Project name: 11b8a66b238bafb

Chain sequence(s)	A: LIKENNMRMMKVVLEGSVNGHQQFKCTGEGEGNNPYMGTQTMMRIKVIEGGPLPFAFDILATSFAAASRTFIKYPKGIPDFFKQSSFPEGFTWEERVTRYEDGGVIITVMQDTSLEDGCCLVYHHAQVVRGVNFPSNNGAVMQKKTKGWEPNTEMMMYPADGGLRGYTTHMALKVDGGGHLLSCSSFVTTYRSKKTVGNIKMPGIHAVSHRLERLEESDNNEMMFVVQRREHHAVAKFAGLGGG
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:03:09)
[INFO]       Main:     Simulation completed successfully.                                          (00:03:10)

• Minimal score value: -3.1675
• Maximal score value: 1.2468
• Average score: -0.7815
• Total score value: -172.7203

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
4	L	A	0.8412
5	I	A	-0.6644
6	K	A	-2.6084
7	E	A	-2.8088
8	N	A	-2.9750
9	M	A	0.0000
10	R	A	-2.3551
11	M	A	0.0000
12	K	A	-1.9152
13	V	A	0.0000
14	V	A	-0.5115
15	L	A	0.0000
16	E	A	-1.5611
17	G	A	-1.8223
18	S	A	0.0000
19	V	A	0.0000
20	N	A	-1.3449
21	G	A	-1.4444
22	H	A	-1.4607
23	Q	A	-2.3537
24	F	A	0.0000
25	K	A	-1.3174
26	C	A	0.0000
27	T	A	-0.6462
28	G	A	0.0000
29	E	A	-1.9141
30	G	A	0.0000
31	E	A	-1.8979
32	G	A	0.0000
33	N	A	-1.4816
34	P	A	0.0000
35	Y	A	0.2494
36	M	A	0.5850
37	G	A	0.0000
38	T	A	-0.6269
39	Q	A	0.0000
40	T	A	-1.3394
41	M	A	0.0000
42	R	A	-1.6036
43	I	A	0.0000
44	K	A	-0.6412
45	V	A	0.0000
46	I	A	0.6366
47	E	A	-1.5645
48	G	A	-1.2540
49	G	A	-0.9690
50	P	A	-0.7175
51	L	A	0.0000
52	P	A	-0.6679
53	F	A	0.0000
54	A	A	0.0000
55	F	A	0.0000
56	D	A	0.0000
57	I	A	0.0000
58	L	A	0.0000
59	A	A	0.0000
60	T	A	-0.0186
61	S	A	0.0000
62	F	A	0.0000
66	S	A	-0.0345
67	R	A	0.0000
68	T	A	0.0000
69	F	A	0.0000
70	I	A	0.0000
71	K	A	-0.1363
72	Y	A	-0.5789
73	P	A	-1.0026
74	K	A	-2.1019
75	G	A	-1.2925
76	I	A	0.0000
77	P	A	-1.0121
78	D	A	-0.8626
79	F	A	0.0000
80	F	A	0.0000
81	K	A	-0.0095
82	Q	A	-0.8151
83	S	A	0.0000
84	F	A	0.0000
85	P	A	-0.4146
86	E	A	-0.9887
87	G	A	0.0000
88	F	A	0.0000
89	T	A	-1.1048
90	W	A	0.0000
91	E	A	-0.4938
92	R	A	0.0000
93	V	A	0.2225
94	T	A	0.0000
95	R	A	-2.3412
96	Y	A	0.0000
97	E	A	-2.6552
98	D	A	-2.0209
99	G	A	-1.5871
100	G	A	0.0000
101	V	A	-0.9454
102	I	A	0.0000
103	T	A	-0.5091
104	V	A	0.0000
105	M	A	-0.3646
106	Q	A	0.0000
107	D	A	-1.2212
108	T	A	0.0000
109	S	A	-1.0344
110	L	A	-1.0539
111	E	A	-2.8483
112	D	A	-2.7846
113	G	A	-1.8995
114	C	A	-1.6086
115	L	A	0.0000
116	V	A	-1.2001
117	Y	A	0.0000
118	H	A	-0.8701
119	A	A	0.0000
120	Q	A	-1.7999
121	V	A	0.0000
122	R	A	-2.0666
123	G	A	0.0000
124	V	A	-0.1469
125	N	A	-1.1736
126	F	A	0.0000
127	P	A	-1.1085
128	S	A	-1.2876
129	N	A	-1.8040
130	G	A	-1.2932
131	A	A	-1.8245
132	V	A	0.0000
133	M	A	-1.1714
134	Q	A	-1.7672
135	K	A	-2.1545
136	K	A	-2.7755
137	T	A	-2.4678
138	K	A	-2.9984
139	G	A	-1.6465
140	W	A	0.0000
141	E	A	-1.5968
142	P	A	-1.3433
143	N	A	-0.9766
144	T	A	-0.5325
145	E	A	0.0000
146	M	A	0.4339
147	M	A	0.0000
148	Y	A	0.2191
149	P	A	-0.5421
150	A	A	-1.2827
151	D	A	-2.2755
152	G	A	-1.9451
153	G	A	-1.6410
154	L	A	0.0000
155	R	A	-0.8644
156	G	A	0.0000
157	Y	A	0.6255
158	T	A	0.0000
159	H	A	-1.0369
160	M	A	0.0000
161	A	A	-1.0623
162	L	A	0.0000
163	K	A	-2.3684
164	V	A	-2.4819
165	D	A	-3.1675
166	G	A	-2.0731
167	G	A	-1.8491
168	G	A	-1.6296
169	H	A	-1.9225
170	L	A	-0.9957
171	S	A	-1.5100
172	C	A	0.0000
173	S	A	-0.9683
174	F	A	0.0000
175	V	A	0.4181
176	T	A	0.0000
177	T	A	-0.5349
178	Y	A	0.0000
179	R	A	-2.6038
180	S	A	-1.5420
181	K	A	-1.3229
182	K	A	-0.9000
183	T	A	0.0197
184	V	A	0.9806
185	G	A	-0.4574
186	N	A	-1.4709
187	I	A	-1.2356
188	K	A	-1.9518
189	M	A	-0.9643
190	P	A	0.0000
191	G	A	-0.0351
192	I	A	0.5846
193	H	A	0.0000
194	A	A	0.0000
195	V	A	0.0000
196	S	A	-0.7398
197	H	A	0.0000
198	R	A	-2.2290
199	L	A	-1.7111
200	E	A	-1.9412
201	R	A	-1.8809
202	L	A	-1.2889
203	E	A	-2.6997
204	E	A	-3.0694
205	S	A	-2.2913
206	D	A	-2.5435
207	N	A	-2.0164
208	E	A	-1.8505
209	M	A	-0.6761
210	F	A	-0.7540
211	V	A	0.0000
212	V	A	0.0000
213	Q	A	0.0000
214	R	A	-2.3491
215	E	A	-1.8173
216	H	A	-1.3491
217	A	A	0.0000
218	V	A	-0.1138
219	A	A	0.0000
220	K	A	-0.6132
221	F	A	1.2468
222	A	A	0.6276
223	G	A	0.4562
224	L	A	1.1820
225	G	A	0.4027
226	G	A	0.5136
227	G	A	-0.1836