Project name: DI1120011 chain A

Chain sequence(s)	A: ILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICCIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEEL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5547
• Maximal score value: 2.119
• Average score: -0.7465
• Total score value: -268.7438

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
4	I	A	2.1190
5	L	A	1.2404
6	P	A	0.0000
7	I	A	0.0000
8	R	A	-1.5050
9	F	A	-0.6936
10	Q	A	-1.8696
11	E	A	-1.9010
12	H	A	-1.4460
13	L	A	-1.0955
14	Q	A	-1.3545
15	L	A	0.0000
16	Q	A	-1.9402
17	N	A	-1.8148
18	L	A	-1.2261
19	G	A	-1.3220
20	I	A	0.0000
21	N	A	-2.0478
22	P	A	-1.4786
23	A	A	-0.7754
24	N	A	-0.8903
25	I	A	0.0000
26	G	A	-0.0906
27	F	A	0.6398
28	S	A	-0.0329
29	T	A	-0.2014
30	L	A	0.0000
31	T	A	0.0423
32	M	A	0.0000
33	E	A	-0.4562
34	S	A	-0.7518
35	D	A	-1.4624
36	K	A	-1.8530
37	F	A	0.0000
38	I	A	0.0000
39	C	A	0.0000
40	I	A	0.0000
41	R	A	-1.1327
42	E	A	0.0000
43	K	A	-2.2492
44	V	A	-0.8338
45	G	A	-1.5060
46	E	A	-2.4933
47	Q	A	-1.9420
48	A	A	-1.8781
49	Q	A	-1.7475
50	V	A	0.0000
51	V	A	0.0000
52	I	A	0.0000
53	I	A	0.0000
54	D	A	-1.8535
55	M	A	-1.8643
56	N	A	-2.5944
57	D	A	-3.0320
58	P	A	-1.8428
59	S	A	-1.6263
60	N	A	-2.0437
61	P	A	-1.2290
62	I	A	-0.6935
63	R	A	-1.7917
64	R	A	-2.3379
65	P	A	-1.6866
66	I	A	0.0000
67	S	A	-0.6319
68	A	A	-0.7967
69	D	A	-1.2293
70	S	A	-0.6630
71	A	A	0.0000
72	I	A	0.0000
73	M	A	0.0000
74	N	A	0.0000
75	P	A	-0.1128
76	A	A	-0.1423
77	S	A	-0.5585
78	K	A	-0.9948
79	V	A	0.0000
80	I	A	0.0000
81	A	A	0.0000
82	L	A	0.0000
83	K	A	0.0000
84	A	A	-1.2068
85	G	A	-1.8010
86	K	A	-2.5155
87	T	A	-1.3273
88	L	A	0.0000
89	Q	A	-0.9121
90	I	A	0.0000
91	F	A	-0.8930
92	N	A	-1.0827
93	I	A	-1.3023
94	E	A	-1.8923
95	M	A	-0.8666
96	K	A	-1.9959
97	S	A	-1.4851
98	K	A	-1.7102
99	M	A	-0.6818
100	K	A	-1.2157
101	A	A	-0.6913
102	H	A	-0.8833
103	T	A	-1.1780
104	M	A	0.0000
105	T	A	-1.1773
106	D	A	-2.4467
107	D	A	-3.1222
108	V	A	0.0000
109	T	A	-1.0253
110	F	A	-0.5252
111	W	A	0.0000
112	K	A	-0.3694
113	W	A	0.0000
114	I	A	0.2808
115	S	A	0.5464
116	L	A	1.3113
117	N	A	-0.0566
118	T	A	0.0000
119	V	A	0.0000
120	A	A	0.0000
121	L	A	0.0000
122	V	A	0.0000
123	T	A	0.0000
124	D	A	-3.1294
125	N	A	-3.0620
126	A	A	0.0000
127	V	A	0.0000
128	Y	A	-0.1869
129	H	A	0.0000
130	W	A	0.0000
131	S	A	-0.9128
132	M	A	-1.3586
133	E	A	-2.7456
134	G	A	-2.4126
135	E	A	-2.8053
136	S	A	-1.9692
137	Q	A	-1.7397
138	P	A	0.0000
139	V	A	0.6535
140	K	A	-0.8850
141	M	A	-0.5603
142	F	A	0.0000
143	D	A	-2.7771
144	R	A	-2.0804
145	H	A	-1.4859
146	S	A	-0.9740
147	S	A	-0.7533
148	L	A	0.0000
149	A	A	-0.9787
150	G	A	-0.8771
151	C	A	-0.6700
152	Q	A	-0.8565
153	I	A	0.0000
154	I	A	0.0128
155	N	A	-0.5506
156	Y	A	0.0000
157	R	A	-0.4224
158	T	A	-0.5911
159	D	A	0.0000
160	A	A	-1.0092
161	K	A	-2.0394
162	Q	A	-1.3749
163	K	A	-2.0736
164	W	A	-1.0657
165	L	A	0.0000
166	L	A	0.0000
167	L	A	0.0000
168	T	A	0.0000
169	G	A	0.0000
170	I	A	-0.1856
171	S	A	-0.4658
172	A	A	-1.1646
173	Q	A	-2.0807
174	Q	A	-2.4033
175	N	A	-2.4459
176	R	A	-1.9986
177	V	A	-0.6254
178	V	A	-0.6156
179	G	A	0.0000
180	A	A	-0.3737
181	M	A	0.0000
182	Q	A	0.0000
183	L	A	0.0000
184	Y	A	0.0000
185	S	A	0.0000
186	V	A	-1.6289
187	D	A	-3.0038
188	R	A	-3.1412
189	K	A	-2.4598
190	V	A	-0.7381
191	S	A	-0.9814
192	Q	A	-1.0279
193	P	A	-1.0226
194	I	A	-0.7200
195	E	A	-1.0482
196	G	A	0.0000
197	H	A	0.0000
198	A	A	0.0000
199	A	A	0.0000
200	S	A	0.0000
201	F	A	0.0000
202	A	A	0.0000
203	Q	A	-1.5054
204	F	A	0.0000
205	K	A	-3.5547
206	M	A	0.0000
207	E	A	-3.0022
208	G	A	-2.1458
209	N	A	-2.5954
210	A	A	-2.1251
211	E	A	-3.4065
212	E	A	-3.2800
213	S	A	0.0000
214	T	A	0.0000
215	L	A	0.0000
216	F	A	0.0000
217	C	A	0.0000
218	F	A	0.0000
219	A	A	0.0000
220	V	A	0.0000
221	R	A	-1.0883
222	G	A	-1.1566
223	Q	A	-1.3318
224	A	A	-1.0286
225	G	A	-0.9226
226	G	A	-0.9272
227	K	A	-1.3576
228	L	A	0.0000
229	H	A	-0.7778
230	I	A	0.0000
231	I	A	-0.6629
232	E	A	-0.6678
233	V	A	0.0000
234	G	A	-0.9361
235	T	A	-0.3801
236	P	A	-1.1591
237	P	A	-1.2296
238	T	A	-0.8393
239	G	A	-1.2394
240	N	A	-2.1856
241	Q	A	-2.0677
242	P	A	-1.3032
243	F	A	0.0000
244	P	A	-1.3271
245	K	A	-1.9407
246	K	A	-1.1070
247	A	A	-0.9043
248	V	A	-0.6724
249	D	A	-1.5923
250	V	A	0.0000
251	F	A	0.8744
252	F	A	-0.1304
253	P	A	-0.5328
254	P	A	-1.4424
255	E	A	-2.4719
256	A	A	0.0000
257	Q	A	-2.4520
258	N	A	-2.3063
259	D	A	0.0000
260	F	A	0.0000
261	P	A	0.0000
262	V	A	0.3021
263	A	A	0.1292
264	M	A	0.0000
265	Q	A	0.0000
266	I	A	-0.5232
267	S	A	0.0000
268	E	A	-2.8099
269	K	A	-2.7540
270	H	A	0.0000
271	D	A	0.0000
272	V	A	0.0000
273	V	A	0.0000
274	F	A	0.0000
275	L	A	0.0000
276	I	A	0.0000
277	T	A	0.0000
278	K	A	-0.2452
279	Y	A	-0.2392
280	G	A	0.0000
281	Y	A	-0.4805
282	I	A	0.0000
283	H	A	0.0000
284	L	A	0.0000
285	Y	A	0.0000
286	D	A	0.0000
287	L	A	0.0000
288	E	A	-0.7136
289	T	A	-0.3975
290	G	A	0.0000
291	T	A	-0.1739
292	C	A	0.2952
293	I	A	0.0000
294	Y	A	0.0000
295	M	A	-0.0600
296	N	A	-1.3192
297	R	A	-1.3356
298	I	A	-0.5600
299	S	A	0.0000
300	G	A	-1.0628
301	E	A	-1.3690
302	T	A	-0.7068
303	I	A	0.0000
304	F	A	0.3361
305	V	A	0.3626
306	T	A	0.0298
307	A	A	0.0000
308	P	A	-0.9418
309	H	A	-1.3412
310	E	A	-2.1063
311	A	A	-0.9673
312	T	A	-1.1786
313	A	A	-1.4905
314	G	A	0.0000
315	I	A	0.0000
316	I	A	0.0000
317	G	A	0.0000
318	V	A	0.0000
319	N	A	0.0000
320	R	A	-1.5481
321	K	A	-2.2461
322	G	A	0.0000
323	Q	A	-1.6143
324	V	A	0.0000
325	L	A	0.0000
326	S	A	0.0000
327	V	A	0.0000
328	C	A	0.0000
329	V	A	0.0000
330	E	A	0.0000
331	E	A	-2.5150
332	E	A	-2.2382
333	N	A	-1.0622
334	I	A	0.0000
335	I	A	0.0000
336	P	A	-0.4988
337	Y	A	0.4176
338	I	A	0.0000
339	T	A	0.0000
340	N	A	-0.5328
341	V	A	1.2349
342	L	A	0.2758
343	Q	A	-1.1099
344	N	A	-1.1005
345	P	A	-1.2044
346	D	A	-1.7567
347	L	A	0.0000
348	A	A	0.0000
349	L	A	0.1480
350	R	A	-0.1679
351	M	A	0.0000
352	A	A	0.0000
353	V	A	1.2402
354	R	A	-0.2146
355	N	A	-1.1249
356	N	A	-1.1521
357	L	A	0.0000
358	A	A	-1.2437
359	G	A	-1.4287
360	A	A	-0.8725
361	E	A	-2.2723
362	E	A	-1.9043
363	L	A	-0.3376