Project name: d7963ce9ebb9c74

Chain sequence(s)	A: DEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.2326
• Maximal score value: 2.6474
• Average score: -0.9278
• Total score value: -225.453

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	A	-2.4354
2	E	A	-2.3387
3	P	A	-1.6801
4	P	A	-1.3299
5	Q	A	-1.1342
6	S	A	-0.6335
7	P	A	0.0000
8	W	A	-0.9271
9	D	A	0.0000
10	R	A	-0.1330
11	V	A	0.0000
12	K	A	0.0000
13	D	A	0.0000
14	L	A	0.0000
15	A	A	0.0000
16	T	A	0.0000
17	V	A	0.0000
18	Y	A	0.2920
19	V	A	0.0000
20	D	A	0.0000
21	V	A	0.0000
22	L	A	0.4695
23	K	A	0.0000
24	D	A	0.0000
25	S	A	0.0000
26	G	A	0.0000
27	R	A	0.0000
28	D	A	-0.5981
29	Y	A	0.0814
30	V	A	0.0000
31	S	A	-0.8415
32	Q	A	-0.7610
33	F	A	-0.8743
34	E	A	-1.5294
35	G	A	-0.9392
36	S	A	-0.3455
37	A	A	0.0720
38	L	A	1.1486
39	G	A	0.3518
40	K	A	-0.3755
41	Q	A	-0.9422
42	L	A	0.2591
43	N	A	-0.4911
44	L	A	-0.3345
45	K	A	-1.3432
46	L	A	-0.2249
47	L	A	-1.0798
48	D	A	-2.1779
49	N	A	-2.2275
50	W	A	-1.6383
51	D	A	-2.1414
52	S	A	-1.0813
53	V	A	-0.0552
54	T	A	-0.6504
55	S	A	-0.3348
56	T	A	0.0000
57	F	A	0.0000
58	S	A	-1.3151
59	K	A	-1.4795
60	L	A	-1.2554
61	R	A	-2.3645
62	E	A	-1.9661
63	Q	A	0.0000
64	L	A	-0.2645
65	G	A	-0.7175
66	P	A	-0.5373
67	V	A	0.1451
68	T	A	-0.7017
69	Q	A	-1.7225
70	E	A	-2.2630
71	F	A	0.0000
72	W	A	-1.3794
73	D	A	-2.9904
74	N	A	-2.1997
75	L	A	-1.6339
76	E	A	-2.7633
77	K	A	-2.6197
78	E	A	-2.5350
79	T	A	-2.3355
80	E	A	-2.8901
81	G	A	-2.3280
82	L	A	-2.1211
83	R	A	-3.0130
84	Q	A	-2.9679
85	E	A	-3.2450
86	M	A	0.0000
87	S	A	0.0000
88	K	A	-2.2197
89	D	A	-1.9002
90	L	A	0.0000
91	E	A	0.0000
92	E	A	-1.2583
93	V	A	0.0000
94	K	A	0.0000
95	A	A	0.0000
96	K	A	-0.3689
97	V	A	0.0000
98	Q	A	0.0000
99	P	A	0.0000
100	Y	A	-0.4127
101	L	A	0.0000
102	D	A	-2.0739
103	D	A	-2.8956
104	F	A	0.0000
105	Q	A	0.0000
106	K	A	-3.4215
107	K	A	-2.9119
108	W	A	0.0000
109	Q	A	-3.1136
110	E	A	-3.2809
111	E	A	0.0000
112	M	A	0.0000
113	E	A	-3.3281
114	L	A	-1.7004
115	Y	A	0.0000
116	R	A	-3.1722
117	Q	A	-2.9178
118	K	A	-1.8890
119	V	A	-1.3264
120	E	A	-2.4277
121	P	A	-0.8006
122	L	A	0.0714
123	R	A	-1.3865
124	A	A	-0.9373
125	E	A	-1.5664
126	L	A	-0.4441
127	Q	A	-1.3692
128	E	A	-1.8576
129	G	A	-1.2907
130	A	A	-1.1732
131	R	A	-2.2606
132	Q	A	-2.2452
133	K	A	-2.1255
134	L	A	0.0000
135	H	A	-2.1286
136	E	A	-1.7327
137	L	A	-0.1111
138	Q	A	-0.8518
139	E	A	-1.5160
140	K	A	-1.7330
141	L	A	-0.7047
142	S	A	-0.1816
143	P	A	0.4087
144	L	A	0.4120
145	G	A	-1.6840
146	E	A	-3.2678
147	E	A	-3.5805
148	M	A	-2.0780
149	R	A	-3.6785
150	D	A	-4.2326
151	R	A	-3.4022
152	A	A	-2.6065
153	R	A	-3.4331
154	A	A	-2.4624
155	H	A	-1.6266
156	V	A	-1.1417
157	D	A	-2.5031
158	A	A	-1.1508
159	L	A	-1.2610
160	R	A	-1.9424
161	T	A	-1.1479
162	H	A	0.0000
163	L	A	-0.7862
164	A	A	-0.7215
165	P	A	-1.1796
166	Y	A	0.0000
167	S	A	-1.5414
168	D	A	-2.5448
169	E	A	-1.8891
170	L	A	-1.5668
171	R	A	-2.8852
172	Q	A	-2.0345
173	R	A	0.0000
174	L	A	-0.4735
175	A	A	-0.2057
176	A	A	-0.6032
177	R	A	0.0000
178	L	A	0.3571
179	E	A	-1.2663
180	A	A	0.0000
181	L	A	0.0000
182	K	A	-1.0065
183	E	A	0.0000
184	N	A	-1.2504
185	G	A	-1.1386
186	G	A	-0.9938
187	A	A	-0.9393
188	R	A	-1.3245
189	L	A	0.2483
190	A	A	-0.5825
191	E	A	-1.7205
192	Y	A	-0.8851
193	H	A	-1.0504
194	A	A	0.0000
195	K	A	0.0000
196	A	A	-0.6189
197	T	A	-0.6249
198	E	A	-1.3195
199	H	A	-0.9671
200	L	A	0.2969
201	S	A	0.0260
202	T	A	-0.0465
203	L	A	0.9768
204	S	A	-0.8008
205	E	A	-2.5491
206	K	A	-2.7202
207	A	A	-1.7184
208	K	A	-1.2208
209	P	A	-0.6981
210	A	A	-0.8236
211	L	A	-0.8486
212	E	A	-2.7010
213	D	A	-2.5759
214	L	A	-1.3123
215	R	A	-2.3499
216	Q	A	-1.5887
217	G	A	-0.2518
218	L	A	1.8493
219	L	A	2.3547
220	P	A	2.1211
221	V	A	2.6474
222	L	A	1.9732
223	E	A	-0.1993
224	S	A	0.4653
225	F	A	0.3972
226	K	A	-0.3039
227	V	A	0.0000
228	S	A	0.5500
229	F	A	2.0646
230	L	A	1.1757
231	S	A	0.3840
232	A	A	0.6116
233	L	A	0.0000
234	E	A	-0.6983
235	E	A	-0.6760
236	Y	A	0.4048
237	T	A	0.1370
238	K	A	-0.3178
239	K	A	0.0000
240	L	A	0.4416
241	N	A	-0.4246
242	T	A	-0.8964
243	Q	A	-1.3631