Project name: sssdd

Chain sequence(s)	A: NYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASALNLCAISIDRYTAVAMPTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYSQQKEKKATQMAAIVAGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILH
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.859
• Maximal score value: 3.0578
• Average score: -0.3239
• Total score value: -137.0062

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
35	N	A	0.1709
36	Y	A	1.5108
37	Y	A	1.9143
38	A	A	0.0000
39	T	A	1.3485
40	L	A	1.7009
41	L	A	0.0000
42	T	A	1.4515
43	L	A	2.3882
44	L	A	2.1275
45	I	A	1.9547
46	A	A	2.2166
47	V	A	2.8474
48	I	A	0.0000
49	V	A	2.7951
50	F	A	3.0578
51	G	A	2.2386
52	N	A	0.0000
53	V	A	2.0280
54	L	A	0.0000
55	V	A	0.0000
56	C	A	0.5619
57	M	A	0.1592
58	A	A	0.0000
59	V	A	0.0000
60	S	A	-1.3761
61	R	A	-2.5597
62	E	A	-2.7755
63	K	A	-2.7978
64	A	A	-1.5498
65	L	A	0.0000
66	Q	A	-1.7665
67	T	A	-0.9830
68	T	A	-0.8786
69	T	A	0.0000
70	N	A	0.0000
71	Y	A	0.1189
72	L	A	0.0000
73	I	A	0.0000
74	V	A	0.8346
75	S	A	0.0000
76	L	A	0.0000
77	A	A	0.0000
78	V	A	1.2635
79	A	A	0.0000
80	D	A	0.0000
81	L	A	1.4769
82	L	A	1.0047
83	V	A	0.0000
84	A	A	0.0000
85	T	A	0.5868
86	L	A	0.7067
87	V	A	0.0000
88	M	A	0.0000
89	P	A	0.4310
90	W	A	0.5544
91	V	A	0.0000
92	V	A	1.2061
93	Y	A	1.1505
94	L	A	0.4755
95	E	A	0.7692
96	V	A	1.8050
97	V	A	0.5134
98	G	A	-0.4949
99	E	A	-1.5232
100	W	A	-1.0828
101	K	A	-1.9675
102	F	A	-0.9213
103	S	A	-0.9091
104	R	A	-1.7725
105	I	A	0.7033
106	H	A	-0.2408
107	C	A	0.0000
108	D	A	0.6161
109	I	A	0.8053
110	F	A	0.0000
111	V	A	0.0000
112	T	A	0.0000
113	L	A	0.8734
114	D	A	0.2021
115	V	A	0.0000
116	M	A	0.8813
117	M	A	0.0000
118	C	A	0.2079
119	T	A	0.0000
120	A	A	0.0000
121	S	A	0.0000
122	A	A	0.0000
123	L	A	0.8445
124	N	A	0.0000
125	L	A	0.0000
126	C	A	0.8609
127	A	A	0.0000
128	I	A	0.0000
129	S	A	0.0000
130	I	A	1.0686
131	D	A	0.0000
132	R	A	0.0000
133	Y	A	0.6541
134	T	A	0.5477
135	A	A	0.1811
136	V	A	0.0000
137	A	A	0.3232
138	M	A	0.7016
139	P	A	0.1132
144	T	A	-1.0793
145	R	A	-1.9212
146	Y	A	-0.7362
147	S	A	-1.3197
148	S	A	-1.6676
149	K	A	-2.4598
150	R	A	-2.4245
151	R	A	-1.1541
152	V	A	0.0000
153	T	A	-0.1030
154	V	A	1.1693
155	M	A	1.0446
156	I	A	1.5673
157	S	A	1.6795
158	I	A	2.5203
159	V	A	0.0000
160	W	A	1.9652
161	V	A	2.6960
162	L	A	2.4461
163	S	A	0.0000
164	F	A	2.6960
165	T	A	1.5757
166	I	A	1.3861
167	S	A	0.0000
168	C	A	1.3207
169	P	A	0.6140
170	L	A	0.0000
171	L	A	1.8215
172	F	A	1.4256
173	G	A	-0.4330
174	L	A	0.0000
175	N	A	-1.4471
176	N	A	-1.8437
177	A	A	-1.6483
178	D	A	-1.7929
179	Q	A	-2.4316
180	N	A	-2.9025
181	E	A	-2.4961
182	C	A	0.0000
183	I	A	0.0000
184	I	A	0.8790
185	A	A	0.1669
186	N	A	0.0000
187	P	A	0.3947
188	A	A	0.6909
189	F	A	1.2217
190	V	A	1.9616
191	V	A	2.5766
192	Y	A	1.8838
193	S	A	1.4115
194	S	A	0.0000
195	I	A	2.6841
196	V	A	2.0867
197	S	A	0.0000
198	F	A	0.0000
199	Y	A	2.2182
200	V	A	2.7794
201	P	A	0.0000
202	F	A	2.5568
203	I	A	3.0231
204	V	A	2.9723
205	T	A	2.3040
206	L	A	2.6844
207	L	A	2.8822
208	V	A	2.0486
209	Y	A	0.0000
210	I	A	2.0955
211	K	A	0.7025
212	I	A	0.0000
213	Y	A	0.9893
214	I	A	0.2016
215	V	A	0.0000
216	L	A	-1.6054
217	R	A	-3.0054
218	R	A	-3.6503
219	R	A	-3.3275
220	R	A	-3.3340
221	K	A	-3.5769
222	R	A	-3.8590
1002	N	A	-2.5881
1003	I	A	0.0000
1004	F	A	0.0000
1005	E	A	-1.8131
1006	M	A	0.0000
1007	L	A	0.0000
1008	R	A	-1.6065
1009	I	A	-0.1265
1010	D	A	-1.0600
1011	E	A	-1.6449
1012	G	A	-1.3963
1013	L	A	0.0000
1014	R	A	-2.4383
1015	L	A	-1.1530
1016	K	A	-1.4010
1017	I	A	0.0000
1018	Y	A	-1.2163
1019	K	A	-2.0892
1020	D	A	-2.0596
1021	T	A	-1.7304
1022	E	A	-2.6980
1023	G	A	-2.2242
1024	Y	A	-1.5487
1025	Y	A	0.0000
1026	T	A	0.0000
1027	I	A	0.0000
1028	G	A	0.0000
1029	I	A	0.0000
1030	G	A	-0.8151
1031	H	A	-0.3023
1032	L	A	-0.2168
1033	L	A	0.0000
1034	T	A	-0.9883
1035	K	A	-1.8442
1036	S	A	-1.0034
1037	P	A	-0.6406
1038	S	A	-0.4150
1039	L	A	0.0064
1040	N	A	-1.3176
1041	A	A	-1.2306
1042	A	A	0.0000
1043	K	A	-2.1128
1044	S	A	-2.3408
1045	E	A	-2.8617
1046	L	A	0.0000
1047	D	A	-3.2027
1048	K	A	-3.2536
1049	A	A	-2.0740
1050	I	A	0.0000
1051	G	A	-2.4552
1052	R	A	-3.2687
1053	N	A	-2.9030
1054	T	A	-2.0169
1055	N	A	-1.8703
1056	G	A	0.0000
1057	V	A	0.1365
1058	I	A	0.0000
1059	T	A	-1.8255
1060	K	A	-3.0473
1061	D	A	-3.4101
1062	E	A	-2.3270
1063	A	A	0.0000
1064	E	A	-3.3398
1065	K	A	-3.0175
1066	L	A	0.0000
1067	F	A	0.0000
1068	N	A	-2.2524
1069	Q	A	-2.1908
1070	D	A	-1.4852
1071	V	A	0.0000
1072	D	A	-2.3808
1073	A	A	-1.5883
1074	A	A	-1.3397
1075	V	A	-1.5198
1076	R	A	-2.2766
1077	G	A	-1.8603
1078	I	A	0.0000
1079	L	A	-1.8372
1080	R	A	-2.5567
1081	N	A	-2.1675
1082	A	A	-1.6335
1083	K	A	-2.4068
1084	L	A	0.0000
1085	K	A	-2.4584
1086	P	A	-1.8396
1087	V	A	0.0000
1088	Y	A	0.0000
1089	D	A	-2.4286
1090	S	A	-2.0719
1091	L	A	0.0000
1092	D	A	-1.8873
1093	A	A	-1.1389
1094	V	A	0.0000
1095	R	A	-1.1460
1096	R	A	-1.2056
1097	A	A	0.0000
1098	A	A	0.0000
1099	L	A	0.0000
1100	I	A	0.0000
1101	N	A	0.0000
1102	M	A	0.0000
1103	V	A	0.0000
1104	F	A	-0.1671
1105	Q	A	-0.5148
1106	M	A	-0.1883
1107	G	A	-0.5058
1108	E	A	-1.2278
1109	T	A	-0.8595
1110	G	A	-0.5903
1111	V	A	0.0000
1112	A	A	0.0000
1113	G	A	-0.9603
1114	F	A	-0.8342
1115	T	A	-1.2771
1116	N	A	-1.7107
1117	S	A	0.0000
1118	L	A	0.0000
1119	R	A	-2.3609
1120	M	A	-2.4656
1121	L	A	0.0000
1122	Q	A	-2.4709
1123	Q	A	-2.5524
1124	K	A	-3.4406
1125	R	A	-3.0193
1126	W	A	-2.4516
1127	D	A	-2.6480
1128	E	A	-1.7369
1129	A	A	0.0000
1130	A	A	-1.0557
1131	V	A	0.3023
1132	N	A	-0.7345
1133	L	A	0.0000
1134	A	A	-1.2318
1135	K	A	-2.0538
1136	S	A	-2.0203
1137	R	A	-2.9745
1138	W	A	0.0000
1139	Y	A	-2.3540
1140	N	A	-3.0938
1141	Q	A	-2.4735
1142	T	A	-1.8548
1143	P	A	-2.2500
1144	N	A	-2.4168
1145	R	A	0.0000
1146	A	A	0.0000
1147	K	A	-2.6595
1148	R	A	-2.1700
1149	V	A	0.0000
1150	I	A	0.0000
1151	T	A	-1.8762
1152	T	A	0.0000
1153	F	A	0.0000
1154	R	A	-2.4191
1155	T	A	-1.4347
1156	G	A	-1.2041
1157	T	A	-1.4049
1158	W	A	0.0000
1159	D	A	-2.0288
1160	A	A	-1.3380
1161	Y	A	-0.6221
364	S	A	-1.1238
365	Q	A	-1.6757
366	Q	A	-2.4120
367	K	A	-2.9398
368	E	A	-2.6736
369	K	A	-2.8539
370	K	A	-2.9685
371	A	A	-1.7419
372	T	A	0.0000
373	Q	A	-1.8355
374	M	A	0.0000
375	A	A	0.0000
376	A	A	-0.1078
377	I	A	0.2647
378	V	A	0.0000
379	A	A	0.6678
380	G	A	0.8613
381	V	A	1.2774
382	F	A	0.0000
383	I	A	1.5866
384	I	A	2.4216
385	C	A	0.0000
386	W	A	0.0000
387	L	A	1.6021
388	P	A	1.4384
389	F	A	1.4153
390	F	A	0.0000
391	I	A	1.4716
392	T	A	0.0000
393	H	A	1.2348
394	I	A	1.5934
395	L	A	0.8705
396	N	A	-0.3779
397	I	A	1.2024
398	H	A	0.0638
399	C	A	-0.0355
400	D	A	-1.3081
401	C	A	-0.5872
402	N	A	-1.4267
403	I	A	-0.2422
404	P	A	0.4722
405	P	A	0.7817
406	V	A	2.0892
407	L	A	1.7222
408	Y	A	1.3029
409	S	A	1.1128
410	A	A	1.2441
411	F	A	1.5399
412	T	A	0.9936
413	W	A	0.9293
414	L	A	1.3986
415	G	A	0.0000
416	Y	A	0.0000
417	V	A	1.3579
418	N	A	0.0000
419	S	A	0.0000
420	A	A	0.0000
421	V	A	1.3939
422	N	A	0.0000
423	P	A	0.0000
424	I	A	2.0683
425	I	A	0.0000
426	Y	A	0.0000
427	T	A	0.5074
428	T	A	0.8751
429	F	A	0.9304
430	N	A	0.0000
431	I	A	0.8215
432	E	A	-0.6247
433	F	A	0.0000
434	R	A	-0.9364
435	K	A	-1.4201
436	A	A	0.0000
437	F	A	0.0000
438	L	A	0.2025
439	K	A	-1.0757
440	I	A	0.3913
441	L	A	0.9704
442	H	A	-0.4200