Project name: e0e7de327f7fe37

Chain sequence(s)	A: EFDWQDPLVLEEQLTTDEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGVLGPTIKGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKYLPQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTLNGTKTWITNSPMADLFVVWARCEDGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGVIIMDGVEVPEENVLPGASSLGGPFGCLNNARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.8682
• Maximal score value: 1.5984
• Average score: -0.652
• Total score value: -254.2733

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
3	E	A	-1.1255
4	F	A	0.6652
5	D	A	-0.6511
6	W	A	-0.3692
7	Q	A	-1.0932
8	D	A	-0.2914
9	P	A	0.6831
10	L	A	1.5891
11	V	A	0.4576
12	L	A	0.0000
13	E	A	-1.4976
14	E	A	-2.1355
15	Q	A	-1.6056
16	L	A	0.0000
17	T	A	-0.8870
18	T	A	-0.7295
19	D	A	-1.1200
20	E	A	0.0000
21	I	A	-0.0975
22	L	A	0.6693
23	I	A	0.1384
24	R	A	-0.6589
25	D	A	-1.2442
26	T	A	-0.4679
27	F	A	0.0000
28	R	A	-2.8772
29	T	A	-2.4069
30	Y	A	-2.1229
31	C	A	0.0000
32	Q	A	-3.1154
33	E	A	-3.6031
34	R	A	-3.3575
35	L	A	0.0000
36	M	A	-1.3375
37	P	A	-1.1824
38	R	A	-0.4926
39	I	A	0.0000
40	L	A	0.0522
41	L	A	0.3467
42	A	A	0.0000
43	N	A	0.0000
44	R	A	-1.2358
45	N	A	-1.5940
46	E	A	-1.4068
47	V	A	-0.1417
48	F	A	0.0000
49	H	A	-0.9391
50	R	A	-1.2297
51	E	A	-1.9837
52	I	A	0.0000
53	I	A	0.0000
54	S	A	-1.8715
55	E	A	-1.5519
56	M	A	0.0000
57	G	A	0.0000
58	E	A	-2.0368
59	L	A	-0.3043
60	G	A	-0.6133
61	V	A	0.0000
62	L	A	0.0000
63	G	A	0.0000
64	P	A	0.0000
65	T	A	-0.5816
66	I	A	0.0000
67	K	A	-1.8132
68	G	A	-1.3906
69	Y	A	-1.0339
70	G	A	-0.9797
71	C	A	-0.7849
72	A	A	-0.2991
73	G	A	-0.6966
74	V	A	-0.3301
75	S	A	-0.6271
76	S	A	0.0000
77	V	A	0.0000
78	A	A	0.0000
79	Y	A	0.0000
80	G	A	0.0000
81	L	A	0.0000
82	L	A	0.0000
83	A	A	0.0000
84	R	A	0.0000
85	E	A	0.0000
86	L	A	0.0000
87	E	A	0.0000
88	R	A	-0.6035
89	V	A	0.0000
90	D	A	0.0000
91	S	A	0.0000
92	G	A	0.0000
93	Y	A	0.0000
94	R	A	0.0000
95	S	A	0.0000
96	A	A	0.0000
97	M	A	0.0000
98	S	A	0.0000
99	V	A	0.0000
100	Q	A	0.0000
101	S	A	0.0000
102	S	A	0.0000
103	L	A	0.0000
104	V	A	0.0000
105	M	A	0.0000
106	H	A	0.0256
107	P	A	0.0000
108	I	A	0.0000
109	Y	A	-0.0969
110	A	A	0.0677
111	Y	A	-0.1114
112	G	A	-0.9285
113	S	A	-1.8042
114	E	A	-2.4056
115	E	A	-3.5150
116	Q	A	0.0000
117	R	A	-2.2140
118	Q	A	-3.0524
119	K	A	-3.0971
120	Y	A	0.0000
121	L	A	0.0000
122	P	A	-1.5750
123	Q	A	-1.9404
124	L	A	0.0000
125	A	A	0.0000
126	K	A	-2.2469
127	G	A	0.0000
128	E	A	-2.5481
129	L	A	-0.9612
130	L	A	0.0000
131	G	A	0.0000
132	C	A	0.0000
133	F	A	0.0000
134	G	A	0.0000
135	L	A	0.2576
136	T	A	-0.2902
137	E	A	0.0000
138	P	A	-0.9376
139	N	A	-1.9792
140	S	A	0.0000
141	G	A	-1.3205
142	S	A	-1.2132
143	D	A	-1.8636
144	P	A	-1.2266
145	S	A	-1.0049
146	S	A	-1.3528
147	M	A	0.0000
148	E	A	-2.3207
149	T	A	0.0000
150	R	A	-3.0425
151	A	A	0.0000
152	H	A	-1.7911
153	Y	A	-1.0751
154	N	A	-1.4809
155	S	A	-1.3884
156	S	A	-1.5092
157	N	A	-2.4741
158	K	A	-2.9332
159	S	A	0.0000
160	Y	A	0.0000
161	T	A	-1.2699
162	L	A	0.0000
163	N	A	-2.7840
164	G	A	-1.7407
165	T	A	-0.9236
166	K	A	0.0000
167	T	A	0.2962
168	W	A	1.0313
169	I	A	0.0000
170	T	A	0.1597
171	N	A	0.0000
172	S	A	0.0000
173	P	A	-0.6912
174	M	A	-0.3597
175	A	A	0.0000
176	D	A	0.0000
177	L	A	0.0000
178	F	A	0.0000
179	V	A	0.0000
180	V	A	0.0000
181	W	A	0.0000
182	A	A	0.0000
183	R	A	-2.2287
184	C	A	0.0000
185	E	A	-3.1701
186	D	A	-2.9012
187	G	A	-2.0604
188	C	A	-1.1225
189	I	A	0.0000
190	R	A	-0.8610
191	G	A	0.0000
192	F	A	0.0000
193	L	A	0.0000
194	L	A	0.0000
195	E	A	-1.8520
196	K	A	-2.4894
197	G	A	-1.9275
198	M	A	-1.7834
199	R	A	-2.7170
200	G	A	-2.2583
201	L	A	-1.6446
202	S	A	-1.0135
203	A	A	-0.5418
204	P	A	-1.0408
205	R	A	-1.8855
206	I	A	-1.0844
207	Q	A	-1.7239
208	G	A	-0.7437
209	K	A	0.0249
210	F	A	1.1371
211	S	A	0.3208
212	L	A	0.0000
213	R	A	-0.6503
214	A	A	0.0000
215	S	A	0.0000
216	A	A	0.0000
217	T	A	0.0000
218	G	A	0.0000
219	V	A	0.1435
220	I	A	0.0000
221	I	A	-0.3165
222	M	A	0.0000
223	D	A	-2.7202
224	G	A	-2.3338
225	V	A	0.0000
226	E	A	-1.5747
227	V	A	0.0000
228	P	A	-1.8304
229	E	A	-2.4221
230	E	A	-2.7623
231	N	A	-1.5395
232	V	A	-0.9344
233	L	A	0.0000
234	P	A	-0.8467
235	G	A	-0.5785
236	A	A	0.0000
237	S	A	-0.6001
238	S	A	-0.3225
239	L	A	0.1100
240	G	A	-0.2175
241	G	A	0.0000
242	P	A	0.0000
243	F	A	0.6173
244	G	A	0.1330
245	C	A	0.0000
246	L	A	0.1273
247	N	A	-0.1627
248	N	A	-0.3125
249	A	A	0.0000
250	R	A	0.0000
251	Y	A	0.0000
252	G	A	0.0000
253	I	A	0.0000
254	A	A	0.0000
255	W	A	0.0000
256	G	A	0.0000
257	V	A	0.0000
258	L	A	0.0000
259	G	A	0.0000
260	A	A	0.0000
261	S	A	0.0000
262	E	A	0.0000
263	F	A	-0.0356
264	C	A	0.0000
265	L	A	0.0000
266	H	A	-0.9856
267	T	A	-0.7294
268	A	A	0.0000
269	R	A	-1.3877
270	Q	A	-1.6603
271	Y	A	-1.0218
272	A	A	0.0000
273	L	A	-0.2529
274	D	A	-1.7201
275	R	A	-1.5683
276	M	A	0.0181
277	Q	A	0.0042
278	F	A	1.5984
279	G	A	0.6093
280	V	A	0.0825
281	P	A	-0.3371
282	L	A	-0.6292
283	A	A	-1.4096
284	R	A	-1.9169
285	N	A	-1.7689
286	Q	A	-1.9362
287	L	A	-0.3542
288	I	A	0.0000
289	Q	A	-2.7759
290	K	A	-2.8130
291	K	A	-2.2412
292	L	A	0.0000
293	A	A	-1.8639
294	D	A	-2.6725
295	M	A	0.0000
296	L	A	-0.5788
297	T	A	-0.4873
298	E	A	-0.6000
299	I	A	0.0000
300	T	A	0.0000
301	L	A	1.4863
302	G	A	0.0000
303	L	A	0.0000
304	H	A	0.3377
305	A	A	0.1382
306	C	A	0.0000
307	L	A	-0.6142
308	Q	A	-1.1913
309	L	A	0.0000
310	G	A	0.0000
311	R	A	-2.0533
312	L	A	-2.3077
313	K	A	-2.8967
314	D	A	-3.4508
315	Q	A	-3.5905
316	D	A	-3.8682
317	K	A	-3.2995
318	A	A	-2.1010
319	A	A	-0.8609
320	P	A	-0.1419
321	E	A	-0.3222
322	M	A	0.0113
323	V	A	0.0000
324	S	A	0.0000
325	L	A	0.5232
326	L	A	0.0000
327	K	A	0.0000
328	R	A	-0.9712
329	N	A	-0.5122
330	N	A	0.0000
331	C	A	0.0000
332	G	A	-1.2560
333	K	A	-1.6451
334	A	A	0.0000
335	L	A	-1.7384
336	D	A	-2.7365
337	I	A	0.0000
338	A	A	0.0000
339	R	A	-3.3352
340	Q	A	-3.0144
341	A	A	0.0000
342	R	A	-2.4629
343	D	A	-2.8109
344	M	A	0.0000
345	L	A	0.0000
346	G	A	-1.1594
347	G	A	-0.6741
348	N	A	-0.6404
349	G	A	0.0000
350	I	A	1.0385
351	S	A	-0.0167
352	D	A	-0.5342
353	E	A	-1.4200
354	Y	A	-0.3580
355	H	A	-0.3250
356	V	A	0.0000
357	I	A	-0.2281
358	R	A	0.0000
359	H	A	0.0000
360	A	A	0.0000
361	M	A	-0.1267
362	N	A	0.0000
363	L	A	0.0000
364	E	A	-1.2127
365	A	A	-0.4931
366	V	A	0.0000
367	N	A	-1.1107
368	T	A	-0.7741
369	Y	A	-0.1165
370	E	A	-0.2383
371	G	A	-0.7253
372	T	A	-0.8732
373	H	A	-1.2355
374	D	A	-1.6336
375	I	A	-0.5768
376	H	A	0.0000
377	A	A	-0.4793
378	L	A	0.3137
379	I	A	0.2830
380	L	A	0.1891
381	G	A	0.2880
382	R	A	-0.6354
383	A	A	0.2663
384	I	A	1.5770
385	T	A	0.6617
386	G	A	0.2352
387	I	A	1.2203
388	Q	A	-0.2100
389	A	A	-0.1142
390	F	A	0.0589
391	T	A	-0.6233
392	K	A	-1.6433