| Chain sequence(s) |
A: TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSWDERTKEEVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVWARRWWWGNVFSCSVMHEALHNHYTQKSLSRSPGKTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSWDERTKEEVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVWARRWWWGNVFSCSVMHEALHNHYTQKSLSRSPGK
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:05:58)
[INFO] Main: Simulation completed successfully. (00:06:01)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | T | A | 0.1501 | |
| 2 | C | A | 0.4887 | |
| 3 | P | A | 0.0637 | |
| 4 | P | A | 0.1128 | |
| 5 | C | A | 0.5665 | |
| 6 | P | A | -0.2331 | |
| 7 | A | A | -0.4880 | |
| 8 | P | A | -0.7692 | |
| 9 | E | A | -1.3391 | |
| 10 | L | A | 0.3417 | |
| 11 | L | A | 1.1802 | |
| 12 | G | A | -0.0332 | |
| 13 | G | A | -0.3996 | |
| 14 | P | A | 0.0000 | |
| 15 | S | A | -0.0337 | |
| 16 | V | A | 0.0000 | |
| 17 | F | A | 1.1510 | |
| 18 | L | A | 0.8963 | |
| 19 | F | A | 1.1691 | |
| 20 | P | A | -0.1874 | |
| 21 | P | A | 0.0000 | |
| 22 | K | A | -1.9762 | |
| 23 | P | A | -1.3332 | |
| 24 | K | A | -1.2679 | |
| 25 | D | A | -1.3472 | |
| 26 | T | A | 0.0000 | |
| 27 | L | A | 0.0000 | |
| 28 | M | A | 0.2669 | |
| 29 | I | A | 1.4183 | |
| 30 | S | A | 0.0504 | |
| 31 | R | A | -1.2288 | |
| 32 | T | A | -0.8170 | |
| 33 | P | A | 0.0000 | |
| 34 | E | A | -1.1754 | |
| 35 | V | A | 0.0000 | |
| 36 | T | A | 0.2126 | |
| 37 | C | A | 0.0000 | |
| 38 | V | A | 0.7492 | |
| 39 | V | A | 0.0000 | |
| 40 | V | A | -0.5466 | |
| 41 | D | A | -1.6098 | |
| 42 | V | A | 0.0000 | |
| 43 | S | A | -2.0895 | |
| 44 | H | A | -2.6482 | |
| 45 | E | A | -2.9677 | |
| 46 | D | A | -2.5923 | |
| 47 | P | A | -2.7302 | |
| 48 | E | A | -3.1174 | |
| 49 | V | A | -2.0177 | |
| 50 | K | A | -2.2331 | |
| 51 | F | A | -1.1470 | |
| 52 | N | A | -1.1598 | |
| 53 | W | A | 0.0000 | |
| 54 | Y | A | -0.6706 | |
| 55 | V | A | -0.8747 | |
| 56 | D | A | -2.0225 | |
| 57 | G | A | -0.8506 | |
| 58 | V | A | 0.5157 | |
| 59 | E | A | -0.8406 | |
| 60 | V | A | -0.6389 | |
| 61 | H | A | -1.9273 | |
| 62 | N | A | -2.1990 | |
| 63 | A | A | -1.9197 | |
| 64 | K | A | -2.4576 | |
| 65 | T | A | -1.9634 | |
| 66 | K | A | -2.3160 | |
| 67 | P | A | -2.3000 | |
| 68 | R | A | -3.3352 | |
| 69 | E | A | -3.2192 | |
| 70 | E | A | -3.1790 | |
| 71 | Q | A | -1.6130 | |
| 72 | Y | A | 0.1089 | |
| 73 | N | A | -0.9817 | |
| 74 | S | A | -1.3200 | |
| 75 | T | A | -1.7970 | |
| 76 | Y | A | 0.0000 | |
| 77 | R | A | -2.2292 | |
| 78 | V | A | 0.0000 | |
| 79 | V | A | 0.0000 | |
| 80 | S | A | 0.0000 | |
| 81 | V | A | 0.0000 | |
| 82 | L | A | 0.0000 | |
| 83 | T | A | -0.8164 | |
| 84 | V | A | 0.0000 | |
| 85 | L | A | 0.7805 | |
| 86 | H | A | -0.1376 | |
| 87 | Q | A | -1.0276 | |
| 88 | D | A | -1.4612 | |
| 89 | W | A | 0.0000 | |
| 90 | L | A | -1.0057 | |
| 91 | N | A | -2.2849 | |
| 92 | G | A | -2.2539 | |
| 93 | K | A | -2.3681 | |
| 94 | E | A | -2.4230 | |
| 95 | Y | A | 0.0000 | |
| 96 | K | A | -1.6441 | |
| 97 | C | A | 0.0000 | |
| 98 | K | A | -1.4707 | |
| 99 | V | A | 0.0000 | |
| 100 | S | A | -1.4876 | |
| 101 | N | A | 0.0000 | |
| 102 | K | A | -2.5845 | |
| 103 | A | A | -1.6178 | |
| 104 | L | A | -0.5359 | |
| 105 | P | A | -0.2861 | |
| 106 | A | A | -0.2867 | |
| 107 | P | A | -0.9532 | |
| 108 | I | A | -0.5158 | |
| 109 | E | A | -2.0283 | |
| 110 | K | A | -1.2819 | |
| 111 | T | A | -1.0732 | |
| 112 | I | A | -0.3648 | |
| 113 | S | A | -1.3754 | |
| 114 | K | A | -1.5621 | |
| 115 | A | A | -1.2916 | |
| 116 | K | A | -2.4069 | |
| 117 | G | A | -2.0275 | |
| 118 | Q | A | -2.2164 | |
| 119 | P | A | -1.9204 | |
| 120 | R | A | -2.3749 | |
| 121 | E | A | -2.7838 | |
| 122 | P | A | 0.0000 | |
| 123 | Q | A | -1.3853 | |
| 124 | V | A | 0.0000 | |
| 125 | Y | A | 0.0000 | |
| 126 | T | A | 0.0000 | |
| 127 | L | A | 0.0000 | |
| 128 | P | A | -0.2695 | |
| 129 | P | A | -0.7818 | |
| 130 | S | A | 0.0000 | |
| 131 | W | A | -0.8378 | |
| 132 | D | A | -2.1144 | |
| 133 | E | A | 0.0000 | |
| 134 | R | A | -2.7190 | |
| 135 | T | A | -1.9910 | |
| 136 | K | A | -2.3617 | |
| 137 | E | A | -2.8621 | |
| 138 | E | A | -2.3033 | |
| 139 | V | A | 0.0000 | |
| 140 | S | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | T | A | 0.0000 | |
| 143 | C | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | K | A | -0.6008 | |
| 147 | G | A | -1.0892 | |
| 148 | F | A | 0.0000 | |
| 149 | Y | A | -1.1219 | |
| 150 | P | A | 0.0000 | |
| 151 | S | A | -0.1682 | |
| 152 | D | A | -1.1413 | |
| 153 | I | A | -0.5706 | |
| 154 | A | A | 0.0000 | |
| 155 | V | A | 0.0000 | |
| 156 | E | A | -1.4296 | |
| 157 | W | A | 0.0000 | |
| 158 | E | A | -2.0357 | |
| 159 | S | A | 0.0000 | |
| 160 | N | A | -1.8713 | |
| 161 | G | A | -1.8230 | |
| 162 | Q | A | -2.3507 | |
| 163 | P | A | -2.0322 | |
| 164 | E | A | -1.9600 | |
| 165 | N | A | -2.1974 | |
| 166 | N | A | -1.6011 | |
| 167 | Y | A | -1.2406 | |
| 168 | K | A | -1.1363 | |
| 169 | T | A | -0.4249 | |
| 170 | T | A | 0.0000 | |
| 171 | P | A | -0.1443 | |
| 172 | P | A | 0.2002 | |
| 173 | V | A | 0.6293 | |
| 174 | L | A | 1.0238 | |
| 175 | D | A | -0.3736 | |
| 176 | S | A | -1.0908 | |
| 177 | D | A | -1.8312 | |
| 178 | G | A | -0.7560 | |
| 179 | S | A | 0.0000 | |
| 180 | F | A | 0.2374 | |
| 181 | F | A | 0.0000 | |
| 182 | L | A | 0.0000 | |
| 183 | Y | A | 0.0000 | |
| 184 | S | A | 0.0000 | |
| 185 | K | A | 0.0000 | |
| 186 | L | A | 0.0000 | |
| 187 | T | A | -0.6317 | |
| 188 | V | A | 0.0000 | |
| 189 | W | A | -0.9115 | |
| 190 | A | A | 0.0000 | |
| 191 | R | A | -1.5463 | |
| 192 | R | A | -0.6290 | |
| 193 | W | A | 0.0000 | |
| 194 | W | A | -0.2421 | |
| 195 | W | A | 0.5100 | |
| 196 | G | A | -0.1502 | |
| 197 | N | A | -0.3269 | |
| 198 | V | A | 0.0135 | |
| 199 | F | A | 0.0000 | |
| 200 | S | A | -1.2363 | |
| 201 | C | A | 0.0000 | |
| 202 | S | A | 0.0000 | |
| 203 | V | A | 0.0000 | |
| 204 | M | A | -0.5239 | |
| 205 | H | A | 0.0000 | |
| 206 | E | A | -1.1013 | |
| 207 | A | A | -1.5370 | |
| 208 | L | A | -1.4710 | |
| 209 | H | A | -1.7459 | |
| 210 | N | A | -1.6537 | |
| 211 | H | A | -1.1204 | |
| 212 | Y | A | -0.5681 | |
| 213 | T | A | -0.9771 | |
| 214 | Q | A | -1.6701 | |
| 215 | K | A | -1.5256 | |
| 216 | S | A | -0.7453 | |
| 217 | L | A | 0.0000 | |
| 218 | S | A | -0.5373 | |
| 219 | R | A | -1.2519 | |
| 220 | S | A | -1.2392 | |
| 221 | P | A | -1.2847 | |
| 222 | G | A | -1.6754 | |
| 223 | K | A | -2.0340 | |
| 424 | T | A | 0.1483 | |
| 425 | C | A | 0.4818 | |
| 426 | P | A | 0.0565 | |
| 427 | P | A | 0.1111 | |
| 428 | C | A | 0.5644 | |
| 429 | P | A | -0.2331 | |
| 430 | A | A | -0.3332 | |
| 431 | P | A | -0.5339 | |
| 432 | E | A | -0.9660 | |
| 433 | L | A | 1.2370 | |
| 434 | L | A | 1.6457 | |
| 435 | G | A | 0.1218 | |
| 436 | G | A | -0.3021 | |
| 437 | P | A | 0.0000 | |
| 438 | S | A | -0.0980 | |
| 439 | V | A | 0.0000 | |
| 440 | F | A | 0.8090 | |
| 441 | L | A | 0.0000 | |
| 442 | F | A | 0.9207 | |
| 443 | P | A | -0.2078 | |
| 444 | P | A | 0.0000 | |
| 445 | K | A | -1.9276 | |
| 446 | P | A | -1.3616 | |
| 447 | K | A | -1.3902 | |
| 448 | D | A | 0.0000 | |
| 449 | T | A | 0.0000 | |
| 450 | L | A | -0.3406 | |
| 451 | M | A | 0.4048 | |
| 452 | I | A | 1.4393 | |
| 453 | S | A | 0.1376 | |
| 454 | R | A | -1.0006 | |
| 455 | T | A | -0.7288 | |
| 456 | P | A | 0.0000 | |
| 457 | E | A | -1.0654 | |
| 458 | V | A | 0.0000 | |
| 459 | T | A | 0.0802 | |
| 460 | C | A | 0.0000 | |
| 461 | V | A | 0.0000 | |
| 462 | V | A | 0.0000 | |
| 463 | V | A | -0.7886 | |
| 464 | D | A | -1.6156 | |
| 465 | V | A | 0.0000 | |
| 466 | S | A | -1.9256 | |
| 467 | H | A | -2.6448 | |
| 468 | E | A | -2.9935 | |
| 469 | D | A | -2.6747 | |
| 470 | P | A | -2.7508 | |
| 471 | E | A | -3.1346 | |
| 472 | V | A | -2.0209 | |
| 473 | K | A | -2.2335 | |
| 474 | F | A | -1.1493 | |
| 475 | N | A | -1.3133 | |
| 476 | W | A | 0.0000 | |
| 477 | Y | A | -0.9548 | |
| 478 | V | A | -1.0708 | |
| 479 | D | A | -2.2385 | |
| 480 | G | A | -1.1000 | |
| 481 | V | A | 0.1587 | |
| 482 | E | A | -1.4245 | |
| 483 | V | A | -1.0324 | |
| 484 | H | A | -1.9405 | |
| 485 | N | A | -2.0312 | |
| 486 | A | A | -1.7905 | |
| 487 | K | A | -2.3737 | |
| 488 | T | A | -2.0428 | |
| 489 | K | A | -2.6121 | |
| 490 | P | A | -2.5813 | |
| 491 | R | A | -3.8096 | |
| 492 | E | A | -4.1172 | |
| 493 | E | A | -3.6609 | |
| 494 | Q | A | -2.1410 | |
| 495 | Y | A | 0.1195 | |
| 496 | N | A | -0.9023 | |
| 497 | S | A | -1.3912 | |
| 498 | T | A | -2.1081 | |
| 499 | Y | A | 0.0000 | |
| 500 | R | A | -2.6455 | |
| 501 | V | A | 0.0000 | |
| 502 | V | A | 0.0000 | |
| 503 | S | A | 0.0000 | |
| 504 | V | A | 0.0000 | |
| 505 | L | A | 0.0000 | |
| 506 | T | A | -0.6460 | |
| 507 | V | A | 0.0000 | |
| 508 | L | A | 0.3853 | |
| 509 | H | A | -0.2505 | |
| 510 | Q | A | -1.2340 | |
| 511 | D | A | -1.3414 | |
| 512 | W | A | 0.0000 | |
| 513 | L | A | -1.0105 | |
| 514 | N | A | -2.2089 | |
| 515 | G | A | -2.0848 | |
| 516 | K | A | -2.2497 | |
| 517 | E | A | -2.2425 | |
| 518 | Y | A | 0.0000 | |
| 519 | K | A | -1.6993 | |
| 520 | C | A | 0.0000 | |
| 521 | K | A | -1.4438 | |
| 522 | V | A | 0.0000 | |
| 523 | S | A | -1.4470 | |
| 524 | N | A | 0.0000 | |
| 525 | K | A | -2.5996 | |
| 526 | A | A | -1.5981 | |
| 527 | L | A | -0.6297 | |
| 528 | P | A | -0.1801 | |
| 529 | A | A | -0.2310 | |
| 530 | P | A | -0.8516 | |
| 531 | I | A | -0.5511 | |
| 532 | E | A | -2.0308 | |
| 533 | K | A | -1.2733 | |
| 534 | T | A | -1.0713 | |
| 535 | I | A | -0.2772 | |
| 536 | S | A | -1.2117 | |
| 537 | K | A | -1.3629 | |
| 538 | A | A | -1.2153 | |
| 539 | K | A | -2.3571 | |
| 540 | G | A | -2.0161 | |
| 541 | Q | A | -2.2088 | |
| 542 | P | A | -1.9229 | |
| 543 | R | A | -2.3846 | |
| 544 | E | A | -2.8234 | |
| 545 | P | A | 0.0000 | |
| 546 | Q | A | -1.4536 | |
| 547 | V | A | 0.0000 | |
| 548 | Y | A | 0.0000 | |
| 549 | T | A | 0.0000 | |
| 550 | L | A | 0.0000 | |
| 551 | P | A | -0.2405 | |
| 552 | P | A | 0.0000 | |
| 553 | S | A | 0.0000 | |
| 554 | W | A | -0.2301 | |
| 555 | D | A | -1.7197 | |
| 556 | E | A | 0.0000 | |
| 557 | R | A | -1.8818 | |
| 558 | T | A | -1.7578 | |
| 559 | K | A | -2.7894 | |
| 560 | E | A | -3.0869 | |
| 561 | E | A | -2.6804 | |
| 562 | V | A | 0.0000 | |
| 563 | S | A | 0.0000 | |
| 564 | L | A | 0.0000 | |
| 565 | T | A | 0.0000 | |
| 566 | C | A | 0.0000 | |
| 567 | L | A | 0.0000 | |
| 568 | V | A | 0.0000 | |
| 569 | K | A | -0.6268 | |
| 570 | G | A | -1.1510 | |
| 571 | F | A | 0.0000 | |
| 572 | Y | A | -1.1380 | |
| 573 | P | A | 0.0000 | |
| 574 | S | A | -0.1711 | |
| 575 | D | A | -1.1572 | |
| 576 | I | A | -0.6025 | |
| 577 | A | A | 0.0000 | |
| 578 | V | A | 0.0000 | |
| 579 | E | A | -1.4968 | |
| 580 | W | A | 0.0000 | |
| 581 | E | A | -1.8482 | |
| 582 | S | A | 0.0000 | |
| 583 | N | A | -1.8165 | |
| 584 | G | A | -1.7714 | |
| 585 | Q | A | -2.2736 | |
| 586 | P | A | -1.9839 | |
| 587 | E | A | -1.9297 | |
| 588 | N | A | -2.1944 | |
| 589 | N | A | -1.5913 | |
| 590 | Y | A | -1.1987 | |
| 591 | K | A | -1.0081 | |
| 592 | T | A | -0.3562 | |
| 593 | T | A | 0.0000 | |
| 594 | P | A | -0.1563 | |
| 595 | P | A | 0.1858 | |
| 596 | V | A | 0.5697 | |
| 597 | L | A | 0.9197 | |
| 598 | D | A | -0.4957 | |
| 599 | S | A | -1.1517 | |
| 600 | D | A | -1.8695 | |
| 601 | G | A | -0.8134 | |
| 602 | S | A | 0.0000 | |
| 603 | F | A | 0.1983 | |
| 604 | F | A | 0.0000 | |
| 605 | L | A | 0.0000 | |
| 606 | Y | A | 0.0000 | |
| 607 | S | A | 0.0000 | |
| 608 | K | A | 0.0000 | |
| 609 | L | A | 0.0000 | |
| 610 | T | A | -0.6910 | |
| 611 | V | A | 0.0000 | |
| 612 | W | A | -1.0071 | |
| 613 | A | A | 0.0000 | |
| 614 | R | A | -1.2118 | |
| 615 | R | A | -0.4628 | |
| 616 | W | A | 0.0000 | |
| 617 | W | A | 0.5594 | |
| 618 | W | A | 0.8937 | |
| 619 | G | A | 0.0358 | |
| 620 | N | A | -0.2353 | |
| 621 | V | A | -0.1365 | |
| 622 | F | A | 0.0000 | |
| 623 | S | A | 0.0000 | |
| 624 | C | A | 0.0000 | |
| 625 | S | A | 0.0000 | |
| 626 | V | A | 0.0000 | |
| 627 | M | A | -0.4365 | |
| 628 | H | A | 0.0000 | |
| 629 | E | A | -1.1960 | |
| 630 | A | A | -1.5769 | |
| 631 | L | A | -1.5019 | |
| 632 | H | A | -1.7532 | |
| 633 | N | A | -1.6139 | |
| 634 | H | A | -1.1122 | |
| 635 | Y | A | -0.2756 | |
| 636 | T | A | -0.5086 | |
| 637 | Q | A | -0.7974 | |
| 638 | K | A | -1.0534 | |
| 639 | S | A | -0.5129 | |
| 640 | L | A | 0.0000 | |
| 641 | S | A | -0.4466 | |
| 642 | R | A | -0.9509 | |
| 643 | S | A | -0.9789 | |
| 644 | P | A | -1.1891 | |
| 645 | G | A | -1.6115 | |
| 646 | K | A | -2.0038 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine