | -0.6457 | |
| 166 | G | A | -1.0881 | |
| 167 | A | A | -0.6170 | |
| 168 | G | A | -0.5795 | |
| 169 | S | A | -0.2872 | |
| 170 | P | A | -0.4023 | |
| 171 | A | A | 0.0000 | |
| 172 | P | A | 0.0834 | |
| 173 | L | A | 0.6896 | |
| 174 | P | A | 0.0769 | |
| 175 | A | A | 0.0000 | |
| 176 | D | A | -0.9511 | |
| 177 | A | A | 0.0000 | |
| 178 | L | A | 0.0000 | |
| 179 | V | A | 0.0000 | |
| 180 | S | A | 0.0000 | |
| 181 | A | A | 0.2135 | |
| 182 | F | A | 0.4846 | |
| 183 | C | A | 0.3515 | |
| 184 | L | A | 0.0000 | |
| 185 | E | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | V | A | 0.0934 | |
| 188 | S | A | 0.0000 | |
| 189 | P | A | -0.6479 | |
| 190 | D | A | -0.9555 | |
| 191 | L | A | -0.4165 | |
| 192 | A | A | -0.5867 | |
| 193 | S | A | -1.0738 | |
| 194 | F | A | 0.0000 | |
| 195 | Q | A | -1.7972 | |
| 196 | R | A | -2.3120 | |
| 197 | A | A | 0.0000 | |
| 198 | L | A | 0.0000 | |
| 199 | D | A | -1.6691 | |
| 200 | H | A | 0.0000 | |
| 201 | I | A | 0.0000 | |
| 202 | T | A | 0.0000 | |
| 203 | T | A | -0.5352 | |
| 204 | L | A | 0.0000 | |
| 205 | L | A | 0.0000 | |
| 206 | R | A | -0.6542 | |
| 207 | P | A | -0.2963 | |
| 208 | G | A | -0.1235 | |
| 209 | G | A | 0.0000 | |
| 210 | H | A | 0.0000 | |
| 211 | L | A | 0.0000 | |
| 212 | L | A | 0.0000 | |
| 213 | L | A | 0.0000 | |
| 214 | I | A | 0.0000 | |
| 215 | G | A | 0.0000 | |
| 216 | A | A | 0.0000 | |
| 217 | L | A | 0.0000 | |
| 218 | E | A | -2.3295 | |
| 219 | E | A | 0.0000 | |
| 220 | S | A | -0.7091 | |
| 221 | W | A | -0.3948 | |
| 222 | Y | A | -0.1807 | |
| 223 | L | A | -0.7114 | |
| 224 | A | A | 0.0000 | |
| 225 | G | A | -2.4542 | |
| 226 | E | A | -3.1559 | |
| 227 | A | A | 0.0000 | |
| 228 | R | A | -2.3044 | |
| 229 | L | A | 0.0000 | |
| 230 | T | A | -0.4420 | |
| 231 | V | A | 0.0000 | |
| 232 | V | A | 0.0000 | |
| 233 | P | A | -1.4138 | |
| 234 | V | A | 0.0000 | |
| 235 | S | A | -1.8933 | |
| 236 | E | A | -2.2589 | |
| 237 | E | A | -2.6562 | |
| 238 | E | A | -2.1528 | |
| 239 | V | A | 0.0000 | |
| 240 | R | A | -2.1550 | |
| 241 | E | A | -2.6577 | |
| 242 | A | A | 0.0000 | |
| 243 | L | A | 0.0000 | |
| 244 | V | A | -0.0880 | |
| 245 | R | A | -1.8313 | |
| 246 | S | A | -1.1352 | |
| 247 | G | A | -0.0924 | |
| 248 | Y | A | 0.0000 | |
| 249 | K | A | -0.7753 | |
| 250 | V | A | -0.6677 | |
| 251 | R | A | -1.1592 | |
| 252 | D | A | -1.1546 | |
| 253 | L | A | -1.1524 | |
| 254 | R | A | -1.5541 | |
| 255 | T | A | -0.2763 | |
| 256 | Y | A | 0.0000 | |
| 257 | I | A | 1.7719 | |
| 258 | M | A | 0.0000 | |
| 259 | P | A | -0.3525 | |
