Project name: 5%_pro_6fxn

Chain sequence(s)	A: SELTQDPAVSVALGQTVRVTCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCSSRDSSGNHWVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTVQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.1736
• Maximal score value: 2.5162
• Average score: -0.6899
• Total score value: -297.3305

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	S	A	-1.5065
3	E	A	-2.3237
4	L	A	0.0000
5	T	A	-1.3833
6	Q	A	-1.4240
7	D	A	-2.2855
8	P	A	-1.6933
9	A	A	0.0000
10	V	A	-0.7585
11	S	A	-0.4558
12	V	A	0.0000
13	A	A	-0.0777
14	L	A	-0.0727
15	G	A	-0.9289
16	Q	A	-1.3292
17	T	A	-1.2058
18	V	A	0.0000
19	R	A	-1.8889
20	V	A	0.0000
21	T	A	-1.1157
22	C	A	0.0000
23	Q	A	-1.9948
24	G	A	-2.1327
25	D	A	-2.5920
26	S	A	0.0000
27	L	A	0.0000
28	R	A	-2.5483
29	S	A	-1.2163
30	Y	A	-0.3240
31	Y	A	-0.4066
32	A	A	0.0000
33	S	A	0.0000
34	W	A	0.0000
35	Y	A	0.0000
36	Q	A	-0.3613
37	Q	A	0.0000
38	K	A	-1.6025
39	P	A	-1.3548
40	G	A	-1.2370
41	Q	A	-1.6701
42	A	A	-0.9164
43	P	A	0.0000
44	V	A	0.8528
45	L	A	0.0000
46	V	A	0.0000
47	I	A	0.0000
48	Y	A	-1.1424
49	G	A	0.0000
50	K	A	-2.6381
51	N	A	-2.4582
52	N	A	-2.1338
53	R	A	-1.7831
54	P	A	-0.5733
55	S	A	-0.6242
56	G	A	-0.7837
57	I	A	-0.7287
58	P	A	-1.2759
59	D	A	-2.1437
60	R	A	-1.3812
61	F	A	0.0000
62	S	A	-1.5445
63	G	A	-1.4304
64	S	A	-1.1488
65	S	A	-1.1913
66	S	A	-1.0475
67	G	A	-1.6256
68	N	A	-1.8889
69	T	A	-1.2738
70	A	A	0.0000
71	S	A	0.0000
72	L	A	0.0000
73	T	A	-0.9703
74	I	A	0.0000
75	T	A	-1.2117
76	G	A	-0.9208
77	A	A	0.0000
78	Q	A	-1.4376
79	A	A	0.0000
80	E	A	-2.3852
81	D	A	0.0000
82	E	A	-2.3029
83	A	A	0.0000
84	D	A	-2.1516
85	Y	A	0.0000
86	Y	A	0.0000
87	C	A	0.0000
88	S	A	-0.1223
89	S	A	0.0000
90	R	A	-0.6209
91	D	A	-1.1995
92	S	A	-1.3504
93	S	A	-0.6332
94	G	A	-0.5298
95	N	A	-0.9046
96	H	A	-0.7872
97	W	A	0.0000
98	V	A	-0.5053
99	F	A	-0.4489
100	G	A	0.0000
101	G	A	-1.4407
102	G	A	0.0000
103	T	A	0.0000
104	E	A	-2.3878
105	L	A	0.0000
106	T	A	-0.6063
107	V	A	0.0000
108	L	A	0.4671
109	G	A	-0.1597
110	Q	A	0.0000
111	P	A	-0.9885
112	K	A	-2.1805
113	A	A	-1.2296
114	A	A	-0.6824
115	P	A	0.0000
116	S	A	-0.1012
117	V	A	-0.2371
118	T	A	-0.2300
119	L	A	-0.1921
120	F	A	0.0000
121	P	A	-0.1764
122	P	A	0.0000
123	S	A	-1.0073
124	S	A	-1.3940
125	E	A	-1.9838
126	E	A	0.0000
127	L	A	-1.9514
128	Q	A	-2.2735
129	A	A	-1.9008
130	N	A	-2.7141
131	K	A	-2.8207
132	A	A	0.0000
133	T	A	0.0000
134	L	A	0.0000
135	V	A	0.0000
136	C	A	0.0000
137	L	A	0.0000
138	I	A	0.0000
139	S	A	-0.4043
140	D	A	-0.9176
141	F	A	0.0000
142	Y	A	-1.1326
143	P	A	-1.0657
144	G	A	-0.8241
145	A	A	-0.3202
146	V	A	-0.1479
147	T	A	-0.1364
148	V	A	0.1239
149	A	A	-0.1892
150	W	A	0.0000
151	K	A	-0.9873
152	A	A	0.0000
153	D	A	-1.5805
154	S	A	-1.0139
155	S	A	-0.8550
156	P	A	-0.9259
157	V	A	-0.5396
158	K	A	-1.4567
159	A	A	-0.5731
160	G	A	-0.1478
161	V	A	0.4622
162	E	A	0.3335
163	T	A	0.3161
164	T	A	0.0640
165	T	A	-0.1202
166	P	A	-0.2540
167	S	A	-0.5256
168	K	A	-1.3274
169	Q	A	-1.1272
170	S	A	-1.3088
171	N	A	-1.8520
172	N	A	-1.9021
173	K	A	-1.6450
174	Y	A	-0.7032
175	A	A	0.0000
176	A	A	0.0000
177	S	A	0.0000
178	S	A	0.0000
179	Y	A	0.0000
180	L	A	1.1996
181	S	A	0.1455
182	L	A	0.0000
183	T	A	-1.9011
184	P	A	-2.4761
185	E	A	-3.1736
186	Q	A	-2.4328
187	W	A	0.0000
188	K	A	-3.1077
189	S	A	0.0000
190	H	A	-2.4092
191	R	A	-2.6156
192	S	A	-1.6513
193	Y	A	0.0000
194	S	A	0.0000
195	C	A	0.0000
196	Q	A	-0.9713
197	V	A	0.0000
198	T	A	-0.6289
199	H	A	0.0000
200	E	A	-2.3059
201	G	A	-1.4249
202	S	A	-0.8287
203	T	A	-0.5970
204	V	A	-0.4594
205	E	A	-1.7213
206	K	A	-1.4432
207	T	A	-0.9355
208	V	A	0.0000
209	A	A	-0.9351
210	P	A	-1.0323
2	V	A	1.0587
3	Q	A	-0.9192
4	L	A	0.0000
5	Q	A	-1.7340
6	Q	A	-1.1980
7	S	A	-1.1953
8	G	A	-0.9712
9	A	A	0.0000
10	E	A	-1.1880
11	V	A	-0.8327
12	K	A	-1.5619
13	K	A	-2.4562
14	P	A	-2.1014
15	G	A	-1.5637
16	S	A	-1.3118
17	S	A	-1.5531
18	V	A	0.0000
19	R	A	-2.4674
20	V	A	0.0000
21	S	A	-0.9995
22	C	A	0.0000
23	K	A	-1.2586
24	A	A	0.0000
25	S	A	-0.7038
26	G	A	-0.5945
27	G	A	-1.0011
28	T	A	-1.2541
29	F	A	0.0000
30	N	A	-1.7427
31	N	A	-0.6465
32	N	A	-0.5025
33	A	A	0.0100
34	I	A	0.0000
35	N	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	R	A	0.0000
39	Q	A	-0.6538
40	A	A	-1.0013
41	P	A	-0.8463
42	G	A	-1.2235
43	Q	A	-1.7693
44	G	A	-1.3104
45	L	A	0.0000
46	E	A	-0.7343
47	W	A	0.0000
48	M	A	0.0000
49	G	A	0.0000
50	G	A	0.0000
51	I	A	0.3912
52	I	A	0.3560
53	P	A	-0.3955
54	M	A	0.4282
55	F	A	1.9203
56	G	A	0.4951
57	T	A	0.0536
58	A	A	-0.1808
59	K	A	-1.0572
60	Y	A	-0.6794
61	S	A	-1.3026
62	Q	A	-2.2271
63	N	A	-2.2652
64	F	A	0.0000
65	Q	A	-2.1705
66	G	A	-1.5523
67	R	A	-1.3291
68	V	A	0.0000
69	A	A	-0.8224
70	I	A	0.0000
71	T	A	-0.5307
72	A	A	-1.2919
73	D	A	-2.6973
74	E	A	-2.8635
75	S	A	-1.7372
76	T	A	-1.3934
77	G	A	0.0000
78	T	A	-1.4589
79	A	A	0.0000
80	S	A	-1.0950
81	M	A	0.0000
82	E	A	-2.0504
83	L	A	0.0000
84	S	A	-1.3279
85	S	A	-1.2220
86	L	A	0.0000
87	R	A	-2.7412
88	S	A	-2.1533
89	E	A	-2.4919
90	D	A	0.0000
91	T	A	-0.8452
92	A	A	0.0000
93	V	A	0.1460
94	Y	A	0.0000
95	Y	A	0.0000
96	C	A	0.0000
97	A	A	0.0000
98	R	A	-0.3920
99	S	A	0.0000
100	R	A	-0.3424
101	D	A	0.5583
102	L	A	1.5202
103	L	A	2.5162
104	L	A	2.3839
105	F	A	1.2169
106	P	A	0.6893
107	H	A	-0.6407
108	H	A	-0.7918
109	A	A	0.0000
110	L	A	0.0000
111	S	A	-0.0111
112	P	A	-0.0367
113	W	A	-0.3489
114	G	A	0.0000
115	R	A	-2.3054
116	G	A	-1.1222
117	T	A	0.0000
118	M	A	-0.2040
119	V	A	0.0000
120	T	A	-0.6457
121	V	A	0.0000
122	S	A	-1.1276
123	S	A	-0.9482
124	A	A	-0.5935
125	S	A	-0.6992
126	T	A	-0.7936
127	K	A	-1.1512
128	G	A	-1.3080
129	P	A	-0.6596
130	S	A	-0.3473
131	V	A	0.0000
132	F	A	0.0000
133	P	A	-1.0629
134	L	A	0.0000
135	A	A	-0.9182
136	P	A	0.0000
137	S	A	-0.9385
138	S	A	-1.2504
139	K	A	-2.0041
140	S	A	-1.4376
141	T	A	-0.8667
142	S	A	-0.8761
143	G	A	-0.8192
144	G	A	-1.1086
145	T	A	-0.8631
146	A	A	0.0000
147	A	A	0.0000
148	L	A	0.0000
149	G	A	0.0000
150	C	A	0.0000
151	L	A	0.0000
152	V	A	0.0000
153	K	A	-0.4136
154	D	A	-0.4686
155	Y	A	0.0000
156	F	A	-0.2815
157	P	A	0.0000
158	E	A	-0.8591
159	P	A	-0.9422
160	V	A	0.0000
161	T	A	-0.5564
162	V	A	-0.3066
163	S	A	-0.3167
164	W	A	0.0000
165	N	A	-0.6466
166	S	A	-0.5674
167	G	A	-0.3812
168	A	A	-0.1733
169	L	A	-0.0237
170	T	A	-0.1874
171	S	A	-0.3090
172	G	A	-0.3748
173	V	A	0.1093
174	H	A	-0.1827
175	T	A	-0.0190
176	F	A	0.0000
177	P	A	-0.0706
178	A	A	0.1801
179	V	A	0.0000
180	L	A	1.1132
181	Q	A	0.1933
182	S	A	-0.1815
183	S	A	-0.2664
184	G	A	-0.0708
185	L	A	0.1196
186	Y	A	0.2656
187	S	A	0.0000
188	L	A	0.0000
189	S	A	0.0000
190	S	A	0.0000
191	V	A	0.0000
192	V	A	0.0000
193	T	A	-0.2484
194	V	A	0.0000
195	P	A	-0.4817
196	S	A	-0.8856
197	S	A	-0.7791
198	S	A	-0.6045
199	L	A	-1.0095
200	G	A	-1.0201
201	T	A	-0.8396
202	Q	A	-1.5209
203	T	A	-1.2901
204	Y	A	0.0000
205	I	A	-1.2389
206	C	A	0.0000
207	N	A	0.0000
208	V	A	0.0000
209	N	A	-1.7735
210	H	A	0.0000
211	K	A	-2.7009
212	P	A	-1.6990
213	S	A	-1.7232
214	N	A	-2.4894
215	T	A	-2.0185
216	K	A	-2.6210
217	V	A	-1.6607
218	D	A	-2.5822
219	K	A	-2.3245
220	K	A	-2.5794
221	V	A	0.0000
222	E	A	-2.5054
223	P	A	-1.2348