Project name: 10aeb6c2752f0e6

Chain sequence(s)	A: MRVLYLLFSFLFIFLMPLPGVFGGIGDPVTCLKSGAICHPVFCPRRYKQIGTCGLPGTKCCKKPEAAKRVKVKSMSKGPGPGSVIPMLMSFGPGPGHLSFLTFSWAAYTPSIQAIVPLLVPEEGPGPGMWIFLLSNKLSGHSVGPGPGKGEVVVNGRIAYVPQGPGPGPEEELVKANSWNQFLQSGKKVSEYARKKLAATERTYGLRFKDQRVHVVSKSERVKMPKKKKEEDIRKLVTMYPDNITIAEERKKRLSFFTGFDSVEH
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:04:29)
[INFO]       Main:     Simulation completed successfully.                                          (00:04:31)

• Minimal score value: -4.9096
• Maximal score value: 5.8088
• Average score: -0.0597
• Total score value: -15.8216

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	1.3815
2	R	A	0.5371
3	V	A	2.8483
4	L	A	3.5207
5	Y	A	3.5632
6	L	A	3.5965
7	L	A	4.4118
8	F	A	5.3173
9	S	A	4.7289
10	F	A	5.3989
11	L	A	5.4636
12	F	A	5.8088
13	I	A	5.7526
14	F	A	5.4951
15	L	A	4.6686
16	M	A	3.5380
17	P	A	2.3518
18	L	A	2.7373
19	P	A	0.9293
20	G	A	0.9932
21	V	A	2.5419
22	F	A	2.5085
23	G	A	0.7468
24	G	A	0.0570
25	I	A	-0.0015
26	G	A	-0.7211
27	D	A	-0.5901
28	P	A	0.4671
29	V	A	1.3190
30	T	A	0.0875
31	C	A	0.0000
32	L	A	1.1927
33	K	A	-0.5783
34	S	A	-0.2358
35	G	A	-0.6789
36	A	A	0.0000
37	I	A	0.5547
38	C	A	0.9263
39	H	A	0.4670
40	P	A	1.0207
41	V	A	2.1793
42	F	A	1.9389
43	C	A	-0.2709
44	P	A	-1.3825
45	R	A	-2.8173
46	R	A	-3.4159
47	Y	A	-2.8146
48	K	A	-3.0300
49	Q	A	-1.7609
50	I	A	-0.7385
51	G	A	-0.9367
52	T	A	-0.8068
53	C	A	0.0000
54	G	A	-0.3070
55	L	A	0.7013
56	P	A	0.2481
57	G	A	0.3660
58	T	A	0.4569
59	K	A	-0.1966
60	C	A	0.0000
61	C	A	0.0000
62	K	A	-2.2419
63	K	A	-3.3228
64	P	A	-2.6605
65	E	A	-2.6337
66	A	A	-1.8221
67	A	A	-1.6049
68	K	A	-2.6022
69	R	A	-2.0326
70	V	A	-0.1643
71	K	A	-1.3497
72	V	A	0.4605
73	K	A	-0.9276
74	S	A	-0.5081
75	M	A	0.1290
76	S	A	-0.9631
77	K	A	-1.8947
78	G	A	-1.5120
79	P	A	-1.2505
80	G	A	-1.1203
81	P	A	-0.6490
82	G	A	-0.2330
83	S	A	0.8807
84	V	A	2.5713
85	I	A	3.0991
86	P	A	2.2067
87	M	A	2.6777
88	L	A	2.8884
89	M	A	2.3220
90	S	A	1.6207
91	F	A	1.8938
92	G	A	0.3109
93	P	A	-0.3078
94	G	A	-0.8190
95	P	A	-0.9726
96	G	A	-0.8532
97	H	A	-0.4212
98	L	A	1.4904
99	S	A	1.5317
100	F	A	3.0742
101	L	A	3.1412
102	T	A	2.2599
103	F	A	2.8360
104	S	A	1.5162
105	W	A	1.8705
106	A	A	1.1753
107	A	A	0.9650
108	Y	A	1.4581
109	T	A	0.7131
110	P	A	0.2865
111	S	A	0.4210
112	I	A	1.5195
113	Q	A	0.4722
114	A	A	1.4312
115	I	A	2.9918
116	V	A	3.0649
117	P	A	2.5242
118	L	A	3.3653
119	L	A	3.0275
120	V	A	2.1402
121	P	A	-0.2236
122	E	A	-2.4094
123	E	A	-2.9103
124	G	A	-2.0952
125	P	A	-1.3068
126	G	A	-0.9358
127	P	A	-0.0618
128	G	A	0.6868
129	M	A	2.1334
130	W	A	3.2352
131	I	A	4.2115
132	F	A	4.0617
133	L	A	3.2118
134	L	A	2.7689
135	S	A	1.2292
136	N	A	-0.7472
137	K	A	-1.1961
138	L	A	0.2016
139	S	A	-0.7765
140	G	A	-0.9016
141	H	A	-0.6880
142	S	A	-0.1343
143	V	A	0.9753
144	G	A	-0.0227
145	P	A	-0.5144
146	G	A	-0.9775
147	P	A	-1.1806
148	G	A	-2.0649
149	K	A	-2.2729
150	G	A	-1.4660
151	E	A	-0.4055
152	V	A	1.4844
153	V	A	2.0894
154	V	A	1.2175
155	N	A	-0.6802
156	G	A	-0.6128
157	R	A	-0.6124
158	I	A	1.6052
159	A	A	1.7023
160	Y	A	1.7151
161	V	A	1.4210
162	P	A	-0.1791
163	Q	A	-1.4483
164	G	A	-1.1026
165	P	A	-1.0717
166	G	A	-1.0929
167	P	A	-1.6602
168	G	A	-1.6246
169	P	A	-1.6689
170	E	A	-2.4425
171	E	A	-2.3654
172	E	A	-2.5055
173	L	A	-0.3437
174	V	A	0.0006
175	K	A	-1.8036
176	A	A	-1.1038
177	N	A	-1.2641
178	S	A	-0.2523
179	W	A	0.2323
180	N	A	-1.2341
181	Q	A	-0.9405
182	F	A	1.0634
183	L	A	0.8727
184	Q	A	-0.9028
185	S	A	-0.8553
186	G	A	-1.3114
187	K	A	-1.9202
188	K	A	-2.1052
189	V	A	-0.2530
190	S	A	-1.0299
191	E	A	-2.3523
192	Y	A	-0.7715
193	A	A	-1.2275
194	R	A	-2.6541
195	K	A	-3.0539
196	K	A	-2.5681
197	L	A	-1.1543
198	A	A	-1.8374
199	A	A	-1.6690
200	T	A	-1.0750
201	E	A	-1.2864
202	R	A	-1.8943
203	T	A	-0.4259
204	Y	A	0.4357
205	G	A	-0.2660
206	L	A	0.4199
207	R	A	-1.3906
208	F	A	-0.7722
209	K	A	-2.5943
210	D	A	-3.2195
211	Q	A	-2.7153
212	R	A	-2.0516
213	V	A	0.7930
214	H	A	0.6061
215	V	A	2.1648
216	V	A	2.0110
217	S	A	-0.2524
218	K	A	-1.9235
219	S	A	-2.0169
220	E	A	-3.0163
221	R	A	-2.4964
222	V	A	-0.3613
223	K	A	-1.5697
224	M	A	-1.0526
225	P	A	-1.8172
226	K	A	-3.2691
227	K	A	-3.8508
228	K	A	-4.3173
229	K	A	-4.8636
230	E	A	-4.9096
231	E	A	-4.6708
232	D	A	-3.7982
233	I	A	-2.6200
234	R	A	-3.5351
235	K	A	-2.5796
236	L	A	-0.1278
237	V	A	0.0418
238	T	A	-0.0477
239	M	A	1.0108
240	Y	A	1.0474
241	P	A	-0.2110
242	D	A	-1.8065
243	N	A	-1.3126
244	I	A	0.5576
245	T	A	0.5421
246	I	A	1.6517
247	A	A	0.1558
248	E	A	-2.6692
249	E	A	-4.0278
250	R	A	-4.6041
251	K	A	-4.3103
252	K	A	-3.8254
253	R	A	-2.7902
254	L	A	-0.1275
255	S	A	0.9134
256	F	A	2.9204
257	F	A	3.3655
258	T	A	1.4993
259	G	A	0.9723
260	F	A	1.3619
261	D	A	-0.7800
262	S	A	-0.3415
263	V	A	0.3055
264	E	A	-1.7260
265	H	A	-1.4403