| 260 | A | A | -0.6937 | |
| 261 | H | A | -1.3421 | |
| 262 | L | A | 0.0000 | |
| 263 | Q | A | -1.6454 | |
| 264 | T | A | -0.9703 | |
| 265 | G | A | -0.5890 | |
| 266 | V | A | -0.4916 | |
| 267 | D | A | 0.0000 | |
| 268 | D | A | -1.0785 | |
| 269 | V | A | 0.0000 | |
| 270 | K | A | -1.2357 | |
| 271 | G | A | 0.0000 | |
| 272 | V | A | 0.0000 | |
| 273 | F | A | 0.0000 | |
| 274 | F | A | 0.0000 | |
| 275 | A | A | 0.0000 | |
| 276 | W | A | 0.0000 | |
| 277 | A | A | 0.0000 | |
| 278 | Q | A | -0.3526 | |
| 279 | K | A | 0.1905 | |
| 280 | V | A | 1.2853 | |
| 16 | S | B | -0.3834 | |
| 17 | A | B | -0.2752 | |
| 18 | P | B | -0.4011 | |
| 19 | G | B | -0.5602 | |
| 20 | Q | B | -0.3774 | |
| 21 | A | B | -0.1743 | |
| 22 | A | B | -0.0778 | |
| 23 | V | B | -0.1212 | |
| 24 | A | B | -0.4117 | |
| 25 | S | B | -0.7779 | |
| 26 | A | B | -1.3501 | |
| 27 | Y | B | 0.0000 | |
| 28 | Q | B | -2.0578 | |
| 29 | R | B | -3.2441 | |
| 30 | F | B | 0.0000 | |
| 31 | E | B | -1.9821 | |
| 32 | P | B | 0.0000 | |
| 33 | R | B | -1.6360 | |
| 34 | A | B | -1.6463 | |
| 35 | Y | B | -1.0327 | |
| 36 | L | B | 0.0000 | |
| 37 | R | B | -2.2213 | |
| 38 | N | B | -1.3130 | |
| 39 | N | B | -0.9905 | |
| 40 | Y | B | 0.0000 | |
| 41 | A | B | -1.1648 | |
| 42 | P | B | -0.9868 | |
| 43 | P | B | -1.2198 | |
| 44 | R | B | 0.0000 | |
| 45 | G | B | 0.0000 | |
| 46 | D | B | -1.1844 | |
| 47 | L | B | 0.0000 | |
| 48 | C | B | -1.4164 | |
| 49 | N | B | -2.1577 | |
| 50 | P | B | -1.7992 | |
| 51 | N | B | -1.8359 | |
| 52 | G | B | -1.1328 | |
| 53 | V | B | 0.0000 | |
| 54 | G | B | 0.0000 | |
| 55 | P | B | 0.0000 | |
| 56 | W | B | -0.6744 | |
| 57 | K | B | 0.0000 | |
| 58 | L | B | 0.0000 | |
| 59 | R | B | -1.3827 | |
| 60 | C | B | 0.0000 | |
| 61 | L | B | 0.0000 | |
| 62 | A | B | 0.0000 | |
| 63 | Q | B | -1.3240 | |
| 64 | T | B | 0.0000 | |
| 65 | F | B | 0.0000 | |
| 66 | A | B | -0.8746 | |
| 67 | T | B | -1.0291 | |
| 68 | G | B | -1.4534 | |
| 69 | E | B | -1.9650 | |
| 70 | V | B | 0.0000 | |
| 71 | S | B | -1.5924 | |
| 72 | G | B | -1.9159 | |
| 73 | R | B | -2.7146 | |
| 74 | T | B | 0.0000 | |
| 75 | L | B | 0.0000 | |
| 76 | I | B | 0.0000 | |
| 77 | D | B | 0.0000 | |
| 78 | I | B | 0.0000 | |
| 79 | G | B | 0.1267 | |
| 80 | S | B | 0.0000 | |
| 81 | G | B | -0.1362 | |
| 82 | P | B | 0.0000 | |
| 83 | T | B | 0.0000 | |
| 84 | V | B | 0.0000 | |
| 85 | Y | B | 0.0000 | |
| 86 | Q | B | 0.0000 | |
| 87 | L | B | 0.0000 | |
| 88 | L | B | 0.0000 | |
| 89 | S | B | 0.0000 | |
| 90 | A | B | 0.0000 | |
| 91 | C | B | 0.0000 | |
| 92 | S | B | -0.7745 | |
| 93 | H | B | -1.5015 | |
| 94 | F | B | 0.0000 | |
| 95 | E | B | -2.9380 | |
| 96 | D | B | 0.0000 | |
| 97 | I | B | 0.0000 | |
| 98 | T | B | 0.0000 | |
| 99 | M | B | 0.0000 | |
| 100 | T | B | 0.0000 | |
| 101 | D | B | 0.0000 | |
| 102 | F | B | 0.3242 | |
| 103 | L | B | 0.0000 | |
| 104 | E | B | -1.7074 | |
| 105 | V | B | -0.7766 | |
| 106 | N | B | 0.0000 | |
| 107 | R | B | -1.2564 | |
| 108 | Q | B | -1.6906 | |
| 109 | E | B | 0.0000 | |
| 110 | L | B | 0.0000 | |
| 111 | G | B | -1.5299 | |
| 112 | R | B | -2.3065 | |
| 113 | W | B | 0.0000 | |
| 114 | L | B | -1.8534 | |
| 115 | Q | B | -2.7883 | |
| 116 | E | B | -3.7962 | |
| 117 | E | B | -3.4675 | |
| 118 | P | B | -2.1496 | |
| 119 | G | B | -1.5429 | |
| 120 | A | B | -1.9510 | |
| 121 | F | B | -1.3385 | |
| 122 | N | B | -1.6058 | |
| 123 | W | B | 0.0000 | |
| 124 | S | B | -0.4071 | |
| 125 | M | B | -0.1120 | |
| 126 | Y | B | 0.0000 | |
| 127 | S | B | 0.0000 | |
| 128 | Q | B | 0.0000 | |
| 129 | H | B | 0.0000 | |
| 130 | A | B | 0.0000 | |
| 131 | C | B | 0.0000 | |
| 132 | L | B | -1.0094 | |
| 133 | I | B | -1.1394 | |
| 134 | E | B | -1.4479 | |
| 135 | G | B | -1.8522 | |
| 136 | K | B | -2.4975 | |
| 137 | G | B | -1.9932 | |
| 138 | E | B | -2.4967 | |
| 139 | C | B | 0.0000 | |
| 140 | W | B | -1.3015 | |
| 141 | Q | B | -2.0815 | |
| 142 | D | B | -3.1742 | |
| 143 | K | B | 0.0000 | |
| 144 | E | B | -2.1958 | |
| 145 | R | B | -3.1878 | |
| 146 | Q | B | -2.2935 | |
| 147 | L | B | 0.0000 | |
| 148 | R | B | -1.9454 | |
| 149 | A | B | -1.4597 | |
| 150 | R | B | -1.9606 | |
| 151 | V | B | 0.0000 | |
| 152 | K | B | -2.0355 | |
| 153 | R | B | -0.9944 | |
| 154 | V | B | -0.3517 | |
| 155 | L | B | -0.2068 | |
| 156 | P | B | -0.3080 | |
| 157 | I | B | 0.0000 | |
| 158 | D | B | -0.6470 | |
| 159 | V | B | 0.0000 | |
| 160 | H | B | -1.3533 | |
| 161 | Q | B | -1.6657 | |
| 162 | P | B | -1.6473 | |
| 163 | Q | B | -1.7153 | |
| 164 | P | B | 0.0000 | |
| 165 | L | B | -0.6390 | |
| 166 | G | B | -1.0078 | |
| 167 | A | B | -0.6211 | |
| 168 | G | B | -0.5893 | |
| 169 | S | B | -0.4268 | |
| 170 | P | B | -0.2541 | |
| 171 | A | B | 0.0000 | |
| 172 | P | B | 0.0349 | |
| 173 | L | B | 0.5818 | |
| 174 | P | B | 0.0142 | |
| 175 | A | B | 0.0000 | |
| 176 | D | B | -0.9701 | |
| 177 | A | B | 0.0000 | |
| 178 | L | B | 0.0000 | |
| 179 | V | B | 0.0000 | |
| 180 | S | B | 0.0000 | |
| 181 | A | B | 0.2284 | |
| 182 | F | B | 0.4984 | |
| 183 | C | B | 0.3265 | |
| 184 | L | B | 0.0000 | |
| 185 | E | B | 0.0000 | |
| 186 | A | B | 0.0000 | |
| 187 | V | B | 0.0161 | |
| 188 | S | B | 0.0000 | |
| 189 | P | B | -0.7901 | |
| 190 | D | B | -1.2074 | |
| 191 | L | B | -0.7085 | |
| 192 | A | B | -0.7270 | |
| 193 | S | B | -1.1705 | |
| 194 | F | B | 0.0000 | |
| 195 | Q | B | -1.8890 | |
| 196 | R | B | -2.2618 | |
| 197 | A | B | 0.0000 | |
| 198 | L | B | 0.0000 | |
| 199 | D | B | -1.7999 | |
| 200 | H | B | 0.0000 | |
| 201 | I | B | 0.0000 | |
| 202 | T | B | 0.0000 | |
| 203 | T | B | -0.5506 | |
| 204 | L | B | 0.0000 | |
| 205 | L | B | 0.0000 | |
| 206 | R | B | -0.6785 | |
| 207 | P | B | -0.3045 | |
| 208 | G | B | -0.2511 | |
| 209 | G | B | 0.0000 | |
| 210 | H | B | 0.0000 | |
| 211 | L | B | 0.0000 | |
| 212 | L | B | 0.0000 | |
| 213 | L | B | 0.0000 | |
| 214 | I | B | 0.0000 | |
| 215 | G | B | 0.0000 | |
| 216 | A | B | 0.0000 | |
| 217 | L | B | 0.0000 | |
| 218 | E | B | -2.2509 | |
| 219 | E | B | 0.0000 | |
| 220 | S | B | -0.6426 | |
| 221 | W | B | -0.4538 | |
| 222 | Y | B | -0.3764 | |
| 223 | L | B | -0.9698 | |
| 224 | A | B | 0.0000 | |
| 225 | G | B | -2.3466 | |
| 226 | E | B | -2.9114 | |
| 227 | A | B | 0.0000 | |
| 228 | R | B | -2.3661 | |
| 229 | L | B | 0.0000 | |
| 230 | T | B | -0.4395 | |
| 231 | V | B | 0.0000 | |
| 232 | V | B | 0.0000 | |
| 233 | P | B | -1.4031 | |
| 234 | V | B | 0.0000 | |
| 235 | S | B | -2.3627 | |
| 236 | E | B | -2.8112 | |
| 237 | E | B | -3.6739 | |
| 238 | E | B | -3.1129 | |
| 239 | V | B | 0.0000 | |
| 240 | R | B | -3.7590 | |
| 241 | E | B | -3.5668 | |
| 242 | A | B | 0.0000 | |
| 243 | L | B | 0.0000 | |
| 244 | V | B | -0.9015 | |
| 245 | R | B | -2.2415 | |
| 246 | S | B | -1.3547 | |
| 247 | G | B | -0.3683 | |
| 248 | Y | B | 0.0000 | |
| 249 | K | B | -1.6309 | |
| 250 | V | B | -1.3137 | |
| 251 | R | B | -1.2845 | |
| 252 | D | B | -1.1740 | |
| 253 | L | B | -0.8640 | |
| 254 | R | B | -0.6124 | |
| 255 | T | B | 0.2274 | |
| 256 | Y | B | 0.7331 | |
| 257 | I | B | 1.8741 | |
| 258 | M | B | 0.0000 | |
| 259 | P | B | -0.2683 | |
| 260 | A | B | -0.5940 | |
| 261 | H | B | -1.2918 | |
| 262 | L | B | 0.0000 | |
| 263 | Q | B | -1.4909 | |
| 264 | T | B | -1.0027 | |
| 265 | G | B | -0.7387 | |
| 266 | V | B | 0.0000 | |
| 267 | D | B | -0.7863 | |
| 268 | D | B | -1.0778 | |
| 269 | V | B | 0.0000 | |
| 270 | K | B | -0.9703 | |
| 271 | G | B | 0.0000 | |
| 272 | V | B | 0.0000 | |
| 273 | F | B | 0.0000 | |
| 274 | F | B | 0.0000 | |
| 275 | A | B | 0.0000 | |
| 276 | W | B | 0.0000 | |
| 277 | A | B | 0.0000 | |
| 278 | Q | B | -0.6619 | |
| 279 | K | B | -0.0364 | |
| 280 | V | B | 1.0880 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine