| Chain sequence(s) |
A: LPFGEVFNATRFASVYAWNRKRISNVADYSVLYNSASFSTFKYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPNGVEGFNYFPLQSYGFQPTNGVGYQPYRVVVLSFELAIRMTQSPSFLSASVGDRVTITRASQDINSFLAWYQQRPGKAPKLLIYGASNLETGVPSRFSGGGSGTDFTLTISSLQPEDIATYYQQYDKLPTFGQGTRLEIVQLLETGGGLVKPGGSLRLSAASGFSLSDYYMNWIRQAPGKGLEWVAYISSSSGYTNYGDSVDGRFTISRDAKNSLYLQMNSLRVEDTAVYYVRDRDDFWSGYYKWGLGTLVTVS
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:03:35)
[INFO] Main: Simulation completed successfully. (00:03:37)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | L | A | 1.8553 | |
| 3 | P | A | -0.4108 | |
| 4 | F | A | 0.0000 | |
| 5 | G | A | -1.5843 | |
| 6 | E | A | -2.6059 | |
| 7 | V | A | 0.0000 | |
| 8 | F | A | 0.0000 | |
| 9 | N | A | -2.3168 | |
| 10 | A | A | -1.6072 | |
| 11 | T | A | -1.1584 | |
| 12 | R | A | -1.9375 | |
| 13 | F | A | 0.0000 | |
| 14 | A | A | -0.4407 | |
| 15 | S | A | -0.2738 | |
| 16 | V | A | 0.0000 | |
| 17 | Y | A | 0.6642 | |
| 18 | A | A | 0.4014 | |
| 19 | W | A | 0.0000 | |
| 20 | N | A | -0.5815 | |
| 21 | R | A | -0.7117 | |
| 22 | K | A | -0.8015 | |
| 23 | R | A | -1.0238 | |
| 24 | I | A | -0.2531 | |
| 25 | S | A | -0.7146 | |
| 26 | N | A | -0.8908 | |
| 28 | V | A | 2.0077 | |
| 29 | A | A | 0.8487 | |
| 30 | D | A | -0.0565 | |
| 31 | Y | A | 0.0000 | |
| 32 | S | A | 0.0207 | |
| 33 | V | A | 0.7042 | |
| 34 | L | A | 0.0000 | |
| 35 | Y | A | 0.4251 | |
| 36 | N | A | -0.5503 | |
| 37 | S | A | -0.1708 | |
| 38 | A | A | -0.1024 | |
| 39 | S | A | -0.3018 | |
| 40 | F | A | 0.0000 | |
| 41 | S | A | -0.0994 | |
| 42 | T | A | -0.0477 | |
| 43 | F | A | 0.0710 | |
| 44 | K | A | -0.6326 | |
| 46 | Y | A | -0.1802 | |
| 47 | G | A | -0.4298 | |
| 48 | V | A | -0.2611 | |
| 49 | S | A | -0.6686 | |
| 50 | P | A | -0.7796 | |
| 51 | T | A | -1.0453 | |
| 52 | K | A | -1.9318 | |
| 53 | L | A | 0.0000 | |
| 54 | N | A | -1.8344 | |
| 55 | D | A | -2.0384 | |
| 56 | L | A | -0.1765 | |
| 57 | C | A | 0.2471 | |
| 58 | F | A | 0.5379 | |
| 59 | T | A | 0.0404 | |
| 60 | N | A | -0.4745 | |
| 61 | V | A | 0.0000 | |
| 62 | Y | A | -0.3290 | |
| 63 | A | A | 0.0000 | |
| 64 | D | A | 0.0000 | |
| 65 | S | A | 0.0000 | |
| 66 | F | A | 0.0000 | |
| 67 | V | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | R | A | -0.1535 | |
| 70 | G | A | -0.5422 | |
| 71 | D | A | -1.5469 | |
| 72 | E | A | 0.0000 | |
| 73 | V | A | -1.2932 | |
| 74 | R | A | -2.3173 | |
| 75 | Q | A | -1.6971 | |
| 76 | I | A | 0.0000 | |
| 77 | A | A | -0.9899 | |
| 78 | P | A | -1.5847 | |
| 79 | G | A | -1.4681 | |
| 80 | Q | A | -1.4836 | |
| 81 | T | A | -1.1064 | |
| 82 | G | A | -0.7188 | |
| 83 | K | A | -0.8925 | |
| 84 | I | A | 0.0000 | |
| 85 | A | A | 0.0000 | |
| 86 | D | A | -1.2543 | |
| 87 | Y | A | -1.0635 | |
| 88 | N | A | 0.0000 | |
| 89 | Y | A | 0.0000 | |
| 90 | K | A | -1.4297 | |
| 91 | L | A | 0.0000 | |
| 92 | P | A | -1.8724 | |
| 93 | D | A | -2.8732 | |
| 94 | D | A | -2.6667 | |
| 95 | F | A | -1.1577 | |
| 96 | T | A | -0.3819 | |
| 97 | G | A | 0.0207 | |
| 99 | V | A | 0.0000 | |
| 100 | I | A | 0.0000 | |
| 101 | A | A | 0.0000 | |
| 102 | W | A | 0.0000 | |
| 103 | N | A | -0.2834 | |
| 104 | S | A | 0.0000 | |
| 105 | N | A | -0.7208 | |
| 106 | N | A | -1.4118 | |
| 107 | L | A | -0.5912 | |
| 108 | D | A | 0.0000 | |
| 109 | S | A | -0.9127 | |
| 110 | K | A | -1.2261 | |
| 111 | V | A | 0.5630 | |
| 112 | G | A | -0.0453 | |
| 113 | G | A | -0.3037 | |
| 114 | N | A | 0.0000 | |
| 115 | Y | A | 0.2695 | |
| 116 | N | A | -0.7623 | |
| 117 | Y | A | 0.0000 | |
| 118 | L | A | 0.2756 | |
| 119 | Y | A | 0.0000 | |
| 120 | R | A | 0.0000 | |
| 121 | L | A | 0.6333 | |
| 122 | F | A | 0.0618 | |
| 123 | R | A | -1.2428 | |
| 124 | K | A | -2.3180 | |
| 125 | S | A | -1.8153 | |
| 126 | N | A | -2.2875 | |
| 127 | L | A | 0.0000 | |
| 128 | K | A | -2.5220 | |
| 129 | P | A | -1.6435 | |
| 130 | F | A | -0.8322 | |
| 131 | E | A | -1.9139 | |
| 132 | R | A | -0.9870 | |
| 133 | D | A | -0.2413 | |
| 134 | I | A | 1.0616 | |
| 135 | S | A | 0.0207 | |
| 136 | T | A | -0.2463 | |
| 137 | E | A | -1.5708 | |
| 138 | I | A | -0.5272 | |
| 139 | Y | A | -0.5362 | |
| 140 | Q | A | -1.4988 | |
| 141 | A | A | -0.6558 | |
| 142 | G | A | -0.6793 | |
| 143 | S | A | -0.7279 | |
| 144 | T | A | -0.8842 | |
| 145 | P | A | -0.8600 | |
| 147 | N | A | -1.5550 | |
| 148 | G | A | -0.6306 | |
| 149 | V | A | 0.4896 | |
| 150 | E | A | -0.8154 | |
| 151 | G | A | 0.0055 | |
| 152 | F | A | 1.1180 | |
| 153 | N | A | -0.4834 | |
| 155 | Y | A | 0.7003 | |
| 156 | F | A | 0.9198 | |
| 157 | P | A | 0.0000 | |
| 158 | L | A | 0.3665 | |
| 159 | Q | A | -0.0654 | |
| 160 | S | A | -0.0408 | |
| 161 | Y | A | 0.0000 | |
| 162 | G | A | -0.0338 | |
| 163 | F | A | 0.0000 | |
| 164 | Q | A | -0.5888 | |
| 165 | P | A | -0.7245 | |
| 166 | T | A | -0.0761 | |
| 167 | N | A | 0.0858 | |
| 168 | G | A | 0.4988 | |
| 169 | V | A | 1.3861 | |
| 170 | G | A | 0.2903 | |
| 171 | Y | A | 0.9733 | |
| 172 | Q | A | 0.1800 | |
| 173 | P | A | 0.0000 | |
| 174 | Y | A | 0.0493 | |
| 175 | R | A | -0.4928 | |
| 176 | V | A | 0.0000 | |
| 177 | V | A | 0.0000 | |
| 178 | V | A | 0.0000 | |
| 179 | L | A | 0.0000 | |
| 180 | S | A | 0.0000 | |
| 181 | F | A | 0.0000 | |
| 182 | E | A | 0.0133 | |
| 183 | L | A | 1.2347 | |
| 184 | A | A | -0.7133 | |
| 185 | I | A | -1.0373 | |
| 186 | R | A | -1.8445 | |
| 187 | M | A | 0.0000 | |
| 188 | T | A | -1.0762 | |
| 189 | Q | A | -0.6907 | |
| 190 | S | A | -0.4302 | |
| 191 | P | A | -0.1497 | |
| 192 | S | A | -0.1154 | |
| 193 | F | A | 0.5811 | |
| 194 | L | A | 0.0000 | |
| 195 | S | A | -0.0307 | |
| 196 | A | A | -0.1629 | |
| 197 | S | A | 0.1841 | |
| 198 | V | A | 1.0287 | |
| 199 | G | A | -0.7266 | |
| 200 | D | A | -1.5208 | |
| 201 | R | A | -2.1599 | |
| 202 | V | A | -0.9466 | |
| 203 | T | A | -0.3729 | |
| 204 | I | A | 0.0000 | |
| 205 | T | A | -0.3422 | |
| 207 | R | A | -0.9879 | |
| 208 | A | A | 0.0000 | |
| 209 | S | A | -1.0997 | |
| 210 | Q | A | -1.1587 | |
| 211 | D | A | -1.0009 | |
| 212 | I | A | 0.0000 | |
| 213 | N | A | -0.7294 | |
| 214 | S | A | -0.2174 | |
| 215 | F | A | 0.2493 | |
| 216 | L | A | 0.0000 | |
| 217 | A | A | 0.0000 | |
| 218 | W | A | 0.0000 | |
| 219 | Y | A | 0.0000 | |
| 220 | Q | A | 0.0000 | |
| 221 | Q | A | 0.0000 | |
| 222 | R | A | -1.7036 | |
| 223 | P | A | -1.4221 | |
| 224 | G | A | -1.5357 | |
| 225 | K | A | -1.9832 | |
| 226 | A | A | -0.7872 | |
| 227 | P | A | 0.0000 | |
| 228 | K | A | -1.5132 | |
| 229 | L | A | 0.0000 | |
| 230 | L | A | 0.0000 | |
| 231 | I | A | 0.0000 | |
| 232 | Y | A | -0.0391 | |
| 233 | G | A | 0.0792 | |
| 234 | A | A | 0.0000 | |
| 235 | S | A | -0.5312 | |
| 236 | N | A | -0.6635 | |
| 237 | L | A | 0.1588 | |
| 238 | E | A | 0.0000 | |
| 239 | T | A | -0.2028 | |
| 240 | G | A | -0.3561 | |
| 241 | V | A | -0.1146 | |
| 242 | P | A | -0.3019 | |
| 243 | S | A | -0.4521 | |
| 244 | R | A | -0.9987 | |
| 245 | F | A | 0.0000 | |
| 246 | S | A | -0.4618 | |
| 247 | G | A | -0.4196 | |
| 248 | G | A | -0.6792 | |
| 249 | G | A | -0.6842 | |
| 250 | S | A | -0.8479 | |
| 251 | G | A | -0.9579 | |
| 252 | T | A | 0.0000 | |
| 253 | D | A | -0.9356 | |
| 254 | F | A | 0.0000 | |
| 255 | T | A | -0.4047 | |
| 256 | L | A | 0.0000 | |
| 257 | T | A | 0.0000 | |
| 258 | I | A | 0.0000 | |
| 259 | S | A | -1.3703 | |
| 260 | S | A | -1.1578 | |
| 261 | L | A | 0.0000 | |
| 262 | Q | A | -0.6711 | |
| 263 | P | A | -0.8297 | |
| 264 | E | A | -2.0339 | |
| 265 | D | A | 0.0000 | |
| 266 | I | A | -0.7370 | |
| 267 | A | A | 0.0000 | |
| 268 | T | A | -0.7478 | |
| 269 | Y | A | 0.0000 | |
| 270 | Y | A | 0.0000 | |
| 272 | Q | A | 0.0000 | |
| 273 | Q | A | 0.0000 | |
| 274 | Y | A | -0.3956 | |
| 275 | D | A | -1.4248 | |
| 276 | K | A | -1.5478 | |
| 277 | L | A | -0.0317 | |
| 278 | P | A | -0.1559 | |
| 279 | T | A | -0.6077 | |
| 280 | F | A | -0.5521 | |
| 281 | G | A | 0.0000 | |
| 282 | Q | A | -1.7635 | |
| 283 | G | A | -1.0796 | |
| 284 | T | A | 0.0000 | |
| 285 | R | A | -1.0036 | |
| 286 | L | A | 0.0000 | |
| 287 | E | A | -0.5600 | |
| 288 | I | A | 1.0320 | |
| 289 | V | A | 1.7486 | |
| 290 | Q | A | 0.7430 | |
| 291 | L | A | 0.0000 | |
| 292 | L | A | 1.0632 | |
| 293 | E | A | 0.5343 | |
| 294 | T | A | -0.0673 | |
| 295 | G | A | -0.7471 | |
| 296 | G | A | 0.1296 | |
| 297 | G | A | 0.6820 | |
| 298 | L | A | 1.4058 | |
| 299 | V | A | -0.1754 | |
| 300 | K | A | -1.7856 | |
| 301 | P | A | -1.6744 | |
| 302 | G | A | -1.5897 | |
| 303 | G | A | -1.3691 | |
| 304 | S | A | -1.3458 | |
| 305 | L | A | -0.8386 | |
| 306 | R | A | -2.0393 | |
| 307 | L | A | 0.0000 | |
| 308 | S | A | -0.5413 | |
| 310 | A | A | -0.1925 | |
| 311 | A | A | 0.0000 | |
| 312 | S | A | 0.2753 | |
| 313 | G | A | 0.2016 | |
| 314 | F | A | 1.0982 | |
| 315 | S | A | -0.2164 | |
| 316 | L | A | 0.0000 | |
| 317 | S | A | -1.3741 | |
| 318 | D | A | -1.7806 | |
| 319 | Y | A | -0.8487 | |
| 320 | Y | A | -0.0491 | |
| 321 | M | A | 0.0000 | |
| 322 | N | A | 0.0000 | |
| 323 | W | A | 0.0000 | |
| 324 | I | A | 0.0000 | |
| 325 | R | A | 0.0000 | |
| 326 | Q | A | -0.5824 | |
| 327 | A | A | -1.1324 | |
| 328 | P | A | -1.1059 | |
| 329 | G | A | -1.7153 | |
| 330 | K | A | -2.3971 | |
| 331 | G | A | -1.6246 | |
| 332 | L | A | 0.0000 | |
| 333 | E | A | -0.9481 | |
| 334 | W | A | 0.0000 | |
| 335 | V | A | 0.0000 | |
| 336 | A | A | 0.0000 | |
| 337 | Y | A | 0.2379 | |
| 338 | I | A | 0.0000 | |
| 339 | S | A | 0.0000 | |
| 340 | S | A | -0.3769 | |
| 341 | S | A | -0.1203 | |
| 342 | S | A | -0.2891 | |
| 343 | G | A | -0.0699 | |
| 344 | Y | A | 1.0338 | |
| 345 | T | A | 0.3906 | |
| 346 | N | A | -0.3020 | |
| 347 | Y | A | -1.0410 | |
| 348 | G | A | 0.0000 | |
| 349 | D | A | -2.5245 | |
| 350 | S | A | -1.9116 | |
| 351 | V | A | 0.0000 | |
| 352 | D | A | -2.7822 | |
| 353 | G | A | -1.8218 | |
| 354 | R | A | -1.4105 | |
| 355 | F | A | 0.0000 | |
| 356 | T | A | -0.8466 | |
| 357 | I | A | 0.0000 | |
| 358 | S | A | -0.5607 | |
| 359 | R | A | -1.3992 | |
| 360 | D | A | -2.0575 | |
| 362 | A | A | -1.4658 | |
| 363 | K | A | -2.5995 | |
| 364 | N | A | -2.3523 | |
| 365 | S | A | -1.5923 | |
| 366 | L | A | 0.0000 | |
| 367 | Y | A | -0.6280 | |
| 368 | L | A | 0.0000 | |
| 369 | Q | A | -1.2208 | |
| 370 | M | A | 0.0000 | |
| 371 | N | A | -1.3596 | |
| 372 | S | A | -1.4795 | |
| 373 | L | A | 0.0000 | |
| 374 | R | A | -2.2400 | |
| 375 | V | A | -0.3178 | |
| 376 | E | A | -1.6122 | |
| 377 | D | A | 0.0000 | |
| 378 | T | A | 0.0668 | |
| 379 | A | A | 0.0000 | |
| 380 | V | A | 0.9612 | |
| 381 | Y | A | 0.0000 | |
| 382 | Y | A | 0.0000 | |
| 384 | V | A | 0.0000 | |
| 385 | R | A | -0.9110 | |
| 386 | D | A | 0.0000 | |
| 387 | R | A | -1.5439 | |
| 388 | D | A | -0.9276 | |
| 389 | D | A | -1.2050 | |
| 390 | F | A | 1.1228 | |
| 391 | W | A | 1.0381 | |
| 392 | S | A | 0.1751 | |
| 393 | G | A | 0.0000 | |
| 394 | Y | A | 0.0000 | |
| 395 | Y | A | 0.0000 | |
| 396 | K | A | -2.2619 | |
| 398 | W | A | -0.1161 | |
| 399 | G | A | 0.0000 | |
| 400 | L | A | 1.2547 | |
| 401 | G | A | 0.8820 | |
| 402 | T | A | 1.0168 | |
| 403 | L | A | 1.7210 | |
| 404 | V | A | 0.0000 | |
| 405 | T | A | 0.5054 | |
| 406 | V | A | 0.0000 | |
| 407 | S | A | -0.2746 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine